Clinical outcomes of patients requiring ventilatory support in Brazilian intensive care units: a multicenter, prospective, cohort study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-04

AUTHORS

Luciano CP Azevedo, Marcelo Park, Jorge IF Salluh, Alvaro Rea-Neto, Vicente C Souza-Dantas, Pedro Varaschin, Mirella C Oliveira, Paulo Fernando GMM Tierno, Felipe dal-Pizzol, Ulysses VA Silva, Marcos Knibel, Antonio P Nassar, Rossine A Alves, Juliana C Ferreira, Cassiano Teixeira, Valeria Rezende, Amadeu Martinez, Paula M Luciano, Guilherme Schettino, Marcio Soares, The ERICC (Epidemiology of Respiratory Insufficiency in Critical Care) investigators

ABSTRACT

INTRODUCTION: Contemporary information on mechanical ventilation (MV) use in emerging countries is limited. Moreover, most epidemiological studies on ventilatory support were carried out before significant developments, such as lung protective ventilation or broader application of non-invasive ventilation (NIV). We aimed to evaluate the clinical characteristics, outcomes and risk factors for hospital mortality and failure of NIV in patients requiring ventilatory support in Brazilian intensive care units (ICU). METHODS: In a multicenter, prospective, cohort study, a total of 773 adult patients admitted to 45 ICUs over a two-month period requiring invasive ventilation or NIV for more than 24 hours were evaluated. Causes of ventilatory support, prior chronic health status and physiological data were assessed. Multivariate analysis was used to identifiy variables associated with hospital mortality and NIV failure. RESULTS: Invasive MV and NIV were used as initial ventilatory support in 622 (80%) and 151 (20%) patients. Failure with subsequent intubation occurred in 54% of NIV patients. The main reasons for ventilatory support were pneumonia (27%), neurologic disorders (19%) and non-pulmonary sepsis (12%). ICU and hospital mortality rates were 34% and 42%. Using the Berlin definition, acute respiratory distress syndrome (ARDS) was diagnosed in 31% of the patients with a hospital mortality of 52%. In the multivariate analysis, age (odds ratio (OR), 1.03; 95% confidence interval (CI), 1.01 to 1.03), comorbidities (OR, 2.30; 95% CI, 1.28 to 3.17), associated organ failures (OR, 1.12; 95% CI, 1.05 to 1.20), moderate (OR, 1.92; 95% CI, 1.10 to 3.35) to severe ARDS (OR, 2.12; 95% CI, 1.01 to 4.41), cumulative fluid balance over the first 72 h of ICU (OR, 2.44; 95% CI, 1.39 to 4.28), higher lactate (OR, 1.78; 95% CI, 1.27 to 2.50), invasive MV (OR, 2.67; 95% CI, 1.32 to 5.39) and NIV failure (OR, 3.95; 95% CI, 1.74 to 8.99) were independently associated with hospital mortality. The predictors of NIV failure were the severity of associated organ dysfunctions (OR, 1.20; 95% CI, 1.05 to 1.34), ARDS (OR, 2.31; 95% CI, 1.10 to 4.82) and positive fluid balance (OR, 2.09; 95% CI, 1.02 to 4.30). CONCLUSIONS: Current mortality of ventilated patients in Brazil is elevated. Implementation of judicious fluid therapy and a watchful use and monitoring of NIV patients are potential targets to improve outcomes in this setting. TRIAL REGISTRATION: ClinicalTrials.gov NCT01268410. More... »

PAGES

r63

References to SciGraph publications

  • 2008-06. A positive fluid balance is associated with a worse outcome in patients with acute renal failure in CRITICAL CARE
  • 2001-11. Predictors of failure of noninvasive positive pressure ventilation in patients with acute hypoxemic respiratory failure: a multi-center study in INTENSIVE CARE MEDICINE
  • 2009-08. Acute respiratory failure in intensive care units. FINNALI: a prospective cohort study in INTENSIVE CARE MEDICINE
  • 1996-07. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure in INTENSIVE CARE MEDICINE
  • 2009-05. Epidemiology of Mechanical Ventilation: Analysis of the SAPS 3 Database in INTENSIVE CARE MEDICINE
  • 2011-02. Impact of delayed admission to intensive care units on mortality of critically ill patients: a cohort study in CRITICAL CARE
  • 2012-03. Non-invasive ventilation in community-acquired pneumonia and severe acute respiratory failure in INTENSIVE CARE MEDICINE
  • 2005-10. SAPS 3—From evaluation of the patient to evaluation of the intensive care unit. Part 2: Development of a prognostic model for hospital mortality at ICU admission in INTENSIVE CARE MEDICINE
  • 2006-11. Increased use of noninvasive ventilation in French intensive care units in INTENSIVE CARE MEDICINE
  • 2011-12. The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation in INTENSIVE CARE MEDICINE
  • 2006-11. Benefits and risks of success or failure of noninvasive ventilation in INTENSIVE CARE MEDICINE
  • 2009-08. The FINNALI study on acute respiratory failure: not the final cut in INTENSIVE CARE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/cc12594

    DOI

    http://dx.doi.org/10.1186/cc12594

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010078566

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23557378


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Public Health and Health Services", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brazil", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cohort Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hospital Mortality", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intensive Care Units", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Noninvasive Ventilation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Respiration, Artificial", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo", 
              "id": "https://www.grid.ac/institutes/grid.411074.7", 
              "name": [
                "Research and Education Institute, Hospital S\u00edrio-Liban\u00eas, Rua Cel. Nicolau dos Santos 69 - S\u00e3o Paulo, 01308-060, Brazil", 
                "ICU, Emergency Medicine Department, Hospital das Clinicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, Av. Eneas Carvalho Aguiar 255, 05403-000, S\u00e3o Paulo, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Azevedo", 
            "givenName": "Luciano CP", 
            "id": "sg:person.013074764662.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013074764662.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo", 
              "id": "https://www.grid.ac/institutes/grid.411074.7", 
              "name": [
                "Research and Education Institute, Hospital S\u00edrio-Liban\u00eas, Rua Cel. Nicolau dos Santos 69 - S\u00e3o Paulo, 01308-060, Brazil", 
                "ICU, Emergency Medicine Department, Hospital das Clinicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, Av. Eneas Carvalho Aguiar 255, 05403-000, S\u00e3o Paulo, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Park", 
            "givenName": "Marcelo", 
            "id": "sg:person.0662570614.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662570614.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "D\u2019Or Institute for Research and Education", 
              "id": "https://www.grid.ac/institutes/grid.472984.4", 
              "name": [
                "D'Or Institute for Research and Education, Rua Dinis Cordeiro 30, 22281-100, Rio de Janeiro, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Salluh", 
            "givenName": "Jorge IF", 
            "id": "sg:person.013270211504.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013270211504.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CEPETI - Centro de Estudos e Pesquisas em Terapia Intensiva, Rua Monte Castelo 366, 82530-200, Curitiba, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rea-Neto", 
            "givenName": "Alvaro", 
            "id": "sg:person.01212072521.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212072521.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Instituto Nacional do C\u00e2ncer", 
              "id": "https://www.grid.ac/institutes/grid.419166.d", 
              "name": [
                "ICU, Instituto Nacional de C\u00e2ncer - Hospital do C\u00e2ncer I, Pra\u00e7a Cruz Vermelha 23, 20230-130, Rio de Janeiro, Brazil", 
                "ICU, Hospital Pasteur, Av. Amaro Cavalcanti 495, 20735-040, Rio de Janeiro, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Souza-Dantas", 
            "givenName": "Vicente C", 
            "id": "sg:person.01234576536.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234576536.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "ICU, Hospital Pasteur, Av. Amaro Cavalcanti 495, 20735-040, Rio de Janeiro, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Varaschin", 
            "givenName": "Pedro", 
            "id": "sg:person.0625335304.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625335304.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "CEPETI - Centro de Estudos e Pesquisas em Terapia Intensiva, Rua Monte Castelo 366, 82530-200, Curitiba, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oliveira", 
            "givenName": "Mirella C", 
            "id": "sg:person.01050756575.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050756575.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo", 
              "id": "https://www.grid.ac/institutes/grid.411074.7", 
              "name": [
                "Surgical Emergency Department, ICU,Hospital das Clinicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, Av. Eneas Carvalho Aguiar 255, 05403-000, S\u00e3o Paulo, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tierno", 
            "givenName": "Paulo Fernando GMM", 
            "id": "sg:person.07475427574.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07475427574.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "ICU, Hospital S\u00e3o Jos\u00e9, Rua Cel. Pedro Benedet 630, 88801-250, Crici\u00fama, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "dal-Pizzol", 
            "givenName": "Felipe", 
            "id": "sg:person.0754340750.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754340750.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital de C\u00e2ncer de Barretos", 
              "id": "https://www.grid.ac/institutes/grid.427783.d", 
              "name": [
                "ICU, Funda\u00e7\u00e3o Pio XII, Hospital de C\u00e2ncer de Barretos, Rua Antenor Duarte Vilela 1331, 14780-000, Barretos, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Silva", 
            "givenName": "Ulysses VA", 
            "id": "sg:person.0666622540.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666622540.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "ICU, Hospital S\u00e3o Lucas, Travessa Frederico Pamplona 32, 22061-080, Rio de Janeiro, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Knibel", 
            "givenName": "Marcos", 
            "id": "sg:person.01203430231.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203430231.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "ICU, Hospital S\u00e3o Camilo Pomp\u00e9ia, Av. Pompeia 1178, 05024-000, S\u00e3o Paulo, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nassar", 
            "givenName": "Antonio P", 
            "id": "sg:person.01027566431.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027566431.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Regional Publico do Araguaia", 
              "id": "https://www.grid.ac/institutes/grid.490177.c", 
              "name": [
                "ICU, Hospital Regional P\u00fablico do Araguaia - Av. Brasil, s/n Qd. 30, 68552-735, Reden\u00e7\u00e3o, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alves", 
            "givenName": "Rossine A", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "AC Camargo Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413320.7", 
              "name": [
                "ICU, Hospital A. C. Camargo, R. Professor Ant\u00f4nio Prudente 109, 01509-010, S\u00e3o Paulo, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ferreira", 
            "givenName": "Juliana C", 
            "id": "sg:person.0647215377.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647215377.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital Moinhos de Vento", 
              "id": "https://www.grid.ac/institutes/grid.414856.a", 
              "name": [
                "ICU, Hospital Moinhos de Vento, Rua Ramiro Barcelos 910, 90035-001, Porto Alegre, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Teixeira", 
            "givenName": "Cassiano", 
            "id": "sg:person.01340077245.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340077245.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "ICU, Hospital Geral de Roraima, Av. Brg. Eduardo Gomes 3388, 69305-284, Boa Vista, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rezende", 
            "givenName": "Valeria", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "ICU, Hospital Espanhol, Av. Sete de Setembro 4161, 40140-110, Salvador, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Martinez", 
            "givenName": "Amadeu", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "ICU, Hospital Estadual Am\u00e9rico Brasiliense, Alameda Dr. Aldo Lupo 1260, 14802-520, Am\u00e9rico Brasiliense, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Luciano", 
            "givenName": "Paula M", 
            "id": "sg:person.0643757463.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643757463.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hospital S\u00edrio-Liban\u00eas", 
              "id": "https://www.grid.ac/institutes/grid.413471.4", 
              "name": [
                "Research and Education Institute, Hospital S\u00edrio-Liban\u00eas, Rua Cel. Nicolau dos Santos 69 - S\u00e3o Paulo, 01308-060, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schettino", 
            "givenName": "Guilherme", 
            "id": "sg:person.012204040047.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012204040047.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "D\u2019Or Institute for Research and Education", 
              "id": "https://www.grid.ac/institutes/grid.472984.4", 
              "name": [
                "D'Or Institute for Research and Education, Rua Dinis Cordeiro 30, 22281-100, Rio de Janeiro, Brazil"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Soares", 
            "givenName": "Marcio", 
            "id": "sg:person.01220264701.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220264701.36"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "The ERICC (Epidemiology of Respiratory Insufficiency in Critical Care) investigators", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1056/nejmoa1011802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000148720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e3181ef4460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000583030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e3181ef4460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000583030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ccm.0b013e3181ef4460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000583030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-009-1518-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001660260", 
              "https://doi.org/10.1007/s00134-009-1518-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-009-1518-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001660260", 
              "https://doi.org/10.1007/s00134-009-1518-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-009-1518-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001660260", 
              "https://doi.org/10.1007/s00134-009-1518-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.200706-893oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002871268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4067/s0034-98872008000800001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003879151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-005-2763-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003983402", 
              "https://doi.org/10.1007/s00134-005-2763-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-005-2763-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003983402", 
              "https://doi.org/10.1007/s00134-005-2763-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.287.3.345", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006458934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcrc.2011.06.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006623817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/ajrccm.161.5.9902018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008383462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/aje/kwm012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008808283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-011-2380-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008841209", 
              "https://doi.org/10.1007/s00134-011-2380-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000243800.28251.ae", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015945139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000243800.28251.ae", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015945139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/ajrccm.149.3.7509706", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016290551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199802053380602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016875509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.128.5.3098", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017243501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-001-1114-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017250664", 
              "https://doi.org/10.1007/s00134-001-1114-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc9975", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017482269", 
              "https://doi.org/10.1186/cc9975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2012.5669", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018033502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2012.13730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018359232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.121.5.1602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020261059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.121.5.1602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020261059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0021-9681(87)90171-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020988115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-009-1519-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026845004", 
              "https://doi.org/10.1007/s00134-009-1519-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-009-1519-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026845004", 
              "https://doi.org/10.1007/s00134-009-1519-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-009-1519-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026845004", 
              "https://doi.org/10.1007/s00134-009-1519-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm200005043421801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026999880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.118.4.1100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027722022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1378/chest.118.4.1100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027722022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcrc.2010.12.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029141941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-012-2475-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029323838", 
              "https://doi.org/10.1007/s00134-012-2475-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1399-6576.2005.00898.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030737953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1399-6576.2005.00898.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030737953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc6916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033411669", 
              "https://doi.org/10.1186/cc6916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.200805-722oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035364360"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-009-1449-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036045439", 
              "https://doi.org/10.1007/s00134-009-1449-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-009-1449-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036045439", 
              "https://doi.org/10.1007/s00134-009-1449-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1164/rccm.201106-1094oc", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036663164"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000214309.95032.65", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038303200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000214309.95032.65", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038303200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000050454.01978.3b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038794529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000050454.01978.3b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038794529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1473-3099(10)70074-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039796239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa062200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042949627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-006-0229-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043876426", 
              "https://doi.org/10.1007/s00134-006-0229-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-006-0229-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043876426", 
              "https://doi.org/10.1007/s00134-006-0229-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000300084.67277.90", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044072714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000300084.67277.90", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044072714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jcrc.2010.10.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046610864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000127784.54727.56", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047513654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.ccm.0000127784.54727.56", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047513654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ta.0b013e3181a601b3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048321377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ta.0b013e3181a601b3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048321377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ta.0b013e3181a601b3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048321377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-006-0324-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049153457", 
              "https://doi.org/10.1007/s00134-006-0324-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-006-0324-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049153457", 
              "https://doi.org/10.1007/s00134-006-0324-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01709751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052044737", 
              "https://doi.org/10.1007/bf01709751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01709751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052044737", 
              "https://doi.org/10.1007/bf01709751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00003246-200211000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052054294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00003246-200211000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052054294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org//s0034-98872008000800001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077800358"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-04", 
        "datePublishedReg": "2013-04-01", 
        "description": "INTRODUCTION: Contemporary information on mechanical ventilation (MV) use in emerging countries is limited. Moreover, most epidemiological studies on ventilatory support were carried out before significant developments, such as lung protective ventilation or broader application of non-invasive ventilation (NIV). We aimed to evaluate the clinical characteristics, outcomes and risk factors for hospital mortality and failure of NIV in patients requiring ventilatory support in Brazilian intensive care units (ICU).\nMETHODS: In a multicenter, prospective, cohort study, a total of 773 adult patients admitted to 45 ICUs over a two-month period requiring invasive ventilation or NIV for more than 24 hours were evaluated. Causes of ventilatory support, prior chronic health status and physiological data were assessed. Multivariate analysis was used to identifiy variables associated with hospital mortality and NIV failure.\nRESULTS: Invasive MV and NIV were used as initial ventilatory support in 622 (80%) and 151 (20%) patients. Failure with subsequent intubation occurred in 54% of NIV patients. The main reasons for ventilatory support were pneumonia (27%), neurologic disorders (19%) and non-pulmonary sepsis (12%). ICU and hospital mortality rates were 34% and 42%. Using the Berlin definition, acute respiratory distress syndrome (ARDS) was diagnosed in 31% of the patients with a hospital mortality of 52%. In the multivariate analysis, age (odds ratio (OR), 1.03; 95% confidence interval (CI), 1.01 to 1.03), comorbidities (OR, 2.30; 95% CI, 1.28 to 3.17), associated organ failures (OR, 1.12; 95% CI, 1.05 to 1.20), moderate (OR, 1.92; 95% CI, 1.10 to 3.35) to severe ARDS (OR, 2.12; 95% CI, 1.01 to 4.41), cumulative fluid balance over the first 72 h of ICU (OR, 2.44; 95% CI, 1.39 to 4.28), higher lactate (OR, 1.78; 95% CI, 1.27 to 2.50), invasive MV (OR, 2.67; 95% CI, 1.32 to 5.39) and NIV failure (OR, 3.95; 95% CI, 1.74 to 8.99) were independently associated with hospital mortality. The predictors of NIV failure were the severity of associated organ dysfunctions (OR, 1.20; 95% CI, 1.05 to 1.34), ARDS (OR, 2.31; 95% CI, 1.10 to 4.82) and positive fluid balance (OR, 2.09; 95% CI, 1.02 to 4.30).\nCONCLUSIONS: Current mortality of ventilated patients in Brazil is elevated. Implementation of judicious fluid therapy and a watchful use and monitoring of NIV patients are potential targets to improve outcomes in this setting.\nTRIAL REGISTRATION: ClinicalTrials.gov NCT01268410.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/cc12594", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1117766", 
            "issn": [
              "1364-8535", 
              "1466-609X"
            ], 
            "name": "Critical Care", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "17"
          }
        ], 
        "name": "Clinical outcomes of patients requiring ventilatory support in Brazilian intensive care units: a multicenter, prospective, cohort study", 
        "pagination": "r63", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "30039a4ea54a704d38c9ba0a1572116412c026e64e01a1f6c5b8e8aa3966e82b"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23557378"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9801902"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/cc12594"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1010078566"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/cc12594", 
          "https://app.dimensions.ai/details/publication/pub.1010078566"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T01:12", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000536.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2Fcc12594"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/cc12594'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/cc12594'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/cc12594'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/cc12594'


     

    This table displays all metadata directly associated to this object as RDF triples.

    449 TRIPLES      21 PREDICATES      88 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/cc12594 schema:about N1346531a926e44bda840f65747392969
    2 N17b8977325834818819a2866712654bc
    3 N1960e56b0f154479bfbc35c864ad77cc
    4 N1b50883fe6614f808e80898249e21df6
    5 N25a088bc480a441a88488becda9d83ef
    6 N2eeee9748eb447eaa85fe5eb5b18d6a9
    7 N38864b4b7e8e4a24a5db74fda6480257
    8 N88bb8403fd8f464c82e44c8a6fcee5ab
    9 Na45d11aae55f47e8b70d9dc1e7d78be7
    10 Nad0786ff3db84ee0853fde40c602bf5e
    11 Nb2469102008f45fe83d5cc0b8765fffd
    12 Nb575816e25484cc395542c388ff133ec
    13 Nf3091c2c9bef4f9097fcdba48ba2b3a0
    14 Nf789c72a5d174030800996f8f94ac0a3
    15 Nfe1fbd5d67d24716b2bb4665ac25dbff
    16 anzsrc-for:11
    17 anzsrc-for:1117
    18 schema:author N3e15ba04d2d040f9beee62d5c200b404
    19 schema:citation sg:pub.10.1007/bf01709751
    20 sg:pub.10.1007/s00134-001-1114-4
    21 sg:pub.10.1007/s00134-005-2763-5
    22 sg:pub.10.1007/s00134-006-0229-z
    23 sg:pub.10.1007/s00134-006-0324-1
    24 sg:pub.10.1007/s00134-009-1449-9
    25 sg:pub.10.1007/s00134-009-1518-0
    26 sg:pub.10.1007/s00134-009-1519-z
    27 sg:pub.10.1007/s00134-011-2380-4
    28 sg:pub.10.1007/s00134-012-2475-6
    29 sg:pub.10.1186/cc6916
    30 sg:pub.10.1186/cc9975
    31 https://doi.org//s0034-98872008000800001
    32 https://doi.org/10.1001/jama.2012.13730
    33 https://doi.org/10.1001/jama.2012.5669
    34 https://doi.org/10.1001/jama.287.3.345
    35 https://doi.org/10.1016/0021-9681(87)90171-8
    36 https://doi.org/10.1016/j.jcrc.2010.10.010
    37 https://doi.org/10.1016/j.jcrc.2010.12.015
    38 https://doi.org/10.1016/j.jcrc.2011.06.014
    39 https://doi.org/10.1016/s1473-3099(10)70074-8
    40 https://doi.org/10.1056/nejm199802053380602
    41 https://doi.org/10.1056/nejm200005043421801
    42 https://doi.org/10.1056/nejmoa062200
    43 https://doi.org/10.1056/nejmoa1011802
    44 https://doi.org/10.1093/aje/kwm012
    45 https://doi.org/10.1097/00003246-200211000-00008
    46 https://doi.org/10.1097/01.ccm.0000050454.01978.3b
    47 https://doi.org/10.1097/01.ccm.0000127784.54727.56
    48 https://doi.org/10.1097/01.ccm.0000214309.95032.65
    49 https://doi.org/10.1097/01.ccm.0000243800.28251.ae
    50 https://doi.org/10.1097/01.ccm.0000300084.67277.90
    51 https://doi.org/10.1097/ccm.0b013e3181ef4460
    52 https://doi.org/10.1097/ta.0b013e3181a601b3
    53 https://doi.org/10.1111/j.1399-6576.2005.00898.x
    54 https://doi.org/10.1164/ajrccm.149.3.7509706
    55 https://doi.org/10.1164/ajrccm.161.5.9902018
    56 https://doi.org/10.1164/rccm.200706-893oc
    57 https://doi.org/10.1164/rccm.200805-722oc
    58 https://doi.org/10.1164/rccm.201106-1094oc
    59 https://doi.org/10.1378/chest.118.4.1100
    60 https://doi.org/10.1378/chest.121.5.1602
    61 https://doi.org/10.1378/chest.128.5.3098
    62 https://doi.org/10.4067/s0034-98872008000800001
    63 schema:datePublished 2013-04
    64 schema:datePublishedReg 2013-04-01
    65 schema:description INTRODUCTION: Contemporary information on mechanical ventilation (MV) use in emerging countries is limited. Moreover, most epidemiological studies on ventilatory support were carried out before significant developments, such as lung protective ventilation or broader application of non-invasive ventilation (NIV). We aimed to evaluate the clinical characteristics, outcomes and risk factors for hospital mortality and failure of NIV in patients requiring ventilatory support in Brazilian intensive care units (ICU). METHODS: In a multicenter, prospective, cohort study, a total of 773 adult patients admitted to 45 ICUs over a two-month period requiring invasive ventilation or NIV for more than 24 hours were evaluated. Causes of ventilatory support, prior chronic health status and physiological data were assessed. Multivariate analysis was used to identifiy variables associated with hospital mortality and NIV failure. RESULTS: Invasive MV and NIV were used as initial ventilatory support in 622 (80%) and 151 (20%) patients. Failure with subsequent intubation occurred in 54% of NIV patients. The main reasons for ventilatory support were pneumonia (27%), neurologic disorders (19%) and non-pulmonary sepsis (12%). ICU and hospital mortality rates were 34% and 42%. Using the Berlin definition, acute respiratory distress syndrome (ARDS) was diagnosed in 31% of the patients with a hospital mortality of 52%. In the multivariate analysis, age (odds ratio (OR), 1.03; 95% confidence interval (CI), 1.01 to 1.03), comorbidities (OR, 2.30; 95% CI, 1.28 to 3.17), associated organ failures (OR, 1.12; 95% CI, 1.05 to 1.20), moderate (OR, 1.92; 95% CI, 1.10 to 3.35) to severe ARDS (OR, 2.12; 95% CI, 1.01 to 4.41), cumulative fluid balance over the first 72 h of ICU (OR, 2.44; 95% CI, 1.39 to 4.28), higher lactate (OR, 1.78; 95% CI, 1.27 to 2.50), invasive MV (OR, 2.67; 95% CI, 1.32 to 5.39) and NIV failure (OR, 3.95; 95% CI, 1.74 to 8.99) were independently associated with hospital mortality. The predictors of NIV failure were the severity of associated organ dysfunctions (OR, 1.20; 95% CI, 1.05 to 1.34), ARDS (OR, 2.31; 95% CI, 1.10 to 4.82) and positive fluid balance (OR, 2.09; 95% CI, 1.02 to 4.30). CONCLUSIONS: Current mortality of ventilated patients in Brazil is elevated. Implementation of judicious fluid therapy and a watchful use and monitoring of NIV patients are potential targets to improve outcomes in this setting. TRIAL REGISTRATION: ClinicalTrials.gov NCT01268410.
    66 schema:genre research_article
    67 schema:inLanguage en
    68 schema:isAccessibleForFree true
    69 schema:isPartOf N35a62c8d57b64066a5014cf897aaa1d7
    70 Ncdfa1766b46640afb971dbc428146a59
    71 sg:journal.1117766
    72 schema:name Clinical outcomes of patients requiring ventilatory support in Brazilian intensive care units: a multicenter, prospective, cohort study
    73 schema:pagination r63
    74 schema:productId N070a1291a14441c098b5e265cf5a60ae
    75 N67ff8a69ea0f4c46a32648558d4914c8
    76 Nba853b79b8ce4d3fb4853f091575ae15
    77 Nc419a6fa17ae454b84d975a05d08263d
    78 Nda42639b7d15498495e8385b6f89f3b9
    79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010078566
    80 https://doi.org/10.1186/cc12594
    81 schema:sdDatePublished 2019-04-11T01:12
    82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    83 schema:sdPublisher Nd7fd6972fb524a2eae224a8915c663cd
    84 schema:url http://link.springer.com/10.1186%2Fcc12594
    85 sgo:license sg:explorer/license/
    86 sgo:sdDataset articles
    87 rdf:type schema:ScholarlyArticle
    88 N070a1291a14441c098b5e265cf5a60ae schema:name dimensions_id
    89 schema:value pub.1010078566
    90 rdf:type schema:PropertyValue
    91 N087058b0a79a4d9ba5cc7096ebdc08b3 schema:name ICU, Hospital São Camilo Pompéia, Av. Pompeia 1178, 05024-000, São Paulo, Brazil
    92 rdf:type schema:Organization
    93 N0f74d036945544a8afd3648e0b8396a0 rdf:first sg:person.0643757463.07
    94 rdf:rest Nd3025097645e4fea9b8a7c26db14a94d
    95 N1346531a926e44bda840f65747392969 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Brazil
    97 rdf:type schema:DefinedTerm
    98 N17b8977325834818819a2866712654bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Humans
    100 rdf:type schema:DefinedTerm
    101 N1960e56b0f154479bfbc35c864ad77cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Intensive Care Units
    103 rdf:type schema:DefinedTerm
    104 N1b50883fe6614f808e80898249e21df6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Adult
    106 rdf:type schema:DefinedTerm
    107 N25a088bc480a441a88488becda9d83ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Treatment Outcome
    109 rdf:type schema:DefinedTerm
    110 N2eeee9748eb447eaa85fe5eb5b18d6a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Respiration, Artificial
    112 rdf:type schema:DefinedTerm
    113 N302d8aba3e584a3d82efdaf412494c39 rdf:first sg:person.01027566431.63
    114 rdf:rest N31266fef4dee478797b4767b83c3476f
    115 N31266fef4dee478797b4767b83c3476f rdf:first N4931f09f45e446a588b057472efd20df
    116 rdf:rest N91a746654d0842779c1cc993785b102b
    117 N35a62c8d57b64066a5014cf897aaa1d7 schema:volumeNumber 17
    118 rdf:type schema:PublicationVolume
    119 N361a37c81c0b48f9846aaec786fc2e4f rdf:first sg:person.07475427574.13
    120 rdf:rest N52ef4ea271b34231b522fab50f05e015
    121 N38864b4b7e8e4a24a5db74fda6480257 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Middle Aged
    123 rdf:type schema:DefinedTerm
    124 N395b64e81dad4edb87ec1c5cdde368d7 rdf:first N5cf58bf223eb4beab73511a09b046933
    125 rdf:rest N5d8384b126b14a12b68d5a4f1d51b936
    126 N3a8394238cb84f6c970db7e69bbb9fbb schema:familyName The ERICC (Epidemiology of Respiratory Insufficiency in Critical Care) investigators
    127 rdf:type schema:Person
    128 N3e15ba04d2d040f9beee62d5c200b404 rdf:first sg:person.013074764662.35
    129 rdf:rest N423f3b521cb2401d9aaae1181f894d96
    130 N423f3b521cb2401d9aaae1181f894d96 rdf:first sg:person.0662570614.59
    131 rdf:rest Nc1d7b356da3942408a040d50d1403045
    132 N430e1b683c924e079ffba85ec5c3ad19 schema:name ICU, Hospital São José, Rua Cel. Pedro Benedet 630, 88801-250, Criciúma, Brazil
    133 rdf:type schema:Organization
    134 N4931f09f45e446a588b057472efd20df schema:affiliation https://www.grid.ac/institutes/grid.490177.c
    135 schema:familyName Alves
    136 schema:givenName Rossine A
    137 rdf:type schema:Person
    138 N49d85e16858544f98792033c3340cacf rdf:first sg:person.01220264701.36
    139 rdf:rest N6adc7fa0f41341afb409dcaa3e865492
    140 N52ef4ea271b34231b522fab50f05e015 rdf:first sg:person.0754340750.91
    141 rdf:rest Nf529b5eb41d140ce97063193f4cf57c7
    142 N5a421372377d4d7c8e7e39dbf32c91b7 rdf:first sg:person.0625335304.31
    143 rdf:rest Nd0e1f26ed71941a39a48fbb1360a6666
    144 N5cf58bf223eb4beab73511a09b046933 schema:affiliation N78f8613381b843e7a5828fc82ed13e2c
    145 schema:familyName Rezende
    146 schema:givenName Valeria
    147 rdf:type schema:Person
    148 N5d8384b126b14a12b68d5a4f1d51b936 rdf:first Nf84e821776f148ae88272cc6b71eee97
    149 rdf:rest N0f74d036945544a8afd3648e0b8396a0
    150 N6300bd5398a146f39247a713ba53bc69 schema:name ICU, Hospital Estadual Américo Brasiliense, Alameda Dr. Aldo Lupo 1260, 14802-520, Américo Brasiliense, Brazil
    151 rdf:type schema:Organization
    152 N67ff8a69ea0f4c46a32648558d4914c8 schema:name nlm_unique_id
    153 schema:value 9801902
    154 rdf:type schema:PropertyValue
    155 N6adc7fa0f41341afb409dcaa3e865492 rdf:first N3a8394238cb84f6c970db7e69bbb9fbb
    156 rdf:rest rdf:nil
    157 N70b5295b4e82470689850d45744c33a1 rdf:first sg:person.01234576536.13
    158 rdf:rest N5a421372377d4d7c8e7e39dbf32c91b7
    159 N78f8613381b843e7a5828fc82ed13e2c schema:name ICU, Hospital Geral de Roraima, Av. Brg. Eduardo Gomes 3388, 69305-284, Boa Vista, Brazil
    160 rdf:type schema:Organization
    161 N7f8e8fea8a7b45d291232a5d95e7f946 schema:name ICU, Hospital Pasteur, Av. Amaro Cavalcanti 495, 20735-040, Rio de Janeiro, Brazil
    162 rdf:type schema:Organization
    163 N8241eea0dcc84e2a935c88a28c6fabb4 schema:name ICU, Hospital Espanhol, Av. Sete de Setembro 4161, 40140-110, Salvador, Brazil
    164 rdf:type schema:Organization
    165 N88bb8403fd8f464c82e44c8a6fcee5ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Aged, 80 and over
    167 rdf:type schema:DefinedTerm
    168 N91a746654d0842779c1cc993785b102b rdf:first sg:person.0647215377.13
    169 rdf:rest Nb52f06975f4648afa36f1dc116f2a584
    170 Na45d11aae55f47e8b70d9dc1e7d78be7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Male
    172 rdf:type schema:DefinedTerm
    173 Nad0786ff3db84ee0853fde40c602bf5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Noninvasive Ventilation
    175 rdf:type schema:DefinedTerm
    176 Nb2469102008f45fe83d5cc0b8765fffd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Cohort Studies
    178 rdf:type schema:DefinedTerm
    179 Nb3db7b2230e142f89c7c94c9db8f72e4 schema:name CEPETI - Centro de Estudos e Pesquisas em Terapia Intensiva, Rua Monte Castelo 366, 82530-200, Curitiba, Brazil
    180 rdf:type schema:Organization
    181 Nb52f06975f4648afa36f1dc116f2a584 rdf:first sg:person.01340077245.66
    182 rdf:rest N395b64e81dad4edb87ec1c5cdde368d7
    183 Nb575816e25484cc395542c388ff133ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Hospital Mortality
    185 rdf:type schema:DefinedTerm
    186 Nba853b79b8ce4d3fb4853f091575ae15 schema:name readcube_id
    187 schema:value 30039a4ea54a704d38c9ba0a1572116412c026e64e01a1f6c5b8e8aa3966e82b
    188 rdf:type schema:PropertyValue
    189 Nbd3a8dc325344f2ca4d8d9efecdd75d0 rdf:first sg:person.01212072521.68
    190 rdf:rest N70b5295b4e82470689850d45744c33a1
    191 Nc1d7b356da3942408a040d50d1403045 rdf:first sg:person.013270211504.49
    192 rdf:rest Nbd3a8dc325344f2ca4d8d9efecdd75d0
    193 Nc419a6fa17ae454b84d975a05d08263d schema:name pubmed_id
    194 schema:value 23557378
    195 rdf:type schema:PropertyValue
    196 Ncb609e3f498042c390434c8521b3f734 schema:name CEPETI - Centro de Estudos e Pesquisas em Terapia Intensiva, Rua Monte Castelo 366, 82530-200, Curitiba, Brazil
    197 rdf:type schema:Organization
    198 Ncd6ee1683fac47a4a3fda90f9c3ccc57 rdf:first sg:person.01203430231.62
    199 rdf:rest N302d8aba3e584a3d82efdaf412494c39
    200 Ncdfa1766b46640afb971dbc428146a59 schema:issueNumber 2
    201 rdf:type schema:PublicationIssue
    202 Nd0e1f26ed71941a39a48fbb1360a6666 rdf:first sg:person.01050756575.06
    203 rdf:rest N361a37c81c0b48f9846aaec786fc2e4f
    204 Nd3025097645e4fea9b8a7c26db14a94d rdf:first sg:person.012204040047.71
    205 rdf:rest N49d85e16858544f98792033c3340cacf
    206 Nd7fd6972fb524a2eae224a8915c663cd schema:name Springer Nature - SN SciGraph project
    207 rdf:type schema:Organization
    208 Nda42639b7d15498495e8385b6f89f3b9 schema:name doi
    209 schema:value 10.1186/cc12594
    210 rdf:type schema:PropertyValue
    211 Nee29adc992c641e3a519a90d4831b403 schema:name ICU, Hospital São Lucas, Travessa Frederico Pamplona 32, 22061-080, Rio de Janeiro, Brazil
    212 rdf:type schema:Organization
    213 Nf3091c2c9bef4f9097fcdba48ba2b3a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Female
    215 rdf:type schema:DefinedTerm
    216 Nf529b5eb41d140ce97063193f4cf57c7 rdf:first sg:person.0666622540.65
    217 rdf:rest Ncd6ee1683fac47a4a3fda90f9c3ccc57
    218 Nf789c72a5d174030800996f8f94ac0a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    219 schema:name Prospective Studies
    220 rdf:type schema:DefinedTerm
    221 Nf84e821776f148ae88272cc6b71eee97 schema:affiliation N8241eea0dcc84e2a935c88a28c6fabb4
    222 schema:familyName Martinez
    223 schema:givenName Amadeu
    224 rdf:type schema:Person
    225 Nfe1fbd5d67d24716b2bb4665ac25dbff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    226 schema:name Aged
    227 rdf:type schema:DefinedTerm
    228 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    229 schema:name Medical and Health Sciences
    230 rdf:type schema:DefinedTerm
    231 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
    232 schema:name Public Health and Health Services
    233 rdf:type schema:DefinedTerm
    234 sg:journal.1117766 schema:issn 1364-8535
    235 1466-609X
    236 schema:name Critical Care
    237 rdf:type schema:Periodical
    238 sg:person.01027566431.63 schema:affiliation N087058b0a79a4d9ba5cc7096ebdc08b3
    239 schema:familyName Nassar
    240 schema:givenName Antonio P
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027566431.63
    242 rdf:type schema:Person
    243 sg:person.01050756575.06 schema:affiliation Ncb609e3f498042c390434c8521b3f734
    244 schema:familyName Oliveira
    245 schema:givenName Mirella C
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050756575.06
    247 rdf:type schema:Person
    248 sg:person.01203430231.62 schema:affiliation Nee29adc992c641e3a519a90d4831b403
    249 schema:familyName Knibel
    250 schema:givenName Marcos
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203430231.62
    252 rdf:type schema:Person
    253 sg:person.01212072521.68 schema:affiliation Nb3db7b2230e142f89c7c94c9db8f72e4
    254 schema:familyName Rea-Neto
    255 schema:givenName Alvaro
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212072521.68
    257 rdf:type schema:Person
    258 sg:person.01220264701.36 schema:affiliation https://www.grid.ac/institutes/grid.472984.4
    259 schema:familyName Soares
    260 schema:givenName Marcio
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220264701.36
    262 rdf:type schema:Person
    263 sg:person.012204040047.71 schema:affiliation https://www.grid.ac/institutes/grid.413471.4
    264 schema:familyName Schettino
    265 schema:givenName Guilherme
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012204040047.71
    267 rdf:type schema:Person
    268 sg:person.01234576536.13 schema:affiliation https://www.grid.ac/institutes/grid.419166.d
    269 schema:familyName Souza-Dantas
    270 schema:givenName Vicente C
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234576536.13
    272 rdf:type schema:Person
    273 sg:person.013074764662.35 schema:affiliation https://www.grid.ac/institutes/grid.411074.7
    274 schema:familyName Azevedo
    275 schema:givenName Luciano CP
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013074764662.35
    277 rdf:type schema:Person
    278 sg:person.013270211504.49 schema:affiliation https://www.grid.ac/institutes/grid.472984.4
    279 schema:familyName Salluh
    280 schema:givenName Jorge IF
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013270211504.49
    282 rdf:type schema:Person
    283 sg:person.01340077245.66 schema:affiliation https://www.grid.ac/institutes/grid.414856.a
    284 schema:familyName Teixeira
    285 schema:givenName Cassiano
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340077245.66
    287 rdf:type schema:Person
    288 sg:person.0625335304.31 schema:affiliation N7f8e8fea8a7b45d291232a5d95e7f946
    289 schema:familyName Varaschin
    290 schema:givenName Pedro
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625335304.31
    292 rdf:type schema:Person
    293 sg:person.0643757463.07 schema:affiliation N6300bd5398a146f39247a713ba53bc69
    294 schema:familyName Luciano
    295 schema:givenName Paula M
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643757463.07
    297 rdf:type schema:Person
    298 sg:person.0647215377.13 schema:affiliation https://www.grid.ac/institutes/grid.413320.7
    299 schema:familyName Ferreira
    300 schema:givenName Juliana C
    301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647215377.13
    302 rdf:type schema:Person
    303 sg:person.0662570614.59 schema:affiliation https://www.grid.ac/institutes/grid.411074.7
    304 schema:familyName Park
    305 schema:givenName Marcelo
    306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662570614.59
    307 rdf:type schema:Person
    308 sg:person.0666622540.65 schema:affiliation https://www.grid.ac/institutes/grid.427783.d
    309 schema:familyName Silva
    310 schema:givenName Ulysses VA
    311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666622540.65
    312 rdf:type schema:Person
    313 sg:person.07475427574.13 schema:affiliation https://www.grid.ac/institutes/grid.411074.7
    314 schema:familyName Tierno
    315 schema:givenName Paulo Fernando GMM
    316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07475427574.13
    317 rdf:type schema:Person
    318 sg:person.0754340750.91 schema:affiliation N430e1b683c924e079ffba85ec5c3ad19
    319 schema:familyName dal-Pizzol
    320 schema:givenName Felipe
    321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754340750.91
    322 rdf:type schema:Person
    323 sg:pub.10.1007/bf01709751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052044737
    324 https://doi.org/10.1007/bf01709751
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1007/s00134-001-1114-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017250664
    327 https://doi.org/10.1007/s00134-001-1114-4
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1007/s00134-005-2763-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003983402
    330 https://doi.org/10.1007/s00134-005-2763-5
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1007/s00134-006-0229-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1043876426
    333 https://doi.org/10.1007/s00134-006-0229-z
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1007/s00134-006-0324-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049153457
    336 https://doi.org/10.1007/s00134-006-0324-1
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1007/s00134-009-1449-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036045439
    339 https://doi.org/10.1007/s00134-009-1449-9
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1007/s00134-009-1518-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001660260
    342 https://doi.org/10.1007/s00134-009-1518-0
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1007/s00134-009-1519-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1026845004
    345 https://doi.org/10.1007/s00134-009-1519-z
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1007/s00134-011-2380-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008841209
    348 https://doi.org/10.1007/s00134-011-2380-4
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1007/s00134-012-2475-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029323838
    351 https://doi.org/10.1007/s00134-012-2475-6
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1186/cc6916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033411669
    354 https://doi.org/10.1186/cc6916
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1186/cc9975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017482269
    357 https://doi.org/10.1186/cc9975
    358 rdf:type schema:CreativeWork
    359 https://doi.org//s0034-98872008000800001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077800358
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1001/jama.2012.13730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018359232
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1001/jama.2012.5669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018033502
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1001/jama.287.3.345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006458934
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1016/0021-9681(87)90171-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020988115
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1016/j.jcrc.2010.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046610864
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1016/j.jcrc.2010.12.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029141941
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1016/j.jcrc.2011.06.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006623817
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1016/s1473-3099(10)70074-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039796239
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1056/nejm199802053380602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016875509
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1056/nejm200005043421801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026999880
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1056/nejmoa062200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042949627
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1056/nejmoa1011802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000148720
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1093/aje/kwm012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008808283
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1097/00003246-200211000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052054294
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1097/01.ccm.0000050454.01978.3b schema:sameAs https://app.dimensions.ai/details/publication/pub.1038794529
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1097/01.ccm.0000127784.54727.56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047513654
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1097/01.ccm.0000214309.95032.65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038303200
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1097/01.ccm.0000243800.28251.ae schema:sameAs https://app.dimensions.ai/details/publication/pub.1015945139
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1097/01.ccm.0000300084.67277.90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044072714
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1097/ccm.0b013e3181ef4460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000583030
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1097/ta.0b013e3181a601b3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048321377
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1111/j.1399-6576.2005.00898.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030737953
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1164/ajrccm.149.3.7509706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016290551
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1164/ajrccm.161.5.9902018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008383462
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1164/rccm.200706-893oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1002871268
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1164/rccm.200805-722oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1035364360
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1164/rccm.201106-1094oc schema:sameAs https://app.dimensions.ai/details/publication/pub.1036663164
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1378/chest.118.4.1100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027722022
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1378/chest.121.5.1602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020261059
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1378/chest.128.5.3098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017243501
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.4067/s0034-98872008000800001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003879151
    422 rdf:type schema:CreativeWork
    423 https://www.grid.ac/institutes/grid.411074.7 schema:alternateName Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
    424 schema:name ICU, Emergency Medicine Department, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, Av. Eneas Carvalho Aguiar 255, 05403-000, São Paulo, Brazil
    425 Research and Education Institute, Hospital Sírio-Libanês, Rua Cel. Nicolau dos Santos 69 - São Paulo, 01308-060, Brazil
    426 Surgical Emergency Department, ICU,Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, Av. Eneas Carvalho Aguiar 255, 05403-000, São Paulo, Brazil
    427 rdf:type schema:Organization
    428 https://www.grid.ac/institutes/grid.413320.7 schema:alternateName AC Camargo Hospital
    429 schema:name ICU, Hospital A. C. Camargo, R. Professor Antônio Prudente 109, 01509-010, São Paulo, Brazil
    430 rdf:type schema:Organization
    431 https://www.grid.ac/institutes/grid.413471.4 schema:alternateName Hospital Sírio-Libanês
    432 schema:name Research and Education Institute, Hospital Sírio-Libanês, Rua Cel. Nicolau dos Santos 69 - São Paulo, 01308-060, Brazil
    433 rdf:type schema:Organization
    434 https://www.grid.ac/institutes/grid.414856.a schema:alternateName Hospital Moinhos de Vento
    435 schema:name ICU, Hospital Moinhos de Vento, Rua Ramiro Barcelos 910, 90035-001, Porto Alegre, Brazil
    436 rdf:type schema:Organization
    437 https://www.grid.ac/institutes/grid.419166.d schema:alternateName Instituto Nacional do Câncer
    438 schema:name ICU, Hospital Pasteur, Av. Amaro Cavalcanti 495, 20735-040, Rio de Janeiro, Brazil
    439 ICU, Instituto Nacional de Câncer - Hospital do Câncer I, Praça Cruz Vermelha 23, 20230-130, Rio de Janeiro, Brazil
    440 rdf:type schema:Organization
    441 https://www.grid.ac/institutes/grid.427783.d schema:alternateName Hospital de Câncer de Barretos
    442 schema:name ICU, Fundação Pio XII, Hospital de Câncer de Barretos, Rua Antenor Duarte Vilela 1331, 14780-000, Barretos, Brazil
    443 rdf:type schema:Organization
    444 https://www.grid.ac/institutes/grid.472984.4 schema:alternateName D’Or Institute for Research and Education
    445 schema:name D'Or Institute for Research and Education, Rua Dinis Cordeiro 30, 22281-100, Rio de Janeiro, Brazil
    446 rdf:type schema:Organization
    447 https://www.grid.ac/institutes/grid.490177.c schema:alternateName Hospital Regional Publico do Araguaia
    448 schema:name ICU, Hospital Regional Público do Araguaia - Av. Brasil, s/n Qd. 30, 68552-735, Redenção, Brazil
    449 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...