Tranexamic acid: less bleeding and less thrombosis? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-06-29

AUTHORS

Anne Godier, Ian Roberts, Beverley J Hunt

ABSTRACT

The early administration of tranexamic acid (TXA) to bleeding trauma patients reduces all-cause mortality without increasing the risk of vascular occlusive events. Indeed, the risk of arterial thrombosis appears to be reduced with TXA. In this commentary we hypothesize that TXA has an antithrombotic effect and explore potential mechanisms. These include inhibition of the inflammatory effects of plasmin, effects on platelets and effects on factors V and VIII. If proven, these antithrombotic effects would have major implications for the systemic use of TXA in surgical patients, where TXA has been clearly shown to reduce bleeding. More... »

PAGES

135-135

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/cc11374

DOI

http://dx.doi.org/10.1186/cc11374

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039614102

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22748073


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