Oral nystatin prophylaxis in surgical/trauma ICU patients: a randomised clinical trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-04-10

AUTHORS

Mariateresa Giglio, Giuseppina Caggiano, Lidia Dalfino, Nicola Brienza, Ilaria Alicino, Aurelia Sgobio, Antonella Favale, Caterina Coretti, Maria Teresa Montagna, Francesco Bruno, Filomena Puntillo

ABSTRACT

IntroductionCandida prophylaxis in ICU is still a matter of debate. Oral chemoprophylaxis has been advocated to reduce the incidence of Candida colonisation and infection.MethodsWe performed a randomised trial studying a single drug (nystatin) versus control in surgical/trauma ICU patients. Multiple-site testing for fungi was performed in each patient on ICU admission (T0) and subsequently every 3 days (T3, T6, T9, and so forth). The primary evaluation criterion was the time course of the corrected colonisation index.ResultsNinety-nine patients were enrolled. At admission, 69 patients exhibited Candida colonisation: the most frequently colonised body sites were the stomach and the pharynx. The most frequent isolated species was Candida albicans. The corrected colonisation index was similar in the two groups at T0 (P = 0.36), while a significant statistical difference was observed between the treatment and control groups at T6 (median 0.14 and 0.33, respectively; P = 0.0016), at T9 (median 0.00 and 0.28, respectively; P = 0.0001), at T12 (median 0.00 and 0.41, respectively; P = 0.0008), and at T15 (median 0.00 and 0.42, respectively; P < 0.0003). The same results were obtained in the subgroup of patients already colonised at ICU admission.ConclusionThis trial shows that nystatin prophylaxis significantly reduces fungal colonisation in surgical/trauma ICU patients, even if already colonised.Trial registrationClinicalTrials.gov: NCT01495039 More... »

PAGES

r57

References to SciGraph publications

  • 2004-09-15. Prophylaxis and treatment of invasive candidiasis in the intensive care setting in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2006-02-10. Epidemiological trends in nosocomial candidemia in intensive care in BMC INFECTIOUS DISEASES
  • 2005-09-30. Oral nystatin prophylaxis of Candida spp. colonization in ventilated critically ill patients in INTENSIVE CARE MEDICINE
  • 2009-11. Candida Colonization and Candiduria in Critically Ill Patients in the Intensive Care Unit in DRUGS
  • 2007-02-27. Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2008-08-29. Fungal colonization and/or infection in non-neutropenic critically ill patients: results of the EPCAN observational study in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2004-03-13. Economic Impact of Candida Colonization and Candida Infection in the Critically Ill Patient in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2005-09-30. Oral nystatin as antifungal prophylaxis in critically ill patients: an old SDD tool to be renewed? in INTENSIVE CARE MEDICINE
  • 2005-05-14. Impact of selective decontamination of the digestive tract on fungal carriage and infection: systematic review of randomized controlled trials in INTENSIVE CARE MEDICINE
  • 2004-03-17. Epidemiology of Candidaemia in Europe: Results of 28-Month European Confederation of Medical Mycology (ECMM) Hospital-Based Surveillance Study in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2009-06-24. Candida Isolation in Patients Hospitalized on a Surgical Ward: Significance and Mortality-Related Factors in WORLD JOURNAL OF SURGERY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/cc11300

    DOI

    http://dx.doi.org/10.1186/cc11300

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032192537

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22490643


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Administration, Oral", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antifungal Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Candidiasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chi-Square Distribution", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Critical Care", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intensive Care Units", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nystatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Statistics, Nonparametric", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Anaesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Anaesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Giglio", 
            "givenName": "Mariateresa", 
            "id": "sg:person.0741532715.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741532715.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biomedical Science and Human Oncology, Hygiene Section, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Department of Biomedical Science and Human Oncology, Hygiene Section, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Caggiano", 
            "givenName": "Giuseppina", 
            "id": "sg:person.0631367112.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631367112.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Anaesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Anaesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dalfino", 
            "givenName": "Lidia", 
            "id": "sg:person.0646114045.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646114045.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Anaesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Anaesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brienza", 
            "givenName": "Nicola", 
            "id": "sg:person.01145723665.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145723665.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Anaesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Anaesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Alicino", 
            "givenName": "Ilaria", 
            "id": "sg:person.01334572547.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334572547.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Anaesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Anaesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sgobio", 
            "givenName": "Aurelia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Anaesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Anaesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Favale", 
            "givenName": "Antonella", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biomedical Science and Human Oncology, Hygiene Section, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Department of Biomedical Science and Human Oncology, Hygiene Section, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Coretti", 
            "givenName": "Caterina", 
            "id": "sg:person.0673417515.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673417515.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Biomedical Science and Human Oncology, Hygiene Section, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Department of Biomedical Science and Human Oncology, Hygiene Section, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Montagna", 
            "givenName": "Maria Teresa", 
            "id": "sg:person.0661163515.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661163515.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Anaesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Anaesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bruno", 
            "givenName": "Francesco", 
            "id": "sg:person.01030455645.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030455645.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Anaesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy", 
              "id": "http://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Anaesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Puntillo", 
            "givenName": "Filomena", 
            "id": "sg:person.01200320060.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200320060.48"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00134-005-2807-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030076590", 
              "https://doi.org/10.1007/s00134-005-2807-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-009-0120-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023499830", 
              "https://doi.org/10.1007/s00268-009-0120-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/11315640-000000000-00000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035485207", 
              "https://doi.org/10.2165/11315640-000000000-00000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-004-1104-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049836714", 
              "https://doi.org/10.1007/s10096-004-1104-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-005-2654-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022134209", 
              "https://doi.org/10.1007/s00134-005-2654-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-008-0618-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017978603", 
              "https://doi.org/10.1007/s10096-008-0618-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-007-0270-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037150606", 
              "https://doi.org/10.1007/s10096-007-0270-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2334-6-21", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030116738", 
              "https://doi.org/10.1186/1471-2334-6-21"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-004-1215-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013536854", 
              "https://doi.org/10.1007/s10096-004-1215-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-005-2806-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028119312", 
              "https://doi.org/10.1007/s00134-005-2806-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10096-004-1103-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051069641", 
              "https://doi.org/10.1007/s10096-004-1103-y"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-04-10", 
        "datePublishedReg": "2012-04-10", 
        "description": "IntroductionCandida prophylaxis in ICU is still a matter of debate. Oral chemoprophylaxis has been advocated to reduce the incidence of Candida colonisation and infection.MethodsWe performed a randomised trial studying a single drug (nystatin) versus control in surgical/trauma ICU patients. Multiple-site testing for fungi was performed in each patient on ICU admission (T0) and subsequently every 3 days (T3, T6, T9, and so forth). The primary evaluation criterion was the time course of the corrected colonisation index.ResultsNinety-nine patients were enrolled. At admission, 69 patients exhibited Candida colonisation: the most frequently colonised body sites were the stomach and the pharynx. The most frequent isolated species was Candida albicans. The corrected colonisation index was similar in the two groups at T0 (P = 0.36), while a significant statistical difference was observed between the treatment and control groups at T6 (median 0.14 and 0.33, respectively; P = 0.0016), at T9 (median 0.00 and 0.28, respectively; P = 0.0001), at T12 (median 0.00 and 0.41, respectively; P = 0.0008), and at T15 (median 0.00 and 0.42, respectively; P < 0.0003). The same results were obtained in the subgroup of patients already colonised at ICU admission.ConclusionThis trial shows that nystatin prophylaxis significantly reduces fungal colonisation in surgical/trauma ICU patients, even if already colonised.Trial registrationClinicalTrials.gov: NCT01495039", 
        "genre": "article", 
        "id": "sg:pub.10.1186/cc11300", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1117766", 
            "issn": [
              "1364-8535", 
              "1466-609X"
            ], 
            "name": "Critical Care", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "16"
          }
        ], 
        "keywords": [
          "trauma ICU patients", 
          "ICU patients", 
          "nystatin prophylaxis", 
          "ICU admission", 
          "Candida colonisation", 
          "colonisation index", 
          "oral nystatin prophylaxis", 
          "subgroup of patients", 
          "ResultsNinety-nine patients", 
          "multiple site testing", 
          "oral chemoprophylaxis", 
          "primary evaluation criterion", 
          "ConclusionThis trial", 
          "clinical trials", 
          "significant statistical difference", 
          "single drug", 
          "patients", 
          "control group", 
          "matter of debate", 
          "prophylaxis", 
          "body sites", 
          "admission", 
          "statistical difference", 
          "trials", 
          "time course", 
          "Candida albicans", 
          "chemoprophylaxis", 
          "ICU", 
          "group", 
          "infection", 
          "MethodsWe", 
          "incidence", 
          "stomach", 
          "pharynx", 
          "drugs", 
          "index", 
          "subgroups", 
          "treatment", 
          "T12", 
          "days", 
          "T9", 
          "colonisation", 
          "evaluation criteria", 
          "T15", 
          "albicans", 
          "fungal colonisation", 
          "course", 
          "differences", 
          "testing", 
          "same results", 
          "control", 
          "criteria", 
          "T0", 
          "T6", 
          "sites", 
          "results", 
          "fungi", 
          "matter", 
          "debate", 
          "species"
        ], 
        "name": "Oral nystatin prophylaxis in surgical/trauma ICU patients: a randomised clinical trial", 
        "pagination": "r57", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1032192537"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/cc11300"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22490643"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/cc11300", 
          "https://app.dimensions.ai/details/publication/pub.1032192537"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:29", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_557.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/cc11300"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/cc11300'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/cc11300'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/cc11300'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/cc11300'


     

    This table displays all metadata directly associated to this object as RDF triples.

    287 TRIPLES      21 PREDICATES      109 URIs      90 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/cc11300 schema:about N46ed648c308a42e797fe7f3f6ddbae2c
    2 N54b99202625a4573b7ec45cefc4c65e1
    3 N7f37b6e30f264db0a50c649b728c5c47
    4 N8d30eb1822ef4475a53ed47497b00d6b
    5 N8f54c7c33b1a4bafac1786ad5cb3f0b5
    6 N91e3a3bb437846fdbca152f6ee11fd66
    7 N92aee5aa11e940baa9197e0daccb9652
    8 Na23bd5b44922469ab11d7ffd892a895a
    9 Nb1a28bd31b2d4443bb06ecc7cddce48e
    10 Nb3ba417c0bab426ba0494bad6cf7306b
    11 Nba119ee0220b42fda75d4d161077176a
    12 Nd3116330c84f446a82c13bd1fdf9f435
    13 Ndd8b343e42d646f7954e557e266ba53c
    14 anzsrc-for:11
    15 anzsrc-for:1103
    16 schema:author N6aa0bdb36f3842328e8ee41e62d713b9
    17 schema:citation sg:pub.10.1007/s00134-005-2654-9
    18 sg:pub.10.1007/s00134-005-2806-y
    19 sg:pub.10.1007/s00134-005-2807-x
    20 sg:pub.10.1007/s00268-009-0120-5
    21 sg:pub.10.1007/s10096-004-1103-y
    22 sg:pub.10.1007/s10096-004-1104-x
    23 sg:pub.10.1007/s10096-004-1215-4
    24 sg:pub.10.1007/s10096-007-0270-z
    25 sg:pub.10.1007/s10096-008-0618-z
    26 sg:pub.10.1186/1471-2334-6-21
    27 sg:pub.10.2165/11315640-000000000-00000
    28 schema:datePublished 2012-04-10
    29 schema:datePublishedReg 2012-04-10
    30 schema:description IntroductionCandida prophylaxis in ICU is still a matter of debate. Oral chemoprophylaxis has been advocated to reduce the incidence of Candida colonisation and infection.MethodsWe performed a randomised trial studying a single drug (nystatin) versus control in surgical/trauma ICU patients. Multiple-site testing for fungi was performed in each patient on ICU admission (T0) and subsequently every 3 days (T3, T6, T9, and so forth). The primary evaluation criterion was the time course of the corrected colonisation index.ResultsNinety-nine patients were enrolled. At admission, 69 patients exhibited Candida colonisation: the most frequently colonised body sites were the stomach and the pharynx. The most frequent isolated species was Candida albicans. The corrected colonisation index was similar in the two groups at T0 (P = 0.36), while a significant statistical difference was observed between the treatment and control groups at T6 (median 0.14 and 0.33, respectively; P = 0.0016), at T9 (median 0.00 and 0.28, respectively; P = 0.0001), at T12 (median 0.00 and 0.41, respectively; P = 0.0008), and at T15 (median 0.00 and 0.42, respectively; P < 0.0003). The same results were obtained in the subgroup of patients already colonised at ICU admission.ConclusionThis trial shows that nystatin prophylaxis significantly reduces fungal colonisation in surgical/trauma ICU patients, even if already colonised.Trial registrationClinicalTrials.gov: NCT01495039
    31 schema:genre article
    32 schema:isAccessibleForFree true
    33 schema:isPartOf N1296b1f83b154a40a445d034e12fff20
    34 N952bf0c9b1b44f99ab9b3a0aeec3b31e
    35 sg:journal.1117766
    36 schema:keywords Candida albicans
    37 Candida colonisation
    38 ConclusionThis trial
    39 ICU
    40 ICU admission
    41 ICU patients
    42 MethodsWe
    43 ResultsNinety-nine patients
    44 T0
    45 T12
    46 T15
    47 T6
    48 T9
    49 admission
    50 albicans
    51 body sites
    52 chemoprophylaxis
    53 clinical trials
    54 colonisation
    55 colonisation index
    56 control
    57 control group
    58 course
    59 criteria
    60 days
    61 debate
    62 differences
    63 drugs
    64 evaluation criteria
    65 fungal colonisation
    66 fungi
    67 group
    68 incidence
    69 index
    70 infection
    71 matter
    72 matter of debate
    73 multiple site testing
    74 nystatin prophylaxis
    75 oral chemoprophylaxis
    76 oral nystatin prophylaxis
    77 patients
    78 pharynx
    79 primary evaluation criterion
    80 prophylaxis
    81 results
    82 same results
    83 significant statistical difference
    84 single drug
    85 sites
    86 species
    87 statistical difference
    88 stomach
    89 subgroup of patients
    90 subgroups
    91 testing
    92 time course
    93 trauma ICU patients
    94 treatment
    95 trials
    96 schema:name Oral nystatin prophylaxis in surgical/trauma ICU patients: a randomised clinical trial
    97 schema:pagination r57
    98 schema:productId N3679870456c242d2bfb62f2aa8ce1dc4
    99 N6e13a7b42cf64320bbde3ca4553155fe
    100 N7fefaa6e15504115a0866075e9260912
    101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032192537
    102 https://doi.org/10.1186/cc11300
    103 schema:sdDatePublished 2022-12-01T06:29
    104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    105 schema:sdPublisher N89668f8447f240738adfebb6f80133ba
    106 schema:url https://doi.org/10.1186/cc11300
    107 sgo:license sg:explorer/license/
    108 sgo:sdDataset articles
    109 rdf:type schema:ScholarlyArticle
    110 N1296b1f83b154a40a445d034e12fff20 schema:volumeNumber 16
    111 rdf:type schema:PublicationVolume
    112 N12a94b3e17584b6daa516a03dcd28fee rdf:first sg:person.0646114045.56
    113 rdf:rest N173477bbe14e4cfeb7e18449a123f633
    114 N173477bbe14e4cfeb7e18449a123f633 rdf:first sg:person.01145723665.11
    115 rdf:rest Ne4d2cc19b2534d07b16aaa94352b120c
    116 N3679870456c242d2bfb62f2aa8ce1dc4 schema:name pubmed_id
    117 schema:value 22490643
    118 rdf:type schema:PropertyValue
    119 N36f7c9dbc0f8478f90075d92578048cb rdf:first sg:person.0661163515.60
    120 rdf:rest Nbffe46867ca94ee0bc3afb886528e600
    121 N46ed648c308a42e797fe7f3f6ddbae2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Chi-Square Distribution
    123 rdf:type schema:DefinedTerm
    124 N54b99202625a4573b7ec45cefc4c65e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Humans
    126 rdf:type schema:DefinedTerm
    127 N6aa0bdb36f3842328e8ee41e62d713b9 rdf:first sg:person.0741532715.35
    128 rdf:rest Necb0942e9ae44358bd959f139ebe1e09
    129 N6e13a7b42cf64320bbde3ca4553155fe schema:name doi
    130 schema:value 10.1186/cc11300
    131 rdf:type schema:PropertyValue
    132 N7c5f5efe5b8d4d0a850f8d0ceb20d300 rdf:first Nff04a8dff5124c62b0a908e2c9502ca4
    133 rdf:rest N9e6b59b95c6c4e8a910941a5b4040add
    134 N7f37b6e30f264db0a50c649b728c5c47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Intensive Care Units
    136 rdf:type schema:DefinedTerm
    137 N7fefaa6e15504115a0866075e9260912 schema:name dimensions_id
    138 schema:value pub.1032192537
    139 rdf:type schema:PropertyValue
    140 N81121a7c24ce4b7aa3f7d7a9cdcdaa50 schema:affiliation grid-institutes:grid.7644.1
    141 schema:familyName Favale
    142 schema:givenName Antonella
    143 rdf:type schema:Person
    144 N89668f8447f240738adfebb6f80133ba schema:name Springer Nature - SN SciGraph project
    145 rdf:type schema:Organization
    146 N8d30eb1822ef4475a53ed47497b00d6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Critical Care
    148 rdf:type schema:DefinedTerm
    149 N8f54c7c33b1a4bafac1786ad5cb3f0b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Administration, Oral
    151 rdf:type schema:DefinedTerm
    152 N91e3a3bb437846fdbca152f6ee11fd66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Statistics, Nonparametric
    154 rdf:type schema:DefinedTerm
    155 N92aee5aa11e940baa9197e0daccb9652 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Antifungal Agents
    157 rdf:type schema:DefinedTerm
    158 N952bf0c9b1b44f99ab9b3a0aeec3b31e schema:issueNumber 2
    159 rdf:type schema:PublicationIssue
    160 N9e6b59b95c6c4e8a910941a5b4040add rdf:first N81121a7c24ce4b7aa3f7d7a9cdcdaa50
    161 rdf:rest Nba5d966481ac4b45bd817332913d5302
    162 Na23bd5b44922469ab11d7ffd892a895a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Treatment Outcome
    164 rdf:type schema:DefinedTerm
    165 Nb1a28bd31b2d4443bb06ecc7cddce48e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Nystatin
    167 rdf:type schema:DefinedTerm
    168 Nb3ba417c0bab426ba0494bad6cf7306b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Candidiasis
    170 rdf:type schema:DefinedTerm
    171 Nb76ad027af9446d2bebf206a1af8e721 rdf:first sg:person.01200320060.48
    172 rdf:rest rdf:nil
    173 Nba119ee0220b42fda75d4d161077176a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Middle Aged
    175 rdf:type schema:DefinedTerm
    176 Nba5d966481ac4b45bd817332913d5302 rdf:first sg:person.0673417515.00
    177 rdf:rest N36f7c9dbc0f8478f90075d92578048cb
    178 Nbffe46867ca94ee0bc3afb886528e600 rdf:first sg:person.01030455645.40
    179 rdf:rest Nb76ad027af9446d2bebf206a1af8e721
    180 Nd3116330c84f446a82c13bd1fdf9f435 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Male
    182 rdf:type schema:DefinedTerm
    183 Ndd8b343e42d646f7954e557e266ba53c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Female
    185 rdf:type schema:DefinedTerm
    186 Ne4d2cc19b2534d07b16aaa94352b120c rdf:first sg:person.01334572547.26
    187 rdf:rest N7c5f5efe5b8d4d0a850f8d0ceb20d300
    188 Necb0942e9ae44358bd959f139ebe1e09 rdf:first sg:person.0631367112.34
    189 rdf:rest N12a94b3e17584b6daa516a03dcd28fee
    190 Nff04a8dff5124c62b0a908e2c9502ca4 schema:affiliation grid-institutes:grid.7644.1
    191 schema:familyName Sgobio
    192 schema:givenName Aurelia
    193 rdf:type schema:Person
    194 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    195 schema:name Medical and Health Sciences
    196 rdf:type schema:DefinedTerm
    197 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    198 schema:name Clinical Sciences
    199 rdf:type schema:DefinedTerm
    200 sg:journal.1117766 schema:issn 1364-8535
    201 1466-609X
    202 schema:name Critical Care
    203 schema:publisher Springer Nature
    204 rdf:type schema:Periodical
    205 sg:person.01030455645.40 schema:affiliation grid-institutes:grid.7644.1
    206 schema:familyName Bruno
    207 schema:givenName Francesco
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030455645.40
    209 rdf:type schema:Person
    210 sg:person.01145723665.11 schema:affiliation grid-institutes:grid.7644.1
    211 schema:familyName Brienza
    212 schema:givenName Nicola
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145723665.11
    214 rdf:type schema:Person
    215 sg:person.01200320060.48 schema:affiliation grid-institutes:grid.7644.1
    216 schema:familyName Puntillo
    217 schema:givenName Filomena
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200320060.48
    219 rdf:type schema:Person
    220 sg:person.01334572547.26 schema:affiliation grid-institutes:grid.7644.1
    221 schema:familyName Alicino
    222 schema:givenName Ilaria
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334572547.26
    224 rdf:type schema:Person
    225 sg:person.0631367112.34 schema:affiliation grid-institutes:grid.7644.1
    226 schema:familyName Caggiano
    227 schema:givenName Giuseppina
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631367112.34
    229 rdf:type schema:Person
    230 sg:person.0646114045.56 schema:affiliation grid-institutes:grid.7644.1
    231 schema:familyName Dalfino
    232 schema:givenName Lidia
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646114045.56
    234 rdf:type schema:Person
    235 sg:person.0661163515.60 schema:affiliation grid-institutes:grid.7644.1
    236 schema:familyName Montagna
    237 schema:givenName Maria Teresa
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661163515.60
    239 rdf:type schema:Person
    240 sg:person.0673417515.00 schema:affiliation grid-institutes:grid.7644.1
    241 schema:familyName Coretti
    242 schema:givenName Caterina
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673417515.00
    244 rdf:type schema:Person
    245 sg:person.0741532715.35 schema:affiliation grid-institutes:grid.7644.1
    246 schema:familyName Giglio
    247 schema:givenName Mariateresa
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741532715.35
    249 rdf:type schema:Person
    250 sg:pub.10.1007/s00134-005-2654-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022134209
    251 https://doi.org/10.1007/s00134-005-2654-9
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1007/s00134-005-2806-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1028119312
    254 https://doi.org/10.1007/s00134-005-2806-y
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1007/s00134-005-2807-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030076590
    257 https://doi.org/10.1007/s00134-005-2807-x
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1007/s00268-009-0120-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023499830
    260 https://doi.org/10.1007/s00268-009-0120-5
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1007/s10096-004-1103-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1051069641
    263 https://doi.org/10.1007/s10096-004-1103-y
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1007/s10096-004-1104-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049836714
    266 https://doi.org/10.1007/s10096-004-1104-x
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1007/s10096-004-1215-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013536854
    269 https://doi.org/10.1007/s10096-004-1215-4
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1007/s10096-007-0270-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1037150606
    272 https://doi.org/10.1007/s10096-007-0270-z
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1007/s10096-008-0618-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1017978603
    275 https://doi.org/10.1007/s10096-008-0618-z
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1186/1471-2334-6-21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030116738
    278 https://doi.org/10.1186/1471-2334-6-21
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.2165/11315640-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035485207
    281 https://doi.org/10.2165/11315640-000000000-00000
    282 rdf:type schema:CreativeWork
    283 grid-institutes:grid.7644.1 schema:alternateName Anaesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy
    284 Department of Biomedical Science and Human Oncology, Hygiene Section, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy
    285 schema:name Anaesthesia and Intensive Care Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy
    286 Department of Biomedical Science and Human Oncology, Hygiene Section, University of Bari, Piazza G. Cesare 11, 70124, Bari, Italy
    287 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...