Association between serum soluble CD40 ligand levels and mortality in patients with severe sepsis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-03-15

AUTHORS

Leonardo Lorente, María M Martín, Nerea Varo, Juan María Borreguero-León, Jordi Solé-Violán, José Blanquer, Lorenzo Labarta, César Díaz, Alejandro Jiménez, Eduardo Pastor, Felipe Belmonte, Josune Orbe, José A Rodríguez, Eduardo Gómez-Melini, José M Ferrer-Agüero, José Ferreres, María C LLimiñana, José A Páramo

ABSTRACT

IntroductionCD40 Ligand (CD40L) and its soluble counterpart (sCD40L) are proteins that exhibit prothrombotic and proinflammatory properties on binding to their cell surface receptor CD40. The results of small clinical studies suggest that sCD40L levels could play a role in sepsis; however, there are no data on the association between sCD40L levels and mortality of septic patients. Thus, the aim of this study was to determine whether circulating sCD40L levels could be a marker of adverse outcome in a large cohort of patients with severe sepsis.MethodsThis was a multicenter, observational and prospective study carried out in six Spanish intensive care units. Serum levels of sCD40L, tumour necrosis factor-alpha and interleukin-10, and plasma levels of tissue factor were measured in 186 patients with severe sepsis at the time of diagnosis. Serum sCD40L was also measured in 50 age- and sex-matched controls. Survival at 30 days was used as the endpoint.ResultsCirculating sCD40L levels were significantly higher in septic patients than in controls (P = 0.01), and in non-survivors (n = 62) compared to survivors (n = 124) (P = 0.04). However, the levels of CD40L were not different regarding sepsis severity. Logistic regression analysis showed that sCD40L levels >3.5 ng/mL were associated with higher mortality at 30 days (odds ratio = 2.89; 95% confidence interval = 1.37 to 6.07; P = 0.005). The area under the curve of sCD40L levels >3.5 ng/mL as predictor of mortality at 30 days was 0.58 (95% CI = 0.51 to 0.65; P = 0.03).ConclusionsIn conclusion, circulating sCD40L levels are increased in septic patients and are independently associated with mortality in these patients; thus, its modulation could represent an attractive therapeutic target. More... »

PAGES

r97

Journal

TITLE

Critical Care

ISSUE

2

VOLUME

15

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/cc10104

DOI

http://dx.doi.org/10.1186/cc10104

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002821025

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21406105


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355 Laboratory Department, Hospital San Jorge de Huesca, Avenida Martínez de Velasco no. 36, 22004, Huesca, Spain
356 rdf:type schema:Organization
357 grid-institutes:grid.5924.a schema:alternateName Atherosclerosis Research Laboratory, CIMA-University of Navarra, Avda Pío XII no. 55, 31008, Pamplona, Spain
358 schema:name Atherosclerosis Research Laboratory, CIMA-University of Navarra, Avda Pío XII no. 55, 31008, Pamplona, Spain
359 rdf:type schema:Organization
 




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