Breast fibroblasts modulate epithelial cell proliferation in three-dimensional in vitro co-culture View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-02

AUTHORS

Andrea Sadlonova, Zdenek Novak, Martin R Johnson, Damon B Bowe, Sandra R Gault, Grier P Page, Jaideep V Thottassery, Danny R Welch, Andra R Frost

ABSTRACT

BACKGROUND: Stromal fibroblasts associated with in situ and invasive breast carcinoma differ phenotypically from fibroblasts associated with normal breast epithelium, and these alterations in carcinoma-associated fibroblasts (CAF) may promote breast carcinogenesis and cancer progression. A better understanding of the changes that occur in fibroblasts during carcinogenesis and their influence on epithelial cell growth and behavior could lead to novel strategies for the prevention and treatment of breast cancer. To this end, the effect of CAF and normal breast-associated fibroblasts (NAF) on the growth of epithelial cells representative of pre-neoplastic breast disease was assessed. METHODS: NAF and CAF were grown with the nontumorigenic MCF10A epithelial cells and their more transformed, tumorigenic derivative, MCF10AT cells, in direct three-dimensional co-cultures on basement membrane material. The proliferation and apoptosis of MCF10A cells and MCF10AT cells were assessed by 5-bromo-2'-deoxyuridine labeling and TUNEL assay, respectively. Additionally, NAF and CAF were compared for expression of insulin-like growth factor II as a potential mediator of their effects on epithelial cell growth, by ELISA and by quantitative, real-time PCR. RESULTS: In relatively low numbers, both NAF and CAF suppressed proliferation of MCF10A cells. However, only NAF and not CAF significantly inhibited proliferation of the more transformed MCF10AT cells. The degree of growth inhibition varied among NAF or CAF from different individuals. In greater numbers, NAF and CAF have less inhibitory effect on epithelial cell growth. The rate of epithelial cell apoptosis was not affected by NAF or CAF. Mean insulin-like growth factor II levels were not significantly different in NAF versus CAF and did not correlate with the fibroblast effect on epithelial cell proliferation. CONCLUSION: Both NAF and CAF have the ability to inhibit the growth of pre-cancerous breast epithelial cells. NAF have greater inhibitory capacity than CAF, suggesting that the ability of fibroblasts to inhibit epithelial cell proliferation is lost during breast carcinogenesis. Furthermore, as the degree of transformation of the epithelial cells increased they became resistant to the growth-inhibitory effects of CAF. Insulin-like growth factor II could not be implicated as a contributor to this differential effect of NAF and CAF on epithelial cell growth. More... »

PAGES

r46

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/bcr949

DOI

http://dx.doi.org/10.1186/bcr949

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007818794

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15642169


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Communication", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Alabama at Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Pathology, The University of Alabama at Birmingham, Alabama, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sadlonova", 
        "givenName": "Andrea", 
        "id": "sg:person.01146520356.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146520356.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Alabama at Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Pediatrics, The University of Alabama at Birmingham, Alabama, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Novak", 
        "givenName": "Zdenek", 
        "id": "sg:person.0715533543.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715533543.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Alabama at Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Pharmacology and Toxicology, The University of Alabama at Birmingham, Alabama, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johnson", 
        "givenName": "Martin R", 
        "id": "sg:person.011166100617.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011166100617.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Alabama at Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Pharmacology and Toxicology, The University of Alabama at Birmingham, Alabama, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bowe", 
        "givenName": "Damon B", 
        "id": "sg:person.01331062156.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331062156.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Alabama at Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Pathology, The University of Alabama at Birmingham, Alabama, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gault", 
        "givenName": "Sandra R", 
        "id": "sg:person.0605456056.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605456056.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Alabama at Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Biostatistics, The University of Alabama at Birmingham, Alabama, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Page", 
        "givenName": "Grier P", 
        "id": "sg:person.01206322060.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206322060.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Southern Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.454225.0", 
          "name": [
            "Drug Discovery Division, Southern Research Institute, Birmingham, Alabama, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thottassery", 
        "givenName": "Jaideep V", 
        "id": "sg:person.01227575356.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227575356.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Alabama at Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Pathology, The University of Alabama at Birmingham, Alabama, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Welch", 
        "givenName": "Danny R", 
        "id": "sg:person.0647776203.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647776203.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Alabama at Birmingham", 
          "id": "https://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Pathology, The University of Alabama at Birmingham, Alabama, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frost", 
        "givenName": "Andra R", 
        "id": "sg:person.01341352437.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341352437.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1023/a:1006163418479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001147226", 
          "https://doi.org/10.1023/a:1006163418479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004280050442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004786846", 
          "https://doi.org/10.1007/s004280050442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19960103)65:1<120::aid-ijc20>3.0.co;2-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006570107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00665943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008680980", 
          "https://doi.org/10.1007/bf00665943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00665943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008680980", 
          "https://doi.org/10.1007/bf00665943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1992.14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008804173", 
          "https://doi.org/10.1038/bjc.1992.14"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1992.14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008804173", 
          "https://doi.org/10.1038/bjc.1992.14"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.00503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010028163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11626-998-0012-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011638039", 
          "https://doi.org/10.1007/s11626-998-0012-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19960315)77:6<1079::aid-cncr12>3.0.co;2-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011682797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-59259-699-7_11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012355670", 
          "https://doi.org/10.1007/978-1-59259-699-7_11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2184.36.s.1.7.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018068412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910590219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020907580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.137.1.231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021703305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.1041330112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021807045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abio.2001.5570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021903266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.19.1494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026270330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910600114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026450372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1524-4741.1999.00136.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028178031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1524-4741.1999.00136.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028178031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.10898", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028744368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1999.tb00750.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030372775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1999.tb00750.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030372775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19970328)71:1<42::aid-ijc9>3.0.co;2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033664404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000066230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036131899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0303-7207(99)00098-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037024450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-59259-456-6_5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037056499", 
          "https://doi.org/10.1007/978-1-59259-456-6_5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01807035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037122046", 
          "https://doi.org/10.1007/bf01807035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01807035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037122046", 
          "https://doi.org/10.1007/bf01807035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03347295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039572170", 
          "https://doi.org/10.1007/bf03347295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1993.237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042955215", 
          "https://doi.org/10.1038/bjc.1993.237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1993.237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042955215", 
          "https://doi.org/10.1038/bjc.1993.237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1046-2023(03)00032-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045111385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1046-2023(03)00032-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045111385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1046-2023(03)00032-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045111385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910560520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046567785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0934-8832(11)80232-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052433082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074539523", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074782080", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074889435", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.14670/hh-17.599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075036298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.14670/hh-17.623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075036299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0037-1613065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075051617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5301/jbm.2008.3917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075085374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/55.2.231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077289701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077795225", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077957115", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081662655", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082495505", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082770714", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082853627", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083173303", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083336308", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-02", 
    "datePublishedReg": "2004-02-01", 
    "description": "BACKGROUND: Stromal fibroblasts associated with in situ and invasive breast carcinoma differ phenotypically from fibroblasts associated with normal breast epithelium, and these alterations in carcinoma-associated fibroblasts (CAF) may promote breast carcinogenesis and cancer progression. A better understanding of the changes that occur in fibroblasts during carcinogenesis and their influence on epithelial cell growth and behavior could lead to novel strategies for the prevention and treatment of breast cancer. To this end, the effect of CAF and normal breast-associated fibroblasts (NAF) on the growth of epithelial cells representative of pre-neoplastic breast disease was assessed.\nMETHODS: NAF and CAF were grown with the nontumorigenic MCF10A epithelial cells and their more transformed, tumorigenic derivative, MCF10AT cells, in direct three-dimensional co-cultures on basement membrane material. The proliferation and apoptosis of MCF10A cells and MCF10AT cells were assessed by 5-bromo-2'-deoxyuridine labeling and TUNEL assay, respectively. Additionally, NAF and CAF were compared for expression of insulin-like growth factor II as a potential mediator of their effects on epithelial cell growth, by ELISA and by quantitative, real-time PCR.\nRESULTS: In relatively low numbers, both NAF and CAF suppressed proliferation of MCF10A cells. However, only NAF and not CAF significantly inhibited proliferation of the more transformed MCF10AT cells. The degree of growth inhibition varied among NAF or CAF from different individuals. In greater numbers, NAF and CAF have less inhibitory effect on epithelial cell growth. The rate of epithelial cell apoptosis was not affected by NAF or CAF. Mean insulin-like growth factor II levels were not significantly different in NAF versus CAF and did not correlate with the fibroblast effect on epithelial cell proliferation.\nCONCLUSION: Both NAF and CAF have the ability to inhibit the growth of pre-cancerous breast epithelial cells. NAF have greater inhibitory capacity than CAF, suggesting that the ability of fibroblasts to inhibit epithelial cell proliferation is lost during breast carcinogenesis. Furthermore, as the degree of transformation of the epithelial cells increased they became resistant to the growth-inhibitory effects of CAF. Insulin-like growth factor II could not be implicated as a contributor to this differential effect of NAF and CAF on epithelial cell growth.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/bcr949", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2568762", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1022375", 
        "issn": [
          "1465-5411", 
          "1465-542X"
        ], 
        "name": "Breast Cancer Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "7"
      }
    ], 
    "name": "Breast fibroblasts modulate epithelial cell proliferation in three-dimensional in vitro co-culture", 
    "pagination": "r46", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "253e95cc2221eb13fff0ac3c6300de5484748e1c4284decaaba753b32721d119"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15642169"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100927353"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/bcr949"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007818794"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/bcr949", 
      "https://app.dimensions.ai/details/publication/pub.1007818794"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fbcr949"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/bcr949'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/bcr949'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/bcr949'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/bcr949'


 

This table displays all metadata directly associated to this object as RDF triples.

303 TRIPLES      21 PREDICATES      83 URIs      30 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/bcr949 schema:about N0d747f6a74c64c2d922cc076eb82e631
2 N5768858d7d8b4b20a10b49da0cf5f6f9
3 N6b20d00004784536b3246b5ea3409358
4 N80001cdacb04419fbb79319be1507f9a
5 Nb029c25893e74874b90bc01461261172
6 Nce3af75c89d34263a375f257a4f0dd95
7 Nd32bbbbbd8f04e4f8a29bfac9dcee709
8 Ndc80c4cb13094a8a99ca589f56c82bd2
9 Ne2d0b849640a4bcdae2183a8faedd55e
10 anzsrc-for:11
11 anzsrc-for:1112
12 schema:author Nd1fd9eee1dd24dc2a85b25b13a80bc00
13 schema:citation sg:pub.10.1007/978-1-59259-456-6_5
14 sg:pub.10.1007/978-1-59259-699-7_11
15 sg:pub.10.1007/bf00665943
16 sg:pub.10.1007/bf01807035
17 sg:pub.10.1007/bf03347295
18 sg:pub.10.1007/s004280050442
19 sg:pub.10.1007/s11626-998-0012-2
20 sg:pub.10.1023/a:1006163418479
21 sg:pub.10.1038/bjc.1992.14
22 sg:pub.10.1038/bjc.1993.237
23 https://app.dimensions.ai/details/publication/pub.1074539523
24 https://app.dimensions.ai/details/publication/pub.1074782080
25 https://app.dimensions.ai/details/publication/pub.1074889435
26 https://app.dimensions.ai/details/publication/pub.1077795225
27 https://app.dimensions.ai/details/publication/pub.1077957115
28 https://app.dimensions.ai/details/publication/pub.1081662655
29 https://app.dimensions.ai/details/publication/pub.1082495505
30 https://app.dimensions.ai/details/publication/pub.1082770714
31 https://app.dimensions.ai/details/publication/pub.1082853627
32 https://app.dimensions.ai/details/publication/pub.1083173303
33 https://app.dimensions.ai/details/publication/pub.1083336308
34 https://doi.org/10.1002/(sici)1097-0142(19960315)77:6<1079::aid-cncr12>3.0.co;2-z
35 https://doi.org/10.1002/(sici)1097-0215(19960103)65:1<120::aid-ijc20>3.0.co;2-j
36 https://doi.org/10.1002/(sici)1097-0215(19970328)71:1<42::aid-ijc9>3.0.co;2-3
37 https://doi.org/10.1002/ijc.10898
38 https://doi.org/10.1002/ijc.2910560520
39 https://doi.org/10.1002/ijc.2910590219
40 https://doi.org/10.1002/ijc.2910600114
41 https://doi.org/10.1002/jcp.1041330112
42 https://doi.org/10.1006/abio.2001.5570
43 https://doi.org/10.1016/s0303-7207(99)00098-2
44 https://doi.org/10.1016/s0934-8832(11)80232-5
45 https://doi.org/10.1016/s1046-2023(03)00032-x
46 https://doi.org/10.1046/j.1365-2184.36.s.1.7.x
47 https://doi.org/10.1046/j.1524-4741.1999.00136.x
48 https://doi.org/10.1055/s-0037-1613065
49 https://doi.org/10.1083/jcb.137.1.231
50 https://doi.org/10.1093/jnci/55.2.231
51 https://doi.org/10.1093/jnci/94.19.1494
52 https://doi.org/10.1111/j.1349-7006.1999.tb00750.x
53 https://doi.org/10.1159/000066230
54 https://doi.org/10.1242/jcs.00503
55 https://doi.org/10.14670/hh-17.599
56 https://doi.org/10.14670/hh-17.623
57 https://doi.org/10.5301/jbm.2008.3917
58 schema:datePublished 2004-02
59 schema:datePublishedReg 2004-02-01
60 schema:description BACKGROUND: Stromal fibroblasts associated with in situ and invasive breast carcinoma differ phenotypically from fibroblasts associated with normal breast epithelium, and these alterations in carcinoma-associated fibroblasts (CAF) may promote breast carcinogenesis and cancer progression. A better understanding of the changes that occur in fibroblasts during carcinogenesis and their influence on epithelial cell growth and behavior could lead to novel strategies for the prevention and treatment of breast cancer. To this end, the effect of CAF and normal breast-associated fibroblasts (NAF) on the growth of epithelial cells representative of pre-neoplastic breast disease was assessed. METHODS: NAF and CAF were grown with the nontumorigenic MCF10A epithelial cells and their more transformed, tumorigenic derivative, MCF10AT cells, in direct three-dimensional co-cultures on basement membrane material. The proliferation and apoptosis of MCF10A cells and MCF10AT cells were assessed by 5-bromo-2'-deoxyuridine labeling and TUNEL assay, respectively. Additionally, NAF and CAF were compared for expression of insulin-like growth factor II as a potential mediator of their effects on epithelial cell growth, by ELISA and by quantitative, real-time PCR. RESULTS: In relatively low numbers, both NAF and CAF suppressed proliferation of MCF10A cells. However, only NAF and not CAF significantly inhibited proliferation of the more transformed MCF10AT cells. The degree of growth inhibition varied among NAF or CAF from different individuals. In greater numbers, NAF and CAF have less inhibitory effect on epithelial cell growth. The rate of epithelial cell apoptosis was not affected by NAF or CAF. Mean insulin-like growth factor II levels were not significantly different in NAF versus CAF and did not correlate with the fibroblast effect on epithelial cell proliferation. CONCLUSION: Both NAF and CAF have the ability to inhibit the growth of pre-cancerous breast epithelial cells. NAF have greater inhibitory capacity than CAF, suggesting that the ability of fibroblasts to inhibit epithelial cell proliferation is lost during breast carcinogenesis. Furthermore, as the degree of transformation of the epithelial cells increased they became resistant to the growth-inhibitory effects of CAF. Insulin-like growth factor II could not be implicated as a contributor to this differential effect of NAF and CAF on epithelial cell growth.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N0b7ec8cd2f1d4b9cb985ee8a1585b27b
65 Nd7cc09a6183a48c3aa9202881a0f4c6b
66 sg:journal.1022375
67 schema:name Breast fibroblasts modulate epithelial cell proliferation in three-dimensional in vitro co-culture
68 schema:pagination r46
69 schema:productId N056c0738d26b4d1ab17250344bf92680
70 N0aac68d832e047b6a2dba56fc6ed6931
71 N792aae838f8442e0b898f4d16847854a
72 Na3019adc06cc418f8e6db561d363fd70
73 Nb8394bf0a6374a7cbd30b65f9d0ec381
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007818794
75 https://doi.org/10.1186/bcr949
76 schema:sdDatePublished 2019-04-11T01:06
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Nff514a8d058e46deaf553661c9fa89a7
79 schema:url http://link.springer.com/10.1186%2Fbcr949
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N056c0738d26b4d1ab17250344bf92680 schema:name doi
84 schema:value 10.1186/bcr949
85 rdf:type schema:PropertyValue
86 N0aac68d832e047b6a2dba56fc6ed6931 schema:name dimensions_id
87 schema:value pub.1007818794
88 rdf:type schema:PropertyValue
89 N0b7ec8cd2f1d4b9cb985ee8a1585b27b schema:volumeNumber 7
90 rdf:type schema:PublicationVolume
91 N0d747f6a74c64c2d922cc076eb82e631 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Breast Neoplasms
93 rdf:type schema:DefinedTerm
94 N567e751de2c54d96892dc38c3a2abc73 rdf:first sg:person.01331062156.27
95 rdf:rest Nee1025cc136f4bc89c00022bff154956
96 N5768858d7d8b4b20a10b49da0cf5f6f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Cell Communication
98 rdf:type schema:DefinedTerm
99 N6022d4e17a694cfd886d560c4041de47 rdf:first sg:person.0715533543.43
100 rdf:rest N89a737f928e049668be2397d7dd7dccf
101 N6b20d00004784536b3246b5ea3409358 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Epithelial Cells
103 rdf:type schema:DefinedTerm
104 N792aae838f8442e0b898f4d16847854a schema:name readcube_id
105 schema:value 253e95cc2221eb13fff0ac3c6300de5484748e1c4284decaaba753b32721d119
106 rdf:type schema:PropertyValue
107 N80001cdacb04419fbb79319be1507f9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Female
109 rdf:type schema:DefinedTerm
110 N89a737f928e049668be2397d7dd7dccf rdf:first sg:person.011166100617.16
111 rdf:rest N567e751de2c54d96892dc38c3a2abc73
112 N8dea674f7d654b81adc1277d2bb61faf rdf:first sg:person.01227575356.89
113 rdf:rest Nf772286e13994b348773369a5df18e91
114 Na017bce4c2584f598e6c7660d85dbf86 rdf:first sg:person.01341352437.09
115 rdf:rest rdf:nil
116 Na3019adc06cc418f8e6db561d363fd70 schema:name pubmed_id
117 schema:value 15642169
118 rdf:type schema:PropertyValue
119 Nb029c25893e74874b90bc01461261172 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Humans
121 rdf:type schema:DefinedTerm
122 Nb8394bf0a6374a7cbd30b65f9d0ec381 schema:name nlm_unique_id
123 schema:value 100927353
124 rdf:type schema:PropertyValue
125 Nbb907d9fa9804a308ee348cf23ead021 rdf:first sg:person.01206322060.94
126 rdf:rest N8dea674f7d654b81adc1277d2bb61faf
127 Nce3af75c89d34263a375f257a4f0dd95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Fibroblasts
129 rdf:type schema:DefinedTerm
130 Nd1fd9eee1dd24dc2a85b25b13a80bc00 rdf:first sg:person.01146520356.76
131 rdf:rest N6022d4e17a694cfd886d560c4041de47
132 Nd32bbbbbd8f04e4f8a29bfac9dcee709 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Tumor Cells, Cultured
134 rdf:type schema:DefinedTerm
135 Nd7cc09a6183a48c3aa9202881a0f4c6b schema:issueNumber 1
136 rdf:type schema:PublicationIssue
137 Ndc80c4cb13094a8a99ca589f56c82bd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Breast
139 rdf:type schema:DefinedTerm
140 Ne2d0b849640a4bcdae2183a8faedd55e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Cell Proliferation
142 rdf:type schema:DefinedTerm
143 Nee1025cc136f4bc89c00022bff154956 rdf:first sg:person.0605456056.30
144 rdf:rest Nbb907d9fa9804a308ee348cf23ead021
145 Nf772286e13994b348773369a5df18e91 rdf:first sg:person.0647776203.17
146 rdf:rest Na017bce4c2584f598e6c7660d85dbf86
147 Nff514a8d058e46deaf553661c9fa89a7 schema:name Springer Nature - SN SciGraph project
148 rdf:type schema:Organization
149 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
150 schema:name Medical and Health Sciences
151 rdf:type schema:DefinedTerm
152 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
153 schema:name Oncology and Carcinogenesis
154 rdf:type schema:DefinedTerm
155 sg:grant.2568762 http://pending.schema.org/fundedItem sg:pub.10.1186/bcr949
156 rdf:type schema:MonetaryGrant
157 sg:journal.1022375 schema:issn 1465-5411
158 1465-542X
159 schema:name Breast Cancer Research
160 rdf:type schema:Periodical
161 sg:person.011166100617.16 schema:affiliation https://www.grid.ac/institutes/grid.265892.2
162 schema:familyName Johnson
163 schema:givenName Martin R
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011166100617.16
165 rdf:type schema:Person
166 sg:person.01146520356.76 schema:affiliation https://www.grid.ac/institutes/grid.265892.2
167 schema:familyName Sadlonova
168 schema:givenName Andrea
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146520356.76
170 rdf:type schema:Person
171 sg:person.01206322060.94 schema:affiliation https://www.grid.ac/institutes/grid.265892.2
172 schema:familyName Page
173 schema:givenName Grier P
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206322060.94
175 rdf:type schema:Person
176 sg:person.01227575356.89 schema:affiliation https://www.grid.ac/institutes/grid.454225.0
177 schema:familyName Thottassery
178 schema:givenName Jaideep V
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227575356.89
180 rdf:type schema:Person
181 sg:person.01331062156.27 schema:affiliation https://www.grid.ac/institutes/grid.265892.2
182 schema:familyName Bowe
183 schema:givenName Damon B
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331062156.27
185 rdf:type schema:Person
186 sg:person.01341352437.09 schema:affiliation https://www.grid.ac/institutes/grid.265892.2
187 schema:familyName Frost
188 schema:givenName Andra R
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341352437.09
190 rdf:type schema:Person
191 sg:person.0605456056.30 schema:affiliation https://www.grid.ac/institutes/grid.265892.2
192 schema:familyName Gault
193 schema:givenName Sandra R
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605456056.30
195 rdf:type schema:Person
196 sg:person.0647776203.17 schema:affiliation https://www.grid.ac/institutes/grid.265892.2
197 schema:familyName Welch
198 schema:givenName Danny R
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647776203.17
200 rdf:type schema:Person
201 sg:person.0715533543.43 schema:affiliation https://www.grid.ac/institutes/grid.265892.2
202 schema:familyName Novak
203 schema:givenName Zdenek
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715533543.43
205 rdf:type schema:Person
206 sg:pub.10.1007/978-1-59259-456-6_5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037056499
207 https://doi.org/10.1007/978-1-59259-456-6_5
208 rdf:type schema:CreativeWork
209 sg:pub.10.1007/978-1-59259-699-7_11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012355670
210 https://doi.org/10.1007/978-1-59259-699-7_11
211 rdf:type schema:CreativeWork
212 sg:pub.10.1007/bf00665943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008680980
213 https://doi.org/10.1007/bf00665943
214 rdf:type schema:CreativeWork
215 sg:pub.10.1007/bf01807035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037122046
216 https://doi.org/10.1007/bf01807035
217 rdf:type schema:CreativeWork
218 sg:pub.10.1007/bf03347295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039572170
219 https://doi.org/10.1007/bf03347295
220 rdf:type schema:CreativeWork
221 sg:pub.10.1007/s004280050442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004786846
222 https://doi.org/10.1007/s004280050442
223 rdf:type schema:CreativeWork
224 sg:pub.10.1007/s11626-998-0012-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011638039
225 https://doi.org/10.1007/s11626-998-0012-2
226 rdf:type schema:CreativeWork
227 sg:pub.10.1023/a:1006163418479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001147226
228 https://doi.org/10.1023/a:1006163418479
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/bjc.1992.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008804173
231 https://doi.org/10.1038/bjc.1992.14
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/bjc.1993.237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042955215
234 https://doi.org/10.1038/bjc.1993.237
235 rdf:type schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1074539523 schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1074782080 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1074889435 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1077795225 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1077957115 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1081662655 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1082495505 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1082770714 schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1082853627 schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1083173303 schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1083336308 schema:CreativeWork
247 https://doi.org/10.1002/(sici)1097-0142(19960315)77:6<1079::aid-cncr12>3.0.co;2-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1011682797
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1002/(sici)1097-0215(19960103)65:1<120::aid-ijc20>3.0.co;2-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1006570107
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1002/(sici)1097-0215(19970328)71:1<42::aid-ijc9>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033664404
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1002/ijc.10898 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028744368
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1002/ijc.2910560520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046567785
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1002/ijc.2910590219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020907580
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1002/ijc.2910600114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026450372
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1002/jcp.1041330112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021807045
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1006/abio.2001.5570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021903266
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/s0303-7207(99)00098-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037024450
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/s0934-8832(11)80232-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052433082
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/s1046-2023(03)00032-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045111385
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1046/j.1365-2184.36.s.1.7.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018068412
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1046/j.1524-4741.1999.00136.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028178031
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1055/s-0037-1613065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075051617
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1083/jcb.137.1.231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021703305
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1093/jnci/55.2.231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077289701
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1093/jnci/94.19.1494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026270330
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1111/j.1349-7006.1999.tb00750.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030372775
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1159/000066230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036131899
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1242/jcs.00503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010028163
288 rdf:type schema:CreativeWork
289 https://doi.org/10.14670/hh-17.599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075036298
290 rdf:type schema:CreativeWork
291 https://doi.org/10.14670/hh-17.623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075036299
292 rdf:type schema:CreativeWork
293 https://doi.org/10.5301/jbm.2008.3917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075085374
294 rdf:type schema:CreativeWork
295 https://www.grid.ac/institutes/grid.265892.2 schema:alternateName University of Alabama at Birmingham
296 schema:name Department of Biostatistics, The University of Alabama at Birmingham, Alabama, USA
297 Department of Pathology, The University of Alabama at Birmingham, Alabama, USA
298 Department of Pediatrics, The University of Alabama at Birmingham, Alabama, USA
299 Department of Pharmacology and Toxicology, The University of Alabama at Birmingham, Alabama, USA
300 rdf:type schema:Organization
301 https://www.grid.ac/institutes/grid.454225.0 schema:alternateName Southern Research Institute
302 schema:name Drug Discovery Division, Southern Research Institute, Birmingham, Alabama, USA
303 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...