New targets for therapy in breast cancer: Small molecule tyrosine kinase inhibitors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-10

AUTHORS

Nancy U Lin, Eric P Winer

ABSTRACT

Over the past several years many advances have been made in our understanding of critical pathways involved in carcinogenesis and tumor growth. These advances have led to the investigation of small molecule inhibitors of the ErbB family of receptor tyrosine kinases across a broad spectrum of malignancies. In this article we summarize the rationale for targeting members of the ErbB family in breast cancer, and review the preclinical and clinical data for the agents that are furthest in development. In addition, we highlight directions for future research, such as exploration of the potential crosstalk between the ErbB and hormone receptor signal transduction pathways, identification of predictive markers for tumor sensitivity, and development of rational combination regimens that include the tyrosine kinase inhibitors. More... »

PAGES

204

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/bcr919

DOI

http://dx.doi.org/10.1186/bcr919

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018227977

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15318926


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