Tyrosine kinase signalling in breast cancer: Fibroblast growth factors and their receptors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-06

AUTHORS

Clive Dickson, Bradley Spencer-Dene, Christian Dillon, Vera Fantl

ABSTRACT

The fibroblast growth factors [Fgfs (murine), FGFs (human)] constitute a large family of ligands that signal through a class of cell-surface tyrosine kinase receptors. Fgf signalling has been associated in vitro with cellular differentiation as well as mitogenic and motogenic responses. In vivo, Fgfs are critical for animal development, and some have potent angiogenic properties. Several Fgfs have been identified as oncogenes in murine mammary cancer, where their deregulation is associated with proviral insertions of the mouse mammary tumour virus (MMTV). Thus, in some mammary tumours of MMTV-infected mouse strains, integration of viral genomic DNA into the somatic DNA of mammary epithelial cells was found to have caused the inappropriate expression of members of this family of growth factors. Although examination of human breast cancers has shown an altered expression of FGFs or of their receptors in some tumours, their role in the causation of breast disease is unclear and remains controversial. More... »

PAGES

191

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/bcr53

DOI

http://dx.doi.org/10.1186/bcr53

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014298671

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11250709


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