Developing a new generation of breast cancer clinical gene expression tests View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-08

AUTHORS

Zuzana Kos, Torsten O Nielsen

ABSTRACT

When treatment decisions are based purely on clinicopathological factors, many women with estrogen receptor-positive/human epidermal growth factor receptor 2-negative cancers are overtreated. Gene expression profiles are valuable clinical tools that stratify the recurrence risk to identify patients most likely to benefit from adjuvant systemic therapies. Building upon greater understanding of tumor biology and more rigorous approaches to validation (including independent studies with a high level of evidence), several second-generation multigene tests have been developed. In the previous issue, Martin and colleagues report the third clinical validation study for EndoPredict, a distributed assay to assess risk of distant recurrences in estrogen receptor-positive/human epidermal growth factor receptor 2-negative women. The authors confirm the assay's independent prognostic value in premenopausal and postmenopausal, node-positive women treated with contemporary chemotherapy followed by endocrine therapy. EndoPredict did not, however, predict benefit from adding paclitaxel. Predictive signatures for selecting among chemotherapy regimens remain an area needing further development. More... »

PAGES

103

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/bcr3688

DOI

http://dx.doi.org/10.1186/bcr3688

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034269038

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25928431


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