Ontology type: schema:ScholarlyArticle Open Access: True
2013-10
AUTHORSRachel L Atkinson, Wei T Yang, Daniel G Rosen, Melissa D Landis, Helen Wong, Michael T Lewis, Chad J Creighton, Krystal R Sexton, Sue G Hilsenbeck, Aysegul A Sahin, Abenaa M Brewster, Wendy A Woodward, Jenny C Chang
ABSTRACTINTRODUCTION: We hypothesized that cells present in normal tissue that bear cancer stem cell markers may represent a cancer cell of origin or a microenvironment primed for tumor development, and that their presence may correlate with the clinically defined subtypes of breast cancer that show increased tumorigenicity and stem cell features. methods: Normal tissues sampled at least 5 cm from primary tumors (normal adjacent tissue) were obtained from 61 chemotherapy-naive patients with breast cancer treated with mastectomy. Samples were stained simultaneously with immunofluorescence for CD44/CD49f/CD133/2 stem cell markers. We assessed the association between CD44+CD49f+CD133/2+ staining in normal adjacent tissue and breast cancer receptor subtype (defined by the expression of the estrogen (ER), progesterone (PR), or human epidermal growth factor-2 (Her2) receptors). We also examined the correlation between CD44+CD49f+CD133/2+ immunofluorescence and each of two previously published gene signatures, one derived from stem-cell enriched tissue and one from BRCA mutated tissue expected to have defective DNA repair. RESULTS: Patients with triple negative breast cancer (ER–/PR–/HER2–) expressed CD44+CD49f+CD133/2+ in 9 of 9 normal adjacent tissue samples compared with 7 of 52 ER+ and/or Her2+ tumors (P < 0.001). Further, expression of CD44+CD49f+CD133/2+ by normal adjacent tissue correlated positively with a stem cell-derived tumorigenic signature (P <0.001) and inversely with a defective DNA-repair signature (P <0.001). CONCLUSION: Normal cells bearing cancer stem cell markers are associated with the triple negative receptor subtype of breast cancer. This study suggests stem cell staining and gene expression signatures from normal breast tissues represent novel tissue-based risk biomarkers for triple negative breast cancer. Validation of these results in additional studies of normal tissue from cancer-free women could lay the foundation for future targeted triple negative breast cancer prevention strategies. More... »
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http://scigraph.springernature.com/pub.10.1186/bcr3471
DOIhttp://dx.doi.org/10.1186/bcr3471
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"type": "PropertyValue",
"value": [
"24008095"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"100927353"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/bcr3471"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1026013878"
]
}
],
"sameAs": [
"https://doi.org/10.1186/bcr3471",
"https://app.dimensions.ai/details/publication/pub.1026013878"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T00:16",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000513.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1186%2Fbcr3471"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/bcr3471'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/bcr3471'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/bcr3471'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/bcr3471'
This table displays all metadata directly associated to this object as RDF triples.
343 TRIPLES
21 PREDICATES
75 URIs
38 LITERALS
26 BLANK NODES