Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-10

AUTHORS

Funda Meric-Bernstam, Huiqin Chen, Argun Akcakanat, Kim-Anh Do, Ana Lluch, Bryan T Hennessy, Gabriel N Hortobagyi, Gordon B Mills, Ana Maria Gonzalez-Angulo

ABSTRACT

INTRODUCTION: Translation initiation is activated in cancer through increase in eukaryotic initiation factor 4E (eIF4E), eIF4G, phosphorylated eIF4E-binding protein (p4E-BP1) and phosphorylated ribosomal protein S6 (pS6), and decreased programmed cell death protein 4 (pdcd4), a translational inhibitor. Further, translation elongation is deregulated though alterations in eukaryotic elongation factor 2 (eEF2) and eEF2 kinase (eEF2K). We sought to determine the association of these translational aberrations with clinical-pathologic factors and survival outcomes in hormone receptor-positive breast cancer. METHODS: Primary tumors were collected from 190 patients with Stage I to III hormone receptor-positive breast cancer. Expression of eIF4E, eIF4G, 4E-BP1, p4E-BP1 T37/46, p4E-BP1 S65, p4E-BP1 T70, S6, pS6 S235/236, pS6 S240/244, pdcd4, eEF2 and eEF2K was assessed by reverse phase protein arrays. Univariable and multivariable analyses for recurrence-free survival (RFS) and overall survival (OS) were performed. RESULTS: High eEF2, S6, pS6 S240/244, p4E-BP1 T70, and low pdcd4 were significantly associated with node positivity. Median follow-up for living patients was 96 months. CONCLUSIONS: Increased pS6, p4E-BP1, eEF2K and decreased pdcd4 are associated with poor prognosis in hormone receptor-positive breast cancer, suggesting their role as prognostic markers and therapeutic targets. More... »

PAGES

r138

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/bcr3343

DOI

http://dx.doi.org/10.1186/bcr3343

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004937759

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23102376


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Grading", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Biosynthesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Estrogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Progesterone", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Meric-Bernstam", 
        "givenName": "Funda", 
        "id": "sg:person.01065126442.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065126442.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Huiqin", 
        "id": "sg:person.011455050517.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011455050517.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akcakanat", 
        "givenName": "Argun", 
        "id": "sg:person.01115601234.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115601234.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Biostatistics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Do", 
        "givenName": "Kim-Anh", 
        "id": "sg:person.0652735603.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652735603.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Cl\u00ednico Universitario de Valencia", 
          "id": "https://www.grid.ac/institutes/grid.411308.f", 
          "name": [
            "Department of Hematology and Oncology, Hospital Clinico Universitario de Valencia, Avda Blasco Ib\u00e1\u00f1ez, 17, 46010, Valencia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lluch", 
        "givenName": "Ana", 
        "id": "sg:person.01274311013.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274311013.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Beaumont Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414315.6", 
          "name": [
            "Department of Gynecologic Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA", 
            "Department of Medical Oncology, Beaumont Hospital, Beaumont Road, Beaumont, Dublin 9, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hennessy", 
        "givenName": "Bryan T", 
        "id": "sg:person.01153534336.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153534336.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hortobagyi", 
        "givenName": "Gabriel N", 
        "id": "sg:person.01365732165.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365732165.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Systems Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mills", 
        "givenName": "Gordon B", 
        "id": "sg:person.012742742357.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012742742357.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA", 
            "Department of Systems Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonzalez-Angulo", 
        "givenName": "Ana Maria", 
        "id": "sg:person.01066417500.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066417500.42"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/emboj/20.16.4370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001677706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200707018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002662951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.141754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004352318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2007.10.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005302156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-0420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007591479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.15.7282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008298352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(00)00567-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009498638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-1719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010745042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6605044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013480093", 
          "https://doi.org/10.1038/sj.bjc.6605044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6605044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013480093", 
          "https://doi.org/10.1038/sj.bjc.6605044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-08-1026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014559584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2009.11.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016028445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-2924", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016997903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci34753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017218905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1011477108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018968579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci41680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019843818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci41680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019843818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-1282", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021940935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2006.11.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022055794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa041588", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022156409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btm283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022246986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.01716", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023272502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m208821200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025019621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027629034", 
          "https://doi.org/10.1038/sj.bjc.6690012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027629034", 
          "https://doi.org/10.1038/sj.bjc.6690012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-0752", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028652182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1245/s10434-008-0116-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029086443", 
          "https://doi.org/10.1245/s10434-008-0116-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.36.21176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029117742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029184058", 
          "https://doi.org/10.1038/sj.onc.1206433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029184058", 
          "https://doi.org/10.1038/sj.onc.1206433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci32044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029483827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200710215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030236664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1559-0275-8-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032074025", 
          "https://doi.org/10.1186/1559-0275-8-11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-1554", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032850367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-6487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034899821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-1560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035054052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa021967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038600096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.23.1.26-37.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038720965"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1877-1173(09)90002-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040271149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041303476", 
          "https://doi.org/10.1038/ncb1900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041303476", 
          "https://doi.org/10.1038/ncb1900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041824710", 
          "https://doi.org/10.1038/sj.onc.1207545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041824710", 
          "https://doi.org/10.1038/sj.onc.1207545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-0430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042940069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/415530a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043001094", 
          "https://doi.org/10.1038/415530a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/415530a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043001094", 
          "https://doi.org/10.1038/415530a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0406927102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046595134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-07-2357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047317561"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.18.8391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048453787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048881953", 
          "https://doi.org/10.1038/nm1042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048881953", 
          "https://doi.org/10.1038/nm1042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12014-010-9055-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052889308", 
          "https://doi.org/10.1007/s12014-010-9055-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-2334", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053571473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199805000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199805000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199805000-00016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1130276", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062454546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074680068", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075203551", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076588074", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077890898", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082803141", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082827306", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1996.tb00582.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082890083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083173475", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-10", 
    "datePublishedReg": "2012-10-01", 
    "description": "INTRODUCTION: Translation initiation is activated in cancer through increase in eukaryotic initiation factor 4E (eIF4E), eIF4G, phosphorylated eIF4E-binding protein (p4E-BP1) and phosphorylated ribosomal protein S6 (pS6), and decreased programmed cell death protein 4 (pdcd4), a translational inhibitor. Further, translation elongation is deregulated though alterations in eukaryotic elongation factor 2 (eEF2) and eEF2 kinase (eEF2K). We sought to determine the association of these translational aberrations with clinical-pathologic factors and survival outcomes in hormone receptor-positive breast cancer.\nMETHODS: Primary tumors were collected from 190 patients with Stage I to III hormone receptor-positive breast cancer. Expression of eIF4E, eIF4G, 4E-BP1, p4E-BP1 T37/46, p4E-BP1 S65, p4E-BP1 T70, S6, pS6 S235/236, pS6 S240/244, pdcd4, eEF2 and eEF2K was assessed by reverse phase protein arrays. Univariable and multivariable analyses for recurrence-free survival (RFS) and overall survival (OS) were performed.\nRESULTS: High eEF2, S6, pS6 S240/244, p4E-BP1 T70, and low pdcd4 were significantly associated with node positivity. Median follow-up for living patients was 96 months.\nCONCLUSIONS: Increased pS6, p4E-BP1, eEF2K and decreased pdcd4 are associated with poor prognosis in hormone receptor-positive breast cancer, suggesting their role as prognostic markers and therapeutic targets.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/bcr3343", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2705229", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2705121", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7821360", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440196", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438826", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1022375", 
        "issn": [
          "1465-5411", 
          "1465-542X"
        ], 
        "name": "Breast Cancer Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer", 
    "pagination": "r138", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "17877aa60702951f923858415f4e5a234029ecfb58c9f8b00f05a4ed8af678e4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23102376"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100927353"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/bcr3343"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004937759"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/bcr3343", 
      "https://app.dimensions.ai/details/publication/pub.1004937759"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fbcr3343"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/bcr3343'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/bcr3343'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/bcr3343'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/bcr3343'


 

This table displays all metadata directly associated to this object as RDF triples.

369 TRIPLES      21 PREDICATES      98 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/bcr3343 schema:about N24ea07cdf24649ce93571a63dee59f24
2 N2f59047073b74327bb442802386e5669
3 N3d577ca62d9042afbf80b504ffdb7ab6
4 N69b239816c2341ec8a05bddea880c9a7
5 N6c594d259f394378b83c7c8f72a67dae
6 N79b0e91d00df4dada8946e0847c47abe
7 N97977cbe88234994a3f1696250c46bfb
8 N99f4c30c06e44f6e8329614d0a4411dd
9 Nb3beae303d824dafabac26cb5dc27417
10 Nb986f2b870ff4f24a085c80b8140766d
11 Nbfd8076c6866428e97958e5ebbf0934a
12 Ne0c6168313f4494b8526d63a6f6597dd
13 Ne8094f96fc32407cb6dc6b4b4593be13
14 Neb9f3b726a2b4556aaebc56ae3c86150
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author Nabb7cb7e122c4997ad5b4f5b9d1810c7
18 schema:citation sg:pub.10.1007/s12014-010-9055-y
19 sg:pub.10.1038/415530a
20 sg:pub.10.1038/ncb1900
21 sg:pub.10.1038/nm1042
22 sg:pub.10.1038/sj.bjc.6605044
23 sg:pub.10.1038/sj.bjc.6690012
24 sg:pub.10.1038/sj.onc.1206433
25 sg:pub.10.1038/sj.onc.1207545
26 sg:pub.10.1186/1559-0275-8-11
27 sg:pub.10.1245/s10434-008-0116-7
28 https://app.dimensions.ai/details/publication/pub.1074680068
29 https://app.dimensions.ai/details/publication/pub.1075203551
30 https://app.dimensions.ai/details/publication/pub.1076588074
31 https://app.dimensions.ai/details/publication/pub.1077890898
32 https://app.dimensions.ai/details/publication/pub.1082803141
33 https://app.dimensions.ai/details/publication/pub.1082827306
34 https://app.dimensions.ai/details/publication/pub.1083173475
35 https://doi.org/10.1002/j.1460-2075.1996.tb00582.x
36 https://doi.org/10.1016/j.cell.2006.11.046
37 https://doi.org/10.1016/j.febslet.2009.11.041
38 https://doi.org/10.1016/j.molcel.2007.10.019
39 https://doi.org/10.1016/s0960-9822(00)00567-4
40 https://doi.org/10.1016/s1877-1173(09)90002-3
41 https://doi.org/10.1056/nejmoa021967
42 https://doi.org/10.1056/nejmoa041588
43 https://doi.org/10.1073/pnas.0406927102
44 https://doi.org/10.1073/pnas.1011477108
45 https://doi.org/10.1073/pnas.89.15.7282
46 https://doi.org/10.1074/jbc.270.36.21176
47 https://doi.org/10.1074/jbc.m110.141754
48 https://doi.org/10.1074/jbc.m208821200
49 https://doi.org/10.1083/jcb.200707018
50 https://doi.org/10.1083/jcb.200710215
51 https://doi.org/10.1093/bioinformatics/btm283
52 https://doi.org/10.1093/emboj/20.16.4370
53 https://doi.org/10.1097/00000658-199805000-00016
54 https://doi.org/10.1126/science.1130276
55 https://doi.org/10.1128/mcb.23.1.26-37.2003
56 https://doi.org/10.1158/0008-5472.can-05-1554
57 https://doi.org/10.1158/0008-5472.can-07-0752
58 https://doi.org/10.1158/0008-5472.can-07-1719
59 https://doi.org/10.1158/0008-5472.can-07-6487
60 https://doi.org/10.1158/0008-5472.can-11-0420
61 https://doi.org/10.1158/1078-0432.ccr-06-1560
62 https://doi.org/10.1158/1078-0432.ccr-08-2924
63 https://doi.org/10.1158/1078-0432.ccr-10-1282
64 https://doi.org/10.1158/1078-0432.ccr-10-2334
65 https://doi.org/10.1158/1078-0432.ccr-11-0430
66 https://doi.org/10.1158/1535-7163.mct-07-2357
67 https://doi.org/10.1158/1535-7163.mct-08-1026
68 https://doi.org/10.1172/jci32044
69 https://doi.org/10.1172/jci34753
70 https://doi.org/10.1172/jci41680
71 https://doi.org/10.1200/jco.2008.18.8391
72 https://doi.org/10.1242/jcs.01716
73 schema:datePublished 2012-10
74 schema:datePublishedReg 2012-10-01
75 schema:description INTRODUCTION: Translation initiation is activated in cancer through increase in eukaryotic initiation factor 4E (eIF4E), eIF4G, phosphorylated eIF4E-binding protein (p4E-BP1) and phosphorylated ribosomal protein S6 (pS6), and decreased programmed cell death protein 4 (pdcd4), a translational inhibitor. Further, translation elongation is deregulated though alterations in eukaryotic elongation factor 2 (eEF2) and eEF2 kinase (eEF2K). We sought to determine the association of these translational aberrations with clinical-pathologic factors and survival outcomes in hormone receptor-positive breast cancer. METHODS: Primary tumors were collected from 190 patients with Stage I to III hormone receptor-positive breast cancer. Expression of eIF4E, eIF4G, 4E-BP1, p4E-BP1 T37/46, p4E-BP1 S65, p4E-BP1 T70, S6, pS6 S235/236, pS6 S240/244, pdcd4, eEF2 and eEF2K was assessed by reverse phase protein arrays. Univariable and multivariable analyses for recurrence-free survival (RFS) and overall survival (OS) were performed. RESULTS: High eEF2, S6, pS6 S240/244, p4E-BP1 T70, and low pdcd4 were significantly associated with node positivity. Median follow-up for living patients was 96 months. CONCLUSIONS: Increased pS6, p4E-BP1, eEF2K and decreased pdcd4 are associated with poor prognosis in hormone receptor-positive breast cancer, suggesting their role as prognostic markers and therapeutic targets.
76 schema:genre research_article
77 schema:inLanguage en
78 schema:isAccessibleForFree true
79 schema:isPartOf N1b4ec5b4643742c58dbb72244eaf4c9e
80 N5b2692b099994f85819198883890e9ba
81 sg:journal.1022375
82 schema:name Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer
83 schema:pagination r138
84 schema:productId N2b13bc4e16b243f7a8d06a56b49519f2
85 N3f0871a9eabb4319b2855f6451554830
86 N65d71701fdcc4db183601c302d79adbf
87 Na3fd6cfdae8d4cb897df67f0887ab56d
88 Ne5eac1383dd447838d10d0fe17549ce9
89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004937759
90 https://doi.org/10.1186/bcr3343
91 schema:sdDatePublished 2019-04-10T13:15
92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
93 schema:sdPublisher Nbb096c47623146a8b22c2870c961585b
94 schema:url http://link.springer.com/10.1186%2Fbcr3343
95 sgo:license sg:explorer/license/
96 sgo:sdDataset articles
97 rdf:type schema:ScholarlyArticle
98 N0652b7a60dd04bb0a027e0c5e3f838af rdf:first sg:person.0652735603.66
99 rdf:rest Nd97f6cbe75cb48b79d5193ea90e5c954
100 N1b4ec5b4643742c58dbb72244eaf4c9e schema:volumeNumber 14
101 rdf:type schema:PublicationVolume
102 N24ea07cdf24649ce93571a63dee59f24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Receptors, Estrogen
104 rdf:type schema:DefinedTerm
105 N26f79fcb093e48078fe2fd8f206fe934 rdf:first sg:person.01365732165.24
106 rdf:rest Nf044e74fe1c74d65b8126cbd3f1b1ba2
107 N2b13bc4e16b243f7a8d06a56b49519f2 schema:name nlm_unique_id
108 schema:value 100927353
109 rdf:type schema:PropertyValue
110 N2f59047073b74327bb442802386e5669 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Protein Biosynthesis
112 rdf:type schema:DefinedTerm
113 N3d577ca62d9042afbf80b504ffdb7ab6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Models, Biological
115 rdf:type schema:DefinedTerm
116 N3f0871a9eabb4319b2855f6451554830 schema:name doi
117 schema:value 10.1186/bcr3343
118 rdf:type schema:PropertyValue
119 N510ca5a26ef94418a6bb3db8cc0383e4 rdf:first sg:person.011455050517.02
120 rdf:rest N8d544f4dd86c432a8a4f4e2b5755e93f
121 N5b2692b099994f85819198883890e9ba schema:issueNumber 5
122 rdf:type schema:PublicationIssue
123 N65d71701fdcc4db183601c302d79adbf schema:name readcube_id
124 schema:value 17877aa60702951f923858415f4e5a234029ecfb58c9f8b00f05a4ed8af678e4
125 rdf:type schema:PropertyValue
126 N69b239816c2341ec8a05bddea880c9a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Female
128 rdf:type schema:DefinedTerm
129 N6a044e55ff104a29b074731a27cf7c2e rdf:first sg:person.01153534336.84
130 rdf:rest N26f79fcb093e48078fe2fd8f206fe934
131 N6c594d259f394378b83c7c8f72a67dae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Neoplasm Grading
133 rdf:type schema:DefinedTerm
134 N79b0e91d00df4dada8946e0847c47abe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Humans
136 rdf:type schema:DefinedTerm
137 N8d544f4dd86c432a8a4f4e2b5755e93f rdf:first sg:person.01115601234.82
138 rdf:rest N0652b7a60dd04bb0a027e0c5e3f838af
139 N97977cbe88234994a3f1696250c46bfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Breast Neoplasms
141 rdf:type schema:DefinedTerm
142 N99f4c30c06e44f6e8329614d0a4411dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Neoplasm Staging
144 rdf:type schema:DefinedTerm
145 Na3fd6cfdae8d4cb897df67f0887ab56d schema:name pubmed_id
146 schema:value 23102376
147 rdf:type schema:PropertyValue
148 Nabb7cb7e122c4997ad5b4f5b9d1810c7 rdf:first sg:person.01065126442.79
149 rdf:rest N510ca5a26ef94418a6bb3db8cc0383e4
150 Nb3beae303d824dafabac26cb5dc27417 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Adult
152 rdf:type schema:DefinedTerm
153 Nb986f2b870ff4f24a085c80b8140766d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Aged, 80 and over
155 rdf:type schema:DefinedTerm
156 Nbb096c47623146a8b22c2870c961585b schema:name Springer Nature - SN SciGraph project
157 rdf:type schema:Organization
158 Nbfd8076c6866428e97958e5ebbf0934a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Receptors, Progesterone
160 rdf:type schema:DefinedTerm
161 Nd97f6cbe75cb48b79d5193ea90e5c954 rdf:first sg:person.01274311013.83
162 rdf:rest N6a044e55ff104a29b074731a27cf7c2e
163 Ne0c6168313f4494b8526d63a6f6597dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Middle Aged
165 rdf:type schema:DefinedTerm
166 Ne161b83d1c214aba93497b4a95ebc1be rdf:first sg:person.01066417500.42
167 rdf:rest rdf:nil
168 Ne5eac1383dd447838d10d0fe17549ce9 schema:name dimensions_id
169 schema:value pub.1004937759
170 rdf:type schema:PropertyValue
171 Ne8094f96fc32407cb6dc6b4b4593be13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Neoplasm Metastasis
173 rdf:type schema:DefinedTerm
174 Neb9f3b726a2b4556aaebc56ae3c86150 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Aged
176 rdf:type schema:DefinedTerm
177 Nf044e74fe1c74d65b8126cbd3f1b1ba2 rdf:first sg:person.012742742357.13
178 rdf:rest Ne161b83d1c214aba93497b4a95ebc1be
179 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
180 schema:name Medical and Health Sciences
181 rdf:type schema:DefinedTerm
182 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
183 schema:name Oncology and Carcinogenesis
184 rdf:type schema:DefinedTerm
185 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1186/bcr3343
186 rdf:type schema:MonetaryGrant
187 sg:grant.2440196 http://pending.schema.org/fundedItem sg:pub.10.1186/bcr3343
188 rdf:type schema:MonetaryGrant
189 sg:grant.2705121 http://pending.schema.org/fundedItem sg:pub.10.1186/bcr3343
190 rdf:type schema:MonetaryGrant
191 sg:grant.2705229 http://pending.schema.org/fundedItem sg:pub.10.1186/bcr3343
192 rdf:type schema:MonetaryGrant
193 sg:grant.7821360 http://pending.schema.org/fundedItem sg:pub.10.1186/bcr3343
194 rdf:type schema:MonetaryGrant
195 sg:journal.1022375 schema:issn 1465-5411
196 1465-542X
197 schema:name Breast Cancer Research
198 rdf:type schema:Periodical
199 sg:person.01065126442.79 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
200 schema:familyName Meric-Bernstam
201 schema:givenName Funda
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065126442.79
203 rdf:type schema:Person
204 sg:person.01066417500.42 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
205 schema:familyName Gonzalez-Angulo
206 schema:givenName Ana Maria
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066417500.42
208 rdf:type schema:Person
209 sg:person.01115601234.82 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
210 schema:familyName Akcakanat
211 schema:givenName Argun
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115601234.82
213 rdf:type schema:Person
214 sg:person.011455050517.02 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
215 schema:familyName Chen
216 schema:givenName Huiqin
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011455050517.02
218 rdf:type schema:Person
219 sg:person.01153534336.84 schema:affiliation https://www.grid.ac/institutes/grid.414315.6
220 schema:familyName Hennessy
221 schema:givenName Bryan T
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153534336.84
223 rdf:type schema:Person
224 sg:person.012742742357.13 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
225 schema:familyName Mills
226 schema:givenName Gordon B
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012742742357.13
228 rdf:type schema:Person
229 sg:person.01274311013.83 schema:affiliation https://www.grid.ac/institutes/grid.411308.f
230 schema:familyName Lluch
231 schema:givenName Ana
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274311013.83
233 rdf:type schema:Person
234 sg:person.01365732165.24 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
235 schema:familyName Hortobagyi
236 schema:givenName Gabriel N
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365732165.24
238 rdf:type schema:Person
239 sg:person.0652735603.66 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
240 schema:familyName Do
241 schema:givenName Kim-Anh
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652735603.66
243 rdf:type schema:Person
244 sg:pub.10.1007/s12014-010-9055-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1052889308
245 https://doi.org/10.1007/s12014-010-9055-y
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/415530a schema:sameAs https://app.dimensions.ai/details/publication/pub.1043001094
248 https://doi.org/10.1038/415530a
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/ncb1900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041303476
251 https://doi.org/10.1038/ncb1900
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/nm1042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048881953
254 https://doi.org/10.1038/nm1042
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/sj.bjc.6605044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013480093
257 https://doi.org/10.1038/sj.bjc.6605044
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/sj.bjc.6690012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027629034
260 https://doi.org/10.1038/sj.bjc.6690012
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/sj.onc.1206433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029184058
263 https://doi.org/10.1038/sj.onc.1206433
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/sj.onc.1207545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041824710
266 https://doi.org/10.1038/sj.onc.1207545
267 rdf:type schema:CreativeWork
268 sg:pub.10.1186/1559-0275-8-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032074025
269 https://doi.org/10.1186/1559-0275-8-11
270 rdf:type schema:CreativeWork
271 sg:pub.10.1245/s10434-008-0116-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029086443
272 https://doi.org/10.1245/s10434-008-0116-7
273 rdf:type schema:CreativeWork
274 https://app.dimensions.ai/details/publication/pub.1074680068 schema:CreativeWork
275 https://app.dimensions.ai/details/publication/pub.1075203551 schema:CreativeWork
276 https://app.dimensions.ai/details/publication/pub.1076588074 schema:CreativeWork
277 https://app.dimensions.ai/details/publication/pub.1077890898 schema:CreativeWork
278 https://app.dimensions.ai/details/publication/pub.1082803141 schema:CreativeWork
279 https://app.dimensions.ai/details/publication/pub.1082827306 schema:CreativeWork
280 https://app.dimensions.ai/details/publication/pub.1083173475 schema:CreativeWork
281 https://doi.org/10.1002/j.1460-2075.1996.tb00582.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082890083
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.cell.2006.11.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022055794
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.febslet.2009.11.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016028445
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.molcel.2007.10.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005302156
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/s0960-9822(00)00567-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009498638
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/s1877-1173(09)90002-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040271149
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1056/nejmoa021967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038600096
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1056/nejmoa041588 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022156409
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1073/pnas.0406927102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046595134
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1073/pnas.1011477108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018968579
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1073/pnas.89.15.7282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008298352
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1074/jbc.270.36.21176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029117742
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1074/jbc.m110.141754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004352318
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1074/jbc.m208821200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025019621
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1083/jcb.200707018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002662951
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1083/jcb.200710215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030236664
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1093/bioinformatics/btm283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022246986
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1093/emboj/20.16.4370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001677706
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1097/00000658-199805000-00016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060134790
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1126/science.1130276 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062454546
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1128/mcb.23.1.26-37.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038720965
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1158/0008-5472.can-05-1554 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032850367
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1158/0008-5472.can-07-0752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028652182
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1158/0008-5472.can-07-1719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010745042
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1158/0008-5472.can-07-6487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034899821
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1158/0008-5472.can-11-0420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007591479
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1158/1078-0432.ccr-06-1560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035054052
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1158/1078-0432.ccr-08-2924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016997903
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1158/1078-0432.ccr-10-1282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021940935
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1158/1078-0432.ccr-10-2334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053571473
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1158/1078-0432.ccr-11-0430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042940069
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1158/1535-7163.mct-07-2357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047317561
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1158/1535-7163.mct-08-1026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014559584
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1172/jci32044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029483827
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1172/jci34753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017218905
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1172/jci41680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019843818
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1200/jco.2008.18.8391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048453787
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1242/jcs.01716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023272502
356 rdf:type schema:CreativeWork
357 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
358 schema:name Department of Biostatistics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA
359 Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA
360 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA
361 Department of Systems Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA
362 rdf:type schema:Organization
363 https://www.grid.ac/institutes/grid.411308.f schema:alternateName Hospital Clínico Universitario de Valencia
364 schema:name Department of Hematology and Oncology, Hospital Clinico Universitario de Valencia, Avda Blasco Ibáñez, 17, 46010, Valencia, Spain
365 rdf:type schema:Organization
366 https://www.grid.ac/institutes/grid.414315.6 schema:alternateName Beaumont Hospital
367 schema:name Department of Gynecologic Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA
368 Department of Medical Oncology, Beaumont Hospital, Beaumont Road, Beaumont, Dublin 9, Ireland
369 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...