Early vascular deficits are correlated with delayed mammary tumorigenesis in the MMTV-PyMT transgenic mouse following genetic ablation of the NG2 ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-04

AUTHORS

Krissa Gibby, Weon-Kyoo You, Kuniko Kadoya, Hildur Helgadottir, Lawrence JT Young, Lesley G Ellies, Yunchao Chang, Robert D Cardiff, William B Stallcup

ABSTRACT

INTRODUCTION: The neuron-glial antigen 2 (NG2) proteoglycan promotes pericyte recruitment and mediates pericyte interaction with endothelial cells. In the absence of NG2, blood vessel development is negatively impacted in several pathological models. Our goal in this study was to determine the effect of NG2 ablation on the early development and function of blood vessels in mammary tumors in the mammary tumor virus-driven polyoma middle T (MMTV-PyMT) transgenic mouse, and to correlate these vascular changes with alterations in mammary tumor growth. METHODS: Three different tumor paradigms (spontaneous tumors, transplanted tumors, and orthotopic allografts of tumor cell lines) were used to investigate the effects of NG2 ablation on breast cancer progression in the MMTV-PyMT transgenic mouse. In addition to examining effects of NG2 ablation on mammary tumor growth, we also investigated effects on the structure and function of tumor vasculature. RESULTS: Ablation of NG2 led to reduced early progression of spontaneous, transplanted, and orthotopic allograft mammary tumors. NG2 was not expressed by the mammary tumor cells themselves, but instead was found on three components of the tumor stroma. Microvascular pericytes, myeloid cells, and adipocytes were NG2-positive in both mouse and human mammary tumor stroma. The effect of NG2 on tumor progression therefore must be stromal in nature. Ablation of NG2 had several negative effects on early development of the mammary tumor vasculature. In the absence of NG2, pericyte ensheathment of endothelial cells was reduced, along with reduced pericyte maturation, reduced sprouting of endothelial cells, reduced assembly of the vascular basal lamina, and reduced tumor vessel diameter. These early deficits in vessel structure are accompanied by increased vessel leakiness, increased tumor hypoxia, and decreased tumor growth. NG2 ablation also diminishes the number of tumor-associated and TEK tyrosine kinase endothelial (Tie2) expressing macrophages in mammary tumors, providing another possible mechanism for reducing tumor vascularization and growth. CONCLUSIONS: These results emphasize the importance of NG2 in mediating pericyte/endothelial cell communication that is required for proper vessel maturation and function. In the absence of normal pericyte/endothelial cell interaction, poor vascular function results in diminished early progression of mammary tumors. More... »

PAGES

r67

References to SciGraph publications

  • 2008-07. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation in NATURE
  • 2007-03. An intimate interplay between precocious, migrating pericytes and endothelial cells governs human fetal brain angiogenesis in ANGIOGENESIS
  • 2003-09. Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization in ONCOGENE
  • 1989-05. Induction of angiogenesis during the transition from hyperplasia to neoplasia in NATURE
  • 2007-03-19. Effects of FVB/NJ and C57Bl/6J strain backgrounds on mammary tumor phenotype in inducible nitric oxide synthase deficient mice in TRANSGENIC RESEARCH
  • 2003-09. Early Contribution of Pericytes to Angiogenic Sprouting and Tube Formation in ANGIOGENESIS
  • 2011-12. Reduced inflammation accompanies diminished myelin damage and repair in the NG2 null mouse spinal cord in JOURNAL OF NEUROINFLAMMATION
  • 2008-09. The progenitor cell marker NG2/MPG promotes chemoresistance by activation of integrin-dependent PI3K/Akt signaling in ONCOGENE
  • 2011-06. Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11gene expression in forming surface P-selectin ligands in aggressive breast cancer cells in BREAST CANCER RESEARCH
  • 1992-12. Pericyte involvement in capillary sprouting during angiogenesis in situ in CELL AND TISSUE RESEARCH
  • 2000. Preparing Mammary Gland Whole Mounts from Mice in METHODS IN MAMMARY GLAND BIOLOGY AND BREAST CANCER RESEARCH
  • 2003-06. Basement membranes: structure, assembly and role in tumour angiogenesis in NATURE REVIEWS CANCER
  • 2004-09. Pathological angiogenesis is reduced by targeting pericytes via the NG2 proteoglycan in ANGIOGENESIS
  • 2003-06. Tumorigenesis and the angiogenic switch in NATURE REVIEWS CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/bcr3174

    DOI

    http://dx.doi.org/10.1186/bcr3174

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1030305729

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22531600


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