A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-04

AUTHORS

Hyung-cheol Kim, Ji-Young Lee, Hyuna Sung, Ji-Yeob Choi, Sue K Park, Kyoung-Mu Lee, Young Jin Kim, Min Jin Go, Lian Li, Yoon Shin Cho, Miey Park, Dong-Joon Kim, Ji Hee Oh, Jun-Woo Kim, Jae-Pil Jeon, Soon-Young Jeon, Haesook Min, Hyo Mi Kim, Jaekyung Park, Keun-Young Yoo, Dong-Young Noh, Sei-Hyun Ahn, Min Hyuk Lee, Sung-Won Kim, Jong Won Lee, Byeong-Woo Park, Woong-Yang Park, Eun-Hye Kim, Mi Kyung Kim, Wonshik Han, Sang-Ah Lee, Keitaro Matsuo, Chen-Yang Shen, Pei-Ei Wu, Chia-Ni Hsiung, Jong-Young Lee, Hyung-Lae Kim, Bok-Ghee Han, Daehee Kang

ABSTRACT

INTRODUCTION: Although approximately 25 common genetic susceptibility loci have been identified to be independently associated with breast cancer risk through genome-wide association studies (GWAS), the genetic risk variants reported to date only explain a small fraction of the heritability of breast cancer. Furthermore, GWAS-identified loci were primarily identified in women of European descent. METHODS: To evaluate previously identified loci in Korean women and to identify additional novel breast cancer susceptibility variants, we conducted a three-stage GWAS that included 6,322 cases and 5,897 controls. RESULTS: In the validation study using Stage I of the 2,273 cases and 2,052 controls, seven GWAS-identified loci [5q11.2/MAP3K1 (rs889312 and rs16886165), 5p15.2/ROPN1L (rs1092913), 5q12/MRPS30 (rs7716600), 6q25.1/ESR1 (rs2046210 and rs3734802), 8q24.21 (rs1562430), 10q26.13/FGFR2 (rs10736303), and 16q12.1/TOX3 (rs4784227 and rs3803662)] were significantly associated with breast cancer risk in Korean women (Ptrend < 0.05). To identify additional genetic risk variants, we selected the most promising 17 SNPs in Stage I and replicated these SNPs in 2,052 cases and 2,169 controls (Stage II). Four SNPs were further evaluated in 1,997 cases and 1,676 controls (Stage III). SNP rs13393577 at chromosome 2q34, located in the Epidermal Growth Factor Receptor 4 (ERBB4) gene, showed a consistent association with breast cancer risk with combined odds ratios (95% CI) of 1.53 (1.37-1.70) (combined P for trend = 8.8 × 10-14). CONCLUSIONS: This study shows that seven breast cancer susceptibility loci, which were previously identified in European and/or Chinese populations, could be directly replicated in Korean women. Furthermore, this study provides strong evidence implicating rs13393577 at 2q34 as a new risk variant for breast cancer. More... »

PAGES

r56

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/bcr3158

DOI

http://dx.doi.org/10.1186/bcr3158

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021370012

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22452962


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Asian Continental Ancestry Group", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome-Wide Association Study", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Odds Ratio", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, Epidermal Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, ErbB-4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproducibility of Results", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Republic of Korea", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Korea National Institute of Health", 
          "id": "https://www.grid.ac/institutes/grid.415482.e", 
          "name": [
            "Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hyung-cheol", 
        "id": "sg:person.01241305306.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241305306.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea", 
            "Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Ji-Young", 
        "id": "sg:person.012315623520.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012315623520.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sung", 
        "givenName": "Hyuna", 
        "id": "sg:person.01371211365.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371211365.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea", 
            "Cancer Research Institute, Seoul National University, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Choi", 
        "givenName": "Ji-Yeob", 
        "id": "sg:person.07507304257.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07507304257.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea", 
            "Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea", 
            "Cancer Research Institute, Seoul National University, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Sue K", 
        "id": "sg:person.01364776360.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364776360.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea National Open University", 
          "id": "https://www.grid.ac/institutes/grid.411128.f", 
          "name": [
            "Department of Environmental Health, Korea National Open University, 169 Dongsung-Dong, Chongno-Gu, 110-791, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Kyoung-Mu", 
        "id": "sg:person.0734652235.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734652235.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea National Institute of Health", 
          "id": "https://www.grid.ac/institutes/grid.415482.e", 
          "name": [
            "Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Young Jin", 
        "id": "sg:person.01173172106.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173172106.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea National Institute of Health", 
          "id": "https://www.grid.ac/institutes/grid.415482.e", 
          "name": [
            "Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Go", 
        "givenName": "Min Jin", 
        "id": "sg:person.01043702207.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043702207.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tianjin Medical University Cancer Institute and Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411918.4", 
          "name": [
            "Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea", 
            "Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Hospital and Institute, Huan-Hu-Xi Road, Ti-Yuan-Bei, 300060, He Xi District, Tianjin, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Lian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hallym University", 
          "id": "https://www.grid.ac/institutes/grid.256753.0", 
          "name": [
            "Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea", 
            "Department of Biomedical Science, Hallym University, 1 Hallymdaehak-gill, Chuncheon, 200-702, Gangwon-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cho", 
        "givenName": "Yoon Shin", 
        "id": "sg:person.016331315467.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016331315467.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea National Institute of Health", 
          "id": "https://www.grid.ac/institutes/grid.415482.e", 
          "name": [
            "Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Miey", 
        "id": "sg:person.0672122147.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672122147.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea National Institute of Health", 
          "id": "https://www.grid.ac/institutes/grid.415482.e", 
          "name": [
            "Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Dong-Joon", 
        "id": "sg:person.0602520656.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602520656.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea National Institute of Health", 
          "id": "https://www.grid.ac/institutes/grid.415482.e", 
          "name": [
            "Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oh", 
        "givenName": "Ji Hee", 
        "id": "sg:person.0761452454.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761452454.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea National Institute of Health", 
          "id": "https://www.grid.ac/institutes/grid.415482.e", 
          "name": [
            "Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jun-Woo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea National Institute of Health", 
          "id": "https://www.grid.ac/institutes/grid.415482.e", 
          "name": [
            "Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeon", 
        "givenName": "Jae-Pil", 
        "id": "sg:person.01361061630.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361061630.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea National Institute of Health", 
          "id": "https://www.grid.ac/institutes/grid.415482.e", 
          "name": [
            "Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeon", 
        "givenName": "Soon-Young", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea National Institute of Health", 
          "id": "https://www.grid.ac/institutes/grid.415482.e", 
          "name": [
            "Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Min", 
        "givenName": "Haesook", 
        "id": "sg:person.01021416057.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021416057.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea National Institute of Health", 
          "id": "https://www.grid.ac/institutes/grid.415482.e", 
          "name": [
            "Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hyo Mi", 
        "id": "sg:person.0666725147.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666725147.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea National Institute of Health", 
          "id": "https://www.grid.ac/institutes/grid.415482.e", 
          "name": [
            "Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Jaekyung", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoo", 
        "givenName": "Keun-Young", 
        "id": "sg:person.01102121350.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102121350.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Cancer Research Institute, Seoul National University, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea", 
            "Department of Surgery, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Noh", 
        "givenName": "Dong-Young", 
        "id": "sg:person.0734642365.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734642365.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ulsan", 
          "id": "https://www.grid.ac/institutes/grid.267370.7", 
          "name": [
            "Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, 88 Olympic-Ro 43 gil, Songpa-Gu, 138-736, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahn", 
        "givenName": "Sei-Hyun", 
        "id": "sg:person.01345077325.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345077325.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Soonchunhyang University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412678.e", 
          "name": [
            "Department of Surgery, College of Medicine, Soonchunhyang University Hospital, 59 Daesagwan-Ro Yongsan-gu, 140-743, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Min Hyuk", 
        "id": "sg:person.01020377256.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020377256.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Bundang Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412480.b", 
          "name": [
            "Department of Surgery, Breast and Endocrine Service, Seoul National University Bundang Hospital, 82 Gumi-Ro 173gil, Bundang-Gu, 463-707, Gyeonggi-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Sung-Won", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ulsan", 
          "id": "https://www.grid.ac/institutes/grid.267370.7", 
          "name": [
            "Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, 88 Olympic-Ro 43 gil, Songpa-Gu, 138-736, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jong Won", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yonsei University", 
          "id": "https://www.grid.ac/institutes/grid.15444.30", 
          "name": [
            "Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-Ro Seodaemun-Gu, 120-752, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Byeong-Woo", 
        "id": "sg:person.01362302775.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362302775.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea", 
            "Biochemisty and Molecular Biology, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Woong-Yang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea", 
            "Biochemisty and Molecular Biology, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Eun-Hye", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.410914.9", 
          "name": [
            "Carcinogenesis Research Branch, National Cancer Center, 323 Ilsan-Ro, Ilsandong-Gu, 410-769, Goyang-si, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Mi Kyung", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Cancer Research Institute, Seoul National University, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea", 
            "Department of Surgery, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Wonshik", 
        "id": "sg:person.01131237171.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131237171.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kangwon National University", 
          "id": "https://www.grid.ac/institutes/grid.412010.6", 
          "name": [
            "Department of Preventive Medicine, Kangwon National University School of Medicine, 1 Kangwondaehak-gil, Chuncheon-si, 200-701, Kangwon-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Sang-Ah", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aichi Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.410800.d", 
          "name": [
            "Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanakoden, Chikusa-ku, 464-8681, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsuo", 
        "givenName": "Keitaro", 
        "id": "sg:person.01215526415.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215526415.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academia Sinica", 
          "id": "https://www.grid.ac/institutes/grid.28665.3f", 
          "name": [
            "Institute of Biomedical Sciences and Taiwan Biobank, Academia Sinica, 128 Academia Road, Section 2, 115, Nankang, Taipei, Taiwan", 
            "College of Public Health, China Medical University, No. 91, Hsueh-Shih Road, 40402, Taichung, Taiwan", 
            "Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road, Section 2, 115, Nankang, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shen", 
        "givenName": "Chen-Yang", 
        "id": "sg:person.0637627064.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637627064.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academia Sinica", 
          "id": "https://www.grid.ac/institutes/grid.28665.3f", 
          "name": [
            "Institute of Biomedical Sciences and Taiwan Biobank, Academia Sinica, 128 Academia Road, Section 2, 115, Nankang, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Pei-Ei", 
        "id": "sg:person.0617300553.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617300553.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academia Sinica", 
          "id": "https://www.grid.ac/institutes/grid.28665.3f", 
          "name": [
            "Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road, Section 2, 115, Nankang, Taipei, Taiwan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hsiung", 
        "givenName": "Chia-Ni", 
        "id": "sg:person.0631115612.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631115612.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea National Institute of Health", 
          "id": "https://www.grid.ac/institutes/grid.415482.e", 
          "name": [
            "Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Jong-Young", 
        "id": "sg:person.01176761116.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176761116.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea National Institute of Health", 
          "id": "https://www.grid.ac/institutes/grid.415482.e", 
          "name": [
            "Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hyung-Lae", 
        "id": "sg:person.01254774342.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254774342.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Korea National Institute of Health", 
          "id": "https://www.grid.ac/institutes/grid.415482.e", 
          "name": [
            "Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Han", 
        "givenName": "Bok-Ghee", 
        "id": "sg:person.0672067757.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672067757.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University", 
          "id": "https://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea", 
            "Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea", 
            "Cancer Research Institute, Seoul National University, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kang", 
        "givenName": "Daehee", 
        "id": "sg:person.01165114725.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165114725.47"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ng.353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000555917", 
          "https://doi.org/10.1038/ng.353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000555917", 
          "https://doi.org/10.1038/ng.353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djq563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003023824"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-10-0698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004371371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004838062", 
          "https://doi.org/10.1038/ng.354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006256853", 
          "https://doi.org/10.1038/ng.586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006256853", 
          "https://doi.org/10.1038/ng.586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bimj.200610297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007153165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddr228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008298494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/87876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008466971", 
          "https://doi.org/10.1038/87876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)79243-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009703066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-11-0524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013102578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-011-0973-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013994820", 
          "https://doi.org/10.1007/s00439-011-0973-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.genom.9.081307.164242", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018499775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0903103106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020299353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(11)70076-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021450789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-010-1172-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022984330", 
          "https://doi.org/10.1007/s10549-010-1172-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05887", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027991306", 
          "https://doi.org/10.1038/nature05887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029457545", 
          "https://doi.org/10.1038/ng.318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0800441105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030781622"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-0457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031133697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2350-8-s1-s6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033054226", 
          "https://doi.org/10.1186/1471-2350-8-s1-s6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkl236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033716833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.191367098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034333528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034727724", 
          "https://doi.org/10.1038/ng1107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034727724", 
          "https://doi.org/10.1038/ng1107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-3150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036181787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btq419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036490983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038518938", 
          "https://doi.org/10.1038/ng.131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-10-0054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039464292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gepi.20533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039500245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gepi.20533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039500245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1001002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044091804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng2064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045095990", 
          "https://doi.org/10.1038/ng2064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddr405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045333876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047548438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/26.1.362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048518114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35052073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053565592", 
          "https://doi.org/10.1038/35052073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35052073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053565592", 
          "https://doi.org/10.1038/35052073"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35052073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053565592", 
          "https://doi.org/10.1038/35052073"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-04", 
    "datePublishedReg": "2012-04-01", 
    "description": "INTRODUCTION: Although approximately 25 common genetic susceptibility loci have been identified to be independently associated with breast cancer risk through genome-wide association studies (GWAS), the genetic risk variants reported to date only explain a small fraction of the heritability of breast cancer. Furthermore, GWAS-identified loci were primarily identified in women of European descent.\nMETHODS: To evaluate previously identified loci in Korean women and to identify additional novel breast cancer susceptibility variants, we conducted a three-stage GWAS that included 6,322 cases and 5,897 controls.\nRESULTS: In the validation study using Stage I of the 2,273 cases and 2,052 controls, seven GWAS-identified loci [5q11.2/MAP3K1 (rs889312 and rs16886165), 5p15.2/ROPN1L (rs1092913), 5q12/MRPS30 (rs7716600), 6q25.1/ESR1 (rs2046210 and rs3734802), 8q24.21 (rs1562430), 10q26.13/FGFR2 (rs10736303), and 16q12.1/TOX3 (rs4784227 and rs3803662)] were significantly associated with breast cancer risk in Korean women (Ptrend < 0.05). To identify additional genetic risk variants, we selected the most promising 17 SNPs in Stage I and replicated these SNPs in 2,052 cases and 2,169 controls (Stage II). Four SNPs were further evaluated in 1,997 cases and 1,676 controls (Stage III). SNP rs13393577 at chromosome 2q34, located in the Epidermal Growth Factor Receptor 4 (ERBB4) gene, showed a consistent association with breast cancer risk with combined odds ratios (95% CI) of 1.53 (1.37-1.70) (combined P for trend = 8.8 \u00d7 10-14).\nCONCLUSIONS: This study shows that seven breast cancer susceptibility loci, which were previously identified in European and/or Chinese populations, could be directly replicated in Korean women. Furthermore, this study provides strong evidence implicating rs13393577 at 2q34 as a new risk variant for breast cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/bcr3158", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1022375", 
        "issn": [
          "1465-5411", 
          "1465-542X"
        ], 
        "name": "Breast Cancer Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study", 
    "pagination": "r56", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "65d10d2bc591a305a81cf23063f93935314d06e9e88cbd793d7a2060274f8aed"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22452962"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100927353"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/bcr3158"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021370012"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/bcr3158", 
      "https://app.dimensions.ai/details/publication/pub.1021370012"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000512.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fbcr3158"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/bcr3158'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/bcr3158'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/bcr3158'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/bcr3158'


 

This table displays all metadata directly associated to this object as RDF triples.

541 TRIPLES      21 PREDICATES      77 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/bcr3158 schema:about N2b79efa5241e4f0c8cb1724848ac4001
2 N33b823a3756d44698e96dfca6c88d8bc
3 N376f0ba493194eb79a044aba6e07f967
4 N6d7ecf6127f14a9d84b7ab258df1d5d3
5 N843fac9533b54dcb96e6f15ddcd37296
6 N98f738280b5843eeaa05ea14ea58bd56
7 N9e7575fc2b6e40728714c1e23d1cf1a9
8 Nb5debb56376b46d38a87397349617832
9 Ne05bd8d9a7e04b1d973324a9f86a0826
10 Ne120dd35d52a40eb92621c31c14592c3
11 Nea42431732774c96820f51d5e75aa59b
12 Neef3218f9af24bfa8f228dd514a46c79
13 Nf60e6ade08124a518b361ecceba3ef42
14 Nf736661f2d1747d98b00393c924342bf
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author Nf190d0999d2a49b481d1bc98a0f65410
18 schema:citation sg:pub.10.1007/s00439-011-0973-1
19 sg:pub.10.1007/s10549-010-1172-9
20 sg:pub.10.1038/35052073
21 sg:pub.10.1038/87876
22 sg:pub.10.1038/nature05887
23 sg:pub.10.1038/ng.131
24 sg:pub.10.1038/ng.318
25 sg:pub.10.1038/ng.353
26 sg:pub.10.1038/ng.354
27 sg:pub.10.1038/ng.586
28 sg:pub.10.1038/ng1107
29 sg:pub.10.1038/ng2064
30 sg:pub.10.1186/1471-2350-8-s1-s6
31 https://doi.org/10.1002/bimj.200610297
32 https://doi.org/10.1002/gepi.20533
33 https://doi.org/10.1016/s0140-6736(05)79243-6
34 https://doi.org/10.1016/s1470-2045(11)70076-6
35 https://doi.org/10.1073/pnas.0800441105
36 https://doi.org/10.1073/pnas.0903103106
37 https://doi.org/10.1073/pnas.191367098
38 https://doi.org/10.1093/bioinformatics/btq419
39 https://doi.org/10.1093/hmg/ddr228
40 https://doi.org/10.1093/hmg/ddr405
41 https://doi.org/10.1093/jnci/djq563
42 https://doi.org/10.1093/nar/26.1.362
43 https://doi.org/10.1093/nar/gkl236
44 https://doi.org/10.1146/annurev.genom.9.081307.164242
45 https://doi.org/10.1158/0008-5472.can-04-3150
46 https://doi.org/10.1158/1055-9965.epi-10-0054
47 https://doi.org/10.1158/1055-9965.epi-10-0698
48 https://doi.org/10.1158/1055-9965.epi-11-0524
49 https://doi.org/10.1158/1078-0432.ccr-07-0457
50 https://doi.org/10.1371/journal.pgen.1000054
51 https://doi.org/10.1371/journal.pgen.1001002
52 schema:datePublished 2012-04
53 schema:datePublishedReg 2012-04-01
54 schema:description INTRODUCTION: Although approximately 25 common genetic susceptibility loci have been identified to be independently associated with breast cancer risk through genome-wide association studies (GWAS), the genetic risk variants reported to date only explain a small fraction of the heritability of breast cancer. Furthermore, GWAS-identified loci were primarily identified in women of European descent. METHODS: To evaluate previously identified loci in Korean women and to identify additional novel breast cancer susceptibility variants, we conducted a three-stage GWAS that included 6,322 cases and 5,897 controls. RESULTS: In the validation study using Stage I of the 2,273 cases and 2,052 controls, seven GWAS-identified loci [5q11.2/MAP3K1 (rs889312 and rs16886165), 5p15.2/ROPN1L (rs1092913), 5q12/MRPS30 (rs7716600), 6q25.1/ESR1 (rs2046210 and rs3734802), 8q24.21 (rs1562430), 10q26.13/FGFR2 (rs10736303), and 16q12.1/TOX3 (rs4784227 and rs3803662)] were significantly associated with breast cancer risk in Korean women (Ptrend < 0.05). To identify additional genetic risk variants, we selected the most promising 17 SNPs in Stage I and replicated these SNPs in 2,052 cases and 2,169 controls (Stage II). Four SNPs were further evaluated in 1,997 cases and 1,676 controls (Stage III). SNP rs13393577 at chromosome 2q34, located in the Epidermal Growth Factor Receptor 4 (ERBB4) gene, showed a consistent association with breast cancer risk with combined odds ratios (95% CI) of 1.53 (1.37-1.70) (combined P for trend = 8.8 × 10-14). CONCLUSIONS: This study shows that seven breast cancer susceptibility loci, which were previously identified in European and/or Chinese populations, could be directly replicated in Korean women. Furthermore, this study provides strong evidence implicating rs13393577 at 2q34 as a new risk variant for breast cancer.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree true
58 schema:isPartOf N467501e8e6614be9a0e65b665c765633
59 N7088347178a34d2f8f07f017777cb935
60 sg:journal.1022375
61 schema:name A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study
62 schema:pagination r56
63 schema:productId N24e775e2ff8b44248662845599ba2e96
64 Na4b3658258604785b268ced7a83b59e7
65 Ne7132c65df714b75a11aebded57777bc
66 Nf4e2418a5d484de98a1f930a9441fa8e
67 Nf5d99685317344aa86809449b6eed3cc
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021370012
69 https://doi.org/10.1186/bcr3158
70 schema:sdDatePublished 2019-04-10T22:31
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N40f26ea048fb4760a93300f6afc8a2b0
73 schema:url http://link.springer.com/10.1186%2Fbcr3158
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N05ea8db7a1bd4f73bd2be2c035c1889c rdf:first Ndb936b0f85e04abca2d04739480e495f
78 rdf:rest N8fa70a27901842fcb237e5b3290f766c
79 N078096f8dc74429184dc91e6b7928fe8 rdf:first sg:person.0631115612.04
80 rdf:rest N4a806825f1324651a0ded7db028ac5a6
81 N0fc7e3b6c70e47c1bab4fdf422c9a067 rdf:first sg:person.01345077325.35
82 rdf:rest N46ced40e3c9a47b6abf7918dad2d5b73
83 N1d15303bff124effb8f6c2f30e942ed2 schema:affiliation https://www.grid.ac/institutes/grid.412010.6
84 schema:familyName Lee
85 schema:givenName Sang-Ah
86 rdf:type schema:Person
87 N1fc8387cbff240329bdfa540ce1a3789 rdf:first N6fa1769079bb4130b05014a34a052656
88 rdf:rest Nf1f1e2f292264b27a806108a0b20f46c
89 N24e775e2ff8b44248662845599ba2e96 schema:name nlm_unique_id
90 schema:value 100927353
91 rdf:type schema:PropertyValue
92 N29a0ced2263640f9b16210419fdbb5f9 rdf:first sg:person.0637627064.16
93 rdf:rest Nfbdad2a137bb402982a302483c310ad8
94 N2a10fa6ddfd04c3c8460cf1e1de175a8 rdf:first sg:person.01364776360.50
95 rdf:rest Na1d58b239f0e434b8e693defae1fd676
96 N2b79efa5241e4f0c8cb1724848ac4001 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Receptor, ErbB-4
98 rdf:type schema:DefinedTerm
99 N2de6250e3d6c4a6a9639933f65f628dc schema:affiliation https://www.grid.ac/institutes/grid.410914.9
100 schema:familyName Kim
101 schema:givenName Mi Kyung
102 rdf:type schema:Person
103 N33b823a3756d44698e96dfca6c88d8bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Odds Ratio
105 rdf:type schema:DefinedTerm
106 N376f0ba493194eb79a044aba6e07f967 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Asian Continental Ancestry Group
108 rdf:type schema:DefinedTerm
109 N3f1966e9e6824531b512f12182ef4d45 rdf:first sg:person.0761452454.04
110 rdf:rest N05ea8db7a1bd4f73bd2be2c035c1889c
111 N40f26ea048fb4760a93300f6afc8a2b0 schema:name Springer Nature - SN SciGraph project
112 rdf:type schema:Organization
113 N467501e8e6614be9a0e65b665c765633 schema:issueNumber 2
114 rdf:type schema:PublicationIssue
115 N46ced40e3c9a47b6abf7918dad2d5b73 rdf:first sg:person.01020377256.75
116 rdf:rest Nf51bc509d64747b5ab8216f6fa0c1aa7
117 N4a806825f1324651a0ded7db028ac5a6 rdf:first sg:person.01176761116.47
118 rdf:rest N77d62285178048eeb6c6615831c2dcc2
119 N507ac7af18e143b4b810b254c77bbc70 rdf:first sg:person.01043702207.60
120 rdf:rest N9afd83f2738f40e09767bc6eaf0bfdd6
121 N53474d1d3d1d41d78fc1c1494aee402f rdf:first sg:person.07507304257.28
122 rdf:rest N2a10fa6ddfd04c3c8460cf1e1de175a8
123 N5507b8e0a919425db1c771d37c8b93fe rdf:first sg:person.012315623520.37
124 rdf:rest N77cef2372a5e45cda1c684eecf94f2a9
125 N5fe8628207de4b6db744d6a5cd688ea3 rdf:first sg:person.01131237171.52
126 rdf:rest Nd8b61ce74e2548c0a4c724ea6d909695
127 N675ca02e25dd456f9e4772ab7110fa77 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
128 schema:familyName Kim
129 schema:givenName Eun-Hye
130 rdf:type schema:Person
131 N67e39eae920e41e088b850dd17aaf045 rdf:first sg:person.01165114725.47
132 rdf:rest rdf:nil
133 N6bacef6e9e054e87af6921f49f73c744 schema:affiliation https://www.grid.ac/institutes/grid.415482.e
134 schema:familyName Park
135 schema:givenName Jaekyung
136 rdf:type schema:Person
137 N6d7ecf6127f14a9d84b7ab258df1d5d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Humans
139 rdf:type schema:DefinedTerm
140 N6fa1769079bb4130b05014a34a052656 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
141 schema:familyName Park
142 schema:givenName Woong-Yang
143 rdf:type schema:Person
144 N7088347178a34d2f8f07f017777cb935 schema:volumeNumber 14
145 rdf:type schema:PublicationVolume
146 N724bb8ca78124170a21082f1fcdc467a rdf:first sg:person.0672067757.33
147 rdf:rest N67e39eae920e41e088b850dd17aaf045
148 N77cef2372a5e45cda1c684eecf94f2a9 rdf:first sg:person.01371211365.46
149 rdf:rest N53474d1d3d1d41d78fc1c1494aee402f
150 N77d62285178048eeb6c6615831c2dcc2 rdf:first sg:person.01254774342.79
151 rdf:rest N724bb8ca78124170a21082f1fcdc467a
152 N7c70ad07d9694aa59bfb46ca0892672e schema:affiliation https://www.grid.ac/institutes/grid.412480.b
153 schema:familyName Kim
154 schema:givenName Sung-Won
155 rdf:type schema:Person
156 N843fac9533b54dcb96e6f15ddcd37296 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Female
158 rdf:type schema:DefinedTerm
159 N84c8d6a4c8f54d38abf922b94128401c schema:affiliation https://www.grid.ac/institutes/grid.411918.4
160 schema:familyName Li
161 schema:givenName Lian
162 rdf:type schema:Person
163 N8cdf7e929da54d079c2ef49f30ab59eb rdf:first sg:person.01362302775.25
164 rdf:rest N1fc8387cbff240329bdfa540ce1a3789
165 N8fa70a27901842fcb237e5b3290f766c rdf:first sg:person.01361061630.78
166 rdf:rest Nd4783d5045cb441d8564e2493c0b502f
167 N95558681f9a84afbbdc8c9bf305b327b rdf:first Nffd50d67b73f408996736b000d741738
168 rdf:rest N8cdf7e929da54d079c2ef49f30ab59eb
169 N98f738280b5843eeaa05ea14ea58bd56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Breast Neoplasms
171 rdf:type schema:DefinedTerm
172 N9afd83f2738f40e09767bc6eaf0bfdd6 rdf:first N84c8d6a4c8f54d38abf922b94128401c
173 rdf:rest Ndab8c5bedeac4ab888ca713e3b5dd7dd
174 N9c804549f2734594b385089dcd71e445 rdf:first sg:person.0666725147.68
175 rdf:rest Nd043ea2fb2014f42820912015779ea99
176 N9e7575fc2b6e40728714c1e23d1cf1a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Genetic Predisposition to Disease
178 rdf:type schema:DefinedTerm
179 N9fdbe94e66194b27ad42fb3f97833ede rdf:first sg:person.01215526415.55
180 rdf:rest N29a0ced2263640f9b16210419fdbb5f9
181 Na1d58b239f0e434b8e693defae1fd676 rdf:first sg:person.0734652235.70
182 rdf:rest Na88f7d3b4ae54f6eacbbcfc866e6b2ca
183 Na4b3658258604785b268ced7a83b59e7 schema:name dimensions_id
184 schema:value pub.1021370012
185 rdf:type schema:PropertyValue
186 Na88f7d3b4ae54f6eacbbcfc866e6b2ca rdf:first sg:person.01173172106.42
187 rdf:rest N507ac7af18e143b4b810b254c77bbc70
188 Nb1a2b1d408fe4b0bbd85522d9e4aaac1 rdf:first sg:person.01102121350.12
189 rdf:rest Ncc5e5d0ca84b410f927fb7889d10718c
190 Nb5debb56376b46d38a87397349617832 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Receptor, Epidermal Growth Factor
192 rdf:type schema:DefinedTerm
193 Nba39c2a5222342a49bc9b6ba2b7b20a0 rdf:first sg:person.0672122147.15
194 rdf:rest Nedce210c856c474ab6d8bd466a5feaf7
195 Ncc5e5d0ca84b410f927fb7889d10718c rdf:first sg:person.0734642365.35
196 rdf:rest N0fc7e3b6c70e47c1bab4fdf422c9a067
197 Nd043ea2fb2014f42820912015779ea99 rdf:first N6bacef6e9e054e87af6921f49f73c744
198 rdf:rest Nb1a2b1d408fe4b0bbd85522d9e4aaac1
199 Nd4783d5045cb441d8564e2493c0b502f rdf:first Nd4b1238320a24749a96db29f5e6e8ab4
200 rdf:rest Nde838cd72be54c618cc8b1ca942b1d04
201 Nd4b1238320a24749a96db29f5e6e8ab4 schema:affiliation https://www.grid.ac/institutes/grid.415482.e
202 schema:familyName Jeon
203 schema:givenName Soon-Young
204 rdf:type schema:Person
205 Nd6b25c3560a84d88853dc848a7615d7f rdf:first N2de6250e3d6c4a6a9639933f65f628dc
206 rdf:rest N5fe8628207de4b6db744d6a5cd688ea3
207 Nd8b61ce74e2548c0a4c724ea6d909695 rdf:first N1d15303bff124effb8f6c2f30e942ed2
208 rdf:rest N9fdbe94e66194b27ad42fb3f97833ede
209 Ndab8c5bedeac4ab888ca713e3b5dd7dd rdf:first sg:person.016331315467.33
210 rdf:rest Nba39c2a5222342a49bc9b6ba2b7b20a0
211 Ndb936b0f85e04abca2d04739480e495f schema:affiliation https://www.grid.ac/institutes/grid.415482.e
212 schema:familyName Kim
213 schema:givenName Jun-Woo
214 rdf:type schema:Person
215 Nde838cd72be54c618cc8b1ca942b1d04 rdf:first sg:person.01021416057.39
216 rdf:rest N9c804549f2734594b385089dcd71e445
217 Ne05bd8d9a7e04b1d973324a9f86a0826 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
218 schema:name Chromosomes, Human, Pair 2
219 rdf:type schema:DefinedTerm
220 Ne120dd35d52a40eb92621c31c14592c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
221 schema:name Reproducibility of Results
222 rdf:type schema:DefinedTerm
223 Ne7132c65df714b75a11aebded57777bc schema:name readcube_id
224 schema:value 65d10d2bc591a305a81cf23063f93935314d06e9e88cbd793d7a2060274f8aed
225 rdf:type schema:PropertyValue
226 Nea42431732774c96820f51d5e75aa59b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Polymorphism, Single Nucleotide
228 rdf:type schema:DefinedTerm
229 Nedce210c856c474ab6d8bd466a5feaf7 rdf:first sg:person.0602520656.26
230 rdf:rest N3f1966e9e6824531b512f12182ef4d45
231 Neef3218f9af24bfa8f228dd514a46c79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
232 schema:name Case-Control Studies
233 rdf:type schema:DefinedTerm
234 Nf190d0999d2a49b481d1bc98a0f65410 rdf:first sg:person.01241305306.18
235 rdf:rest N5507b8e0a919425db1c771d37c8b93fe
236 Nf1f1e2f292264b27a806108a0b20f46c rdf:first N675ca02e25dd456f9e4772ab7110fa77
237 rdf:rest Nd6b25c3560a84d88853dc848a7615d7f
238 Nf4e2418a5d484de98a1f930a9441fa8e schema:name pubmed_id
239 schema:value 22452962
240 rdf:type schema:PropertyValue
241 Nf51bc509d64747b5ab8216f6fa0c1aa7 rdf:first N7c70ad07d9694aa59bfb46ca0892672e
242 rdf:rest N95558681f9a84afbbdc8c9bf305b327b
243 Nf5d99685317344aa86809449b6eed3cc schema:name doi
244 schema:value 10.1186/bcr3158
245 rdf:type schema:PropertyValue
246 Nf60e6ade08124a518b361ecceba3ef42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
247 schema:name Genome-Wide Association Study
248 rdf:type schema:DefinedTerm
249 Nf736661f2d1747d98b00393c924342bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
250 schema:name Republic of Korea
251 rdf:type schema:DefinedTerm
252 Nfbdad2a137bb402982a302483c310ad8 rdf:first sg:person.0617300553.95
253 rdf:rest N078096f8dc74429184dc91e6b7928fe8
254 Nffd50d67b73f408996736b000d741738 schema:affiliation https://www.grid.ac/institutes/grid.267370.7
255 schema:familyName Lee
256 schema:givenName Jong Won
257 rdf:type schema:Person
258 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
259 schema:name Medical and Health Sciences
260 rdf:type schema:DefinedTerm
261 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
262 schema:name Oncology and Carcinogenesis
263 rdf:type schema:DefinedTerm
264 sg:journal.1022375 schema:issn 1465-5411
265 1465-542X
266 schema:name Breast Cancer Research
267 rdf:type schema:Periodical
268 sg:person.01020377256.75 schema:affiliation https://www.grid.ac/institutes/grid.412678.e
269 schema:familyName Lee
270 schema:givenName Min Hyuk
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020377256.75
272 rdf:type schema:Person
273 sg:person.01021416057.39 schema:affiliation https://www.grid.ac/institutes/grid.415482.e
274 schema:familyName Min
275 schema:givenName Haesook
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021416057.39
277 rdf:type schema:Person
278 sg:person.01043702207.60 schema:affiliation https://www.grid.ac/institutes/grid.415482.e
279 schema:familyName Go
280 schema:givenName Min Jin
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043702207.60
282 rdf:type schema:Person
283 sg:person.01102121350.12 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
284 schema:familyName Yoo
285 schema:givenName Keun-Young
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102121350.12
287 rdf:type schema:Person
288 sg:person.01131237171.52 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
289 schema:familyName Han
290 schema:givenName Wonshik
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131237171.52
292 rdf:type schema:Person
293 sg:person.01165114725.47 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
294 schema:familyName Kang
295 schema:givenName Daehee
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165114725.47
297 rdf:type schema:Person
298 sg:person.01173172106.42 schema:affiliation https://www.grid.ac/institutes/grid.415482.e
299 schema:familyName Kim
300 schema:givenName Young Jin
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173172106.42
302 rdf:type schema:Person
303 sg:person.01176761116.47 schema:affiliation https://www.grid.ac/institutes/grid.415482.e
304 schema:familyName Lee
305 schema:givenName Jong-Young
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176761116.47
307 rdf:type schema:Person
308 sg:person.01215526415.55 schema:affiliation https://www.grid.ac/institutes/grid.410800.d
309 schema:familyName Matsuo
310 schema:givenName Keitaro
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215526415.55
312 rdf:type schema:Person
313 sg:person.012315623520.37 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
314 schema:familyName Lee
315 schema:givenName Ji-Young
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012315623520.37
317 rdf:type schema:Person
318 sg:person.01241305306.18 schema:affiliation https://www.grid.ac/institutes/grid.415482.e
319 schema:familyName Kim
320 schema:givenName Hyung-cheol
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241305306.18
322 rdf:type schema:Person
323 sg:person.01254774342.79 schema:affiliation https://www.grid.ac/institutes/grid.415482.e
324 schema:familyName Kim
325 schema:givenName Hyung-Lae
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254774342.79
327 rdf:type schema:Person
328 sg:person.01345077325.35 schema:affiliation https://www.grid.ac/institutes/grid.267370.7
329 schema:familyName Ahn
330 schema:givenName Sei-Hyun
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345077325.35
332 rdf:type schema:Person
333 sg:person.01361061630.78 schema:affiliation https://www.grid.ac/institutes/grid.415482.e
334 schema:familyName Jeon
335 schema:givenName Jae-Pil
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361061630.78
337 rdf:type schema:Person
338 sg:person.01362302775.25 schema:affiliation https://www.grid.ac/institutes/grid.15444.30
339 schema:familyName Park
340 schema:givenName Byeong-Woo
341 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362302775.25
342 rdf:type schema:Person
343 sg:person.01364776360.50 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
344 schema:familyName Park
345 schema:givenName Sue K
346 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364776360.50
347 rdf:type schema:Person
348 sg:person.01371211365.46 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
349 schema:familyName Sung
350 schema:givenName Hyuna
351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371211365.46
352 rdf:type schema:Person
353 sg:person.016331315467.33 schema:affiliation https://www.grid.ac/institutes/grid.256753.0
354 schema:familyName Cho
355 schema:givenName Yoon Shin
356 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016331315467.33
357 rdf:type schema:Person
358 sg:person.0602520656.26 schema:affiliation https://www.grid.ac/institutes/grid.415482.e
359 schema:familyName Kim
360 schema:givenName Dong-Joon
361 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602520656.26
362 rdf:type schema:Person
363 sg:person.0617300553.95 schema:affiliation https://www.grid.ac/institutes/grid.28665.3f
364 schema:familyName Wu
365 schema:givenName Pei-Ei
366 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617300553.95
367 rdf:type schema:Person
368 sg:person.0631115612.04 schema:affiliation https://www.grid.ac/institutes/grid.28665.3f
369 schema:familyName Hsiung
370 schema:givenName Chia-Ni
371 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631115612.04
372 rdf:type schema:Person
373 sg:person.0637627064.16 schema:affiliation https://www.grid.ac/institutes/grid.28665.3f
374 schema:familyName Shen
375 schema:givenName Chen-Yang
376 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637627064.16
377 rdf:type schema:Person
378 sg:person.0666725147.68 schema:affiliation https://www.grid.ac/institutes/grid.415482.e
379 schema:familyName Kim
380 schema:givenName Hyo Mi
381 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666725147.68
382 rdf:type schema:Person
383 sg:person.0672067757.33 schema:affiliation https://www.grid.ac/institutes/grid.415482.e
384 schema:familyName Han
385 schema:givenName Bok-Ghee
386 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672067757.33
387 rdf:type schema:Person
388 sg:person.0672122147.15 schema:affiliation https://www.grid.ac/institutes/grid.415482.e
389 schema:familyName Park
390 schema:givenName Miey
391 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672122147.15
392 rdf:type schema:Person
393 sg:person.0734642365.35 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
394 schema:familyName Noh
395 schema:givenName Dong-Young
396 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734642365.35
397 rdf:type schema:Person
398 sg:person.0734652235.70 schema:affiliation https://www.grid.ac/institutes/grid.411128.f
399 schema:familyName Lee
400 schema:givenName Kyoung-Mu
401 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734652235.70
402 rdf:type schema:Person
403 sg:person.07507304257.28 schema:affiliation https://www.grid.ac/institutes/grid.31501.36
404 schema:familyName Choi
405 schema:givenName Ji-Yeob
406 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07507304257.28
407 rdf:type schema:Person
408 sg:person.0761452454.04 schema:affiliation https://www.grid.ac/institutes/grid.415482.e
409 schema:familyName Oh
410 schema:givenName Ji Hee
411 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761452454.04
412 rdf:type schema:Person
413 sg:pub.10.1007/s00439-011-0973-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013994820
414 https://doi.org/10.1007/s00439-011-0973-1
415 rdf:type schema:CreativeWork
416 sg:pub.10.1007/s10549-010-1172-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022984330
417 https://doi.org/10.1007/s10549-010-1172-9
418 rdf:type schema:CreativeWork
419 sg:pub.10.1038/35052073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053565592
420 https://doi.org/10.1038/35052073
421 rdf:type schema:CreativeWork
422 sg:pub.10.1038/87876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008466971
423 https://doi.org/10.1038/87876
424 rdf:type schema:CreativeWork
425 sg:pub.10.1038/nature05887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027991306
426 https://doi.org/10.1038/nature05887
427 rdf:type schema:CreativeWork
428 sg:pub.10.1038/ng.131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038518938
429 https://doi.org/10.1038/ng.131
430 rdf:type schema:CreativeWork
431 sg:pub.10.1038/ng.318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029457545
432 https://doi.org/10.1038/ng.318
433 rdf:type schema:CreativeWork
434 sg:pub.10.1038/ng.353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000555917
435 https://doi.org/10.1038/ng.353
436 rdf:type schema:CreativeWork
437 sg:pub.10.1038/ng.354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004838062
438 https://doi.org/10.1038/ng.354
439 rdf:type schema:CreativeWork
440 sg:pub.10.1038/ng.586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006256853
441 https://doi.org/10.1038/ng.586
442 rdf:type schema:CreativeWork
443 sg:pub.10.1038/ng1107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034727724
444 https://doi.org/10.1038/ng1107
445 rdf:type schema:CreativeWork
446 sg:pub.10.1038/ng2064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045095990
447 https://doi.org/10.1038/ng2064
448 rdf:type schema:CreativeWork
449 sg:pub.10.1186/1471-2350-8-s1-s6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033054226
450 https://doi.org/10.1186/1471-2350-8-s1-s6
451 rdf:type schema:CreativeWork
452 https://doi.org/10.1002/bimj.200610297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007153165
453 rdf:type schema:CreativeWork
454 https://doi.org/10.1002/gepi.20533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039500245
455 rdf:type schema:CreativeWork
456 https://doi.org/10.1016/s0140-6736(05)79243-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009703066
457 rdf:type schema:CreativeWork
458 https://doi.org/10.1016/s1470-2045(11)70076-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021450789
459 rdf:type schema:CreativeWork
460 https://doi.org/10.1073/pnas.0800441105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030781622
461 rdf:type schema:CreativeWork
462 https://doi.org/10.1073/pnas.0903103106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020299353
463 rdf:type schema:CreativeWork
464 https://doi.org/10.1073/pnas.191367098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034333528
465 rdf:type schema:CreativeWork
466 https://doi.org/10.1093/bioinformatics/btq419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036490983
467 rdf:type schema:CreativeWork
468 https://doi.org/10.1093/hmg/ddr228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008298494
469 rdf:type schema:CreativeWork
470 https://doi.org/10.1093/hmg/ddr405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045333876
471 rdf:type schema:CreativeWork
472 https://doi.org/10.1093/jnci/djq563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003023824
473 rdf:type schema:CreativeWork
474 https://doi.org/10.1093/nar/26.1.362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048518114
475 rdf:type schema:CreativeWork
476 https://doi.org/10.1093/nar/gkl236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033716833
477 rdf:type schema:CreativeWork
478 https://doi.org/10.1146/annurev.genom.9.081307.164242 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018499775
479 rdf:type schema:CreativeWork
480 https://doi.org/10.1158/0008-5472.can-04-3150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036181787
481 rdf:type schema:CreativeWork
482 https://doi.org/10.1158/1055-9965.epi-10-0054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039464292
483 rdf:type schema:CreativeWork
484 https://doi.org/10.1158/1055-9965.epi-10-0698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004371371
485 rdf:type schema:CreativeWork
486 https://doi.org/10.1158/1055-9965.epi-11-0524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013102578
487 rdf:type schema:CreativeWork
488 https://doi.org/10.1158/1078-0432.ccr-07-0457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031133697
489 rdf:type schema:CreativeWork
490 https://doi.org/10.1371/journal.pgen.1000054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047548438
491 rdf:type schema:CreativeWork
492 https://doi.org/10.1371/journal.pgen.1001002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044091804
493 rdf:type schema:CreativeWork
494 https://www.grid.ac/institutes/grid.15444.30 schema:alternateName Yonsei University
495 schema:name Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-Ro Seodaemun-Gu, 120-752, Seoul, Korea
496 rdf:type schema:Organization
497 https://www.grid.ac/institutes/grid.256753.0 schema:alternateName Hallym University
498 schema:name Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea
499 Department of Biomedical Science, Hallym University, 1 Hallymdaehak-gill, Chuncheon, 200-702, Gangwon-do, Korea
500 rdf:type schema:Organization
501 https://www.grid.ac/institutes/grid.267370.7 schema:alternateName University of Ulsan
502 schema:name Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, 88 Olympic-Ro 43 gil, Songpa-Gu, 138-736, Seoul, Korea
503 rdf:type schema:Organization
504 https://www.grid.ac/institutes/grid.28665.3f schema:alternateName Academia Sinica
505 schema:name College of Public Health, China Medical University, No. 91, Hsueh-Shih Road, 40402, Taichung, Taiwan
506 Institute of Biomedical Sciences and Taiwan Biobank, Academia Sinica, 128 Academia Road, Section 2, 115, Nankang, Taipei, Taiwan
507 Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road, Section 2, 115, Nankang, Taipei, Taiwan
508 rdf:type schema:Organization
509 https://www.grid.ac/institutes/grid.31501.36 schema:alternateName Seoul National University
510 schema:name Biochemisty and Molecular Biology, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea
511 Cancer Research Institute, Seoul National University, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea
512 Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea
513 Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea
514 Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea
515 Department of Surgery, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea
516 rdf:type schema:Organization
517 https://www.grid.ac/institutes/grid.410800.d schema:alternateName Aichi Cancer Center
518 schema:name Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanakoden, Chikusa-ku, 464-8681, Nagoya, Japan
519 rdf:type schema:Organization
520 https://www.grid.ac/institutes/grid.410914.9 schema:alternateName National Cancer Center
521 schema:name Carcinogenesis Research Branch, National Cancer Center, 323 Ilsan-Ro, Ilsandong-Gu, 410-769, Goyang-si, Korea
522 rdf:type schema:Organization
523 https://www.grid.ac/institutes/grid.411128.f schema:alternateName Korea National Open University
524 schema:name Department of Environmental Health, Korea National Open University, 169 Dongsung-Dong, Chongno-Gu, 110-791, Seoul, Korea
525 rdf:type schema:Organization
526 https://www.grid.ac/institutes/grid.411918.4 schema:alternateName Tianjin Medical University Cancer Institute and Hospital
527 schema:name Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Hospital and Institute, Huan-Hu-Xi Road, Ti-Yuan-Bei, 300060, He Xi District, Tianjin, China
528 Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehak-Ro Jongno-Gu, 110-799, Seoul, Korea
529 rdf:type schema:Organization
530 https://www.grid.ac/institutes/grid.412010.6 schema:alternateName Kangwon National University
531 schema:name Department of Preventive Medicine, Kangwon National University School of Medicine, 1 Kangwondaehak-gil, Chuncheon-si, 200-701, Kangwon-do, Korea
532 rdf:type schema:Organization
533 https://www.grid.ac/institutes/grid.412480.b schema:alternateName Seoul National University Bundang Hospital
534 schema:name Department of Surgery, Breast and Endocrine Service, Seoul National University Bundang Hospital, 82 Gumi-Ro 173gil, Bundang-Gu, 463-707, Gyeonggi-do, Korea
535 rdf:type schema:Organization
536 https://www.grid.ac/institutes/grid.412678.e schema:alternateName Soonchunhyang University Hospital
537 schema:name Department of Surgery, College of Medicine, Soonchunhyang University Hospital, 59 Daesagwan-Ro Yongsan-gu, 140-743, Seoul, Korea
538 rdf:type schema:Organization
539 https://www.grid.ac/institutes/grid.415482.e schema:alternateName Korea National Institute of Health
540 schema:name Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, 363-951, Chungcheongbuk-do, Korea
541 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...