Protein expression, survival and docetaxel benefit in node-positive breast cancer treated with adjuvant chemotherapy in the FNCLCC - PACS 01 ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Jocelyne Jacquemier, Jean-Marie Boher, Henri Roche, Benjamin Esterni, Daniel Serin, Pierre Kerbrat, Fabrice Andre, Pascal Finetti, Emmanuelle Charafe-Jauffret, Anne-Laure Martin, Mario Campone, Patrice Viens, Daniel Birnbaum, Frédérique Penault-Llorca, François Bertucci

ABSTRACT

INTRODUCTION: The PACS01 trial has demonstrated that a docetaxel addition to adjuvant anthracycline-based chemotherapy improves disease-free survival (DFS) and overall survival of node-positive early breast cancer (EBC). We searched for prognostic and predictive markers for docetaxel's benefit. METHODS: Tumor samples from 1,099 recruited women were analyzed for the expression of 34 selected proteins using immunohistochemistry. The prognostic and predictive values of each marker and four molecular subtypes (luminal A, luminal B, HER2-overexpressing, and triple-negative) were tested. RESULTS: Progesterone receptor-negativity (HR = 0.66; 95% CI 0.47 to 0.92, P = 0.013), and Ki67-positivity (HR = 1.53; 95% CI 1.12 to 2.08, P = 0.007) were independent adverse prognostic factors. Out of the 34 proteins, only Ki67-positivity was associated with DFS improvement with docetaxel addition (adjusted HR = 0.51, 95% CI 0.33 to 0.79 for Ki67-positive versus HR = 1.10, 95% CI 0.75 to 1.61 for Ki67-negative tumors, P for interaction = 0.012). Molecular subtyping predicted the docetaxel benefit, but without providing additional information to Ki67 status. The luminal A subtype did not benefit from docetaxel (HR = 1.16, 95% CI 0.73 to 1.84); the reduction in the relapse risk was 53% (HR = 0.47, 95% CI 0.22 to 1.01), 34% (HR = 0.66, 95% CI 0.37 to 1.19), and 12% (HR = 0.88, 95% CI 0.49 to 1.57) in the luminal B, HER2-overexpressing, and triple-negative subtypes, respectively. CONCLUSIONS: In patients with node-positive EBC receiving adjuvant anthracycline-based chemotherapy, the most powerful predictor of docetaxel benefit is Ki67-positivity. More... »

PAGES

r109

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/bcr3051

    DOI

    http://dx.doi.org/10.1186/bcr3051

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047184357

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22044691


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    417 https://www.grid.ac/institutes/grid.463833.9 schema:alternateName Centre de Recherche en Cancérologie de Marseille
    418 schema:name Department of BioPathology, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille, UMR891 Inserm, 232, Bd Ste-Marguerite, 13009, Marseille, France
    419 Department of Biostatistics, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille, UMR891 Inserm, 232, Bd Ste-Marguerite, 13009, Marseille, France
    420 Department of Medical Oncology, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille, UMR891 Inserm, 232, Bd Ste-Marguerite, 13009, Marseille, France
    421 Department of Molecular Oncology, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille, UMR891 Inserm, 232, Bd Ste-Marguerite, 13009, Marseille, France
    422 UFR of Medicine, Aix-Marseille University, 58 bd Charles Livon, 13001, Marseille, France
    423 rdf:type schema:Organization
    424 https://www.grid.ac/institutes/grid.482015.a schema:alternateName Institut Sainte Catherine
    425 schema:name Department of Medical Oncology, Institut Sainte-Catherine, 1750 Chemin Lavarin, 84000, Avignon, France
    426 rdf:type schema:Organization
    427 https://www.grid.ac/institutes/grid.5399.6 schema:alternateName Aix-Marseille University
    428 schema:name Department of BioPathology, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille, UMR891 Inserm, 232, Bd Ste-Marguerite, 13009, Marseille, France
    429 Department of Molecular Oncology, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille, UMR891 Inserm, 232, Bd Ste-Marguerite, 13009, Marseille, France
    430 UFR of Medicine, Aix-Marseille University, 58 bd Charles Livon, 13001, Marseille, France
    431 rdf:type schema:Organization
     




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