Mammographic density and breast cancer risk: current understanding and future prospects View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Norman F Boyd, Lisa J Martin, Martin J Yaffe, Salomon Minkin

ABSTRACT

Variations in percent mammographic density (PMD) reflect variations in the amounts of collagen and number of epithelial and non-epithelial cells in the breast. Extensive PMD is associated with a markedly increased risk of invasive breast cancer. The PMD phenotype is important in the context of breast cancer prevention because extensive PMD is common in the population, is strongly associated with risk of the disease, and, unlike most breast cancer risk factors, can be changed. Work now in progress makes it likely that measurement of PMD will be improved in the near future and that understanding of the genetics and biological basis of the association of PMD with breast cancer risk will also improve. Future prospects for the application of PMD include mammographic screening, risk prediction in individuals, breast cancer prevention research, and clinical decision making. More... »

PAGES

223

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/bcr2942

    DOI

    http://dx.doi.org/10.1186/bcr2942

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008028099

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22114898


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    410 Ontario Cancer Institute, 610 University Avenue, M5G 2M9, Toronto, ON, Canada
    411 rdf:type schema:Organization
     




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