Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-06

AUTHORS

Kanokwan Kittiniyom, Karen M Gorse, Fabienne Dalbegue, Jack H Lichy, Jeffery K Taubenberger, Irene F Newsham

ABSTRACT

We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ. Although most cases indicated LOH was clonally inherited, heterogeneity for 18p LOH occurred in 27% of tumors. When compared with other LOH data, 18p LOH was found in conjunction with allelic deletion on 3p, 9p, 17p and 17q, while 13q, 16q, and 11p were less frequently associated. These analyses suggest chromosome 18p11 alteration is a common and early event in breast disease. More... »

PAGES

192

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/bcr294

DOI

http://dx.doi.org/10.1186/bcr294

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014199990

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11305954


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