Menopausal hormone therapy in relation to breast cancer characteristics and prognosis: a cohort study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-10

AUTHORS

Lena U Rosenberg, Fredrik Granath, Paul W Dickman, Kristjana Einarsdóttir, Sara Wedrén, Ingemar Persson, Per Hall

ABSTRACT

INTRODUCTION: Menopausal hormone therapy has been reported to increase the risk of certain subtypes of breast cancer and to be associated with a favorable survival. These associations could either be due to an increased mammographic surveillance or to a biological effect. We assessed these associations in a Swedish cohort of postmenopausal breast cancer patients holding information on mammographic examinations, menopausal hormone therapy use, other breast cancer risk factors, and cancer treatment. METHODS: We analyzed 2,660 postmenopausal women aged 50 to 74 years, diagnosed with invasive breast cancer in 1993 to 1995 and followed until the end of 2003 (median follow-up, 9 years and 3 months). We assessed the influence of hormone therapy before diagnosis on tumor characteristics and breast cancer-specific survival. We analyzed hormone therapy before diagnosis by regimen (estrogen-progestin therapy or estrogen alone therapy), recency (current or past), and duration of use (<5 years or > or = 5 years). RESULTS: Current use, but not past use, compared with never use of hormone therapy before diagnosis seemed to be associated with tumors of low grade and with improved breast cancer-specific survival. The associations were stronger with longer duration, but did not vary significantly by regimen. The favorable survival among current users of hormone therapy was only partly explained by differences in available tumor characteristics and mammographic surveillance. CONCLUSIONS: We conclude that current menopausal hormone therapy, especially long term, is associated with favorable tumor characteristics and survival. More... »

PAGES

r78

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/bcr2145

DOI

http://dx.doi.org/10.1186/bcr2145

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015583909

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18803850


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Estrogen Replacement Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hormone Replacement Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mammography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Menopause", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sweden", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Burden", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm, Sweden", 
            "Department of Clinical Sciences, Danderyd's Hospital, Karolinska Institutet, SE-182 88, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rosenberg", 
        "givenName": "Lena U", 
        "id": "sg:person.01233766467.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233766467.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Medicine, Unit of Clinical Epidemiology, Karolinska Institutet, SE-171 76, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Granath", 
        "givenName": "Fredrik", 
        "id": "sg:person.01236024473.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236024473.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dickman", 
        "givenName": "Paul W", 
        "id": "sg:person.01265436000.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265436000.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Einarsd\u00f3ttir", 
        "givenName": "Kristjana", 
        "id": "sg:person.01232472231.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232472231.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Institute of Environmental Medicine, Unit of Cardiovascular Epidemiology, 171 77, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wedr\u00e9n", 
        "givenName": "Sara", 
        "id": "sg:person.0675167567.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675167567.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Persson", 
        "givenName": "Ingemar", 
        "id": "sg:person.0605541460.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605541460.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hall", 
        "givenName": "Per", 
        "id": "sg:person.01010701573.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010701573.25"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.bjc.6601996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001019937", 
          "https://doi.org/10.1038/sj.bjc.6601996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001019937", 
          "https://doi.org/10.1038/sj.bjc.6601996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.320.7231.348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001901847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.289.24.3243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001930703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002276713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01806152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004097503", 
          "https://doi.org/10.1007/bf01806152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01806152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004097503", 
          "https://doi.org/10.1007/bf01806152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1024953926221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005559641", 
          "https://doi.org/10.1023/a:1024953926221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007547297", 
          "https://doi.org/10.1038/sj.bjc.6690543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007547297", 
          "https://doi.org/10.1038/sj.bjc.6690543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(199806)79:3<278::aid-ijc12>3.0.co;2-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007566544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.1991.tb00229.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010222506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.1991.tb00229.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010222506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02573064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010864959", 
          "https://doi.org/10.1007/bf02573064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02573064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010864959", 
          "https://doi.org/10.1007/bf02573064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djm059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013052948"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/92.4.328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015903237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016952194", 
          "https://doi.org/10.1038/sj.bjc.6602501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016952194", 
          "https://doi.org/10.1038/sj.bjc.6602501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(03)14596-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020008556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/del393", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021442208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.22542", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023352172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-004-3777-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026799779", 
          "https://doi.org/10.1007/s10549-004-3777-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-004-3777-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026799779", 
          "https://doi.org/10.1007/s10549-004-3777-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(03)14065-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032081225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmsr070105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034085571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/erc.1.00758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035338919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/erc.1.00758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035338919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.283.4.485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035924988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910490409", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039289018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/91.3.264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042339510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.breast.2004.08.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046046065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/02841869509093948", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047992692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djm111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051647255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19990505)81:3<339::aid-ijc5>3.0.co;2-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052381053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.295.14.1647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053336255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.312.7047.1646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062776278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.312.7047.1646", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062776278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jms.9.2.70", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062818414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jms.9.2.70", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062818414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.05.151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1999.17.6.1680", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074549750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076606390", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076791722", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.aje.a115328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079312843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.9.3115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083316837"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-10", 
    "datePublishedReg": "2008-10-01", 
    "description": "INTRODUCTION: Menopausal hormone therapy has been reported to increase the risk of certain subtypes of breast cancer and to be associated with a favorable survival. These associations could either be due to an increased mammographic surveillance or to a biological effect. We assessed these associations in a Swedish cohort of postmenopausal breast cancer patients holding information on mammographic examinations, menopausal hormone therapy use, other breast cancer risk factors, and cancer treatment.\nMETHODS: We analyzed 2,660 postmenopausal women aged 50 to 74 years, diagnosed with invasive breast cancer in 1993 to 1995 and followed until the end of 2003 (median follow-up, 9 years and 3 months). We assessed the influence of hormone therapy before diagnosis on tumor characteristics and breast cancer-specific survival. We analyzed hormone therapy before diagnosis by regimen (estrogen-progestin therapy or estrogen alone therapy), recency (current or past), and duration of use (<5 years or > or = 5 years).\nRESULTS: Current use, but not past use, compared with never use of hormone therapy before diagnosis seemed to be associated with tumors of low grade and with improved breast cancer-specific survival. The associations were stronger with longer duration, but did not vary significantly by regimen. The favorable survival among current users of hormone therapy was only partly explained by differences in available tumor characteristics and mammographic surveillance.\nCONCLUSIONS: We conclude that current menopausal hormone therapy, especially long term, is associated with favorable tumor characteristics and survival.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/bcr2145", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1022375", 
        "issn": [
          "1465-5411", 
          "1465-542X"
        ], 
        "name": "Breast Cancer Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Menopausal hormone therapy in relation to breast cancer characteristics and prognosis: a cohort study", 
    "pagination": "r78", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4a4007961f734a8b5e56d182af6febc4299f97ede3a2b46720ce950c3dc54b44"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18803850"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100927353"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/bcr2145"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015583909"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/bcr2145", 
      "https://app.dimensions.ai/details/publication/pub.1015583909"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000511.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Fbcr2145"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/bcr2145'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/bcr2145'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/bcr2145'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/bcr2145'


 

This table displays all metadata directly associated to this object as RDF triples.

299 TRIPLES      21 PREDICATES      83 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/bcr2145 schema:about N0fecc2e4767449b7a47a9323f52b01f9
2 N13978cb3bdda4a918a59cbd5c1559bf1
3 N2486aa05859947c7b0c9d6f01c35a5d1
4 N260e842a36c6417f9ec9c0e8c6189e59
5 N2815ef8959474b499f533e1da233b304
6 N2b1403c1bd8d4b4ba5decf447d20e9bb
7 N3656b8437a30434d9e5bde33fea27f31
8 N3a9e359aa18644d5a277ee9801bd52e6
9 N4e4020e91fce441eb83ba7c8147ef1e4
10 N5506853b736f443f9fc8618f7bb282cc
11 N58e72c3c20234327ac25613b152744e0
12 N5fc66386de814b87b4bacbdee8fbd06d
13 N8865655a1d51494493b39bc796532773
14 Nb11f76ebbf004cb5adbeda7cf5066f99
15 Nb84103e5448b4ce9bc502cd82838e538
16 Nbcbbea1b5c7541db8151e328171e25ea
17 Nc2c2c70fdd574854b6e842542d864c91
18 Ned27cb73831f40f5b0fbf9a506654f24
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author Ne524916174dc4752bc13bce92961b3c5
22 schema:citation sg:pub.10.1007/bf01806152
23 sg:pub.10.1007/bf02573064
24 sg:pub.10.1007/s10549-004-3777-3
25 sg:pub.10.1023/a:1024953926221
26 sg:pub.10.1038/sj.bjc.6601996
27 sg:pub.10.1038/sj.bjc.6602501
28 sg:pub.10.1038/sj.bjc.6690543
29 https://app.dimensions.ai/details/publication/pub.1076606390
30 https://app.dimensions.ai/details/publication/pub.1076791722
31 https://doi.org/10.1001/jama.283.4.485
32 https://doi.org/10.1001/jama.289.24.3243
33 https://doi.org/10.1001/jama.295.14.1647
34 https://doi.org/10.1002/(sici)1097-0215(199806)79:3<278::aid-ijc12>3.0.co;2-5
35 https://doi.org/10.1002/(sici)1097-0215(19990505)81:3<339::aid-ijc5>3.0.co;2-6
36 https://doi.org/10.1002/ijc.22542
37 https://doi.org/10.1002/ijc.2910490409
38 https://doi.org/10.1002/path.1691
39 https://doi.org/10.1016/j.breast.2004.08.018
40 https://doi.org/10.1016/s0140-6736(03)14065-2
41 https://doi.org/10.1016/s0140-6736(03)14596-5
42 https://doi.org/10.1056/nejmsr070105
43 https://doi.org/10.1093/humrep/del393
44 https://doi.org/10.1093/jnci/91.3.264
45 https://doi.org/10.1093/jnci/92.4.328
46 https://doi.org/10.1093/jnci/djm059
47 https://doi.org/10.1093/jnci/djm111
48 https://doi.org/10.1093/oxfordjournals.aje.a115328
49 https://doi.org/10.1111/j.1365-2559.1991.tb00229.x
50 https://doi.org/10.1136/bmj.312.7047.1646
51 https://doi.org/10.1136/bmj.320.7231.348
52 https://doi.org/10.1136/jms.9.2.70
53 https://doi.org/10.1200/jco.1998.16.9.3115
54 https://doi.org/10.1200/jco.1999.17.6.1680
55 https://doi.org/10.1200/jco.2003.05.151
56 https://doi.org/10.1677/erc.1.00758
57 https://doi.org/10.3109/02841869509093948
58 schema:datePublished 2008-10
59 schema:datePublishedReg 2008-10-01
60 schema:description INTRODUCTION: Menopausal hormone therapy has been reported to increase the risk of certain subtypes of breast cancer and to be associated with a favorable survival. These associations could either be due to an increased mammographic surveillance or to a biological effect. We assessed these associations in a Swedish cohort of postmenopausal breast cancer patients holding information on mammographic examinations, menopausal hormone therapy use, other breast cancer risk factors, and cancer treatment. METHODS: We analyzed 2,660 postmenopausal women aged 50 to 74 years, diagnosed with invasive breast cancer in 1993 to 1995 and followed until the end of 2003 (median follow-up, 9 years and 3 months). We assessed the influence of hormone therapy before diagnosis on tumor characteristics and breast cancer-specific survival. We analyzed hormone therapy before diagnosis by regimen (estrogen-progestin therapy or estrogen alone therapy), recency (current or past), and duration of use (<5 years or > or = 5 years). RESULTS: Current use, but not past use, compared with never use of hormone therapy before diagnosis seemed to be associated with tumors of low grade and with improved breast cancer-specific survival. The associations were stronger with longer duration, but did not vary significantly by regimen. The favorable survival among current users of hormone therapy was only partly explained by differences in available tumor characteristics and mammographic surveillance. CONCLUSIONS: We conclude that current menopausal hormone therapy, especially long term, is associated with favorable tumor characteristics and survival.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf Nbb6c6525ff464a378b82b73f4fa7b891
65 Nf522384582ad47d48211a8e2ab9e81ef
66 sg:journal.1022375
67 schema:name Menopausal hormone therapy in relation to breast cancer characteristics and prognosis: a cohort study
68 schema:pagination r78
69 schema:productId N0b66db384b4f48e1b367a472c2e1626d
70 N344afa50625844fb842e6257c2572290
71 N8e451ff57d5745f5913101a6e25bb593
72 Ncbd6e88d96a94ef4aa761b02981b7e19
73 Ne39d4b1b62fe4eed86282aee12ab2759
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015583909
75 https://doi.org/10.1186/bcr2145
76 schema:sdDatePublished 2019-04-10T23:24
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher N9f831bcf80064b8692b2b23924106b1b
79 schema:url http://link.springer.com/10.1186%2Fbcr2145
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N0b66db384b4f48e1b367a472c2e1626d schema:name dimensions_id
84 schema:value pub.1015583909
85 rdf:type schema:PropertyValue
86 N0fecc2e4767449b7a47a9323f52b01f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Risk Factors
88 rdf:type schema:DefinedTerm
89 N13978cb3bdda4a918a59cbd5c1559bf1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Cohort Studies
91 rdf:type schema:DefinedTerm
92 N13e776ad45ac4f469274c9cc9020ed24 rdf:first sg:person.01265436000.33
93 rdf:rest N6fc7079df8344a4c9492192f74d6239a
94 N2486aa05859947c7b0c9d6f01c35a5d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Humans
96 rdf:type schema:DefinedTerm
97 N260e842a36c6417f9ec9c0e8c6189e59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Aged
99 rdf:type schema:DefinedTerm
100 N2815ef8959474b499f533e1da233b304 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Prognosis
102 rdf:type schema:DefinedTerm
103 N2b1403c1bd8d4b4ba5decf447d20e9bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Breast Neoplasms
105 rdf:type schema:DefinedTerm
106 N344afa50625844fb842e6257c2572290 schema:name pubmed_id
107 schema:value 18803850
108 rdf:type schema:PropertyValue
109 N3656b8437a30434d9e5bde33fea27f31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Hormone Replacement Therapy
111 rdf:type schema:DefinedTerm
112 N36633ebb4adf4fb987dda3e911d6c6a2 rdf:first sg:person.01010701573.25
113 rdf:rest rdf:nil
114 N3a9e359aa18644d5a277ee9801bd52e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Mammography
116 rdf:type schema:DefinedTerm
117 N4e4020e91fce441eb83ba7c8147ef1e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Female
119 rdf:type schema:DefinedTerm
120 N5506853b736f443f9fc8618f7bb282cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Estrogen Replacement Therapy
122 rdf:type schema:DefinedTerm
123 N58e72c3c20234327ac25613b152744e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Survival Analysis
125 rdf:type schema:DefinedTerm
126 N5f6889edb5a44d4cb40a2fdfaafdbcd2 rdf:first sg:person.0675167567.31
127 rdf:rest N622439d9e43b4d51980c208d663702ea
128 N5fc66386de814b87b4bacbdee8fbd06d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Tumor Burden
130 rdf:type schema:DefinedTerm
131 N622439d9e43b4d51980c208d663702ea rdf:first sg:person.0605541460.05
132 rdf:rest N36633ebb4adf4fb987dda3e911d6c6a2
133 N6fc7079df8344a4c9492192f74d6239a rdf:first sg:person.01232472231.27
134 rdf:rest N5f6889edb5a44d4cb40a2fdfaafdbcd2
135 N7e91a58a0609445bb7c677d929f4f03a rdf:first sg:person.01236024473.41
136 rdf:rest N13e776ad45ac4f469274c9cc9020ed24
137 N8865655a1d51494493b39bc796532773 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Lymphatic Metastasis
139 rdf:type schema:DefinedTerm
140 N8e451ff57d5745f5913101a6e25bb593 schema:name doi
141 schema:value 10.1186/bcr2145
142 rdf:type schema:PropertyValue
143 N9f831bcf80064b8692b2b23924106b1b schema:name Springer Nature - SN SciGraph project
144 rdf:type schema:Organization
145 Nb11f76ebbf004cb5adbeda7cf5066f99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Follow-Up Studies
147 rdf:type schema:DefinedTerm
148 Nb84103e5448b4ce9bc502cd82838e538 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Middle Aged
150 rdf:type schema:DefinedTerm
151 Nbb6c6525ff464a378b82b73f4fa7b891 schema:issueNumber 5
152 rdf:type schema:PublicationIssue
153 Nbcbbea1b5c7541db8151e328171e25ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Carcinoma
155 rdf:type schema:DefinedTerm
156 Nc2c2c70fdd574854b6e842542d864c91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Menopause
158 rdf:type schema:DefinedTerm
159 Ncbd6e88d96a94ef4aa761b02981b7e19 schema:name readcube_id
160 schema:value 4a4007961f734a8b5e56d182af6febc4299f97ede3a2b46720ce950c3dc54b44
161 rdf:type schema:PropertyValue
162 Ne39d4b1b62fe4eed86282aee12ab2759 schema:name nlm_unique_id
163 schema:value 100927353
164 rdf:type schema:PropertyValue
165 Ne524916174dc4752bc13bce92961b3c5 rdf:first sg:person.01233766467.00
166 rdf:rest N7e91a58a0609445bb7c677d929f4f03a
167 Ned27cb73831f40f5b0fbf9a506654f24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Sweden
169 rdf:type schema:DefinedTerm
170 Nf522384582ad47d48211a8e2ab9e81ef schema:volumeNumber 10
171 rdf:type schema:PublicationVolume
172 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
173 schema:name Medical and Health Sciences
174 rdf:type schema:DefinedTerm
175 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
176 schema:name Oncology and Carcinogenesis
177 rdf:type schema:DefinedTerm
178 sg:journal.1022375 schema:issn 1465-5411
179 1465-542X
180 schema:name Breast Cancer Research
181 rdf:type schema:Periodical
182 sg:person.01010701573.25 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
183 schema:familyName Hall
184 schema:givenName Per
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010701573.25
186 rdf:type schema:Person
187 sg:person.01232472231.27 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
188 schema:familyName Einarsdóttir
189 schema:givenName Kristjana
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232472231.27
191 rdf:type schema:Person
192 sg:person.01233766467.00 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
193 schema:familyName Rosenberg
194 schema:givenName Lena U
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233766467.00
196 rdf:type schema:Person
197 sg:person.01236024473.41 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
198 schema:familyName Granath
199 schema:givenName Fredrik
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01236024473.41
201 rdf:type schema:Person
202 sg:person.01265436000.33 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
203 schema:familyName Dickman
204 schema:givenName Paul W
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265436000.33
206 rdf:type schema:Person
207 sg:person.0605541460.05 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
208 schema:familyName Persson
209 schema:givenName Ingemar
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605541460.05
211 rdf:type schema:Person
212 sg:person.0675167567.31 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
213 schema:familyName Wedrén
214 schema:givenName Sara
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675167567.31
216 rdf:type schema:Person
217 sg:pub.10.1007/bf01806152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004097503
218 https://doi.org/10.1007/bf01806152
219 rdf:type schema:CreativeWork
220 sg:pub.10.1007/bf02573064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010864959
221 https://doi.org/10.1007/bf02573064
222 rdf:type schema:CreativeWork
223 sg:pub.10.1007/s10549-004-3777-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026799779
224 https://doi.org/10.1007/s10549-004-3777-3
225 rdf:type schema:CreativeWork
226 sg:pub.10.1023/a:1024953926221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005559641
227 https://doi.org/10.1023/a:1024953926221
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/sj.bjc.6601996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001019937
230 https://doi.org/10.1038/sj.bjc.6601996
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/sj.bjc.6602501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016952194
233 https://doi.org/10.1038/sj.bjc.6602501
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/sj.bjc.6690543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007547297
236 https://doi.org/10.1038/sj.bjc.6690543
237 rdf:type schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1076606390 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1076791722 schema:CreativeWork
240 https://doi.org/10.1001/jama.283.4.485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035924988
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1001/jama.289.24.3243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001930703
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1001/jama.295.14.1647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053336255
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1002/(sici)1097-0215(199806)79:3<278::aid-ijc12>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007566544
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1002/(sici)1097-0215(19990505)81:3<339::aid-ijc5>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052381053
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1002/ijc.22542 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023352172
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1002/ijc.2910490409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039289018
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1002/path.1691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002276713
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.breast.2004.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046046065
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/s0140-6736(03)14065-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032081225
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/s0140-6736(03)14596-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020008556
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1056/nejmsr070105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034085571
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1093/humrep/del393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021442208
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1093/jnci/91.3.264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042339510
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1093/jnci/92.4.328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015903237
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1093/jnci/djm059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013052948
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1093/jnci/djm111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051647255
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1093/oxfordjournals.aje.a115328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079312843
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1111/j.1365-2559.1991.tb00229.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010222506
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1136/bmj.312.7047.1646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062776278
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1136/bmj.320.7231.348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001901847
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1136/jms.9.2.70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062818414
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1200/jco.1998.16.9.3115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083316837
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1200/jco.1999.17.6.1680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074549750
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1200/jco.2003.05.151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203623
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1677/erc.1.00758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035338919
291 rdf:type schema:CreativeWork
292 https://doi.org/10.3109/02841869509093948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047992692
293 rdf:type schema:CreativeWork
294 https://www.grid.ac/institutes/grid.4714.6 schema:alternateName Karolinska Institute
295 schema:name Department of Clinical Sciences, Danderyd's Hospital, Karolinska Institutet, SE-182 88, Stockholm, Sweden
296 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77, Stockholm, Sweden
297 Department of Medicine, Unit of Clinical Epidemiology, Karolinska Institutet, SE-171 76, Stockholm, Sweden
298 Institute of Environmental Medicine, Unit of Cardiovascular Epidemiology, 171 77, Stockholm, Sweden
299 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...