Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-08

AUTHORS

Mustafa Akkiprik, Yumei Feng, Huamin Wang, Kexin Chen, Limei Hu, Aysegul Sahin, Savitri Krishnamurthy, Ayse Ozer, Xishan Hao, Wei Zhang

ABSTRACT

The insulin-like growth factor axis, which has been shown to protect cells from apoptosis, plays an essential role in normal cell physiology and in cancer development. The family of insulin-like growth factor binding proteins (IGFBPs) has been shown to have a diverse spectrum of functions in cell growth, death, motility, and tissue remodeling. Among the six IGFBP family members, IGFBP-5 has recently been shown to play an important role in the biology of breast cancer, especially in breast cancer metastasis; however, the exact mechanisms of action remain obscure and sometimes paradoxical. An in-depth understanding of IGFBP-5 would shed light on its potential role as a target for breast cancer therapeutics. More... »

PAGES

212

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/bcr2116

DOI

http://dx.doi.org/10.1186/bcr2116

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017997305

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18710598


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