What autoantibody tests should become widely available to help scleroderma diagnosis and management? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-07-08

AUTHORS

Yoshinao Muro, Kazumitsu Sugiura, Masashi Akiyama

ABSTRACT

Anti-Th/To autoantibodies have been recognized as serological markers of systemic sclerosis (SSc) for more than 20 years. However, validated immunoassay kits to test this specificity have not been commercially available. SSc autoantibodies are basically mutually exclusive and are associated with a certain subset of the disease and/or with organ involvement. Anti-Th/To are generally considered to be markers of the limited cutaneous type of SSc with the involvement of certain internal organs. The excellent correlation between anti-Rpp25 as detected by their novel chemiluminescent method and anti-Th/To as detected by immunoprecipitation suggest that the new assays may become widely available tests for clinicians in future and could help to clarify the clinical significance of anti-Th/To in SSc as well as other conditions over different races or countries. More... »

PAGES

116-116

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/ar4241

DOI

http://dx.doi.org/10.1186/ar4241

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035266997

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23856077


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