Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-10

AUTHORS

Joachim Pircher, Monika Merkle, Markus Wörnle, Andrea Ribeiro, Thomas Czermak, Yvonn Stampnik, Hanna Mannell, Markus Niemeyer, Volker Vielhauer, Florian Krötz

ABSTRACT

INTRODUCTION: Elevated serum levels of the proinflammatory cytokine tumor necrosis factor alpha (TNFα) correlate with an increased risk for atherothrombotic events and TNFα is known to induce prothrombotic molecules in endothelial cells. Based on the preexisting evidence for the impact of TNFα in the pathogenesis of autoimmune disorders and their known association with an acquired hypercoagulability, we investigated the effects of TNFα and the role of the TNF receptor subtypes TNFR1 and TNFR2 for arteriolar thrombosis in vivo. METHODS: Arteriolar thrombosis and platelet-rolling in vivo were investigated in wildtype, TNFR1-/-, TNFR2-/- and TNFR1-/R2-/- C57BL/6 mice using intravital microscopy in the dorsal skinfold chamber microcirculation model. In vitro, expression of prothrombotic molecules was assessed in human endothelial cells by real-time PCR and flow cytometry. RESULTS: In wildtype mice, stimulation with TNFα significantly accelerated thrombotic vessel occlusion in vivo upon ferric chloride injury. Arteriolar thrombosis was much more pronounced in TNFR1-/- animals, where TNFα additionally led to increased platelet-endothelium-interaction. TNFα dependent prothrombotic effects were not observed in TNFR2-/- and TNFR1-/R2- mice. In vitro, stimulation of human platelet rich plasma with TNFα did not influence aggregation properties. In human endothelial cells, TNFα induced superoxide production, p-selectin, tissue factor and PAI-1, and suppressed thrombomodulin, resulting in an accelerated endothelial dependent blood clotting in vitro. Additionally, TNFα caused the release of soluble mediators by endothelial cells which induced prothrombotic and suppressed anticoagulant genes comparable to direct TNFα effects. CONCLUSIONS: TNFα accelerates thrombus formation in an in vivo model of arteriolar thrombosis. Its prothrombotic effects in vivo require TNFR2 and are partly compensated by TNFR1. In vitro studies indicate endothelial mechanisms to be responsible for prothrombotic TNFα effects. Our results support a more selective therapeutic approach in anticytokine therapy favouring TNFR2 specific antagonists. More... »

PAGES

r225

References to SciGraph publications

  • 1992-12. HMEC-1: Establishment of an Immortalized Human Microvascular Endothelial Cell Line in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2012-01. Thrombomodulin and its role in inflammation in SEMINARS IN IMMUNOPATHOLOGY
  • 2003-09. Signalling pathways of the TNF superfamily: a double-edged sword in NATURE REVIEWS IMMUNOLOGY
  • 2003-01. Tumor necrosis factor signaling in CELL DEATH & DIFFERENTIATION
  • 1962-06. Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal in NATURE
  • 2004-07. Nuclear factor-κB: its role in health and disease in JOURNAL OF MOLECULAR MEDICINE
  • 2002-12. Inflammation in atherosclerosis in NATURE
  • 2008-02. The role of tumor necrosis factor-alpha in systemic lupus erythematosus in ARTHRITIS RESEARCH & THERAPY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/ar4064

    DOI

    http://dx.doi.org/10.1186/ar4064

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022468438

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23079185


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Endothelium, Vascular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "In Vitro Techniques", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Knockout", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Microcirculation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "P-Selectin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Plasminogen Activator Inhibitor 1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Tumor Necrosis Factor, Type I", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Tumor Necrosis Factor, Type II", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Skin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Superoxides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Thrombomodulin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Thromboplastin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Thrombosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Necrosis Factor-alpha", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Ludwig Maximilian University of Munich", 
              "id": "https://www.grid.ac/institutes/grid.5252.0", 
              "name": [
                "Medizinische Klinik und Poliklinik IV, Innenstadt, Ludwig Maximilians University M\u00fcnchen, Ziemssenstr. 1, 80336, Munich, Germany", 
                "Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians University M\u00fcnchen, Marchioninistr. 27, 81377, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pircher", 
            "givenName": "Joachim", 
            "id": "sg:person.0721725163.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721725163.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ludwig Maximilian University of Munich", 
              "id": "https://www.grid.ac/institutes/grid.5252.0", 
              "name": [
                "Medizinische Klinik und Poliklinik IV, Innenstadt, Ludwig Maximilians University M\u00fcnchen, Ziemssenstr. 1, 80336, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Merkle", 
            "givenName": "Monika", 
            "id": "sg:person.0720666526.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720666526.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ludwig Maximilian University of Munich", 
              "id": "https://www.grid.ac/institutes/grid.5252.0", 
              "name": [
                "Medizinische Klinik und Poliklinik IV, Innenstadt, Ludwig Maximilians University M\u00fcnchen, Ziemssenstr. 1, 80336, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "W\u00f6rnle", 
            "givenName": "Markus", 
            "id": "sg:person.01324153077.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324153077.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ludwig Maximilian University of Munich", 
              "id": "https://www.grid.ac/institutes/grid.5252.0", 
              "name": [
                "Medizinische Klinik und Poliklinik IV, Innenstadt, Ludwig Maximilians University M\u00fcnchen, Ziemssenstr. 1, 80336, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ribeiro", 
            "givenName": "Andrea", 
            "id": "sg:person.0757215107.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757215107.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ludwig Maximilian University of Munich", 
              "id": "https://www.grid.ac/institutes/grid.5252.0", 
              "name": [
                "Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians University M\u00fcnchen, Marchioninistr. 27, 81377, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Czermak", 
            "givenName": "Thomas", 
            "id": "sg:person.0645307113.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645307113.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ludwig Maximilian University of Munich", 
              "id": "https://www.grid.ac/institutes/grid.5252.0", 
              "name": [
                "Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians University M\u00fcnchen, Marchioninistr. 27, 81377, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stampnik", 
            "givenName": "Yvonn", 
            "id": "sg:person.0744653434.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744653434.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ludwig Maximilian University of Munich", 
              "id": "https://www.grid.ac/institutes/grid.5252.0", 
              "name": [
                "Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians University M\u00fcnchen, Marchioninistr. 27, 81377, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mannell", 
            "givenName": "Hanna", 
            "id": "sg:person.0753530564.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753530564.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Gynecology, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Ismaninger Strasse 22, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Niemeyer", 
            "givenName": "Markus", 
            "id": "sg:person.01075764113.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075764113.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ludwig Maximilian University of Munich", 
              "id": "https://www.grid.ac/institutes/grid.5252.0", 
              "name": [
                "Medizinische Klinik und Poliklinik IV, Innenstadt, Ludwig Maximilians University M\u00fcnchen, Ziemssenstr. 1, 80336, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vielhauer", 
            "givenName": "Volker", 
            "id": "sg:person.0773035466.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773035466.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Invasive Cardiology, Clinic Starnberg, O\u00dfwaldstr. 1, 82319, Munich, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kr\u00f6tz", 
            "givenName": "Florian", 
            "id": "sg:person.01021643764.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021643764.29"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1146/annurev.immunol.14.1.397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000299859"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001371417", 
              "https://doi.org/10.1038/nature01323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001371417", 
              "https://doi.org/10.1038/nature01323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000143933.20616.1b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002152237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000143933.20616.1b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002152237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199901143400207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003372113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2011.153536", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003914648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.0000054612.26458.b2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004626754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000095974.95122.ec", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006260580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000095974.95122.ec", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006260580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci27196", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006736246"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/1523-1747.ep12613748", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010462004", 
              "https://doi.org/10.1111/1523-1747.ep12613748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1538-7836.2009.03582.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011989186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1538-7836.2009.03582.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011989186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cvr/cvr265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012932608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-04-325225", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015065760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000255551.33365.22", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017840396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.atv.0000255551.33365.22", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017840396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cellsig.2009.09.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019560340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci36389", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021406479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401189", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021657597", 
              "https://doi.org/10.1038/sj.cdd.4401189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.cdd.4401189", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021657597", 
              "https://doi.org/10.1038/sj.cdd.4401189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.atherosclerosis.2004.05.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023742350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs20080196", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023789966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs20080196", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023789966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1359-6101(02)00019-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024294792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(01)00237-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029042615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00281-011-0282-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029049275", 
              "https://doi.org/10.1007/s00281-011-0282-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(96)91687-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031463417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2005-03-1247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032582707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.106.650671", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036938958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037702320", 
              "https://doi.org/10.1038/nri1184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037702320", 
              "https://doi.org/10.1038/nri1184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037702320", 
              "https://doi.org/10.1038/nri1184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00109-004-0555-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038896545", 
              "https://doi.org/10.1007/s00109-004-0555-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1525-0016(03)00065-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042594232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1525-0016(03)00065-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042594232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.amjmed.2008.06.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043351512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.0000143234.51796.a9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043834383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.20878", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043927886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.12.18.2821", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045078007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci19284", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045182938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.21593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047623680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ibd.21593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047623680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/cyto.2002.0889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048297849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2353/ajpath.2006.050491", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049020846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/ar2341", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050190298", 
              "https://doi.org/10.1186/ar2341"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/194927b0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052048522", 
              "https://doi.org/10.1038/194927b0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1538-7836.2003.00261.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053102889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2006-05-020875", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064122635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1566524043360636", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069185622"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.2001.281.4.c1173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074877731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077075359", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083288709", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-10", 
        "datePublishedReg": "2012-10-01", 
        "description": "INTRODUCTION: Elevated serum levels of the proinflammatory cytokine tumor necrosis factor alpha (TNF\u03b1) correlate with an increased risk for atherothrombotic events and TNF\u03b1 is known to induce prothrombotic molecules in endothelial cells. Based on the preexisting evidence for the impact of TNF\u03b1 in the pathogenesis of autoimmune disorders and their known association with an acquired hypercoagulability, we investigated the effects of TNF\u03b1 and the role of the TNF receptor subtypes TNFR1 and TNFR2 for arteriolar thrombosis in vivo.\nMETHODS: Arteriolar thrombosis and platelet-rolling in vivo were investigated in wildtype, TNFR1-/-, TNFR2-/- and TNFR1-/R2-/- C57BL/6 mice using intravital microscopy in the dorsal skinfold chamber microcirculation model. In vitro, expression of prothrombotic molecules was assessed in human endothelial cells by real-time PCR and flow cytometry.\nRESULTS: In wildtype mice, stimulation with TNF\u03b1 significantly accelerated thrombotic vessel occlusion in vivo upon ferric chloride injury. Arteriolar thrombosis was much more pronounced in TNFR1-/- animals, where TNF\u03b1 additionally led to increased platelet-endothelium-interaction. TNF\u03b1 dependent prothrombotic effects were not observed in TNFR2-/- and TNFR1-/R2- mice. In vitro, stimulation of human platelet rich plasma with TNF\u03b1 did not influence aggregation properties. In human endothelial cells, TNF\u03b1 induced superoxide production, p-selectin, tissue factor and PAI-1, and suppressed thrombomodulin, resulting in an accelerated endothelial dependent blood clotting in vitro. Additionally, TNF\u03b1 caused the release of soluble mediators by endothelial cells which induced prothrombotic and suppressed anticoagulant genes comparable to direct TNF\u03b1 effects.\nCONCLUSIONS: TNF\u03b1 accelerates thrombus formation in an in vivo model of arteriolar thrombosis. Its prothrombotic effects in vivo require TNFR2 and are partly compensated by TNFR1. In vitro studies indicate endothelial mechanisms to be responsible for prothrombotic TNF\u03b1 effects. Our results support a more selective therapeutic approach in anticytokine therapy favouring TNFR2 specific antagonists.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/ar4064", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1297499", 
            "issn": [
              "1478-6354", 
              "1478-6362"
            ], 
            "name": "Arthritis Research & Therapy", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "14"
          }
        ], 
        "name": "Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2", 
        "pagination": "r225", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "6b0b712006855b3e227078a324265a6889a8161f5f7eb39a5ec58828abf5e92c"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23079185"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101154438"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/ar4064"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1022468438"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/ar4064", 
          "https://app.dimensions.ai/details/publication/pub.1022468438"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:16", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000512.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2Far4064"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/ar4064'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/ar4064'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/ar4064'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/ar4064'


     

    This table displays all metadata directly associated to this object as RDF triples.

    356 TRIPLES      21 PREDICATES      93 URIs      42 LITERALS      30 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/ar4064 schema:about N09f0b88191a14522bc5be21208aef13d
    2 N124acd6bdeb94d66bd8161f11db347cb
    3 N1cad409b70c44489bb3af2f756bbc65f
    4 N323576a168f8409ba49c5a13798a1e9a
    5 N3e2b3f9c94d84150aca0f493960eb90e
    6 N474b7e1fa32f49d180a10c2d311888ea
    7 N6493e040f11a482f8f2b301a4c296045
    8 N71d583ed1563427cbf4a26edc7e96f02
    9 N75ce59b353374089991e72d8ddc50f3b
    10 N76ef0b64bfef4e9fbf750a42819e089e
    11 N779e9c23da724635a34fe38382744f42
    12 N815896ea253345abb3362e4c488a4997
    13 N851d53202de641cbb1578f53371b25e9
    14 Na1aab1656a04407f9179944dc338f2f8
    15 Nbce4ac8e4cb84e78a8d729558add5a6f
    16 Nc28bd95a681446aea8c7783532c0a9f0
    17 Nc28c98289a7f4d539f6ad82354d16d58
    18 Nd3b4ecacf74f48099d57d2c6f1539b9b
    19 Nd74ee1f6cb64434aa5e9e7bcb87da1c5
    20 Nd97702e441924ef48d1d6e22ec5112aa
    21 Ne1e9d47072514a4f8b088dc965700830
    22 anzsrc-for:11
    23 anzsrc-for:1102
    24 schema:author Ndd2486c0e01f47e8bb82765f686305f0
    25 schema:citation sg:pub.10.1007/s00109-004-0555-y
    26 sg:pub.10.1007/s00281-011-0282-8
    27 sg:pub.10.1038/194927b0
    28 sg:pub.10.1038/nature01323
    29 sg:pub.10.1038/nri1184
    30 sg:pub.10.1038/sj.cdd.4401189
    31 sg:pub.10.1111/1523-1747.ep12613748
    32 sg:pub.10.1186/ar2341
    33 https://app.dimensions.ai/details/publication/pub.1077075359
    34 https://app.dimensions.ai/details/publication/pub.1083288709
    35 https://doi.org/10.1002/art.20878
    36 https://doi.org/10.1002/ibd.21593
    37 https://doi.org/10.1006/cyto.2002.0889
    38 https://doi.org/10.1016/j.amjmed.2008.06.014
    39 https://doi.org/10.1016/j.atherosclerosis.2004.05.033
    40 https://doi.org/10.1016/j.cellsig.2009.09.015
    41 https://doi.org/10.1016/s0092-8674(01)00237-9
    42 https://doi.org/10.1016/s0140-6736(96)91687-6
    43 https://doi.org/10.1016/s1359-6101(02)00019-9
    44 https://doi.org/10.1016/s1525-0016(03)00065-0
    45 https://doi.org/10.1042/cs20080196
    46 https://doi.org/10.1046/j.1538-7836.2003.00261.x
    47 https://doi.org/10.1056/nejm199901143400207
    48 https://doi.org/10.1093/cvr/cvr265
    49 https://doi.org/10.1101/gad.12.18.2821
    50 https://doi.org/10.1111/j.1538-7836.2009.03582.x
    51 https://doi.org/10.1136/ard.2011.153536
    52 https://doi.org/10.1146/annurev.immunol.14.1.397
    53 https://doi.org/10.1152/ajpcell.2001.281.4.c1173
    54 https://doi.org/10.1161/01.atv.0000095974.95122.ec
    55 https://doi.org/10.1161/01.atv.0000143933.20616.1b
    56 https://doi.org/10.1161/01.atv.0000255551.33365.22
    57 https://doi.org/10.1161/01.cir.0000054612.26458.b2
    58 https://doi.org/10.1161/01.cir.0000143234.51796.a9
    59 https://doi.org/10.1161/circulationaha.106.650671
    60 https://doi.org/10.1172/jci19284
    61 https://doi.org/10.1172/jci27196
    62 https://doi.org/10.1172/jci36389
    63 https://doi.org/10.1182/blood-2005-03-1247
    64 https://doi.org/10.1182/blood-2006-05-020875
    65 https://doi.org/10.1182/blood-2011-04-325225
    66 https://doi.org/10.2174/1566524043360636
    67 https://doi.org/10.2353/ajpath.2006.050491
    68 schema:datePublished 2012-10
    69 schema:datePublishedReg 2012-10-01
    70 schema:description INTRODUCTION: Elevated serum levels of the proinflammatory cytokine tumor necrosis factor alpha (TNFα) correlate with an increased risk for atherothrombotic events and TNFα is known to induce prothrombotic molecules in endothelial cells. Based on the preexisting evidence for the impact of TNFα in the pathogenesis of autoimmune disorders and their known association with an acquired hypercoagulability, we investigated the effects of TNFα and the role of the TNF receptor subtypes TNFR1 and TNFR2 for arteriolar thrombosis in vivo. METHODS: Arteriolar thrombosis and platelet-rolling in vivo were investigated in wildtype, TNFR1-/-, TNFR2-/- and TNFR1-/R2-/- C57BL/6 mice using intravital microscopy in the dorsal skinfold chamber microcirculation model. In vitro, expression of prothrombotic molecules was assessed in human endothelial cells by real-time PCR and flow cytometry. RESULTS: In wildtype mice, stimulation with TNFα significantly accelerated thrombotic vessel occlusion in vivo upon ferric chloride injury. Arteriolar thrombosis was much more pronounced in TNFR1-/- animals, where TNFα additionally led to increased platelet-endothelium-interaction. TNFα dependent prothrombotic effects were not observed in TNFR2-/- and TNFR1-/R2- mice. In vitro, stimulation of human platelet rich plasma with TNFα did not influence aggregation properties. In human endothelial cells, TNFα induced superoxide production, p-selectin, tissue factor and PAI-1, and suppressed thrombomodulin, resulting in an accelerated endothelial dependent blood clotting in vitro. Additionally, TNFα caused the release of soluble mediators by endothelial cells which induced prothrombotic and suppressed anticoagulant genes comparable to direct TNFα effects. CONCLUSIONS: TNFα accelerates thrombus formation in an in vivo model of arteriolar thrombosis. Its prothrombotic effects in vivo require TNFR2 and are partly compensated by TNFR1. In vitro studies indicate endothelial mechanisms to be responsible for prothrombotic TNFα effects. Our results support a more selective therapeutic approach in anticytokine therapy favouring TNFR2 specific antagonists.
    71 schema:genre research_article
    72 schema:inLanguage en
    73 schema:isAccessibleForFree true
    74 schema:isPartOf N316e92aba20c40e28f517c1c677e01a6
    75 Nd082f27f32ba41c78e864a1d1e9f14f8
    76 sg:journal.1297499
    77 schema:name Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2
    78 schema:pagination r225
    79 schema:productId N45333b68a93f4d1189502c1cd67625e8
    80 N9591107e073740eb93fe47f07c1a5182
    81 Nb0fbdf152c494b6cae3913ab185708f5
    82 Nb2a6fd52c73446af800b36cb67239b91
    83 Nf3b20f52d7bb42fbabd91f3df6b5fdf7
    84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022468438
    85 https://doi.org/10.1186/ar4064
    86 schema:sdDatePublished 2019-04-11T00:16
    87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    88 schema:sdPublisher Nf76a149bb9c84580baf5ef2d54c5d05a
    89 schema:url http://link.springer.com/10.1186%2Far4064
    90 sgo:license sg:explorer/license/
    91 sgo:sdDataset articles
    92 rdf:type schema:ScholarlyArticle
    93 N0609c270ccc24000ab140c47bb8dc01d rdf:first sg:person.01021643764.29
    94 rdf:rest rdf:nil
    95 N09f0b88191a14522bc5be21208aef13d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Mice
    97 rdf:type schema:DefinedTerm
    98 N124acd6bdeb94d66bd8161f11db347cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Thromboplastin
    100 rdf:type schema:DefinedTerm
    101 N1cad409b70c44489bb3af2f756bbc65f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Skin
    103 rdf:type schema:DefinedTerm
    104 N2a67fc3911bc450fa548ba8d0f14ca70 rdf:first sg:person.0720666526.06
    105 rdf:rest N333a0b47aaf74aac96d2b29f56b0bafd
    106 N316e92aba20c40e28f517c1c677e01a6 schema:issueNumber 5
    107 rdf:type schema:PublicationIssue
    108 N323576a168f8409ba49c5a13798a1e9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Female
    110 rdf:type schema:DefinedTerm
    111 N333a0b47aaf74aac96d2b29f56b0bafd rdf:first sg:person.01324153077.14
    112 rdf:rest N63daef6883fe48ddb86d4b577d737a38
    113 N36111ed327784eb9bc6063f56387673d rdf:first sg:person.0744653434.37
    114 rdf:rest Ne982b6acfd6d42cfbb8c8a03a9364ddd
    115 N3e2b3f9c94d84150aca0f493960eb90e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name In Vitro Techniques
    117 rdf:type schema:DefinedTerm
    118 N45333b68a93f4d1189502c1cd67625e8 schema:name nlm_unique_id
    119 schema:value 101154438
    120 rdf:type schema:PropertyValue
    121 N474b7e1fa32f49d180a10c2d311888ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Superoxides
    123 rdf:type schema:DefinedTerm
    124 N57a123b1aacb4c1b9956e579a7b39268 schema:name Department of Gynecology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Strasse 22, Munich, Germany
    125 rdf:type schema:Organization
    126 N63daef6883fe48ddb86d4b577d737a38 rdf:first sg:person.0757215107.84
    127 rdf:rest Nb86742bec3664c85b18ed0bb56fd4de4
    128 N6493e040f11a482f8f2b301a4c296045 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Mice, Inbred C57BL
    130 rdf:type schema:DefinedTerm
    131 N71d583ed1563427cbf4a26edc7e96f02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Endothelium, Vascular
    133 rdf:type schema:DefinedTerm
    134 N75ce59b353374089991e72d8ddc50f3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Cells, Cultured
    136 rdf:type schema:DefinedTerm
    137 N76ef0b64bfef4e9fbf750a42819e089e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Thrombomodulin
    139 rdf:type schema:DefinedTerm
    140 N779e9c23da724635a34fe38382744f42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name P-Selectin
    142 rdf:type schema:DefinedTerm
    143 N815896ea253345abb3362e4c488a4997 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Disease Models, Animal
    145 rdf:type schema:DefinedTerm
    146 N851d53202de641cbb1578f53371b25e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Tumor Necrosis Factor-alpha
    148 rdf:type schema:DefinedTerm
    149 N93a9cd98b66345059ac1ee08ae986ce8 rdf:first sg:person.0773035466.01
    150 rdf:rest N0609c270ccc24000ab140c47bb8dc01d
    151 N9591107e073740eb93fe47f07c1a5182 schema:name readcube_id
    152 schema:value 6b0b712006855b3e227078a324265a6889a8161f5f7eb39a5ec58828abf5e92c
    153 rdf:type schema:PropertyValue
    154 Na1aab1656a04407f9179944dc338f2f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Mice, Knockout
    156 rdf:type schema:DefinedTerm
    157 Nb0fbdf152c494b6cae3913ab185708f5 schema:name pubmed_id
    158 schema:value 23079185
    159 rdf:type schema:PropertyValue
    160 Nb266143ebff5422d9a08292c0006c16d rdf:first sg:person.01075764113.94
    161 rdf:rest N93a9cd98b66345059ac1ee08ae986ce8
    162 Nb2a6fd52c73446af800b36cb67239b91 schema:name doi
    163 schema:value 10.1186/ar4064
    164 rdf:type schema:PropertyValue
    165 Nb86742bec3664c85b18ed0bb56fd4de4 rdf:first sg:person.0645307113.89
    166 rdf:rest N36111ed327784eb9bc6063f56387673d
    167 Nbce4ac8e4cb84e78a8d729558add5a6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Plasminogen Activator Inhibitor 1
    169 rdf:type schema:DefinedTerm
    170 Nc28bd95a681446aea8c7783532c0a9f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Thrombosis
    172 rdf:type schema:DefinedTerm
    173 Nc28c98289a7f4d539f6ad82354d16d58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Microcirculation
    175 rdf:type schema:DefinedTerm
    176 Nd082f27f32ba41c78e864a1d1e9f14f8 schema:volumeNumber 14
    177 rdf:type schema:PublicationVolume
    178 Nd3b4ecacf74f48099d57d2c6f1539b9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Male
    180 rdf:type schema:DefinedTerm
    181 Nd74ee1f6cb64434aa5e9e7bcb87da1c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Receptors, Tumor Necrosis Factor, Type II
    183 rdf:type schema:DefinedTerm
    184 Nd97702e441924ef48d1d6e22ec5112aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Receptors, Tumor Necrosis Factor, Type I
    186 rdf:type schema:DefinedTerm
    187 Ndd2486c0e01f47e8bb82765f686305f0 rdf:first sg:person.0721725163.76
    188 rdf:rest N2a67fc3911bc450fa548ba8d0f14ca70
    189 Ne1e9d47072514a4f8b088dc965700830 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Animals
    191 rdf:type schema:DefinedTerm
    192 Ne982b6acfd6d42cfbb8c8a03a9364ddd rdf:first sg:person.0753530564.36
    193 rdf:rest Nb266143ebff5422d9a08292c0006c16d
    194 Neb78cbbd734948eba498e2debb767de9 schema:name Invasive Cardiology, Clinic Starnberg, Oßwaldstr. 1, 82319, Munich, Germany
    195 rdf:type schema:Organization
    196 Nf3b20f52d7bb42fbabd91f3df6b5fdf7 schema:name dimensions_id
    197 schema:value pub.1022468438
    198 rdf:type schema:PropertyValue
    199 Nf76a149bb9c84580baf5ef2d54c5d05a schema:name Springer Nature - SN SciGraph project
    200 rdf:type schema:Organization
    201 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    202 schema:name Medical and Health Sciences
    203 rdf:type schema:DefinedTerm
    204 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    205 schema:name Cardiorespiratory Medicine and Haematology
    206 rdf:type schema:DefinedTerm
    207 sg:journal.1297499 schema:issn 1478-6354
    208 1478-6362
    209 schema:name Arthritis Research & Therapy
    210 rdf:type schema:Periodical
    211 sg:person.01021643764.29 schema:affiliation Neb78cbbd734948eba498e2debb767de9
    212 schema:familyName Krötz
    213 schema:givenName Florian
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021643764.29
    215 rdf:type schema:Person
    216 sg:person.01075764113.94 schema:affiliation N57a123b1aacb4c1b9956e579a7b39268
    217 schema:familyName Niemeyer
    218 schema:givenName Markus
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075764113.94
    220 rdf:type schema:Person
    221 sg:person.01324153077.14 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
    222 schema:familyName Wörnle
    223 schema:givenName Markus
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324153077.14
    225 rdf:type schema:Person
    226 sg:person.0645307113.89 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
    227 schema:familyName Czermak
    228 schema:givenName Thomas
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645307113.89
    230 rdf:type schema:Person
    231 sg:person.0720666526.06 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
    232 schema:familyName Merkle
    233 schema:givenName Monika
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720666526.06
    235 rdf:type schema:Person
    236 sg:person.0721725163.76 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
    237 schema:familyName Pircher
    238 schema:givenName Joachim
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721725163.76
    240 rdf:type schema:Person
    241 sg:person.0744653434.37 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
    242 schema:familyName Stampnik
    243 schema:givenName Yvonn
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744653434.37
    245 rdf:type schema:Person
    246 sg:person.0753530564.36 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
    247 schema:familyName Mannell
    248 schema:givenName Hanna
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753530564.36
    250 rdf:type schema:Person
    251 sg:person.0757215107.84 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
    252 schema:familyName Ribeiro
    253 schema:givenName Andrea
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757215107.84
    255 rdf:type schema:Person
    256 sg:person.0773035466.01 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
    257 schema:familyName Vielhauer
    258 schema:givenName Volker
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773035466.01
    260 rdf:type schema:Person
    261 sg:pub.10.1007/s00109-004-0555-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1038896545
    262 https://doi.org/10.1007/s00109-004-0555-y
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1007/s00281-011-0282-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029049275
    265 https://doi.org/10.1007/s00281-011-0282-8
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/194927b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052048522
    268 https://doi.org/10.1038/194927b0
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/nature01323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001371417
    271 https://doi.org/10.1038/nature01323
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/nri1184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037702320
    274 https://doi.org/10.1038/nri1184
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/sj.cdd.4401189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021657597
    277 https://doi.org/10.1038/sj.cdd.4401189
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.1111/1523-1747.ep12613748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010462004
    280 https://doi.org/10.1111/1523-1747.ep12613748
    281 rdf:type schema:CreativeWork
    282 sg:pub.10.1186/ar2341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050190298
    283 https://doi.org/10.1186/ar2341
    284 rdf:type schema:CreativeWork
    285 https://app.dimensions.ai/details/publication/pub.1077075359 schema:CreativeWork
    286 https://app.dimensions.ai/details/publication/pub.1083288709 schema:CreativeWork
    287 https://doi.org/10.1002/art.20878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043927886
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1002/ibd.21593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047623680
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1006/cyto.2002.0889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048297849
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/j.amjmed.2008.06.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043351512
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.atherosclerosis.2004.05.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023742350
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.cellsig.2009.09.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019560340
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/s0092-8674(01)00237-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029042615
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/s0140-6736(96)91687-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031463417
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/s1359-6101(02)00019-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024294792
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/s1525-0016(03)00065-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042594232
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1042/cs20080196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023789966
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1046/j.1538-7836.2003.00261.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053102889
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1056/nejm199901143400207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003372113
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1093/cvr/cvr265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012932608
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1101/gad.12.18.2821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045078007
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1111/j.1538-7836.2009.03582.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011989186
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1136/ard.2011.153536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003914648
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1146/annurev.immunol.14.1.397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000299859
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1152/ajpcell.2001.281.4.c1173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074877731
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1161/01.atv.0000095974.95122.ec schema:sameAs https://app.dimensions.ai/details/publication/pub.1006260580
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1161/01.atv.0000143933.20616.1b schema:sameAs https://app.dimensions.ai/details/publication/pub.1002152237
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1161/01.atv.0000255551.33365.22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017840396
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1161/01.cir.0000054612.26458.b2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004626754
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1161/01.cir.0000143234.51796.a9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043834383
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1161/circulationaha.106.650671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036938958
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1172/jci19284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045182938
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1172/jci27196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006736246
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1172/jci36389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021406479
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1182/blood-2005-03-1247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032582707
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1182/blood-2006-05-020875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064122635
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1182/blood-2011-04-325225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015065760
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.2174/1566524043360636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069185622
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.2353/ajpath.2006.050491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049020846
    352 rdf:type schema:CreativeWork
    353 https://www.grid.ac/institutes/grid.5252.0 schema:alternateName Ludwig Maximilian University of Munich
    354 schema:name Medizinische Klinik und Poliklinik IV, Innenstadt, Ludwig Maximilians University München, Ziemssenstr. 1, 80336, Munich, Germany
    355 Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians University München, Marchioninistr. 27, 81377, Munich, Germany
    356 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...