Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-10

AUTHORS

Joachim Pircher, Monika Merkle, Markus Wörnle, Andrea Ribeiro, Thomas Czermak, Yvonn Stampnik, Hanna Mannell, Markus Niemeyer, Volker Vielhauer, Florian Krötz

ABSTRACT

INTRODUCTION: Elevated serum levels of the proinflammatory cytokine tumor necrosis factor alpha (TNFα) correlate with an increased risk for atherothrombotic events and TNFα is known to induce prothrombotic molecules in endothelial cells. Based on the preexisting evidence for the impact of TNFα in the pathogenesis of autoimmune disorders and their known association with an acquired hypercoagulability, we investigated the effects of TNFα and the role of the TNF receptor subtypes TNFR1 and TNFR2 for arteriolar thrombosis in vivo. METHODS: Arteriolar thrombosis and platelet-rolling in vivo were investigated in wildtype, TNFR1-/-, TNFR2-/- and TNFR1-/R2-/- C57BL/6 mice using intravital microscopy in the dorsal skinfold chamber microcirculation model. In vitro, expression of prothrombotic molecules was assessed in human endothelial cells by real-time PCR and flow cytometry. RESULTS: In wildtype mice, stimulation with TNFα significantly accelerated thrombotic vessel occlusion in vivo upon ferric chloride injury. Arteriolar thrombosis was much more pronounced in TNFR1-/- animals, where TNFα additionally led to increased platelet-endothelium-interaction. TNFα dependent prothrombotic effects were not observed in TNFR2-/- and TNFR1-/R2- mice. In vitro, stimulation of human platelet rich plasma with TNFα did not influence aggregation properties. In human endothelial cells, TNFα induced superoxide production, p-selectin, tissue factor and PAI-1, and suppressed thrombomodulin, resulting in an accelerated endothelial dependent blood clotting in vitro. Additionally, TNFα caused the release of soluble mediators by endothelial cells which induced prothrombotic and suppressed anticoagulant genes comparable to direct TNFα effects. CONCLUSIONS: TNFα accelerates thrombus formation in an in vivo model of arteriolar thrombosis. Its prothrombotic effects in vivo require TNFR2 and are partly compensated by TNFR1. In vitro studies indicate endothelial mechanisms to be responsible for prothrombotic TNFα effects. Our results support a more selective therapeutic approach in anticytokine therapy favouring TNFR2 specific antagonists. More... »

PAGES

r225

References to SciGraph publications

  • 1992-12. HMEC-1: Establishment of an Immortalized Human Microvascular Endothelial Cell Line in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2012-01. Thrombomodulin and its role in inflammation in SEMINARS IN IMMUNOPATHOLOGY
  • 2003-09. Signalling pathways of the TNF superfamily: a double-edged sword in NATURE REVIEWS IMMUNOLOGY
  • 2003-01. Tumor necrosis factor signaling in CELL DEATH & DIFFERENTIATION
  • 1962-06. Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal in NATURE
  • 2004-07. Nuclear factor-κB: its role in health and disease in JOURNAL OF MOLECULAR MEDICINE
  • 2002-12. Inflammation in atherosclerosis in NATURE
  • 2008-02. The role of tumor necrosis factor-alpha in systemic lupus erythematosus in ARTHRITIS RESEARCH & THERAPY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/ar4064

    DOI

    http://dx.doi.org/10.1186/ar4064

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022468438

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23079185


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