Takayasu's arteritis is associated with HLA-B*52, but not with HLA-B*51, in Turkey View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-02-06

AUTHORS

Ziver Sahin, Muge Bıcakcıgil, Kenan Aksu, Sevil Kamali, Servet Akar, Fatos Onen, Omer Karadag, Zeynep Ozbalkan, Askin Ates, Huseyin TE Ozer, Vuslat Yilmaz, Emire Seyahi, Mehmet A Ozturk, Ayse Cefle, Veli Cobankara, A Mesut Onat, Ercan Tunc, Nursen Düzgün, Sibel Z Aydin, Neslihan Yilmaz, İzzet Fresko, Yasar Karaaslan, Sedat Kiraz, Nurullah Akkoc, Murat Inanc, Gokhan Keser, F Aytul Uyar, Haner Direskeneli, Güher Saruhan-Direskeneli

ABSTRACT

INTRODUCTION: HLA-B*51 and HLA-B*52 are two close human leukocyte antigen (HLA) allele groups with minor amino acid differences. However, they are associated with two different vasculitides (HLA-B*51 in Behçet's disease and HLA-B*52 in Takayasu's arteritis (TAK)) and with major clinical and immunological differences. In this study, we aimed to screen a large cohort of TAK patients from Turkey for the presence of HLA-B*51 and HLA-B*52 as susceptibility and severity factors. METHODS: TAK patients (n = 330) followed at a total of 15 centers were included in the study. The mean age of the patients was 37.8 years, and 86% were women. DNA samples from the patients and healthy controls (HC; n = 210) were isolated, and the presence of HLA-B*51 or HLA-B*52 was screened for by using PCR with sequence-specific primers. RESULTS: We found a significant association of HLA-B*52 with TAK (20.9% vs HC = 6.7%, P = 0.000, OR = 3.7, 95% CI = 2.02 to 6.77). The distribution of HLA-B*51 did not differ between TAK patients and HCs (22.7% vs 24.8%, OR = 0.9, 95% CI = 0.60 to 1.34). The presence of HLA-B*52 decreased in late-onset patients (> 40 years of age; 12.0%, P = 0.024, OR = 0.43, 95% CI = 0.20 to 0.91). Patients with angiographic type I disease with limited aortic involvement also had a lower presence of HLA-B*52 compared to those with all other disease subtypes (13.1% vs 26%, P = 0.005, OR = 0.43, 95% CI = 0.23 to 0.78). CONCLUSIONS: In this study, the previously reported association of TAK with HLA-B*52 in other populations was confirmed in patients from Turkey. The functional relevance of HLA-B*52 in TAK pathogenesis needs to be explored further. More... »

PAGES

r27-r27

Journal

TITLE

Arthritis Research & Therapy

ISSUE

1

VOLUME

14

Author Affiliations

  • Department of Physiology, Istanbul University, Istanbul Faculty of Medicine, Capa 34093, Istanbul, Turkey
  • Department of Rheumatology, Yeditepe University, Faculty of Medicine, Ankara Cad No:102/104, Kozyatagı 34752, Istanbul, Turkey
  • Department of Rheumatology, Ege University, Faculty of Medicine, Ankara Asfalti Uzeri, Bornova 35100, Izmir, Turkey
  • Department of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Capa 34093, Istanbul, Turkey
  • Department of Rheumatology, Dokuz Eylül University, Faculty of Medicine, Dokuz Eylul Universitesi Saglık Yerleskesi, Inciraltı 35340, Izmir, Turkey
  • Department of Rheumatology, Hacettepe University, Faculty of Medicine, Sihhiye 06100, Ankara, Turkey
  • Department of Rheumatology, Ankara Numune Training and Research Hospital, Talatpasa Bulvarı, No:5, Altındag 06100, Ankara, Turkey
  • Department of Rheumatology, Cukurova University, Faculty of Medicine, Balcalı, Sarıcam 01330, Adana, Turkey
  • Department of Rheumatology, Istanbul University, Cerrahpaşa Faculty of Medicine, Kocamustafapaşa Cad. No: 124, Cerrahpaşa 34098, Istanbul, Turkey
  • Department of Rheumatology, Gazi University, Faculty of Medicine, Besevler 06500, Ankara, Turkey
  • Department of Rheumatology, Kocaeli University, Faculty of Medicine, Eski İstanbul Yolu, Umuttepe Yerleşkesi 41380, Kocaeli, Turkey
  • Department of Rheumatology, Pamukkale University Faculty of Medicine, Üniversite Caddesi Kınıklı Kampüsü 20020, Denizli, Turkey
  • Department of Rheumatology, Gaziantep University, Faculty of Medicine, Sahinbey Araştırma Hastanesi 27310, Gaziantep, Turkey
  • Department of Rheumatology, Suleyman Demirel University, Faculty of Medicine, Doğu Kampüsü Morfoloji Binası Kat:2 32260, Isparta, Turkey
  • Department of Rheumatology, Ankara University, Faculty of Medicine, Morfoloji Yerleşkesi, Sıhhıye 06100, Ankara, Turkey
  • Department of Rheumatology, Marmara University, Faculty of Medicine, Mimar Sinan Caddesi, No: 41, Pendik 34890, Istanbul, Turkey
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/ar3730

    DOI

    http://dx.doi.org/10.1186/ar3730

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008608010

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22309845


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