The effect of immunomodulators on the immunogenicity of TNF-blocking therapeutic monoclonal antibodies: a review View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-10

AUTHORS

Charlotte Louise Maria Krieckaert, Geertje Margret Bartelds, Willem Frederik Lems, Gerrit Jan Wolbink

ABSTRACT

Therapeutic monoclonal antibodies have revolutionized the treatment of various inflammatory diseases. Immunogenicity against these antibodies has been shown to be clinically important: it is associated with shorter response duration because of diminishing concentrations in the blood and with infusion reactions. Concomitant immunomodulators in the form of methotrexate or azathioprine reduced the immunogenicity of therapeutic antibodies in rheumatoid arthritis, Crohn disease, and juvenile idiopathic arthritis. The occurrence of adverse events does not increase when immunomodulators are added to therapeutic antibodies. The mechanism whereby methotrexate and azathioprine influence immunogenicity remains unclear. Evidence-based consensus on prescribing concomitant immunomodulators is needed. More... »

PAGES

217

References to SciGraph publications

  • 2010-04. Immunogenicity of Anti-TNF-α Agents in Autoimmune Diseases in CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
  • 2009-08. A systematic medline analysis of therapeutic approaches in ankylosing spondylitis in RHEUMATOLOGY INTERNATIONAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/ar3147

    DOI

    http://dx.doi.org/10.1186/ar3147

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024364202

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21029481


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antibodies, Monoclonal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Therapy, Combination", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunologic Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Inflammation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Necrosis Factor-alpha", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Reade", 
              "id": "https://www.grid.ac/institutes/grid.418029.6", 
              "name": [
                "Department of Rheumatology, Jan van Breemen Institute, Dr Jan van Breemenstraat 2, 1056 AB, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Krieckaert", 
            "givenName": "Charlotte Louise Maria", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Reade", 
              "id": "https://www.grid.ac/institutes/grid.418029.6", 
              "name": [
                "Department of Rheumatology, Jan van Breemen Institute, Dr Jan van Breemenstraat 2, 1056 AB, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bartelds", 
            "givenName": "Geertje Margret", 
            "id": "sg:person.0742157173.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742157173.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Rheumatology, VU Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lems", 
            "givenName": "Willem Frederik", 
            "id": "sg:person.01322502607.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322502607.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Reade", 
              "id": "https://www.grid.ac/institutes/grid.418029.6", 
              "name": [
                "Department of Rheumatology, Jan van Breemen Institute, Dr Jan van Breemenstraat 2, 1056 AB, Amsterdam, The Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wolbink", 
            "givenName": "Gerrit Jan", 
            "id": "sg:person.01326404001.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326404001.62"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1001/archdermatol.2009.347", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001039984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2008.092833", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001592581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2003.013052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006545154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm200011303432202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007288012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.22214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009901742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2036.2009.04027.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010835757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2036.2009.04027.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010835757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00296-009-0973-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016100070", 
              "https://doi.org/10.1007/s00296-009-0973-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00296-009-0973-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016100070", 
              "https://doi.org/10.1007/s00296-009-0973-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00296-009-0973-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016100070", 
              "https://doi.org/10.1007/s00296-009-0973-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1529-0131(199809)41:9<1552::aid-art5>3.0.co;2-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017993092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2009.108787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021461812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2006.057406", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021860535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1398-9995.2009.02280.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023052960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1398-9995.2009.02280.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023052960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2006.099978", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023413827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gut.2006.106781", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025501221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2006.065615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027526204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2006.066761", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032393849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2006.051540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033892423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2036.2008.03828.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038743992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.86.11.4220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039572903"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0706290", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040770620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa020888", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045069711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.21671", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046420942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.21671", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046420942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12016-009-8140-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046932975", 
              "https://doi.org/10.1007/s12016-009-8140-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12016-009-8140-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046932975", 
              "https://doi.org/10.1007/s12016-009-8140-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2009.07.062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048749172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/s10165-008-0045-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048775101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1007/s10165-008-0045-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049773047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(02)08512-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050680804"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2007.072397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050889918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa030815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051982197"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2005.11.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052659543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0904492", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053418450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/ard.2009.109702", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053667009"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2010-10", 
        "datePublishedReg": "2010-10-01", 
        "description": "Therapeutic monoclonal antibodies have revolutionized the treatment of various inflammatory diseases. Immunogenicity against these antibodies has been shown to be clinically important: it is associated with shorter response duration because of diminishing concentrations in the blood and with infusion reactions. Concomitant immunomodulators in the form of methotrexate or azathioprine reduced the immunogenicity of therapeutic antibodies in rheumatoid arthritis, Crohn disease, and juvenile idiopathic arthritis. The occurrence of adverse events does not increase when immunomodulators are added to therapeutic antibodies. The mechanism whereby methotrexate and azathioprine influence immunogenicity remains unclear. Evidence-based consensus on prescribing concomitant immunomodulators is needed.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/ar3147", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1297499", 
            "issn": [
              "1478-6354", 
              "1478-6362"
            ], 
            "name": "Arthritis Research & Therapy", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "12"
          }
        ], 
        "name": "The effect of immunomodulators on the immunogenicity of TNF-blocking therapeutic monoclonal antibodies: a review", 
        "pagination": "217", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "7412b835bc9044300b5d6b157acd3f3acee0bdb6c84d4e61f1e9c18003a182b5"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21029481"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101154438"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/ar3147"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1024364202"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/ar3147", 
          "https://app.dimensions.ai/details/publication/pub.1024364202"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:16", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000512.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2Far3147"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/ar3147'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/ar3147'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/ar3147'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/ar3147'


     

    This table displays all metadata directly associated to this object as RDF triples.

    215 TRIPLES      21 PREDICATES      67 URIs      28 LITERALS      16 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/ar3147 schema:about N06b5b816ae784fe3a46c7c5fbe7dbefa
    2 N136e09c3c565462f9238857035bb2b32
    3 N3059fcd408a34f6489bb61dd28aea365
    4 N357327984b2a4322ac6929e6b8224328
    5 N6125915ff8de47db8f7a81c3d5e7d5d4
    6 Nb3e1cb11577c433b970eabd99fd3755e
    7 Nfbe77d948f06412a8e814301f8af4d14
    8 anzsrc-for:11
    9 anzsrc-for:1103
    10 schema:author N5b70f78ea0e74ef38cbe983f9b7aaa02
    11 schema:citation sg:pub.10.1007/s00296-009-0973-9
    12 sg:pub.10.1007/s12016-009-8140-3
    13 https://doi.org/10.1001/archdermatol.2009.347
    14 https://doi.org/10.1002/1529-0131(199809)41:9<1552::aid-art5>3.0.co;2-w
    15 https://doi.org/10.1002/art.21671
    16 https://doi.org/10.1002/art.22214
    17 https://doi.org/10.1007/s10165-008-0045-0
    18 https://doi.org/10.1016/s0140-6736(02)08512-4
    19 https://doi.org/10.1053/j.gastro.2005.11.030
    20 https://doi.org/10.1053/j.gastro.2009.07.062
    21 https://doi.org/10.1056/nejm200011303432202
    22 https://doi.org/10.1056/nejmoa020888
    23 https://doi.org/10.1056/nejmoa030815
    24 https://doi.org/10.1056/nejmoa0706290
    25 https://doi.org/10.1056/nejmoa0904492
    26 https://doi.org/10.1073/pnas.86.11.4220
    27 https://doi.org/10.1111/j.1365-2036.2008.03828.x
    28 https://doi.org/10.1111/j.1365-2036.2009.04027.x
    29 https://doi.org/10.1111/j.1398-9995.2009.02280.x
    30 https://doi.org/10.1136/ard.2003.013052
    31 https://doi.org/10.1136/ard.2006.051540
    32 https://doi.org/10.1136/ard.2006.057406
    33 https://doi.org/10.1136/ard.2006.065615
    34 https://doi.org/10.1136/ard.2006.066761
    35 https://doi.org/10.1136/ard.2007.072397
    36 https://doi.org/10.1136/ard.2008.092833
    37 https://doi.org/10.1136/ard.2009.108787
    38 https://doi.org/10.1136/ard.2009.109702
    39 https://doi.org/10.1136/gut.2006.099978
    40 https://doi.org/10.1136/gut.2006.106781
    41 https://doi.org/10.3109/s10165-008-0045-0
    42 schema:datePublished 2010-10
    43 schema:datePublishedReg 2010-10-01
    44 schema:description Therapeutic monoclonal antibodies have revolutionized the treatment of various inflammatory diseases. Immunogenicity against these antibodies has been shown to be clinically important: it is associated with shorter response duration because of diminishing concentrations in the blood and with infusion reactions. Concomitant immunomodulators in the form of methotrexate or azathioprine reduced the immunogenicity of therapeutic antibodies in rheumatoid arthritis, Crohn disease, and juvenile idiopathic arthritis. The occurrence of adverse events does not increase when immunomodulators are added to therapeutic antibodies. The mechanism whereby methotrexate and azathioprine influence immunogenicity remains unclear. Evidence-based consensus on prescribing concomitant immunomodulators is needed.
    45 schema:genre research_article
    46 schema:inLanguage en
    47 schema:isAccessibleForFree true
    48 schema:isPartOf N59b58265631a497e9531ce2e5a130d4e
    49 Nf4fb49bf856d4980b6feb8cb604be265
    50 sg:journal.1297499
    51 schema:name The effect of immunomodulators on the immunogenicity of TNF-blocking therapeutic monoclonal antibodies: a review
    52 schema:pagination 217
    53 schema:productId N10874aad98ba4f6ead3f9f1cfbc9a7bb
    54 N336d52e5172f481b9814001b9f30c1ac
    55 N45d037b45f4b45259f664d7e61cc8cf5
    56 N5a8861d1f1564728962f8d72804e510d
    57 Ne09c13f88bed4aec8c276dae080b7aab
    58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024364202
    59 https://doi.org/10.1186/ar3147
    60 schema:sdDatePublished 2019-04-10T13:16
    61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    62 schema:sdPublisher Nf3c56783eea34312b35855c9ec0f87c6
    63 schema:url http://link.springer.com/10.1186%2Far3147
    64 sgo:license sg:explorer/license/
    65 sgo:sdDataset articles
    66 rdf:type schema:ScholarlyArticle
    67 N06b5b816ae784fe3a46c7c5fbe7dbefa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    68 schema:name Animals
    69 rdf:type schema:DefinedTerm
    70 N10874aad98ba4f6ead3f9f1cfbc9a7bb schema:name readcube_id
    71 schema:value 7412b835bc9044300b5d6b157acd3f3acee0bdb6c84d4e61f1e9c18003a182b5
    72 rdf:type schema:PropertyValue
    73 N136e09c3c565462f9238857035bb2b32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    74 schema:name Humans
    75 rdf:type schema:DefinedTerm
    76 N29bb77be129141a9a4937d5e562acc3d rdf:first sg:person.0742157173.45
    77 rdf:rest N4ab9090fcf6b47a7ac118e4a6635a5c6
    78 N3059fcd408a34f6489bb61dd28aea365 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    79 schema:name Drug Therapy, Combination
    80 rdf:type schema:DefinedTerm
    81 N336d52e5172f481b9814001b9f30c1ac schema:name pubmed_id
    82 schema:value 21029481
    83 rdf:type schema:PropertyValue
    84 N357327984b2a4322ac6929e6b8224328 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    85 schema:name Immunologic Factors
    86 rdf:type schema:DefinedTerm
    87 N45d037b45f4b45259f664d7e61cc8cf5 schema:name doi
    88 schema:value 10.1186/ar3147
    89 rdf:type schema:PropertyValue
    90 N4ab9090fcf6b47a7ac118e4a6635a5c6 rdf:first sg:person.01322502607.55
    91 rdf:rest Nbe848a63baa041908c5ea39f08e98b71
    92 N59b58265631a497e9531ce2e5a130d4e schema:issueNumber 5
    93 rdf:type schema:PublicationIssue
    94 N5a8861d1f1564728962f8d72804e510d schema:name dimensions_id
    95 schema:value pub.1024364202
    96 rdf:type schema:PropertyValue
    97 N5b70f78ea0e74ef38cbe983f9b7aaa02 rdf:first N7027f8856bdd40198912c76dee5768ab
    98 rdf:rest N29bb77be129141a9a4937d5e562acc3d
    99 N6125915ff8de47db8f7a81c3d5e7d5d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Tumor Necrosis Factor-alpha
    101 rdf:type schema:DefinedTerm
    102 N7027f8856bdd40198912c76dee5768ab schema:affiliation https://www.grid.ac/institutes/grid.418029.6
    103 schema:familyName Krieckaert
    104 schema:givenName Charlotte Louise Maria
    105 rdf:type schema:Person
    106 Nb3e1cb11577c433b970eabd99fd3755e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Inflammation
    108 rdf:type schema:DefinedTerm
    109 Nbe848a63baa041908c5ea39f08e98b71 rdf:first sg:person.01326404001.62
    110 rdf:rest rdf:nil
    111 Ne09c13f88bed4aec8c276dae080b7aab schema:name nlm_unique_id
    112 schema:value 101154438
    113 rdf:type schema:PropertyValue
    114 Nf3c56783eea34312b35855c9ec0f87c6 schema:name Springer Nature - SN SciGraph project
    115 rdf:type schema:Organization
    116 Nf4fb49bf856d4980b6feb8cb604be265 schema:volumeNumber 12
    117 rdf:type schema:PublicationVolume
    118 Nfbe77d948f06412a8e814301f8af4d14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Antibodies, Monoclonal
    120 rdf:type schema:DefinedTerm
    121 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    122 schema:name Medical and Health Sciences
    123 rdf:type schema:DefinedTerm
    124 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    125 schema:name Clinical Sciences
    126 rdf:type schema:DefinedTerm
    127 sg:journal.1297499 schema:issn 1478-6354
    128 1478-6362
    129 schema:name Arthritis Research & Therapy
    130 rdf:type schema:Periodical
    131 sg:person.01322502607.55 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    132 schema:familyName Lems
    133 schema:givenName Willem Frederik
    134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322502607.55
    135 rdf:type schema:Person
    136 sg:person.01326404001.62 schema:affiliation https://www.grid.ac/institutes/grid.418029.6
    137 schema:familyName Wolbink
    138 schema:givenName Gerrit Jan
    139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326404001.62
    140 rdf:type schema:Person
    141 sg:person.0742157173.45 schema:affiliation https://www.grid.ac/institutes/grid.418029.6
    142 schema:familyName Bartelds
    143 schema:givenName Geertje Margret
    144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742157173.45
    145 rdf:type schema:Person
    146 sg:pub.10.1007/s00296-009-0973-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016100070
    147 https://doi.org/10.1007/s00296-009-0973-9
    148 rdf:type schema:CreativeWork
    149 sg:pub.10.1007/s12016-009-8140-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046932975
    150 https://doi.org/10.1007/s12016-009-8140-3
    151 rdf:type schema:CreativeWork
    152 https://doi.org/10.1001/archdermatol.2009.347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001039984
    153 rdf:type schema:CreativeWork
    154 https://doi.org/10.1002/1529-0131(199809)41:9<1552::aid-art5>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1017993092
    155 rdf:type schema:CreativeWork
    156 https://doi.org/10.1002/art.21671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046420942
    157 rdf:type schema:CreativeWork
    158 https://doi.org/10.1002/art.22214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009901742
    159 rdf:type schema:CreativeWork
    160 https://doi.org/10.1007/s10165-008-0045-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049773047
    161 rdf:type schema:CreativeWork
    162 https://doi.org/10.1016/s0140-6736(02)08512-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050680804
    163 rdf:type schema:CreativeWork
    164 https://doi.org/10.1053/j.gastro.2005.11.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052659543
    165 rdf:type schema:CreativeWork
    166 https://doi.org/10.1053/j.gastro.2009.07.062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048749172
    167 rdf:type schema:CreativeWork
    168 https://doi.org/10.1056/nejm200011303432202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007288012
    169 rdf:type schema:CreativeWork
    170 https://doi.org/10.1056/nejmoa020888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045069711
    171 rdf:type schema:CreativeWork
    172 https://doi.org/10.1056/nejmoa030815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051982197
    173 rdf:type schema:CreativeWork
    174 https://doi.org/10.1056/nejmoa0706290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040770620
    175 rdf:type schema:CreativeWork
    176 https://doi.org/10.1056/nejmoa0904492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053418450
    177 rdf:type schema:CreativeWork
    178 https://doi.org/10.1073/pnas.86.11.4220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039572903
    179 rdf:type schema:CreativeWork
    180 https://doi.org/10.1111/j.1365-2036.2008.03828.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038743992
    181 rdf:type schema:CreativeWork
    182 https://doi.org/10.1111/j.1365-2036.2009.04027.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010835757
    183 rdf:type schema:CreativeWork
    184 https://doi.org/10.1111/j.1398-9995.2009.02280.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023052960
    185 rdf:type schema:CreativeWork
    186 https://doi.org/10.1136/ard.2003.013052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006545154
    187 rdf:type schema:CreativeWork
    188 https://doi.org/10.1136/ard.2006.051540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033892423
    189 rdf:type schema:CreativeWork
    190 https://doi.org/10.1136/ard.2006.057406 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021860535
    191 rdf:type schema:CreativeWork
    192 https://doi.org/10.1136/ard.2006.065615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027526204
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1136/ard.2006.066761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032393849
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1136/ard.2007.072397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050889918
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1136/ard.2008.092833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001592581
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1136/ard.2009.108787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021461812
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1136/ard.2009.109702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053667009
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1136/gut.2006.099978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023413827
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1136/gut.2006.106781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025501221
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.3109/s10165-008-0045-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048775101
    209 rdf:type schema:CreativeWork
    210 https://www.grid.ac/institutes/grid.16872.3a schema:alternateName VU University Medical Center
    211 schema:name Department of Rheumatology, VU Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    212 rdf:type schema:Organization
    213 https://www.grid.ac/institutes/grid.418029.6 schema:alternateName Reade
    214 schema:name Department of Rheumatology, Jan van Breemen Institute, Dr Jan van Breemenstraat 2, 1056 AB, Amsterdam, The Netherlands
    215 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...