Suppression of bone morphogenetic protein inhibitors promotes osteogenic differentiation: therapeutic implications View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-08

AUTHORS

Manolis Heliotis, Eleftherios Tsiridis

ABSTRACT

Bone morphogenetic proteins (BMPs) are expressed during osteogenesis and their action is regulated by corresponding BMP inhibitors. Chordin (a well recognized BMP inhibitor) and BMP-2 are expressed during osteogenic differentiation of human mesenchymal stem cells. Chordin inhibition induces human mesenchymal stem cell differentiation and reduces their proliferation by increasing BMP-2 bioavailability. The potential of suppressing BMP inhibitors is emerging as a biological therapeutic target in bone tissue engineering, because it results in an unopposed synergy between the various growth factors that are involved in osteogenesis, within their physiological milieu. More... »

PAGES

115

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/ar2467

DOI

http://dx.doi.org/10.1186/ar2467

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019794794

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18710600


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