High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-04-02

AUTHORS

Reuben Gobezie, Alvin Kho, Bryan Krastins, David A Sarracino, Thomas S Thornhill, Michael Chase, Peter J Millett, David M Lee

ABSTRACT

The development of increasingly high-throughput and sensitive mass spectroscopy-based proteomic techniques provides new opportunities to examine the physiology and pathophysiology of many biologic fluids and tissues. The purpose of this study was to determine protein expression profiles of high-abundance synovial fluid (SF) proteins in health and in the prevalent joint disease osteoarthritis (OA). A cross-sectional study of 62 patients with early OA (n = 21), patients with late OA (n = 21), and control individuals (n = 20) was conducted. SF proteins were separated by using one-dimensional PAGE, and the in-gel digested proteins were analyzed by electrospray ionization tandem mass spectrometry. A total of 362 spots were examined and 135 high-abundance SF proteins were identified as being expressed across all three study cohorts. A total of 135 SF proteins were identified. Eighteen proteins were found to be significantly differentially expressed between control individuals and OA patients. Two subsets of OA that are not dependent on disease duration were identified using unsupervised analysis of the data. Several novel SF proteins were also identified. Our analyses demonstrate no disease duration-dependent differences in abundant protein composition of SF in OA, and we clearly identified two previously unappreciated yet distinct subsets of protein profiles in this disease cohort. Additionally, our findings reveal novel abundant protein species in healthy SF whose functional contribution to SF physiology was not previously recognized. Finally, our studies identify candidate biomarkers for OA with potential for use as highly sensitive and specific tests for diagnostic purposes or for evaluating therapeutic response. More... »

PAGES

r36-r36

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/ar2172

DOI

http://dx.doi.org/10.1186/ar2172

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038723173

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17407561


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Sectional Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophoresis, Polyacrylamide Gel", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Knee", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteoarthritis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Principal Component Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spectrometry, Mass, Electrospray Ionization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Synovial Fluid", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA", 
          "id": "http://www.grid.ac/institutes/grid.67105.35", 
          "name": [
            "The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gobezie", 
        "givenName": "Reuben", 
        "id": "sg:person.01314401745.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314401745.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA", 
          "id": "http://www.grid.ac/institutes/grid.67105.35", 
          "name": [
            "The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kho", 
        "givenName": "Alvin", 
        "id": "sg:person.011462730657.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011462730657.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA", 
          "id": "http://www.grid.ac/institutes/grid.67105.35", 
          "name": [
            "The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krastins", 
        "givenName": "Bryan", 
        "id": "sg:person.01320263100.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320263100.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA", 
          "id": "http://www.grid.ac/institutes/grid.67105.35", 
          "name": [
            "The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sarracino", 
        "givenName": "David A", 
        "id": "sg:person.0725017033.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725017033.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA", 
          "id": "http://www.grid.ac/institutes/grid.67105.35", 
          "name": [
            "The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thornhill", 
        "givenName": "Thomas S", 
        "id": "sg:person.0662023443.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662023443.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA", 
          "id": "http://www.grid.ac/institutes/grid.67105.35", 
          "name": [
            "The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chase", 
        "givenName": "Michael", 
        "id": "sg:person.01352457111.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352457111.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA", 
          "id": "http://www.grid.ac/institutes/grid.67105.35", 
          "name": [
            "The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Millett", 
        "givenName": "Peter J", 
        "id": "sg:person.01211256740.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211256740.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA", 
          "id": "http://www.grid.ac/institutes/grid.67105.35", 
          "name": [
            "The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "David M", 
        "id": "sg:person.07671766534.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07671766534.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1023/a:1006797522521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004181750", 
          "https://doi.org/10.1023/a:1006797522521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010830001", 
          "https://doi.org/10.1038/ni732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039076536", 
          "https://doi.org/10.1038/nrc745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb1291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049692778", 
          "https://doi.org/10.1038/ncb1291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005258309", 
          "https://doi.org/10.1038/nbt819"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-04-02", 
    "datePublishedReg": "2007-04-02", 
    "description": "The development of increasingly high-throughput and sensitive mass spectroscopy-based proteomic techniques provides new opportunities to examine the physiology and pathophysiology of many biologic fluids and tissues. The purpose of this study was to determine protein expression profiles of high-abundance synovial fluid (SF) proteins in health and in the prevalent joint disease osteoarthritis (OA). A cross-sectional study of 62 patients with early OA (n = 21), patients with late OA (n = 21), and control individuals (n = 20) was conducted. SF proteins were separated by using one-dimensional PAGE, and the in-gel digested proteins were analyzed by electrospray ionization tandem mass spectrometry. A total of 362 spots were examined and 135 high-abundance SF proteins were identified as being expressed across all three study cohorts. A total of 135 SF proteins were identified. Eighteen proteins were found to be significantly differentially expressed between control individuals and OA patients. Two subsets of OA that are not dependent on disease duration were identified using unsupervised analysis of the data. Several novel SF proteins were also identified. Our analyses demonstrate no disease duration-dependent differences in abundant protein composition of SF in OA, and we clearly identified two previously unappreciated yet distinct subsets of protein profiles in this disease cohort. Additionally, our findings reveal novel abundant protein species in healthy SF whose functional contribution to SF physiology was not previously recognized. Finally, our studies identify candidate biomarkers for OA with potential for use as highly sensitive and specific tests for diagnostic purposes or for evaluating therapeutic response.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/ar2172", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2437426", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1297499", 
        "issn": [
          "1478-6354", 
          "1478-6362"
        ], 
        "name": "Arthritis Research & Therapy", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "keywords": [
      "control individuals", 
      "cross-sectional study", 
      "subset of osteoarthritis", 
      "synovial fluid proteins", 
      "disease duration", 
      "OA patients", 
      "study cohort", 
      "late osteoarthritis", 
      "disease cohort", 
      "therapeutic response", 
      "early osteoarthritis", 
      "osteoarthritis", 
      "candidate biomarkers", 
      "patients", 
      "distinct subsets", 
      "fluid proteins", 
      "protein expression profiles", 
      "specific tests", 
      "cohort", 
      "biologic fluids", 
      "functional contribution", 
      "diagnostic purposes", 
      "SF protein", 
      "total", 
      "distinct profiles", 
      "expression profiles", 
      "health", 
      "pathophysiology", 
      "physiology", 
      "tandem mass spectrometry", 
      "individuals", 
      "study", 
      "protein", 
      "subset", 
      "biomarkers", 
      "unsupervised analysis", 
      "protein profiles", 
      "proteomic techniques", 
      "duration", 
      "tissue", 
      "ionization tandem mass spectrometry", 
      "profile", 
      "one-dimensional PAGE", 
      "findings", 
      "SF", 
      "response", 
      "purpose", 
      "protein composition", 
      "electrospray ionization tandem mass spectrometry", 
      "differences", 
      "test", 
      "fluid", 
      "analysis", 
      "mass spectrometry", 
      "use", 
      "protein species", 
      "abundant protein species", 
      "development", 
      "data", 
      "potential", 
      "new opportunities", 
      "spots", 
      "technique", 
      "opportunities", 
      "gel", 
      "spectrometry", 
      "contribution", 
      "species", 
      "composition", 
      "pages", 
      "sensitive mass spectroscopy-based proteomic techniques", 
      "mass spectroscopy-based proteomic techniques", 
      "spectroscopy-based proteomic techniques", 
      "high-abundance synovial fluid (SF) proteins", 
      "prevalent joint disease osteoarthritis", 
      "joint disease osteoarthritis", 
      "disease osteoarthritis", 
      "high-abundance SF proteins", 
      "novel SF proteins", 
      "disease duration-dependent differences", 
      "duration-dependent differences", 
      "abundant protein composition", 
      "novel abundant protein species", 
      "healthy SF", 
      "SF physiology"
    ], 
    "name": "High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis", 
    "pagination": "r36-r36", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038723173"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/ar2172"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17407561"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/ar2172", 
      "https://app.dimensions.ai/details/publication/pub.1038723173"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_450.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/ar2172"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/ar2172'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/ar2172'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/ar2172'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/ar2172'


 

This table displays all metadata directly associated to this object as RDF triples.

266 TRIPLES      22 PREDICATES      128 URIs      115 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/ar2172 schema:about N347c745b50a84709b1bcce84bfa61a25
2 N3f358221565e455db06ad1496db30c0b
3 N56d82a389b314faeb04e69bcc8b14d0a
4 N574cc0aed0474b3fa1db4c19e34a12d8
5 N769fc1b96c394e52af4eaedc41f3011b
6 N835e01c2afb84a7d99ed5fff206a107f
7 N885cfcb8aa16441aa6239522ed270005
8 Nc2eba011098e4830b324c8facc693ef6
9 Nc4de342bfc9a44b1a6f4e3ac64b32ed8
10 Ncb47971f05fb453c8afbc0515e5ecdd1
11 Nec9519fd1d224b1c9642bc6fe58689f6
12 Nf2a6664422ab4f9d8398a3623b324664
13 anzsrc-for:11
14 anzsrc-for:1103
15 schema:author N4433bd9094ba455abcb7a0729510a5a3
16 schema:citation sg:pub.10.1023/a:1006797522521
17 sg:pub.10.1038/nbt819
18 sg:pub.10.1038/ncb1291
19 sg:pub.10.1038/ni732
20 sg:pub.10.1038/nrc745
21 schema:datePublished 2007-04-02
22 schema:datePublishedReg 2007-04-02
23 schema:description The development of increasingly high-throughput and sensitive mass spectroscopy-based proteomic techniques provides new opportunities to examine the physiology and pathophysiology of many biologic fluids and tissues. The purpose of this study was to determine protein expression profiles of high-abundance synovial fluid (SF) proteins in health and in the prevalent joint disease osteoarthritis (OA). A cross-sectional study of 62 patients with early OA (n = 21), patients with late OA (n = 21), and control individuals (n = 20) was conducted. SF proteins were separated by using one-dimensional PAGE, and the in-gel digested proteins were analyzed by electrospray ionization tandem mass spectrometry. A total of 362 spots were examined and 135 high-abundance SF proteins were identified as being expressed across all three study cohorts. A total of 135 SF proteins were identified. Eighteen proteins were found to be significantly differentially expressed between control individuals and OA patients. Two subsets of OA that are not dependent on disease duration were identified using unsupervised analysis of the data. Several novel SF proteins were also identified. Our analyses demonstrate no disease duration-dependent differences in abundant protein composition of SF in OA, and we clearly identified two previously unappreciated yet distinct subsets of protein profiles in this disease cohort. Additionally, our findings reveal novel abundant protein species in healthy SF whose functional contribution to SF physiology was not previously recognized. Finally, our studies identify candidate biomarkers for OA with potential for use as highly sensitive and specific tests for diagnostic purposes or for evaluating therapeutic response.
24 schema:genre article
25 schema:inLanguage en
26 schema:isAccessibleForFree true
27 schema:isPartOf N75e40bacf76b4c12b36b49185cff082f
28 Nce030635045a4592942002e651707392
29 sg:journal.1297499
30 schema:keywords OA patients
31 SF
32 SF physiology
33 SF protein
34 abundant protein composition
35 abundant protein species
36 analysis
37 biologic fluids
38 biomarkers
39 candidate biomarkers
40 cohort
41 composition
42 contribution
43 control individuals
44 cross-sectional study
45 data
46 development
47 diagnostic purposes
48 differences
49 disease cohort
50 disease duration
51 disease duration-dependent differences
52 disease osteoarthritis
53 distinct profiles
54 distinct subsets
55 duration
56 duration-dependent differences
57 early osteoarthritis
58 electrospray ionization tandem mass spectrometry
59 expression profiles
60 findings
61 fluid
62 fluid proteins
63 functional contribution
64 gel
65 health
66 healthy SF
67 high-abundance SF proteins
68 high-abundance synovial fluid (SF) proteins
69 individuals
70 ionization tandem mass spectrometry
71 joint disease osteoarthritis
72 late osteoarthritis
73 mass spectrometry
74 mass spectroscopy-based proteomic techniques
75 new opportunities
76 novel SF proteins
77 novel abundant protein species
78 one-dimensional PAGE
79 opportunities
80 osteoarthritis
81 pages
82 pathophysiology
83 patients
84 physiology
85 potential
86 prevalent joint disease osteoarthritis
87 profile
88 protein
89 protein composition
90 protein expression profiles
91 protein profiles
92 protein species
93 proteomic techniques
94 purpose
95 response
96 sensitive mass spectroscopy-based proteomic techniques
97 species
98 specific tests
99 spectrometry
100 spectroscopy-based proteomic techniques
101 spots
102 study
103 study cohort
104 subset
105 subset of osteoarthritis
106 synovial fluid proteins
107 tandem mass spectrometry
108 technique
109 test
110 therapeutic response
111 tissue
112 total
113 unsupervised analysis
114 use
115 schema:name High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis
116 schema:pagination r36-r36
117 schema:productId N3c94ff704da041139dc422008105c593
118 N48d3a4b5f94046e1834d36bc11cafc67
119 N913e9d6d8e9549b3ac5790e3fb794eda
120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038723173
121 https://doi.org/10.1186/ar2172
122 schema:sdDatePublished 2021-12-01T19:19
123 schema:sdLicense https://scigraph.springernature.com/explorer/license/
124 schema:sdPublisher N376933f2d5404419962d1bc22637b917
125 schema:url https://doi.org/10.1186/ar2172
126 sgo:license sg:explorer/license/
127 sgo:sdDataset articles
128 rdf:type schema:ScholarlyArticle
129 N099f78b01b214bb5aca1e0960e359300 rdf:first sg:person.011462730657.42
130 rdf:rest Nf3dcf14921b94a038e787058409e8bc3
131 N15f05d8054474f45b448007982dbf137 rdf:first sg:person.0725017033.72
132 rdf:rest N86e6d7d8cc534e1891862697f3c24293
133 N320f4750d36f499684a7f325487e71ae rdf:first sg:person.01211256740.06
134 rdf:rest Nf78c0acb692c461b8f826225b974f71a
135 N347c745b50a84709b1bcce84bfa61a25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Electrophoresis, Polyacrylamide Gel
137 rdf:type schema:DefinedTerm
138 N376933f2d5404419962d1bc22637b917 schema:name Springer Nature - SN SciGraph project
139 rdf:type schema:Organization
140 N3c94ff704da041139dc422008105c593 schema:name dimensions_id
141 schema:value pub.1038723173
142 rdf:type schema:PropertyValue
143 N3f358221565e455db06ad1496db30c0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Osteoarthritis
145 rdf:type schema:DefinedTerm
146 N4433bd9094ba455abcb7a0729510a5a3 rdf:first sg:person.01314401745.70
147 rdf:rest N099f78b01b214bb5aca1e0960e359300
148 N48d3a4b5f94046e1834d36bc11cafc67 schema:name doi
149 schema:value 10.1186/ar2172
150 rdf:type schema:PropertyValue
151 N56d82a389b314faeb04e69bcc8b14d0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Humans
153 rdf:type schema:DefinedTerm
154 N574cc0aed0474b3fa1db4c19e34a12d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Spectrometry, Mass, Electrospray Ionization
156 rdf:type schema:DefinedTerm
157 N75e40bacf76b4c12b36b49185cff082f schema:volumeNumber 9
158 rdf:type schema:PublicationVolume
159 N769fc1b96c394e52af4eaedc41f3011b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Principal Component Analysis
161 rdf:type schema:DefinedTerm
162 N835e01c2afb84a7d99ed5fff206a107f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Proteome
164 rdf:type schema:DefinedTerm
165 N86e6d7d8cc534e1891862697f3c24293 rdf:first sg:person.0662023443.26
166 rdf:rest Nb1e48fa9a633457b8a209dd2eccb0dc0
167 N885cfcb8aa16441aa6239522ed270005 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Gene Expression
169 rdf:type schema:DefinedTerm
170 N913e9d6d8e9549b3ac5790e3fb794eda schema:name pubmed_id
171 schema:value 17407561
172 rdf:type schema:PropertyValue
173 Nb1e48fa9a633457b8a209dd2eccb0dc0 rdf:first sg:person.01352457111.06
174 rdf:rest N320f4750d36f499684a7f325487e71ae
175 Nc2eba011098e4830b324c8facc693ef6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Knee
177 rdf:type schema:DefinedTerm
178 Nc4de342bfc9a44b1a6f4e3ac64b32ed8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Gene Expression Profiling
180 rdf:type schema:DefinedTerm
181 Ncb47971f05fb453c8afbc0515e5ecdd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Cross-Sectional Studies
183 rdf:type schema:DefinedTerm
184 Nce030635045a4592942002e651707392 schema:issueNumber 2
185 rdf:type schema:PublicationIssue
186 Nec9519fd1d224b1c9642bc6fe58689f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Synovial Fluid
188 rdf:type schema:DefinedTerm
189 Nf2a6664422ab4f9d8398a3623b324664 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Biomarkers
191 rdf:type schema:DefinedTerm
192 Nf3dcf14921b94a038e787058409e8bc3 rdf:first sg:person.01320263100.10
193 rdf:rest N15f05d8054474f45b448007982dbf137
194 Nf78c0acb692c461b8f826225b974f71a rdf:first sg:person.07671766534.39
195 rdf:rest rdf:nil
196 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
197 schema:name Medical and Health Sciences
198 rdf:type schema:DefinedTerm
199 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
200 schema:name Clinical Sciences
201 rdf:type schema:DefinedTerm
202 sg:grant.2437426 http://pending.schema.org/fundedItem sg:pub.10.1186/ar2172
203 rdf:type schema:MonetaryGrant
204 sg:journal.1297499 schema:issn 1478-6354
205 1478-6362
206 schema:name Arthritis Research & Therapy
207 schema:publisher Springer Nature
208 rdf:type schema:Periodical
209 sg:person.011462730657.42 schema:affiliation grid-institutes:grid.67105.35
210 schema:familyName Kho
211 schema:givenName Alvin
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011462730657.42
213 rdf:type schema:Person
214 sg:person.01211256740.06 schema:affiliation grid-institutes:grid.67105.35
215 schema:familyName Millett
216 schema:givenName Peter J
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211256740.06
218 rdf:type schema:Person
219 sg:person.01314401745.70 schema:affiliation grid-institutes:grid.67105.35
220 schema:familyName Gobezie
221 schema:givenName Reuben
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314401745.70
223 rdf:type schema:Person
224 sg:person.01320263100.10 schema:affiliation grid-institutes:grid.67105.35
225 schema:familyName Krastins
226 schema:givenName Bryan
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320263100.10
228 rdf:type schema:Person
229 sg:person.01352457111.06 schema:affiliation grid-institutes:grid.67105.35
230 schema:familyName Chase
231 schema:givenName Michael
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352457111.06
233 rdf:type schema:Person
234 sg:person.0662023443.26 schema:affiliation grid-institutes:grid.67105.35
235 schema:familyName Thornhill
236 schema:givenName Thomas S
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662023443.26
238 rdf:type schema:Person
239 sg:person.0725017033.72 schema:affiliation grid-institutes:grid.67105.35
240 schema:familyName Sarracino
241 schema:givenName David A
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725017033.72
243 rdf:type schema:Person
244 sg:person.07671766534.39 schema:affiliation grid-institutes:grid.67105.35
245 schema:familyName Lee
246 schema:givenName David M
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07671766534.39
248 rdf:type schema:Person
249 sg:pub.10.1023/a:1006797522521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004181750
250 https://doi.org/10.1023/a:1006797522521
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/nbt819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005258309
253 https://doi.org/10.1038/nbt819
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/ncb1291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049692778
256 https://doi.org/10.1038/ncb1291
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/ni732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010830001
259 https://doi.org/10.1038/ni732
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/nrc745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039076536
262 https://doi.org/10.1038/nrc745
263 rdf:type schema:CreativeWork
264 grid-institutes:grid.67105.35 schema:alternateName The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA
265 schema:name The Case Center for Proteomics, Case Western Reserve University School of Medicine, Euclid Avenue, Cleveland, Ohio 44106, USA
266 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...