Clinical and immunological effects of Rituximab in patients with lupus nephritis refractory to conventional therapy: a pilot study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-06

AUTHORS

Mónica Vigna-Perez, Berenice Hernández-Castro, Octavio Paredes-Saharopulos, Diana Portales-Pérez, Lourdes Baranda, Carlos Abud-Mendoza, Roberto González-Amaro

ABSTRACT

We studied the clinical and immunological effects of Rituximab (anti-CD20) therapy in patients with lupus nephritis. In an open clinical trial, 22 patients with active systemic lupus erythematosis and renal involvement (mainly class III and IV according to the WHO classification) that was refractory to conventional therapy were studied. In all these patients, Rituximab (0.5 to 1.0 g at days 1 and 15) was added to the immunosuppressive therapy and its therapeutic effect was evaluated. In addition, the levels and function of regulatory T lymphocytes and the apoptosis of immune cells were assessed. We found a significant reduction in disease activity (p < 0.05, MEX-SLEDAI index), and proteinuria (p < 0.05) at days 60 and 90 of Rituximab therapy. Although most patients showed improvement in creatinine clearance and erythrocyturia, no significant changes in these parameters were detected. In most patients (20/22), B cell depletion was observed, but no clear-cut effect of Rituximab on complement levels or auto-antibody titers was detected (p > 0.05 in all cases). One patient died at day 70 with invasive histoplasmosis. No important adverse effects of Rituximab therapy were registered in other patients. A significant enhancement in the levels of different CD4+ regulatory cells (TREG, Th3, Tr1), but not CD8+ Ts lymphocytes, was observed at day 30. This increase was sustained for TREG cells at day 90, and accompanied by an improvement in their regulatory function. In addition, we observed an unexpected increase in the apoptosis of T cells at day 30. Interestingly, the enhancement in the suppressive function of TREG cells was not observed in the two patients that showed the poorest clinical response to Rituximab. We conclude that the data obtained in this open clinical trial suggest that Rituximab is a promising candidate for randomized controlled trials in patients with lupus nephritis refractory to the conventional immunosuppressive therapy. The effects of Rituximab on regulatory cells and apoptosis of T lymphocytes are interesting and its possible role in the putative effect of this biological agent in systemic lupus erythematosis deserves additional studies. More... »

PAGES

r83

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/ar1954

DOI

http://dx.doi.org/10.1186/ar1954

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003531501

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16677395


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal, Murine-Derived", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antirheumatic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Therapy, Combination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunologic Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lupus Nephritis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methotrexate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pilot Projects", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rituximab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Autonomous University of San Luis Potos\u00ed", 
          "id": "https://www.grid.ac/institutes/grid.412862.b", 
          "name": [
            "Departamento de Inmunolog\u00eda, Facultad de Medicina, UASLP, San Luis Potos\u00ed, SLP, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vigna-Perez", 
        "givenName": "M\u00f3nica", 
        "id": "sg:person.01222250342.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222250342.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Autonomous University of San Luis Potos\u00ed", 
          "id": "https://www.grid.ac/institutes/grid.412862.b", 
          "name": [
            "Departamento de Inmunolog\u00eda, Facultad de Medicina, UASLP, San Luis Potos\u00ed, SLP, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hern\u00e1ndez-Castro", 
        "givenName": "Berenice", 
        "id": "sg:person.01077150665.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077150665.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Autonomous University of San Luis Potos\u00ed", 
          "id": "https://www.grid.ac/institutes/grid.412862.b", 
          "name": [
            "Departamento de Inmunolog\u00eda, Facultad de Medicina, UASLP, San Luis Potos\u00ed, SLP, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paredes-Saharopulos", 
        "givenName": "Octavio", 
        "id": "sg:person.0637634444.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637634444.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Autonomous University of San Luis Potos\u00ed", 
          "id": "https://www.grid.ac/institutes/grid.412862.b", 
          "name": [
            "Laboratorio de Inmunolog\u00eda Celular y Molecular, Facultad de Ciencias Qu\u00edmicas, UASLP, San Luis Potos\u00ed, SLP, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Portales-P\u00e9rez", 
        "givenName": "Diana", 
        "id": "sg:person.01153773541.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153773541.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Central Dr. Ignacio Morones Prieto", 
          "id": "https://www.grid.ac/institutes/grid.414410.4", 
          "name": [
            "Departamento de Inmunolog\u00eda, Facultad de Medicina, UASLP, San Luis Potos\u00ed, SLP, M\u00e9xico", 
            "Unidad Regional de Reumatolog\u00eda y Osteoporosis, Hospital Central Dr Ignacio Morones Prieto, San Luis Potos\u00ed, SLP, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baranda", 
        "givenName": "Lourdes", 
        "id": "sg:person.0706434562.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706434562.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Central Dr. Ignacio Morones Prieto", 
          "id": "https://www.grid.ac/institutes/grid.414410.4", 
          "name": [
            "Unidad Regional de Reumatolog\u00eda y Osteoporosis, Hospital Central Dr Ignacio Morones Prieto, San Luis Potos\u00ed, SLP, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abud-Mendoza", 
        "givenName": "Carlos", 
        "id": "sg:person.01041754035.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041754035.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Autonomous University of San Luis Potos\u00ed", 
          "id": "https://www.grid.ac/institutes/grid.412862.b", 
          "name": [
            "Departamento de Inmunolog\u00eda, Facultad de Medicina, UASLP, San Luis Potos\u00ed, SLP, M\u00e9xico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonz\u00e1lez-Amaro", 
        "givenName": "Roberto", 
        "id": "sg:person.01246627327.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246627327.64"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/rheumatology/keh618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002093065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rheumatology/keh443", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002529784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.165.10.5970", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003764385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/rheumatology/kei080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004301803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.10541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004571121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20031579", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004960961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20040165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005439923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.bor.0000170479.01451.ab", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007566067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.bor.0000170479.01451.ab", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007566067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.bor.0000170479.01451.ab", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007566067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001813-200211002-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009041921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001813-200211002-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009041921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1074-7613(95)90161-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010596773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2249.2005.02859.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012397631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2249.2005.02859.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012397631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-065x.2001.1820105.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012676651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0804-801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014073897", 
          "https://doi.org/10.1038/nm0804-801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0804-801", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014073897", 
          "https://doi.org/10.1038/nm0804-801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/03009740410010227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015438982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.21351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016675988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.21351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016675988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar1007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018679330", 
          "https://doi.org/10.1186/ar1007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.20857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018844754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.11063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020708763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar1192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021099528", 
          "https://doi.org/10.1186/ar1192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.1999.tb01310.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021910023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5699(91)90094-a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021915365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2004.029694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022309174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.10192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025825370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni0901-816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027284442", 
          "https://doi.org/10.1038/ni0901-816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni0901-816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027284442", 
          "https://doi.org/10.1038/ni0901-816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.20976", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028508707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.20858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029058898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/mai.2000.106635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029570360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.2334901100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034837935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-8411(03)00121-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036311060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-8411(03)00121-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036311060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.10764", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039534151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/sonc.2002.30156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041461608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.20500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042034642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.20592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045095887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0300-9475.2004.01370.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050787169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.20430", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051828584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/10.6.775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052703784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199406303302608", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053336179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.181.3.839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058438599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1191/0961203303lu449cr", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064154350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1191/0961203303lu449cr", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064154350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1191/0961203303lu449cr", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064154350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1615/critrevimmunol.v25.i2.30", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068131861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.166.10.5955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074810677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.166.10.6452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074810742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.176.3.1316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077177439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078803696", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080037334", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082444072", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-06", 
    "datePublishedReg": "2006-06-01", 
    "description": "We studied the clinical and immunological effects of Rituximab (anti-CD20) therapy in patients with lupus nephritis. In an open clinical trial, 22 patients with active systemic lupus erythematosis and renal involvement (mainly class III and IV according to the WHO classification) that was refractory to conventional therapy were studied. In all these patients, Rituximab (0.5 to 1.0 g at days 1 and 15) was added to the immunosuppressive therapy and its therapeutic effect was evaluated. In addition, the levels and function of regulatory T lymphocytes and the apoptosis of immune cells were assessed. We found a significant reduction in disease activity (p < 0.05, MEX-SLEDAI index), and proteinuria (p < 0.05) at days 60 and 90 of Rituximab therapy. Although most patients showed improvement in creatinine clearance and erythrocyturia, no significant changes in these parameters were detected. In most patients (20/22), B cell depletion was observed, but no clear-cut effect of Rituximab on complement levels or auto-antibody titers was detected (p > 0.05 in all cases). One patient died at day 70 with invasive histoplasmosis. No important adverse effects of Rituximab therapy were registered in other patients. A significant enhancement in the levels of different CD4+ regulatory cells (TREG, Th3, Tr1), but not CD8+ Ts lymphocytes, was observed at day 30. This increase was sustained for TREG cells at day 90, and accompanied by an improvement in their regulatory function. In addition, we observed an unexpected increase in the apoptosis of T cells at day 30. Interestingly, the enhancement in the suppressive function of TREG cells was not observed in the two patients that showed the poorest clinical response to Rituximab. We conclude that the data obtained in this open clinical trial suggest that Rituximab is a promising candidate for randomized controlled trials in patients with lupus nephritis refractory to the conventional immunosuppressive therapy. The effects of Rituximab on regulatory cells and apoptosis of T lymphocytes are interesting and its possible role in the putative effect of this biological agent in systemic lupus erythematosis deserves additional studies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/ar1954", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1297499", 
        "issn": [
          "1478-6354", 
          "1478-6362"
        ], 
        "name": "Arthritis Research & Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Clinical and immunological effects of Rituximab in patients with lupus nephritis refractory to conventional therapy: a pilot study", 
    "pagination": "r83", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "10d2a07af7316cdbd0ae12b167d8aa2091eba61e4e5ba7d30d21c5d7f763417d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16677395"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101154438"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/ar1954"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003531501"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/ar1954", 
      "https://app.dimensions.ai/details/publication/pub.1003531501"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T18:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2Far1954"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/ar1954'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/ar1954'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/ar1954'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/ar1954'


 

This table displays all metadata directly associated to this object as RDF triples.

327 TRIPLES      21 PREDICATES      93 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/ar1954 schema:about N03b52c5332f044329ec212ab6bee3a6e
2 N0d358e9679d24086b74f44d84ec56ec1
3 N125f81db1cc84f58a0a61c53fdd39b0a
4 N251084f67eac41eaa2298089e69e747d
5 N2c624074ed2441af936d593c77ddf36c
6 N377542ced3ec48b5ac54889b7c594fac
7 N446fffe660aa4691820566e63f717434
8 N604ed250d9b94a47a2abcd2e5b36c10b
9 N66aad63c8fe4401292088c4b27306331
10 N68b4b91dec3740f693fbd6134de9d071
11 Na7abc2a774a648d0b8f29bdfa1814030
12 Nb52c1f53a5f74311a858e7b20d4bff23
13 Nc1d6a43a94534717bf98f9a5a9507442
14 Nc52c076a2683430da5f58a83b4119c94
15 Nc95ce876de254cc6b746bb55c9bec1c1
16 Nca7ddfb97b1c47f7b8bf5b63e3f87319
17 Ncc0a749c366c45e9941a495e2f882423
18 Nffa626136ae94896b924503690a19296
19 anzsrc-for:11
20 anzsrc-for:1107
21 schema:author N1214ae9d0525431aa898e2bdf586055b
22 schema:citation sg:pub.10.1038/ni0901-816
23 sg:pub.10.1038/nm0804-801
24 sg:pub.10.1186/ar1007
25 sg:pub.10.1186/ar1192
26 https://app.dimensions.ai/details/publication/pub.1078803696
27 https://app.dimensions.ai/details/publication/pub.1080037334
28 https://app.dimensions.ai/details/publication/pub.1082444072
29 https://doi.org/10.1002/art.10192
30 https://doi.org/10.1002/art.10541
31 https://doi.org/10.1002/art.10764
32 https://doi.org/10.1002/art.11063
33 https://doi.org/10.1002/art.20430
34 https://doi.org/10.1002/art.20500
35 https://doi.org/10.1002/art.20592
36 https://doi.org/10.1002/art.20857
37 https://doi.org/10.1002/art.20858
38 https://doi.org/10.1002/art.20976
39 https://doi.org/10.1002/art.21351
40 https://doi.org/10.1016/0167-5699(91)90094-a
41 https://doi.org/10.1016/1074-7613(95)90161-2
42 https://doi.org/10.1016/s0896-8411(03)00121-5
43 https://doi.org/10.1034/j.1600-065x.2001.1820105.x
44 https://doi.org/10.1053/sonc.2002.30156
45 https://doi.org/10.1056/nejm199406303302608
46 https://doi.org/10.1067/mai.2000.106635
47 https://doi.org/10.1073/pnas.2334901100
48 https://doi.org/10.1080/03009740410010227
49 https://doi.org/10.1084/jem.181.3.839
50 https://doi.org/10.1084/jem.20031579
51 https://doi.org/10.1084/jem.20040165
52 https://doi.org/10.1093/intimm/10.6.775
53 https://doi.org/10.1093/rheumatology/keh443
54 https://doi.org/10.1093/rheumatology/keh618
55 https://doi.org/10.1093/rheumatology/kei080
56 https://doi.org/10.1097/00001813-200211002-00002
57 https://doi.org/10.1097/01.bor.0000170479.01451.ab
58 https://doi.org/10.1111/j.0300-9475.2004.01370.x
59 https://doi.org/10.1111/j.1365-2249.2005.02859.x
60 https://doi.org/10.1111/j.1600-065x.1999.tb01310.x
61 https://doi.org/10.1136/ard.2004.029694
62 https://doi.org/10.1191/0961203303lu449cr
63 https://doi.org/10.1615/critrevimmunol.v25.i2.30
64 https://doi.org/10.4049/jimmunol.165.10.5970
65 https://doi.org/10.4049/jimmunol.166.10.5955
66 https://doi.org/10.4049/jimmunol.166.10.6452
67 https://doi.org/10.4049/jimmunol.176.3.1316
68 schema:datePublished 2006-06
69 schema:datePublishedReg 2006-06-01
70 schema:description We studied the clinical and immunological effects of Rituximab (anti-CD20) therapy in patients with lupus nephritis. In an open clinical trial, 22 patients with active systemic lupus erythematosis and renal involvement (mainly class III and IV according to the WHO classification) that was refractory to conventional therapy were studied. In all these patients, Rituximab (0.5 to 1.0 g at days 1 and 15) was added to the immunosuppressive therapy and its therapeutic effect was evaluated. In addition, the levels and function of regulatory T lymphocytes and the apoptosis of immune cells were assessed. We found a significant reduction in disease activity (p < 0.05, MEX-SLEDAI index), and proteinuria (p < 0.05) at days 60 and 90 of Rituximab therapy. Although most patients showed improvement in creatinine clearance and erythrocyturia, no significant changes in these parameters were detected. In most patients (20/22), B cell depletion was observed, but no clear-cut effect of Rituximab on complement levels or auto-antibody titers was detected (p > 0.05 in all cases). One patient died at day 70 with invasive histoplasmosis. No important adverse effects of Rituximab therapy were registered in other patients. A significant enhancement in the levels of different CD4+ regulatory cells (TREG, Th3, Tr1), but not CD8+ Ts lymphocytes, was observed at day 30. This increase was sustained for TREG cells at day 90, and accompanied by an improvement in their regulatory function. In addition, we observed an unexpected increase in the apoptosis of T cells at day 30. Interestingly, the enhancement in the suppressive function of TREG cells was not observed in the two patients that showed the poorest clinical response to Rituximab. We conclude that the data obtained in this open clinical trial suggest that Rituximab is a promising candidate for randomized controlled trials in patients with lupus nephritis refractory to the conventional immunosuppressive therapy. The effects of Rituximab on regulatory cells and apoptosis of T lymphocytes are interesting and its possible role in the putative effect of this biological agent in systemic lupus erythematosis deserves additional studies.
71 schema:genre research_article
72 schema:inLanguage en
73 schema:isAccessibleForFree true
74 schema:isPartOf N513411e7c148471497f41a875e3a9275
75 N72540004a7f343879c8a5577c45a3ed3
76 sg:journal.1297499
77 schema:name Clinical and immunological effects of Rituximab in patients with lupus nephritis refractory to conventional therapy: a pilot study
78 schema:pagination r83
79 schema:productId N17814986e6064a15812b2935d19c92ed
80 N1ed3eeedeb7d40708412574d7a42d7a0
81 N4201ba92c19347b0b89dda8b00a15c0d
82 N77524f8e7bf44eb1a8cdf3f20b86537b
83 N9e4379c33e854c14b778fa06523d0004
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003531501
85 https://doi.org/10.1186/ar1954
86 schema:sdDatePublished 2019-04-10T18:19
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher N148f2935a2524ebfa052b1b2f9986a87
89 schema:url http://link.springer.com/10.1186%2Far1954
90 sgo:license sg:explorer/license/
91 sgo:sdDataset articles
92 rdf:type schema:ScholarlyArticle
93 N03b52c5332f044329ec212ab6bee3a6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Lupus Nephritis
95 rdf:type schema:DefinedTerm
96 N0d358e9679d24086b74f44d84ec56ec1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Pilot Projects
98 rdf:type schema:DefinedTerm
99 N1214ae9d0525431aa898e2bdf586055b rdf:first sg:person.01222250342.52
100 rdf:rest N6e3e2f635ea246149c0b2955a4e76029
101 N125f81db1cc84f58a0a61c53fdd39b0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Drug Therapy, Combination
103 rdf:type schema:DefinedTerm
104 N148f2935a2524ebfa052b1b2f9986a87 schema:name Springer Nature - SN SciGraph project
105 rdf:type schema:Organization
106 N17814986e6064a15812b2935d19c92ed schema:name nlm_unique_id
107 schema:value 101154438
108 rdf:type schema:PropertyValue
109 N1ed3eeedeb7d40708412574d7a42d7a0 schema:name readcube_id
110 schema:value 10d2a07af7316cdbd0ae12b167d8aa2091eba61e4e5ba7d30d21c5d7f763417d
111 rdf:type schema:PropertyValue
112 N23cc8f75dc4948f69d40cdf8a483f805 rdf:first sg:person.01153773541.25
113 rdf:rest N549251acf36448d2a76d156c74872d98
114 N251084f67eac41eaa2298089e69e747d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Antirheumatic Agents
116 rdf:type schema:DefinedTerm
117 N2c624074ed2441af936d593c77ddf36c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Humans
119 rdf:type schema:DefinedTerm
120 N377542ced3ec48b5ac54889b7c594fac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Antibodies, Monoclonal
122 rdf:type schema:DefinedTerm
123 N4201ba92c19347b0b89dda8b00a15c0d schema:name pubmed_id
124 schema:value 16677395
125 rdf:type schema:PropertyValue
126 N446fffe660aa4691820566e63f717434 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Male
128 rdf:type schema:DefinedTerm
129 N513411e7c148471497f41a875e3a9275 schema:issueNumber 3
130 rdf:type schema:PublicationIssue
131 N549251acf36448d2a76d156c74872d98 rdf:first sg:person.0706434562.05
132 rdf:rest N7a474bdd20ef4f608c98454b7ef9bfa2
133 N604ed250d9b94a47a2abcd2e5b36c10b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Antibodies, Monoclonal, Murine-Derived
135 rdf:type schema:DefinedTerm
136 N66aad63c8fe4401292088c4b27306331 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Lymphocyte Activation
138 rdf:type schema:DefinedTerm
139 N68b4b91dec3740f693fbd6134de9d071 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Apoptosis
141 rdf:type schema:DefinedTerm
142 N6e3e2f635ea246149c0b2955a4e76029 rdf:first sg:person.01077150665.84
143 rdf:rest Na34f4b15f6c4410b925edf8ae8eaa79f
144 N72540004a7f343879c8a5577c45a3ed3 schema:volumeNumber 8
145 rdf:type schema:PublicationVolume
146 N77524f8e7bf44eb1a8cdf3f20b86537b schema:name doi
147 schema:value 10.1186/ar1954
148 rdf:type schema:PropertyValue
149 N7a474bdd20ef4f608c98454b7ef9bfa2 rdf:first sg:person.01041754035.29
150 rdf:rest Ne11dde813e1f4165b4cd0d91b54acf19
151 N9e4379c33e854c14b778fa06523d0004 schema:name dimensions_id
152 schema:value pub.1003531501
153 rdf:type schema:PropertyValue
154 Na34f4b15f6c4410b925edf8ae8eaa79f rdf:first sg:person.0637634444.29
155 rdf:rest N23cc8f75dc4948f69d40cdf8a483f805
156 Na7abc2a774a648d0b8f29bdfa1814030 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Female
158 rdf:type schema:DefinedTerm
159 Nb52c1f53a5f74311a858e7b20d4bff23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Immunologic Factors
161 rdf:type schema:DefinedTerm
162 Nc1d6a43a94534717bf98f9a5a9507442 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Methotrexate
164 rdf:type schema:DefinedTerm
165 Nc52c076a2683430da5f58a83b4119c94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Middle Aged
167 rdf:type schema:DefinedTerm
168 Nc95ce876de254cc6b746bb55c9bec1c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name CD4-Positive T-Lymphocytes
170 rdf:type schema:DefinedTerm
171 Nca7ddfb97b1c47f7b8bf5b63e3f87319 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Rituximab
173 rdf:type schema:DefinedTerm
174 Ncc0a749c366c45e9941a495e2f882423 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name T-Lymphocytes
176 rdf:type schema:DefinedTerm
177 Ne11dde813e1f4165b4cd0d91b54acf19 rdf:first sg:person.01246627327.64
178 rdf:rest rdf:nil
179 Nffa626136ae94896b924503690a19296 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Adult
181 rdf:type schema:DefinedTerm
182 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
183 schema:name Medical and Health Sciences
184 rdf:type schema:DefinedTerm
185 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
186 schema:name Immunology
187 rdf:type schema:DefinedTerm
188 sg:journal.1297499 schema:issn 1478-6354
189 1478-6362
190 schema:name Arthritis Research & Therapy
191 rdf:type schema:Periodical
192 sg:person.01041754035.29 schema:affiliation https://www.grid.ac/institutes/grid.414410.4
193 schema:familyName Abud-Mendoza
194 schema:givenName Carlos
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041754035.29
196 rdf:type schema:Person
197 sg:person.01077150665.84 schema:affiliation https://www.grid.ac/institutes/grid.412862.b
198 schema:familyName Hernández-Castro
199 schema:givenName Berenice
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077150665.84
201 rdf:type schema:Person
202 sg:person.01153773541.25 schema:affiliation https://www.grid.ac/institutes/grid.412862.b
203 schema:familyName Portales-Pérez
204 schema:givenName Diana
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153773541.25
206 rdf:type schema:Person
207 sg:person.01222250342.52 schema:affiliation https://www.grid.ac/institutes/grid.412862.b
208 schema:familyName Vigna-Perez
209 schema:givenName Mónica
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222250342.52
211 rdf:type schema:Person
212 sg:person.01246627327.64 schema:affiliation https://www.grid.ac/institutes/grid.412862.b
213 schema:familyName González-Amaro
214 schema:givenName Roberto
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246627327.64
216 rdf:type schema:Person
217 sg:person.0637634444.29 schema:affiliation https://www.grid.ac/institutes/grid.412862.b
218 schema:familyName Paredes-Saharopulos
219 schema:givenName Octavio
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637634444.29
221 rdf:type schema:Person
222 sg:person.0706434562.05 schema:affiliation https://www.grid.ac/institutes/grid.414410.4
223 schema:familyName Baranda
224 schema:givenName Lourdes
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706434562.05
226 rdf:type schema:Person
227 sg:pub.10.1038/ni0901-816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027284442
228 https://doi.org/10.1038/ni0901-816
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/nm0804-801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014073897
231 https://doi.org/10.1038/nm0804-801
232 rdf:type schema:CreativeWork
233 sg:pub.10.1186/ar1007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018679330
234 https://doi.org/10.1186/ar1007
235 rdf:type schema:CreativeWork
236 sg:pub.10.1186/ar1192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021099528
237 https://doi.org/10.1186/ar1192
238 rdf:type schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1078803696 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1080037334 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1082444072 schema:CreativeWork
242 https://doi.org/10.1002/art.10192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025825370
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1002/art.10541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004571121
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1002/art.10764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039534151
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1002/art.11063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020708763
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1002/art.20430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051828584
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1002/art.20500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042034642
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1002/art.20592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045095887
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1002/art.20857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018844754
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1002/art.20858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029058898
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1002/art.20976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028508707
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1002/art.21351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016675988
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/0167-5699(91)90094-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1021915365
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/1074-7613(95)90161-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010596773
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/s0896-8411(03)00121-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036311060
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1034/j.1600-065x.2001.1820105.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012676651
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1053/sonc.2002.30156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041461608
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1056/nejm199406303302608 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053336179
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1067/mai.2000.106635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029570360
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1073/pnas.2334901100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034837935
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1080/03009740410010227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015438982
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1084/jem.181.3.839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058438599
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1084/jem.20031579 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004960961
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1084/jem.20040165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005439923
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1093/intimm/10.6.775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052703784
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1093/rheumatology/keh443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002529784
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1093/rheumatology/keh618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002093065
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1093/rheumatology/kei080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004301803
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1097/00001813-200211002-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009041921
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1097/01.bor.0000170479.01451.ab schema:sameAs https://app.dimensions.ai/details/publication/pub.1007566067
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1111/j.0300-9475.2004.01370.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050787169
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1111/j.1365-2249.2005.02859.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012397631
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1111/j.1600-065x.1999.tb01310.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021910023
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1136/ard.2004.029694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022309174
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1191/0961203303lu449cr schema:sameAs https://app.dimensions.ai/details/publication/pub.1064154350
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1615/critrevimmunol.v25.i2.30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068131861
311 rdf:type schema:CreativeWork
312 https://doi.org/10.4049/jimmunol.165.10.5970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003764385
313 rdf:type schema:CreativeWork
314 https://doi.org/10.4049/jimmunol.166.10.5955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074810677
315 rdf:type schema:CreativeWork
316 https://doi.org/10.4049/jimmunol.166.10.6452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074810742
317 rdf:type schema:CreativeWork
318 https://doi.org/10.4049/jimmunol.176.3.1316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077177439
319 rdf:type schema:CreativeWork
320 https://www.grid.ac/institutes/grid.412862.b schema:alternateName Autonomous University of San Luis Potosí
321 schema:name Departamento de Inmunología, Facultad de Medicina, UASLP, San Luis Potosí, SLP, México
322 Laboratorio de Inmunología Celular y Molecular, Facultad de Ciencias Químicas, UASLP, San Luis Potosí, SLP, México
323 rdf:type schema:Organization
324 https://www.grid.ac/institutes/grid.414410.4 schema:alternateName Hospital Central Dr. Ignacio Morones Prieto
325 schema:name Departamento de Inmunología, Facultad de Medicina, UASLP, San Luis Potosí, SLP, México
326 Unidad Regional de Reumatología y Osteoporosis, Hospital Central Dr Ignacio Morones Prieto, San Luis Potosí, SLP, México
327 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...