Ontology type: schema:ScholarlyArticle Open Access: True
2014-12
AUTHORSChristina L Addison, Gregory R Pond, Huijun Zhao, Sasha Mazzarello, Lisa Vandermeer, Robyn Goldstein, Eitan Amir, Mark Clemons
ABSTRACTWhile de-escalation of bisphosphonates from 4 to 12-weekly dosing has been shown to be clinically non-inferior to standard dosing, there is evidence the de-escalation is associated with increased bone turnover biomarkers. Here we evaluated the effect of de-escalated dosing on a panel of biomarkers and determined their association with incidence of skeletal related events (SREs) in breast cancer patients with 'low risk' bone metastases. As part of a pilot randomized trial, women with baseline C-telopeptide levels <600 ng/L after >3 months of 3-4 weekly pamidronate were randomized to continue pamidronate every 4 weeks or de-escalation to 12-weekly treatment. Serum was analysed for bone biomarkers (C-telopeptide, N-telopeptide, bone-specific alkaline phosphatase, transforming growth factor-β, procollagen type 1 N-propeptide, activinA and bone sialoprotein) using ELISA. The associations between changes in biomarkers, pain scores and SREs were assessed by univariable logistic regression. Numerical increases in all biomarkers were observed between baseline and 12 weeks but were of higher magnitude in the de-escalated arm. Pain scores in the de-escalated treatment arm showed a greater magnitude of pain reduction from baseline to 12 weeks. Neither baseline levels nor changes in biomarkers from baseline to 12 weeks on treatment were associated with on study SREs. Baseline pain as measured by the FACT-BP was associated with increased risk of SRE. In conclusion, biomarkers of bone activity do not appear to predict for SREs in 'low risk' cohorts. However, baseline bone pain appears to be associated with SRE occurrence, a finding which warrants evaluation in larger cohorts. More... »
PAGES577
http://scigraph.springernature.com/pub.10.1186/2193-1801-3-577
DOIhttp://dx.doi.org/10.1186/2193-1801-3-577
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1009429875
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25332877
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Ottawa",
"id": "https://www.grid.ac/institutes/grid.28046.38",
"name": [
"Program for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada",
"Department of Medicine, University of Ottawa, Ottawa, ON, Canada",
"Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada"
],
"type": "Organization"
},
"familyName": "Addison",
"givenName": "Christina L",
"id": "sg:person.01313721130.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313721130.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "McMaster University",
"id": "https://www.grid.ac/institutes/grid.25073.33",
"name": [
"Department of Oncology, McMaster University, Hamilton, Canada"
],
"type": "Organization"
},
"familyName": "Pond",
"givenName": "Gregory R",
"id": "sg:person.01251570265.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251570265.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ottawa Hospital",
"id": "https://www.grid.ac/institutes/grid.412687.e",
"name": [
"Program for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada"
],
"type": "Organization"
},
"familyName": "Zhao",
"givenName": "Huijun",
"id": "sg:person.0640065212.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640065212.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ottawa Hospital",
"id": "https://www.grid.ac/institutes/grid.412687.e",
"name": [
"Program for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada"
],
"type": "Organization"
},
"familyName": "Mazzarello",
"givenName": "Sasha",
"id": "sg:person.0737376756.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737376756.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ottawa Hospital",
"id": "https://www.grid.ac/institutes/grid.412687.e",
"name": [
"Program for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada"
],
"type": "Organization"
},
"familyName": "Vandermeer",
"givenName": "Lisa",
"id": "sg:person.0761055556.65",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761055556.65"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Princess Margaret Cancer Centre",
"id": "https://www.grid.ac/institutes/grid.415224.4",
"name": [
"Princess Margaret Hospital, Toronto, ON, Canada"
],
"type": "Organization"
},
"familyName": "Goldstein",
"givenName": "Robyn",
"id": "sg:person.0732023453.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732023453.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Princess Margaret Cancer Centre",
"id": "https://www.grid.ac/institutes/grid.415224.4",
"name": [
"Princess Margaret Hospital, Toronto, ON, Canada"
],
"type": "Organization"
},
"familyName": "Amir",
"givenName": "Eitan",
"id": "sg:person.01272612235.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272612235.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Ottawa",
"id": "https://www.grid.ac/institutes/grid.28046.38",
"name": [
"Program for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada",
"Department of Medicine, University of Ottawa, Ottawa, ON, Canada"
],
"type": "Organization"
},
"familyName": "Clemons",
"givenName": "Mark",
"id": "sg:person.01216107435.90",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216107435.90"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/j.ctrv.2008.05.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003154829"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3233/bd-2010-0327",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006344494"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6602920",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008659528",
"https://doi.org/10.1038/sj.bjc.6602920"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6602920",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008659528",
"https://doi.org/10.1038/sj.bjc.6602920"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s002239900235",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010878851",
"https://doi.org/10.1007/s002239900235"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf03256280",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011840081",
"https://doi.org/10.1007/bf03256280"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.clon.2007.04.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013906210"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1529-0131(200005)43:5<953::aid-anr1>3.0.co;2-q",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016013566"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.23529",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016505598"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-010-0981-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016809613",
"https://doi.org/10.1007/s10549-010-0981-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-010-0981-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016809613",
"https://doi.org/10.1007/s10549-010-0981-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bonekey.2014.14",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016969441",
"https://doi.org/10.1038/bonekey.2014.14"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1987.13",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017120378",
"https://doi.org/10.1038/bjc.1987.13"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/bjc.1987.13",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017120378",
"https://doi.org/10.1038/bjc.1987.13"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1749-6632.2010.05766.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019414937"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.clon.2012.11.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021693674"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/dji237",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023556722"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/dji237",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023556722"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-014-3015-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023620699",
"https://doi.org/10.1007/s10549-014-3015-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10585-006-9010-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025828666",
"https://doi.org/10.1007/s10585-006-9010-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10585-006-9010-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025828666",
"https://doi.org/10.1007/s10585-006-9010-5"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s002230020042",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026386817",
"https://doi.org/10.1007/s002230020042"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(98)00277-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026546350"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(02)00502-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029464121"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(02)00502-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029464121"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3747/co.19.1011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030497291"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/s10165-011-0455-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030599753"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jbspin.2007.01.039",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031712392"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6601437",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033862119",
"https://doi.org/10.1038/sj.bjc.6601437"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6601437",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033862119",
"https://doi.org/10.1038/sj.bjc.6601437"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/coc.0b013e3182568f7a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035166159"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/coc.0b013e3182568f7a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035166159"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jpainsymman.2008.08.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036416330"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/bbrc.2000.2075",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038602058"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/djt026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040244149"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/djt026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040244149"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/djt026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040244149"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/djt026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040244149"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-014-2906-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041087414",
"https://doi.org/10.1007/s10549-014-2906-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-014-2906-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041087414",
"https://doi.org/10.1007/s10549-014-2906-x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejphar.2013.03.034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041327882"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1359/jbmr.2003.18.10.1789",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042792593"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(13)70174-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045489195"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00316285",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046839614",
"https://doi.org/10.1007/bf00316285"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00316285",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046839614",
"https://doi.org/10.1007/bf00316285"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1054/bjoc.1999.1012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048823579",
"https://doi.org/10.1054/bjoc.1999.1012"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10165-011-0455-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052137198",
"https://doi.org/10.1007/s10165-011-0455-2"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2005.06.091",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053718930"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/13547500701676019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1058382898"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/154405910708601102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064058449"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/154405910708601102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064058449"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/edrv.22.6.0450",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064238557"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jcem.87.5.8512",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064325226"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074575202",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077684144",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083171551",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2014.32.18_suppl.lba9500",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083398372"
],
"type": "CreativeWork"
}
],
"datePublished": "2014-12",
"datePublishedReg": "2014-12-01",
"description": "While de-escalation of bisphosphonates from 4 to 12-weekly dosing has been shown to be clinically non-inferior to standard dosing, there is evidence the de-escalation is associated with increased bone turnover biomarkers. Here we evaluated the effect of de-escalated dosing on a panel of biomarkers and determined their association with incidence of skeletal related events (SREs) in breast cancer patients with 'low risk' bone metastases. As part of a pilot randomized trial, women with baseline C-telopeptide levels <600 ng/L after >3 months of 3-4 weekly pamidronate were randomized to continue pamidronate every 4 weeks or de-escalation to 12-weekly treatment. Serum was analysed for bone biomarkers (C-telopeptide, N-telopeptide, bone-specific alkaline phosphatase, transforming growth factor-\u03b2, procollagen type 1 N-propeptide, activinA and bone sialoprotein) using ELISA. The associations between changes in biomarkers, pain scores and SREs were assessed by univariable logistic regression. Numerical increases in all biomarkers were observed between baseline and 12 weeks but were of higher magnitude in the de-escalated arm. Pain scores in the de-escalated treatment arm showed a greater magnitude of pain reduction from baseline to 12 weeks. Neither baseline levels nor changes in biomarkers from baseline to 12 weeks on treatment were associated with on study SREs. Baseline pain as measured by the FACT-BP was associated with increased risk of SRE. In conclusion, biomarkers of bone activity do not appear to predict for SREs in 'low risk' cohorts. However, baseline bone pain appears to be associated with SRE occurrence, a finding which warrants evaluation in larger cohorts. ",
"genre": "research_article",
"id": "sg:pub.10.1186/2193-1801-3-577",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1047790",
"issn": [
"2193-1801"
],
"name": "SpringerPlus",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "3"
}
],
"name": "Effects of de-escalated bisphosphonate therapy on bone turnover biomarkers in breast cancer patients with bone metastases",
"pagination": "577",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"2cebcaff5837f496cbe053b2505831c950bbe0d30c447ac23a5b98c871a7b2a7"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"25332877"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101597967"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/2193-1801-3-577"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1009429875"
]
}
],
"sameAs": [
"https://doi.org/10.1186/2193-1801-3-577",
"https://app.dimensions.ai/details/publication/pub.1009429875"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T22:31",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000510.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1186%2F2193-1801-3-577"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/2193-1801-3-577'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/2193-1801-3-577'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/2193-1801-3-577'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/2193-1801-3-577'
This table displays all metadata directly associated to this object as RDF triples.
268 TRIPLES
21 PREDICATES
72 URIs
21 LITERALS
9 BLANK NODES