Effects of de-escalated bisphosphonate therapy on bone turnover biomarkers in breast cancer patients with bone metastases View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Christina L Addison, Gregory R Pond, Huijun Zhao, Sasha Mazzarello, Lisa Vandermeer, Robyn Goldstein, Eitan Amir, Mark Clemons

ABSTRACT

While de-escalation of bisphosphonates from 4 to 12-weekly dosing has been shown to be clinically non-inferior to standard dosing, there is evidence the de-escalation is associated with increased bone turnover biomarkers. Here we evaluated the effect of de-escalated dosing on a panel of biomarkers and determined their association with incidence of skeletal related events (SREs) in breast cancer patients with 'low risk' bone metastases. As part of a pilot randomized trial, women with baseline C-telopeptide levels <600 ng/L after >3 months of 3-4 weekly pamidronate were randomized to continue pamidronate every 4 weeks or de-escalation to 12-weekly treatment. Serum was analysed for bone biomarkers (C-telopeptide, N-telopeptide, bone-specific alkaline phosphatase, transforming growth factor-β, procollagen type 1 N-propeptide, activinA and bone sialoprotein) using ELISA. The associations between changes in biomarkers, pain scores and SREs were assessed by univariable logistic regression. Numerical increases in all biomarkers were observed between baseline and 12 weeks but were of higher magnitude in the de-escalated arm. Pain scores in the de-escalated treatment arm showed a greater magnitude of pain reduction from baseline to 12 weeks. Neither baseline levels nor changes in biomarkers from baseline to 12 weeks on treatment were associated with on study SREs. Baseline pain as measured by the FACT-BP was associated with increased risk of SRE. In conclusion, biomarkers of bone activity do not appear to predict for SREs in 'low risk' cohorts. However, baseline bone pain appears to be associated with SRE occurrence, a finding which warrants evaluation in larger cohorts. More... »

PAGES

577

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/2193-1801-3-577

DOI

http://dx.doi.org/10.1186/2193-1801-3-577

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009429875

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25332877


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Ottawa", 
          "id": "https://www.grid.ac/institutes/grid.28046.38", 
          "name": [
            "Program for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada", 
            "Department of Medicine, University of Ottawa, Ottawa, ON, Canada", 
            "Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Addison", 
        "givenName": "Christina L", 
        "id": "sg:person.01313721130.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313721130.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McMaster University", 
          "id": "https://www.grid.ac/institutes/grid.25073.33", 
          "name": [
            "Department of Oncology, McMaster University, Hamilton, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pond", 
        "givenName": "Gregory R", 
        "id": "sg:person.01251570265.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251570265.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Program for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Huijun", 
        "id": "sg:person.0640065212.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640065212.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Program for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mazzarello", 
        "givenName": "Sasha", 
        "id": "sg:person.0737376756.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737376756.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Program for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vandermeer", 
        "givenName": "Lisa", 
        "id": "sg:person.0761055556.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761055556.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Princess Margaret Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.415224.4", 
          "name": [
            "Princess Margaret Hospital, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goldstein", 
        "givenName": "Robyn", 
        "id": "sg:person.0732023453.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732023453.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Princess Margaret Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.415224.4", 
          "name": [
            "Princess Margaret Hospital, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amir", 
        "givenName": "Eitan", 
        "id": "sg:person.01272612235.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272612235.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ottawa", 
          "id": "https://www.grid.ac/institutes/grid.28046.38", 
          "name": [
            "Program for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada", 
            "Department of Medicine, University of Ottawa, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clemons", 
        "givenName": "Mark", 
        "id": "sg:person.01216107435.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216107435.90"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ctrv.2008.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003154829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3233/bd-2010-0327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006344494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602920", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008659528", 
          "https://doi.org/10.1038/sj.bjc.6602920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602920", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008659528", 
          "https://doi.org/10.1038/sj.bjc.6602920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002239900235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010878851", 
          "https://doi.org/10.1007/s002239900235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03256280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011840081", 
          "https://doi.org/10.1007/bf03256280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clon.2007.04.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013906210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1529-0131(200005)43:5<953::aid-anr1>3.0.co;2-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016013566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.23529", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016505598"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-010-0981-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016809613", 
          "https://doi.org/10.1007/s10549-010-0981-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-010-0981-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016809613", 
          "https://doi.org/10.1007/s10549-010-0981-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bonekey.2014.14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016969441", 
          "https://doi.org/10.1038/bonekey.2014.14"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1987.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017120378", 
          "https://doi.org/10.1038/bjc.1987.13"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1987.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017120378", 
          "https://doi.org/10.1038/bjc.1987.13"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.2010.05766.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019414937"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clon.2012.11.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021693674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/dji237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023556722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/dji237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023556722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-014-3015-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023620699", 
          "https://doi.org/10.1007/s10549-014-3015-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10585-006-9010-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025828666", 
          "https://doi.org/10.1007/s10585-006-9010-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10585-006-9010-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025828666", 
          "https://doi.org/10.1007/s10585-006-9010-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002230020042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026386817", 
          "https://doi.org/10.1007/s002230020042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(98)00277-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026546350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(02)00502-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029464121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(02)00502-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029464121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3747/co.19.1011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030497291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/s10165-011-0455-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030599753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jbspin.2007.01.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031712392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033862119", 
          "https://doi.org/10.1038/sj.bjc.6601437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033862119", 
          "https://doi.org/10.1038/sj.bjc.6601437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/coc.0b013e3182568f7a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035166159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/coc.0b013e3182568f7a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035166159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpainsymman.2008.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036416330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2000.2075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038602058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djt026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040244149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djt026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040244149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djt026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040244149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djt026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040244149"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-014-2906-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041087414", 
          "https://doi.org/10.1007/s10549-014-2906-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-014-2906-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041087414", 
          "https://doi.org/10.1007/s10549-014-2906-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2013.03.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041327882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1359/jbmr.2003.18.10.1789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042792593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(13)70174-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045489195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00316285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046839614", 
          "https://doi.org/10.1007/bf00316285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00316285", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046839614", 
          "https://doi.org/10.1007/bf00316285"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.1999.1012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048823579", 
          "https://doi.org/10.1054/bjoc.1999.1012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10165-011-0455-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052137198", 
          "https://doi.org/10.1007/s10165-011-0455-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.06.091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053718930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/13547500701676019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058382898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/154405910708601102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064058449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/154405910708601102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064058449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/edrv.22.6.0450", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064238557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.87.5.8512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064325226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074575202", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077684144", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083171551", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2014.32.18_suppl.lba9500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083398372"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "While de-escalation of bisphosphonates from 4 to 12-weekly dosing has been shown to be clinically non-inferior to standard dosing, there is evidence the de-escalation is associated with increased bone turnover biomarkers. Here we evaluated the effect of de-escalated dosing on a panel of biomarkers and determined their association with incidence of skeletal related events (SREs) in breast cancer patients with 'low risk' bone metastases. As part of a pilot randomized trial, women with baseline C-telopeptide levels <600 ng/L after >3 months of 3-4 weekly pamidronate were randomized to continue pamidronate every 4 weeks or de-escalation to 12-weekly treatment. Serum was analysed for bone biomarkers (C-telopeptide, N-telopeptide, bone-specific alkaline phosphatase, transforming growth factor-\u03b2, procollagen type 1 N-propeptide, activinA and bone sialoprotein) using ELISA. The associations between changes in biomarkers, pain scores and SREs were assessed by univariable logistic regression. Numerical increases in all biomarkers were observed between baseline and 12 weeks but were of higher magnitude in the de-escalated arm. Pain scores in the de-escalated treatment arm showed a greater magnitude of pain reduction from baseline to 12 weeks. Neither baseline levels nor changes in biomarkers from baseline to 12 weeks on treatment were associated with on study SREs. Baseline pain as measured by the FACT-BP was associated with increased risk of SRE. In conclusion, biomarkers of bone activity do not appear to predict for SREs in 'low risk' cohorts. However, baseline bone pain appears to be associated with SRE occurrence, a finding which warrants evaluation in larger cohorts. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/2193-1801-3-577", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1047790", 
        "issn": [
          "2193-1801"
        ], 
        "name": "SpringerPlus", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "name": "Effects of de-escalated bisphosphonate therapy on bone turnover biomarkers in breast cancer patients with bone metastases", 
    "pagination": "577", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2cebcaff5837f496cbe053b2505831c950bbe0d30c447ac23a5b98c871a7b2a7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25332877"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101597967"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/2193-1801-3-577"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1009429875"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/2193-1801-3-577", 
      "https://app.dimensions.ai/details/publication/pub.1009429875"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F2193-1801-3-577"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/2193-1801-3-577'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/2193-1801-3-577'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/2193-1801-3-577'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/2193-1801-3-577'


 

This table displays all metadata directly associated to this object as RDF triples.

268 TRIPLES      21 PREDICATES      72 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/2193-1801-3-577 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N94d62eb4652d41e1b72fbe44a70bea26
4 schema:citation sg:pub.10.1007/bf00316285
5 sg:pub.10.1007/bf03256280
6 sg:pub.10.1007/s002230020042
7 sg:pub.10.1007/s002239900235
8 sg:pub.10.1007/s10165-011-0455-2
9 sg:pub.10.1007/s10549-010-0981-1
10 sg:pub.10.1007/s10549-014-2906-x
11 sg:pub.10.1007/s10549-014-3015-6
12 sg:pub.10.1007/s10585-006-9010-5
13 sg:pub.10.1038/bjc.1987.13
14 sg:pub.10.1038/bonekey.2014.14
15 sg:pub.10.1038/sj.bjc.6601437
16 sg:pub.10.1038/sj.bjc.6602920
17 sg:pub.10.1054/bjoc.1999.1012
18 https://app.dimensions.ai/details/publication/pub.1074575202
19 https://app.dimensions.ai/details/publication/pub.1077684144
20 https://app.dimensions.ai/details/publication/pub.1083171551
21 https://doi.org/10.1002/1529-0131(200005)43:5<953::aid-anr1>3.0.co;2-q
22 https://doi.org/10.1002/cncr.23529
23 https://doi.org/10.1006/bbrc.2000.2075
24 https://doi.org/10.1016/j.clon.2007.04.007
25 https://doi.org/10.1016/j.clon.2012.11.004
26 https://doi.org/10.1016/j.ctrv.2008.05.001
27 https://doi.org/10.1016/j.ejphar.2013.03.034
28 https://doi.org/10.1016/j.jbspin.2007.01.039
29 https://doi.org/10.1016/j.jpainsymman.2008.08.005
30 https://doi.org/10.1016/s0959-8049(02)00502-6
31 https://doi.org/10.1016/s0959-8049(98)00277-9
32 https://doi.org/10.1016/s1470-2045(13)70174-8
33 https://doi.org/10.1080/13547500701676019
34 https://doi.org/10.1093/jnci/dji237
35 https://doi.org/10.1093/jnci/djt026
36 https://doi.org/10.1097/coc.0b013e3182568f7a
37 https://doi.org/10.1111/j.1749-6632.2010.05766.x
38 https://doi.org/10.1177/154405910708601102
39 https://doi.org/10.1200/jco.2005.06.091
40 https://doi.org/10.1200/jco.2014.32.18_suppl.lba9500
41 https://doi.org/10.1210/edrv.22.6.0450
42 https://doi.org/10.1210/jcem.87.5.8512
43 https://doi.org/10.1359/jbmr.2003.18.10.1789
44 https://doi.org/10.3109/s10165-011-0455-2
45 https://doi.org/10.3233/bd-2010-0327
46 https://doi.org/10.3747/co.19.1011
47 schema:datePublished 2014-12
48 schema:datePublishedReg 2014-12-01
49 schema:description While de-escalation of bisphosphonates from 4 to 12-weekly dosing has been shown to be clinically non-inferior to standard dosing, there is evidence the de-escalation is associated with increased bone turnover biomarkers. Here we evaluated the effect of de-escalated dosing on a panel of biomarkers and determined their association with incidence of skeletal related events (SREs) in breast cancer patients with 'low risk' bone metastases. As part of a pilot randomized trial, women with baseline C-telopeptide levels <600 ng/L after >3 months of 3-4 weekly pamidronate were randomized to continue pamidronate every 4 weeks or de-escalation to 12-weekly treatment. Serum was analysed for bone biomarkers (C-telopeptide, N-telopeptide, bone-specific alkaline phosphatase, transforming growth factor-β, procollagen type 1 N-propeptide, activinA and bone sialoprotein) using ELISA. The associations between changes in biomarkers, pain scores and SREs were assessed by univariable logistic regression. Numerical increases in all biomarkers were observed between baseline and 12 weeks but were of higher magnitude in the de-escalated arm. Pain scores in the de-escalated treatment arm showed a greater magnitude of pain reduction from baseline to 12 weeks. Neither baseline levels nor changes in biomarkers from baseline to 12 weeks on treatment were associated with on study SREs. Baseline pain as measured by the FACT-BP was associated with increased risk of SRE. In conclusion, biomarkers of bone activity do not appear to predict for SREs in 'low risk' cohorts. However, baseline bone pain appears to be associated with SRE occurrence, a finding which warrants evaluation in larger cohorts.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree true
53 schema:isPartOf N8c2f4b4926244f75b1f8c59c9e3330d1
54 Nc33187ad5983469c8bf426856f0b209a
55 sg:journal.1047790
56 schema:name Effects of de-escalated bisphosphonate therapy on bone turnover biomarkers in breast cancer patients with bone metastases
57 schema:pagination 577
58 schema:productId N28bc8258a5cf49c59fa16a2ad35212e8
59 N5914bfb5dcb940519794e7da318a31b6
60 N8eaa7a2a4f67422e8202eaf306979292
61 N907a9c76fd3c4b80bef1ee6f92dfd9b7
62 N9fb7842f501c41b481fa48a620c2b303
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009429875
64 https://doi.org/10.1186/2193-1801-3-577
65 schema:sdDatePublished 2019-04-10T22:31
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N26a918c9e3ab421e98e86e233478a6e3
68 schema:url http://link.springer.com/10.1186%2F2193-1801-3-577
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N25cc76791a584449a73e835f903bb0c2 rdf:first sg:person.01272612235.40
73 rdf:rest Nba3b80c81810437fb9eac3f309d28257
74 N26a918c9e3ab421e98e86e233478a6e3 schema:name Springer Nature - SN SciGraph project
75 rdf:type schema:Organization
76 N28bc8258a5cf49c59fa16a2ad35212e8 schema:name doi
77 schema:value 10.1186/2193-1801-3-577
78 rdf:type schema:PropertyValue
79 N49da24263cd3412baf7a0caedf837953 rdf:first sg:person.0732023453.28
80 rdf:rest N25cc76791a584449a73e835f903bb0c2
81 N4eaa96656d394b2498de078a3f3bb021 rdf:first sg:person.01251570265.35
82 rdf:rest N9648d0e1c1b74a99896107c3c26025b5
83 N5914bfb5dcb940519794e7da318a31b6 schema:name readcube_id
84 schema:value 2cebcaff5837f496cbe053b2505831c950bbe0d30c447ac23a5b98c871a7b2a7
85 rdf:type schema:PropertyValue
86 N876540a4fbff4d2d8f40aee62dd87264 rdf:first sg:person.0737376756.24
87 rdf:rest Na9b50413be154617bc7ecc9fa3a9e294
88 N8c2f4b4926244f75b1f8c59c9e3330d1 schema:volumeNumber 3
89 rdf:type schema:PublicationVolume
90 N8eaa7a2a4f67422e8202eaf306979292 schema:name pubmed_id
91 schema:value 25332877
92 rdf:type schema:PropertyValue
93 N907a9c76fd3c4b80bef1ee6f92dfd9b7 schema:name nlm_unique_id
94 schema:value 101597967
95 rdf:type schema:PropertyValue
96 N94d62eb4652d41e1b72fbe44a70bea26 rdf:first sg:person.01313721130.24
97 rdf:rest N4eaa96656d394b2498de078a3f3bb021
98 N9648d0e1c1b74a99896107c3c26025b5 rdf:first sg:person.0640065212.18
99 rdf:rest N876540a4fbff4d2d8f40aee62dd87264
100 N9fb7842f501c41b481fa48a620c2b303 schema:name dimensions_id
101 schema:value pub.1009429875
102 rdf:type schema:PropertyValue
103 Na9b50413be154617bc7ecc9fa3a9e294 rdf:first sg:person.0761055556.65
104 rdf:rest N49da24263cd3412baf7a0caedf837953
105 Nba3b80c81810437fb9eac3f309d28257 rdf:first sg:person.01216107435.90
106 rdf:rest rdf:nil
107 Nc33187ad5983469c8bf426856f0b209a schema:issueNumber 1
108 rdf:type schema:PublicationIssue
109 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
110 schema:name Medical and Health Sciences
111 rdf:type schema:DefinedTerm
112 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
113 schema:name Clinical Sciences
114 rdf:type schema:DefinedTerm
115 sg:journal.1047790 schema:issn 2193-1801
116 schema:name SpringerPlus
117 rdf:type schema:Periodical
118 sg:person.01216107435.90 schema:affiliation https://www.grid.ac/institutes/grid.28046.38
119 schema:familyName Clemons
120 schema:givenName Mark
121 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216107435.90
122 rdf:type schema:Person
123 sg:person.01251570265.35 schema:affiliation https://www.grid.ac/institutes/grid.25073.33
124 schema:familyName Pond
125 schema:givenName Gregory R
126 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251570265.35
127 rdf:type schema:Person
128 sg:person.01272612235.40 schema:affiliation https://www.grid.ac/institutes/grid.415224.4
129 schema:familyName Amir
130 schema:givenName Eitan
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272612235.40
132 rdf:type schema:Person
133 sg:person.01313721130.24 schema:affiliation https://www.grid.ac/institutes/grid.28046.38
134 schema:familyName Addison
135 schema:givenName Christina L
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313721130.24
137 rdf:type schema:Person
138 sg:person.0640065212.18 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
139 schema:familyName Zhao
140 schema:givenName Huijun
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640065212.18
142 rdf:type schema:Person
143 sg:person.0732023453.28 schema:affiliation https://www.grid.ac/institutes/grid.415224.4
144 schema:familyName Goldstein
145 schema:givenName Robyn
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732023453.28
147 rdf:type schema:Person
148 sg:person.0737376756.24 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
149 schema:familyName Mazzarello
150 schema:givenName Sasha
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737376756.24
152 rdf:type schema:Person
153 sg:person.0761055556.65 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
154 schema:familyName Vandermeer
155 schema:givenName Lisa
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761055556.65
157 rdf:type schema:Person
158 sg:pub.10.1007/bf00316285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046839614
159 https://doi.org/10.1007/bf00316285
160 rdf:type schema:CreativeWork
161 sg:pub.10.1007/bf03256280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011840081
162 https://doi.org/10.1007/bf03256280
163 rdf:type schema:CreativeWork
164 sg:pub.10.1007/s002230020042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026386817
165 https://doi.org/10.1007/s002230020042
166 rdf:type schema:CreativeWork
167 sg:pub.10.1007/s002239900235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010878851
168 https://doi.org/10.1007/s002239900235
169 rdf:type schema:CreativeWork
170 sg:pub.10.1007/s10165-011-0455-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052137198
171 https://doi.org/10.1007/s10165-011-0455-2
172 rdf:type schema:CreativeWork
173 sg:pub.10.1007/s10549-010-0981-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016809613
174 https://doi.org/10.1007/s10549-010-0981-1
175 rdf:type schema:CreativeWork
176 sg:pub.10.1007/s10549-014-2906-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041087414
177 https://doi.org/10.1007/s10549-014-2906-x
178 rdf:type schema:CreativeWork
179 sg:pub.10.1007/s10549-014-3015-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023620699
180 https://doi.org/10.1007/s10549-014-3015-6
181 rdf:type schema:CreativeWork
182 sg:pub.10.1007/s10585-006-9010-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025828666
183 https://doi.org/10.1007/s10585-006-9010-5
184 rdf:type schema:CreativeWork
185 sg:pub.10.1038/bjc.1987.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017120378
186 https://doi.org/10.1038/bjc.1987.13
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/bonekey.2014.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016969441
189 https://doi.org/10.1038/bonekey.2014.14
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/sj.bjc.6601437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033862119
192 https://doi.org/10.1038/sj.bjc.6601437
193 rdf:type schema:CreativeWork
194 sg:pub.10.1038/sj.bjc.6602920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008659528
195 https://doi.org/10.1038/sj.bjc.6602920
196 rdf:type schema:CreativeWork
197 sg:pub.10.1054/bjoc.1999.1012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048823579
198 https://doi.org/10.1054/bjoc.1999.1012
199 rdf:type schema:CreativeWork
200 https://app.dimensions.ai/details/publication/pub.1074575202 schema:CreativeWork
201 https://app.dimensions.ai/details/publication/pub.1077684144 schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1083171551 schema:CreativeWork
203 https://doi.org/10.1002/1529-0131(200005)43:5<953::aid-anr1>3.0.co;2-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1016013566
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1002/cncr.23529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016505598
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1006/bbrc.2000.2075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038602058
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.clon.2007.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013906210
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.clon.2012.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021693674
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.ctrv.2008.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003154829
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.ejphar.2013.03.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041327882
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.jbspin.2007.01.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031712392
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.jpainsymman.2008.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036416330
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/s0959-8049(02)00502-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029464121
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/s0959-8049(98)00277-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026546350
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s1470-2045(13)70174-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045489195
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1080/13547500701676019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058382898
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1093/jnci/dji237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023556722
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1093/jnci/djt026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040244149
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1097/coc.0b013e3182568f7a schema:sameAs https://app.dimensions.ai/details/publication/pub.1035166159
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1111/j.1749-6632.2010.05766.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019414937
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1177/154405910708601102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064058449
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1200/jco.2005.06.091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053718930
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1200/jco.2014.32.18_suppl.lba9500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083398372
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1210/edrv.22.6.0450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064238557
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1210/jcem.87.5.8512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064325226
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1359/jbmr.2003.18.10.1789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042792593
248 rdf:type schema:CreativeWork
249 https://doi.org/10.3109/s10165-011-0455-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030599753
250 rdf:type schema:CreativeWork
251 https://doi.org/10.3233/bd-2010-0327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006344494
252 rdf:type schema:CreativeWork
253 https://doi.org/10.3747/co.19.1011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030497291
254 rdf:type schema:CreativeWork
255 https://www.grid.ac/institutes/grid.25073.33 schema:alternateName McMaster University
256 schema:name Department of Oncology, McMaster University, Hamilton, Canada
257 rdf:type schema:Organization
258 https://www.grid.ac/institutes/grid.28046.38 schema:alternateName University of Ottawa
259 schema:name Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada
260 Department of Medicine, University of Ottawa, Ottawa, ON, Canada
261 Program for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada
262 rdf:type schema:Organization
263 https://www.grid.ac/institutes/grid.412687.e schema:alternateName Ottawa Hospital
264 schema:name Program for Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, ON, Canada
265 rdf:type schema:Organization
266 https://www.grid.ac/institutes/grid.415224.4 schema:alternateName Princess Margaret Cancer Centre
267 schema:name Princess Margaret Hospital, Toronto, ON, Canada
268 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...