HER-2 gene amplification in human breast cancer without concurrent HER-2 over-expression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-08-15

AUTHORS

Shiuh-Wen Luoh, Betsy Ramsey, Amy Hanlon Newell, Megan Troxell, Zhi Hu, Koei Chin, Paul Spellman, Susan Olson, Edward Keenan

ABSTRACT

BackgroundTesting for human epidermal growth factor receptor-2 (HER-2) in breast cancer is performed by either immunohistochemistry (IHC) or in situ hybridization (ISH). The growth factor receptor-bound protein-7 (GRB7) gene is in close proximity to HER-2 on chromosome 17q11-12 and codes a signal transduction molecule shown to be an independent adverse marker in breast cancer.MethodsHER-2 and GRB7 protein expression from 613 frozen breast tumors was determined by Western analysis. HER-2 protein results were confirmed with IHC. Commercial HER-2 FISH was performed on a subset of tumors with multi-probe FISH used to assess the extent of HER-2 gene amplification. mRNA expression was determined by Multi-plex RT-PCR.ResultsSeven tumors with GRB7 protein over-expression scored HER-2 FISH amplified but had no HER-2 protein over-expression. Four of the 7 tumors showed elevated GRB7 but not HER-2 mRNA over-expression. The breast cancer cell line HCC3153 did not over-express HER-2 protein but showed HER-2 FISH amplification of a limited segment around the HER-2 gene. Ten breast cancer tumors from the TCGA database had gene copy number increases around HER-2 without HER-2 mRNA or protein over-expression.ConclusionsA subset of human breast cancers that test positive with FISH for HER-2 gene amplification do not over-express HER-2 protein. One mechanism for this discordance is the incomplete amplification of the smallest HER-2 region of chromosome 17q11-12, which includes GRB7. HER-2 gene amplification without protein over-expression is clinically significant because patients with such tumors are unlikely to benefit from HER-2 targeted therapy. More... »

PAGES

386

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/2193-1801-2-386

DOI

http://dx.doi.org/10.1186/2193-1801-2-386

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006714472

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24102037


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Knight Cancer Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA", 
          "id": "http://www.grid.ac/institutes/grid.516136.6", 
          "name": [
            "Division of Hematology and Medical Oncology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, MC L586, 97239, Portland, OR, USA", 
            "Portland VA Medical Center, 3710 SW US Veterans Hospital Road, 97239, Portland, OR, USA", 
            "Knight Cancer Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luoh", 
        "givenName": "Shiuh-Wen", 
        "id": "sg:person.01063735317.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063735317.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Knight Cancer Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA", 
          "id": "http://www.grid.ac/institutes/grid.516136.6", 
          "name": [
            "Department of Physiology and Pharmacology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA", 
            "Knight Cancer Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ramsey", 
        "givenName": "Betsy", 
        "id": "sg:person.01051564616.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051564616.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular and Medical Genetics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA", 
          "id": "http://www.grid.ac/institutes/grid.5288.7", 
          "name": [
            "Department of Molecular and Medical Genetics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hanlon Newell", 
        "givenName": "Amy", 
        "id": "sg:person.0736122603.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736122603.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Knight Cancer Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA", 
          "id": "http://www.grid.ac/institutes/grid.516136.6", 
          "name": [
            "Department of Anatomic Pathology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA", 
            "Knight Cancer Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Troxell", 
        "givenName": "Megan", 
        "id": "sg:person.01164103247.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164103247.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "OHSU Department of Biomedical Engineering and Center for Spatial Systems Biomedicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA", 
          "id": "http://www.grid.ac/institutes/grid.5288.7", 
          "name": [
            "OHSU Department of Biomedical Engineering and Center for Spatial Systems Biomedicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "Zhi", 
        "id": "sg:person.014202717307.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014202717307.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "OHSU Department of Biomedical Engineering and Center for Spatial Systems Biomedicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA", 
          "id": "http://www.grid.ac/institutes/grid.5288.7", 
          "name": [
            "OHSU Department of Biomedical Engineering and Center for Spatial Systems Biomedicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chin", 
        "givenName": "Koei", 
        "id": "sg:person.0757703353.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757703353.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular and Medical Genetics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA", 
          "id": "http://www.grid.ac/institutes/grid.5288.7", 
          "name": [
            "Department of Molecular and Medical Genetics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spellman", 
        "givenName": "Paul", 
        "id": "sg:person.01064253031.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064253031.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Knight Cancer Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA", 
          "id": "http://www.grid.ac/institutes/grid.516136.6", 
          "name": [
            "Department of Molecular and Medical Genetics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA", 
            "Knight Cancer Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olson", 
        "givenName": "Susan", 
        "id": "sg:person.01210053773.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210053773.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Knight Cancer Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA", 
          "id": "http://www.grid.ac/institutes/grid.516136.6", 
          "name": [
            "Knight Cancer Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Keenan", 
        "givenName": "Edward", 
        "id": "sg:person.0673064116.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673064116.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10549-011-1822-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039135340", 
          "https://doi.org/10.1007/s10549-011-1822-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050596563", 
          "https://doi.org/10.1038/sj.onc.1205794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024942368", 
          "https://doi.org/10.1038/nature11412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr2568", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014945794", 
          "https://doi.org/10.1186/bcr2568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-010-1010-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003898733", 
          "https://doi.org/10.1007/s10549-010-1010-0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-08-15", 
    "datePublishedReg": "2013-08-15", 
    "description": "BackgroundTesting for human epidermal growth factor receptor-2 (HER-2) in breast cancer is performed by either immunohistochemistry (IHC) or in situ hybridization (ISH). The growth factor receptor-bound protein-7 (GRB7) gene is in close proximity to HER-2 on chromosome 17q11-12 and codes a signal transduction molecule shown to be an independent adverse marker in breast cancer.MethodsHER-2 and GRB7 protein expression from 613 frozen breast tumors was determined by Western analysis. HER-2 protein results were confirmed with IHC. Commercial HER-2 FISH was performed on a subset of tumors with multi-probe FISH used to assess the extent of HER-2 gene amplification. mRNA expression was determined by Multi-plex RT-PCR.ResultsSeven tumors with GRB7 protein over-expression scored HER-2 FISH amplified but had no HER-2 protein over-expression. Four of the 7 tumors showed elevated GRB7 but not HER-2 mRNA over-expression. The breast cancer cell line HCC3153 did not over-express HER-2 protein but showed HER-2 FISH amplification of a limited segment around the HER-2 gene. Ten breast cancer tumors from the TCGA database had gene copy number increases around HER-2 without HER-2 mRNA or protein over-expression.ConclusionsA subset of human breast cancers that test positive with FISH for HER-2 gene amplification do not over-express HER-2 protein. One mechanism for this discordance is the incomplete amplification of the smallest HER-2 region of chromosome 17q11-12, which includes GRB7. HER-2 gene amplification without protein over-expression is clinically significant because patients with such tumors are unlikely to benefit from HER-2 targeted therapy.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/2193-1801-2-386", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1047790", 
        "issn": [
          "2193-1801"
        ], 
        "name": "SpringerPlus", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "keywords": [
      "chromosome 17q11", 
      "gene amplification", 
      "signal transduction molecules", 
      "Grb7 protein expression", 
      "protein 7 gene", 
      "gene copy number", 
      "Grb7 protein", 
      "human breast cancer", 
      "transduction molecules", 
      "protein results", 
      "copy number", 
      "Western analysis", 
      "protein", 
      "fish", 
      "situ hybridization", 
      "protein expression", 
      "Grb7", 
      "genes", 
      "TCGA database", 
      "expression", 
      "frozen breast tumors", 
      "subset of tumors", 
      "RT-PCR", 
      "mRNA", 
      "amplification", 
      "mRNA expression", 
      "HER-2 gene", 
      "growth factor receptor 2", 
      "factor receptor 2", 
      "receptor 2", 
      "HER-2 protein", 
      "close proximity", 
      "human epidermal growth factor receptor 2", 
      "incomplete amplification", 
      "hybridization", 
      "breast cancer tumors", 
      "breast cancer", 
      "cancer tumors", 
      "cancer", 
      "breast tumors", 
      "limited segment", 
      "immunohistochemistry", 
      "markers", 
      "subset", 
      "epidermal growth factor receptor 2", 
      "molecules", 
      "mechanism", 
      "FISH amplification", 
      "region", 
      "tumors", 
      "proximity", 
      "discordance", 
      "segments", 
      "analysis", 
      "number", 
      "extent", 
      "database", 
      "such tumors", 
      "results", 
      "adverse marker", 
      "therapy", 
      "code", 
      "patients", 
      "ConclusionsA subset"
    ], 
    "name": "HER-2 gene amplification in human breast cancer without concurrent HER-2 over-expression", 
    "pagination": "386", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1006714472"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/2193-1801-2-386"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24102037"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/2193-1801-2-386", 
      "https://app.dimensions.ai/details/publication/pub.1006714472"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_606.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/2193-1801-2-386"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/2193-1801-2-386'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/2193-1801-2-386'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/2193-1801-2-386'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/2193-1801-2-386'


 

This table displays all metadata directly associated to this object as RDF triples.

210 TRIPLES      21 PREDICATES      94 URIs      81 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/2193-1801-2-386 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nbd6bd18b6df14f12ab62f4f7fdde6599
4 schema:citation sg:pub.10.1007/s10549-010-1010-0
5 sg:pub.10.1007/s10549-011-1822-6
6 sg:pub.10.1038/nature11412
7 sg:pub.10.1038/sj.onc.1205794
8 sg:pub.10.1186/bcr2568
9 schema:datePublished 2013-08-15
10 schema:datePublishedReg 2013-08-15
11 schema:description BackgroundTesting for human epidermal growth factor receptor-2 (HER-2) in breast cancer is performed by either immunohistochemistry (IHC) or in situ hybridization (ISH). The growth factor receptor-bound protein-7 (GRB7) gene is in close proximity to HER-2 on chromosome 17q11-12 and codes a signal transduction molecule shown to be an independent adverse marker in breast cancer.MethodsHER-2 and GRB7 protein expression from 613 frozen breast tumors was determined by Western analysis. HER-2 protein results were confirmed with IHC. Commercial HER-2 FISH was performed on a subset of tumors with multi-probe FISH used to assess the extent of HER-2 gene amplification. mRNA expression was determined by Multi-plex RT-PCR.ResultsSeven tumors with GRB7 protein over-expression scored HER-2 FISH amplified but had no HER-2 protein over-expression. Four of the 7 tumors showed elevated GRB7 but not HER-2 mRNA over-expression. The breast cancer cell line HCC3153 did not over-express HER-2 protein but showed HER-2 FISH amplification of a limited segment around the HER-2 gene. Ten breast cancer tumors from the TCGA database had gene copy number increases around HER-2 without HER-2 mRNA or protein over-expression.ConclusionsA subset of human breast cancers that test positive with FISH for HER-2 gene amplification do not over-express HER-2 protein. One mechanism for this discordance is the incomplete amplification of the smallest HER-2 region of chromosome 17q11-12, which includes GRB7. HER-2 gene amplification without protein over-expression is clinically significant because patients with such tumors are unlikely to benefit from HER-2 targeted therapy.
12 schema:genre article
13 schema:isAccessibleForFree true
14 schema:isPartOf Nb7c6eac83ab84f60a23fdac447d3b894
15 Nd73851dfdeed49e6969467b970a2fb31
16 sg:journal.1047790
17 schema:keywords ConclusionsA subset
18 FISH amplification
19 Grb7
20 Grb7 protein
21 Grb7 protein expression
22 HER-2 gene
23 HER-2 protein
24 RT-PCR
25 TCGA database
26 Western analysis
27 adverse marker
28 amplification
29 analysis
30 breast cancer
31 breast cancer tumors
32 breast tumors
33 cancer
34 cancer tumors
35 chromosome 17q11
36 close proximity
37 code
38 copy number
39 database
40 discordance
41 epidermal growth factor receptor 2
42 expression
43 extent
44 factor receptor 2
45 fish
46 frozen breast tumors
47 gene amplification
48 gene copy number
49 genes
50 growth factor receptor 2
51 human breast cancer
52 human epidermal growth factor receptor 2
53 hybridization
54 immunohistochemistry
55 incomplete amplification
56 limited segment
57 mRNA
58 mRNA expression
59 markers
60 mechanism
61 molecules
62 number
63 patients
64 protein
65 protein 7 gene
66 protein expression
67 protein results
68 proximity
69 receptor 2
70 region
71 results
72 segments
73 signal transduction molecules
74 situ hybridization
75 subset
76 subset of tumors
77 such tumors
78 therapy
79 transduction molecules
80 tumors
81 schema:name HER-2 gene amplification in human breast cancer without concurrent HER-2 over-expression
82 schema:pagination 386
83 schema:productId N0fe4ee8c2d4444e38cf24d6fc2fb65fa
84 N9931bebf21484698b889d86300ca95b8
85 Nf65c2f396b6a40798c8f3767eaa1011a
86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006714472
87 https://doi.org/10.1186/2193-1801-2-386
88 schema:sdDatePublished 2022-12-01T06:31
89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
90 schema:sdPublisher Ncf452df5f6f64fd8a102d60d01bb67f4
91 schema:url https://doi.org/10.1186/2193-1801-2-386
92 sgo:license sg:explorer/license/
93 sgo:sdDataset articles
94 rdf:type schema:ScholarlyArticle
95 N0fe4ee8c2d4444e38cf24d6fc2fb65fa schema:name pubmed_id
96 schema:value 24102037
97 rdf:type schema:PropertyValue
98 N15a54d56ac0340edb816b15df80ada52 rdf:first sg:person.01164103247.95
99 rdf:rest Na60d3bb675d04c78b4bcbf38c4cb1025
100 N1aec5686a2c9483b853b6a9e31e946dd rdf:first sg:person.0736122603.34
101 rdf:rest N15a54d56ac0340edb816b15df80ada52
102 N4a95df0518094fb2a2cefc207415b7e0 rdf:first sg:person.0673064116.02
103 rdf:rest rdf:nil
104 N9931bebf21484698b889d86300ca95b8 schema:name doi
105 schema:value 10.1186/2193-1801-2-386
106 rdf:type schema:PropertyValue
107 Na60d3bb675d04c78b4bcbf38c4cb1025 rdf:first sg:person.014202717307.43
108 rdf:rest Ned07592bbd424a84a78a3fb6a0caa2aa
109 Nb7c6eac83ab84f60a23fdac447d3b894 schema:volumeNumber 2
110 rdf:type schema:PublicationVolume
111 Nbd6bd18b6df14f12ab62f4f7fdde6599 rdf:first sg:person.01063735317.71
112 rdf:rest Nc3dd81aed88a474cbaf4596c47776de6
113 Nc3dd81aed88a474cbaf4596c47776de6 rdf:first sg:person.01051564616.14
114 rdf:rest N1aec5686a2c9483b853b6a9e31e946dd
115 Nc84b2d37f0644385b376ca33035ae2b1 rdf:first sg:person.01210053773.27
116 rdf:rest N4a95df0518094fb2a2cefc207415b7e0
117 Ncf452df5f6f64fd8a102d60d01bb67f4 schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 Nd73851dfdeed49e6969467b970a2fb31 schema:issueNumber 1
120 rdf:type schema:PublicationIssue
121 Ned07592bbd424a84a78a3fb6a0caa2aa rdf:first sg:person.0757703353.54
122 rdf:rest Nfb3e214eb85840a0aa3f083c67eab72a
123 Nf65c2f396b6a40798c8f3767eaa1011a schema:name dimensions_id
124 schema:value pub.1006714472
125 rdf:type schema:PropertyValue
126 Nfb3e214eb85840a0aa3f083c67eab72a rdf:first sg:person.01064253031.26
127 rdf:rest Nc84b2d37f0644385b376ca33035ae2b1
128 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
129 schema:name Medical and Health Sciences
130 rdf:type schema:DefinedTerm
131 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
132 schema:name Oncology and Carcinogenesis
133 rdf:type schema:DefinedTerm
134 sg:journal.1047790 schema:issn 2193-1801
135 schema:name SpringerPlus
136 schema:publisher Springer Nature
137 rdf:type schema:Periodical
138 sg:person.01051564616.14 schema:affiliation grid-institutes:grid.516136.6
139 schema:familyName Ramsey
140 schema:givenName Betsy
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051564616.14
142 rdf:type schema:Person
143 sg:person.01063735317.71 schema:affiliation grid-institutes:grid.516136.6
144 schema:familyName Luoh
145 schema:givenName Shiuh-Wen
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063735317.71
147 rdf:type schema:Person
148 sg:person.01064253031.26 schema:affiliation grid-institutes:grid.5288.7
149 schema:familyName Spellman
150 schema:givenName Paul
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064253031.26
152 rdf:type schema:Person
153 sg:person.01164103247.95 schema:affiliation grid-institutes:grid.516136.6
154 schema:familyName Troxell
155 schema:givenName Megan
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164103247.95
157 rdf:type schema:Person
158 sg:person.01210053773.27 schema:affiliation grid-institutes:grid.516136.6
159 schema:familyName Olson
160 schema:givenName Susan
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210053773.27
162 rdf:type schema:Person
163 sg:person.014202717307.43 schema:affiliation grid-institutes:grid.5288.7
164 schema:familyName Hu
165 schema:givenName Zhi
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014202717307.43
167 rdf:type schema:Person
168 sg:person.0673064116.02 schema:affiliation grid-institutes:grid.516136.6
169 schema:familyName Keenan
170 schema:givenName Edward
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673064116.02
172 rdf:type schema:Person
173 sg:person.0736122603.34 schema:affiliation grid-institutes:grid.5288.7
174 schema:familyName Hanlon Newell
175 schema:givenName Amy
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736122603.34
177 rdf:type schema:Person
178 sg:person.0757703353.54 schema:affiliation grid-institutes:grid.5288.7
179 schema:familyName Chin
180 schema:givenName Koei
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757703353.54
182 rdf:type schema:Person
183 sg:pub.10.1007/s10549-010-1010-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003898733
184 https://doi.org/10.1007/s10549-010-1010-0
185 rdf:type schema:CreativeWork
186 sg:pub.10.1007/s10549-011-1822-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039135340
187 https://doi.org/10.1007/s10549-011-1822-6
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/nature11412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024942368
190 https://doi.org/10.1038/nature11412
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/sj.onc.1205794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050596563
193 https://doi.org/10.1038/sj.onc.1205794
194 rdf:type schema:CreativeWork
195 sg:pub.10.1186/bcr2568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014945794
196 https://doi.org/10.1186/bcr2568
197 rdf:type schema:CreativeWork
198 grid-institutes:grid.516136.6 schema:alternateName Knight Cancer Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA
199 schema:name Department of Anatomic Pathology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA
200 Department of Molecular and Medical Genetics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA
201 Department of Physiology and Pharmacology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA
202 Division of Hematology and Medical Oncology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, MC L586, 97239, Portland, OR, USA
203 Knight Cancer Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA
204 Portland VA Medical Center, 3710 SW US Veterans Hospital Road, 97239, Portland, OR, USA
205 rdf:type schema:Organization
206 grid-institutes:grid.5288.7 schema:alternateName Department of Molecular and Medical Genetics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA
207 OHSU Department of Biomedical Engineering and Center for Spatial Systems Biomedicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA
208 schema:name Department of Molecular and Medical Genetics, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA
209 OHSU Department of Biomedical Engineering and Center for Spatial Systems Biomedicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, 97239, Portland, OR, USA
210 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...