Characterization of hepatic tumors using [11C]metomidate through positron emission tomography: comparison with [11C]acetate View Full Text


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Article Info

DATE

2013-02-27

AUTHORS

Anne Roivainen, Alexandru Naum, Heikki Nuutinen, Rauli Leino, Heimo Nurmi, Kjell Någren, Riitta Parkkola, Johanna Virtanen, Markku Kallajoki, Harry Kujari, Jari Ovaska, Peter Roberts, Marko Seppänen

ABSTRACT

BACKGROUND: Using positron emission tomography (PET), we compared two tracers, [11C]metomidate ([11C]MTO) and [11C]acetate ([11C]ACE), for the characterization of hepatic tumors. METHODS: Thirty-three patients underwent PET with [11C]MTO and [11C]ACE and magnetic resonance imaging (MRI). Based on the histology of the tumor biopsy, 14 patients had hepatocellular carcinoma (HCC), 9 patients had focal nodular hyperplasia (FNH), and 10 patients had other types of hepatic tumors. Tumor uptake was evaluated by calculating the maximum and mean standardized uptake value and tumor-to-liver ratio. RESULTS: Altogether, 120 hepatic lesions (59 HCC, 18 FNH, 30 metastases of different primaries, 9 adenomas, and 4 regenerating nodules of liver cirrhosis) were detected by MRI. The overall tumor detection rate was slightly higher for [11C]MTO (39%) than for [11C]ACE (33%). [11C]ACE was more sensitive for HCC detection (50% versus 43%, respectively), whereas [11C]MTO was more sensitive for FNH detection (78% versus 44%, respectively). In HCC patients, the tumor grade correlated with [11C]ACE, but not with [11C]MTO. All of the patients with liver metastases, from various primary tumors (n = 10), were negative for both tracers. CONCLUSIONS: Due to low sensitivity, [11C]MTO and [11C]ACE PET have only limited value in diagnosing hepatic tumors. More... »

PAGES

13-13

References to SciGraph publications

  • 2008-03-13. PET imaging with 11C-acetate in prostate cancer: a biochemical, radiochemical and clinical perspective in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2011-05-07. The potential use of 2-[18F]fluoro-2-deoxy-D-galactose as a PET/CT tracer for detection of hepatocellular carcinoma in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 1999-11-01. Fluorine-18 FDG positron emission tomography for imaging of hepatocellular carcinoma in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/2191-219x-3-13

    DOI

    http://dx.doi.org/10.1186/2191-219x-3-13

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023006175

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23442595


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