SUVref: reducing reconstruction-dependent variation in PET SUV View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-08-18

AUTHORS

Matthew D Kelly, Jerome M Declerck

ABSTRACT

BackgroundWe propose a new methodology, reference Standardised Uptake Value (SUVref), for reducing the quantitative variation resulting from differences in reconstruction protocol. Such variation that is not directly addressed by the use of SUV or the recently proposed PERCIST can impede comparability between positron emission tomography (PET)/CT scans.MethodsSUVref applies a reconstruction-protocol-specific phantom-optimised filter to clinical PET scans for the purpose of improving comparability of quantification. The ability of this filter to reduce variability due to differences in reconstruction protocol was assessed using both phantom and clinical data.ResultsSUVref reduced the variability between recovery coefficients measured with the NEMA image quality phantom across a range of reconstruction protocols to below that measured for a single reconstruction protocol. In addition, it enabled quantitative conformance to the recently proposed EANM guidelines. For the clinical data, a significant reduction in bias and variance in the distribution of differences in SUV, resulting from differences in reconstruction protocol, greatly reduced the number of hot spots that would be misclassified as undergoing a clinically significant change in SUV.ConclusionsSUVref significantly reduces reconstruction-dependent variation in SUV measurements, enabling increased confidence in quantitative comparison of clinical images for monitoring treatment response or disease progression. This new methodology could be similarly applied to reduce variability from scanner hardware. More... »

PAGES

16

References to SciGraph publications

  • 2008-08-15. The Netherlands protocol for standardisation and quantification of FDG whole body PET studies in multi-centre trials in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • 2009-11-14. FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0 in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/2191-219x-1-16

    DOI

    http://dx.doi.org/10.1186/2191-219x-1-16

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1025107920

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22214348


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