Role of biomarkers in the management of antibiotic therapy: an expert panel review: I – currently available biomarkers for clinical ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-07-09

AUTHORS

Anne-Marie Dupuy, François Philippart, Yves Péan, Sigismond Lasocki, Pierre-Emmanuel Charles, Martin Chalumeau, Yann-Eric Claessens, Jean-Pierre Quenot, Christele Gras-Le Guen, Stéphanie Ruiz, Charles-Edouard Luyt, Nicolas Roche, Jean-Paul Stahl, Jean-Pierre Bedos, Jérôme Pugin, Rémy Gauzit, Benoit Misset, Christian Brun-Buisson, for the Maurice Rapin Institute Biomarkers Group

ABSTRACT

In the context of worldwide increasing antimicrobial resistance, good antimicrobial prescribing in more needed than ever; unfortunately, information available to clinicians often are insufficient to rely on. Biomarkers might provide help for decision-making and improve antibiotic management. The purpose of this expert panel review was to examine currently available literature on the potential role of biomarkers to improve antimicrobial prescribing, by answering three questions: 1) Which are the biomarkers available for this purpose?; 2) What is their potential role in the initiation of antibiotic therapy?; and 3) What is their role in the decision to stop antibiotic therapy? To answer these questions, studies reviewed were limited to recent clinical studies (<15 years), involving a substantial number of patients (>50) and restricted to controlled trials and meta-analyses for answering questions 2 and 3. With regard to the first question concerning routinely available biomarkers, which might be useful for antibiotic management of acute infections, these are currently limited to C-reactive protein (CRP) and procalcitonin (PCT). Other promising biomarkers that may prove useful in the near future but need to undergo more extensive clinical testing include sTREM-1, suPAR, ProADM, and Presepsin. New approaches to biomarkers of infections include point-of-care testing and genomics. More... »

PAGES

22

Journal

TITLE

Annals of Intensive Care

ISSUE

1

VOLUME

3

Author Affiliations

  • Département de Biochimie, Hopital Lapeyronie CHU Montpellier, France, 371, avenue du doyen Gaston Giraud, 34295, Cédex 5, Montpellier, France
  • Service de Réanimation polyvalente, Groupe hospitalier Paris Saint Joseph, 185 rue Raymond Losserand, 75014, Paris, France
  • Laboratoire de Microbiologie, Institut Mutualiste Montsouris, 42, Bld Jourdan, 75014, Paris, France
  • Pôle d’Anesthésie Réanimation, CHU d’Angers, 4 rue Larrey, 49933 Angers, Cedex 9, Angers, France
  • Laboratoire Interactions Muqueuses Agents Pathogènes, EA562, UFR Médecine, Université de Bourgogne, 7 Bd Jeanne d’Arc, 21000, Dijon, France
  • Inserm, U953, Paris, France
  • Département d’Urgences Médicales, Centre Hospitalier Princesse Grace, 1 avenue Pasteur, BP 489, 98012, Principauté de, Monaco
  • Centre d’investigation clinique (INSERM CIE 1), 7 Boulevard Jeanne d’Arc, 21079, Dijon, France
  • Clinique Médicale et Service d’Urgences Pédiatriques, Hôpital Mère-Enfant, CHU Nantes, 38 boulevard Jean-Monnet, 44093, cedex 1, Nantes, France
  • Pôle d’Anesthésie-Réanimation, Hôpital de Rangueil, CHU de Toulouse, 1, Ave Pr Jean Poulhès, TSA 50032, 31059, Cedex 9, Toulouse, France
  • Service de Réanimation Médicale, Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, AP-HP & Université Pierre et Marie Curie - Paris VI, 4783,– boulevard de l’Hôpital, 75651, Cedex 13, Paris, France
  • Service de Pneumologie et Soins Intensifs Respiratoires, Hôpitaux Universitaires Paris Centre, AP-HP & Université Paris-Descartes, 27 rue du fbg St Jacques, 75679, Paris, France
  • Service de maladies infectieuses et tropicales, Université 1 de Grenoble, CHU de Grenoble, BP 217, Boulevard de la Chantourne, 38043, Grenoble, France
  • Service de réanimation, Centre hospitalier de Versailles, 177, rue de Versailles, 78150, Le Chesnay, France
  • Intensive Care - SIRS Unit, University Hospitals of Geneva, 4 rue Gabrielle Perret-Gentil, 1211, Geneva 14, Switzerland
  • Unité de réanimation, CHU Hôtel Dieu, AP-HP, Place du Parvis-de-Notre-Dame, 75004, Paris, France
  • Centre de Recherche Clinique, Groupe hospitalier Paris Saint Joseph & Université Paris Descartes, 75014, Paris, France
  • Inserm U957, Institut Pasteur, Paris, France
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/2110-5820-3-22

    DOI

    http://dx.doi.org/10.1186/2110-5820-3-22

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013923556

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23837559


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