Role of biomarkers in the management of antibiotic therapy: an expert panel review II: clinical use of biomarkers for initiation ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-07-08

AUTHORS

Jean-Pierre Quenot, Charles-Edouard Luyt, Nicolas Roche, Martin Chalumeau, Pierre-Emmanuel Charles, Yann-Eric Claessens, Sigismond Lasocki, Jean-Pierre Bedos, Yves Péan, François Philippart, Stéphanie Ruiz, Christele Gras-Leguen, Anne-Marie Dupuy, Jérôme Pugin, Jean-Paul Stahl, Benoit Misset, Rémy Gauzit, Christian Brun-Buisson

ABSTRACT

Biomarker-guided initiation of antibiotic therapy has been studied in four conditions: acute pancreatitis, lower respiratory tract infection (LRTI), meningitis, and sepsis in the ICU. In pancreatitis with suspected infected necrosis, initiating antibiotics best relies on fine-needle aspiration and demonstration of infected material. We suggest that PCT be measured to help predict infection; however, available data are insufficient to decide on initiating antibiotics based on PCT levels. In adult patients suspected of community-acquired LRTI, we suggest withholding antibiotic therapy when the serum PCT level is low (<0.25 ng/mL); in patients having nosocomial LRTI, data are insufficient to recommend initiating therapy based on a single PCT level or even repeated measurements. For children with suspected bacterial meningitis, we recommend using a decision rule as an aid to therapeutic decisions, such as the Bacterial Meningitis Score or the Meningitest®; a single PCT level ≥0.5 ng/mL also may be used, but false-negatives may occur. In adults with suspected bacterial meningitis, we suggest integrating serum PCT measurements in a clinical decision rule to help distinguish between viral and bacterial meningitis, using a 0.5 ng/mL threshold. For ICU patients suspected of community-acquired infection, we do not recommend using a threshold serum PCT value to help the decision to initiate antibiotic therapy; data are insufficient to recommend using PCT serum kinetics for the decision to initiate antibiotic therapy in patients suspected of ICU-acquired infection. In children, CRP can probably be used to help discontinue therapy, although the evidence is limited. In adults, antibiotic discontinuation can be based on an algorithm using repeated PCT measurements. In non-immunocompromised out- or in- patients treated for RTI, antibiotics can be discontinued if the PCT level at day 3 is < 0.25 ng/mL or has decreased by >80-90%, whether or not microbiological documentation has been obtained. For ICU patients who have nonbacteremic sepsis from a known site of infection, antibiotics can be stopped if the PCT level at day 3 is < 0.5 ng/mL or has decreased by >80% relative to the highest level recorded, irrespective of the severity of the infectious episode; in bacteremic patients, a minimal duration of therapy of 5 days is recommended. More... »

PAGES

21

References to SciGraph publications

  • 2008-11-26. Procalcitonin (PCT)-guided algorithm reduces length of antibiotic treatment in surgical intensive care patients with severe sepsis: results of a prospective randomized study in LANGENBECK'S ARCHIVES OF SURGERY
  • 2000-02. The clinical value of procalcitonin in the prediction of infected necrois in acute pancreatitis in INTENSIVE CARE MEDICINE
  • 2006-08-16. Does Serum Procalcitonin Have a Role in Evaluating the Severity of Acute Pancreatitis? A Question Revisited in WORLD JOURNAL OF SURGERY
  • 2000-07. Prospective Validation of a Diagnosis Model as an Aid to Therapeutic Decision-Making in Acute Meningitis in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2009-04-22. Serum procalcitonin for the early recognition of nosocomial infection in the critically ill patients: a preliminary report in BMC INFECTIOUS DISEASES
  • 2011-06-06. Meningitis in adult patients with a negative direct cerebrospinal fluid examination: value of cytochemical markers for differential diagnosis in CRITICAL CARE
  • 1995-04. Multivariate approach to differential diagnosis of acute meningitis in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • 2000-03-01. The Clinical Value of Procalcitonin in the Prediction of Infected Necrois in Acute Pancreatitis in INTENSIVE CARE MEDICINE
  • 2012-10-08. Procalcitonin and procalcitonin kinetics for diagnosis and prognosis of intravascular catheter-related bloodstream infections in selected critically ill patients: a prospective observational study in BMC INFECTIOUS DISEASES
  • 2005-08-18. Procalcitonin-guided antibiotic use versus a standard approach for acute respiratory tract infections in primary care: study protocol for a randomised controlled trial and baseline characteristics of participating general practitioners [ISRCTN73182671] in BMC PRIMARY CARE
  • 2009-06-03. Procalcitonin to guide duration of antibiotic therapy in intensive care patients: a randomized prospective controlled trial in CRITICAL CARE
  • 2004-12-17. Pro-atrial natriuretic peptide is a prognostic marker in sepsis, similar to the APACHE II score: an observational study in CRITICAL CARE
  • 2000-08. Diagnostic relevance of procalcitonin, IL-6, and sICAM-1 in the prediction of infected necrosis in acute pancreatitis in JOURNAL OF GASTROINTESTINAL CANCER
  • 2007-03-29. Improving management of patients with acute cough by C-reactive protein point of care testing and communication training (IMPAC3T): study protocol of a cluster randomised controlled trial in BMC PRIMARY CARE
  • 2011-10-27. Soluble triggering receptor expressed on myeloid cells in severe acute pancreatitis: a biological marker of infected necrosis in INTENSIVE CARE MEDICINE
  • Journal

    TITLE

    Annals of Intensive Care

    ISSUE

    1

    VOLUME

    3

    Author Affiliations

  • Centre d’investigation clinique, INSERM CIE 1, 7 Boulevard Jeanne d’Arc, 21079, Dijon, France
  • Service de Réanimation Médicale, Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Université Pierre et Marie Curie - Paris VI, 47-83 boulevard de l'Hôpital, Cedex 13, 75651, Paris, France
  • Service de Pneumologie et Soins Intensifs Respiratoires, Hôpitaux Universitaires Paris Centre, AP-HP & Université Paris-Descartes, 27 rue du fbg St Jacques, 75679, Paris, France
  • Inserm U953, Paris, France
  • Laboratoire Interactions Muqueuses Agents Pathogènes, EA562, UFR Médecine, Université de Bourgogne, 7 Bd Jeanne d'Arc, 21000, Dijon, France
  • Département d’Urgences Médicales, Centre Hospitalier Princesse Grace, 1 ave Pasteur, BP 489, 98012, Principauté de Monaco, Monaco
  • Pôle d'Anesthésie Réanimation, CHU d’Angers, 4 rue Larrey, 49933 Cedex 9, Angers, France
  • Service de réanimation, Centre hospitalier de Versailles, 177, rue de Versailles, 78150, Le Chesnay, France
  • Laboratoire de Microbiologie, Institut Mutualiste Montsouris, 42, Bld Jourdan, 75014, Paris, France
  • Service de réanimation polyvalente, Groupe hospitalier Paris Saint Joseph, 185 rue Raymond Losserand, 75014, Paris, France
  • Pôle d'Anesthésie-Réanimation, Hôpital de Rangueil, CHU de Toulouse, 1, Ave Pr Jean Poulhès, TSA 50032, Cedex 9, 31059, Toulouse, France
  • Clinique Médicale et Service d'Urgences Pédiatriques, Hôpital Mère-Enfant, CHU Nantes, 38 boulevard Jean-Monnet, 44093, cedex 1, Nantes, France
  • Département de Biochimie, Hopital Lapeyronie, CHU Montpellier, 371, avenue du doyen Gaston Giraud, Cédex 5, 34295, Montpellier, France
  • Intensive Care - SIRS Unit, University Hospitals of Geneva, 4 rue Gabrielle Perret-Gentil, 1211, Geneva 14, Switzerland
  • Service de maladies infectieuses et tropicales, Université 1 de Grenoble, CHU de Grenoble, BP 217, Boulevard de la Chantourne, 38043, Grenoble, France
  • Centre de Recherche Clinique, Groupe hospitalier Paris Saint Joseph, Université Paris Descartes, 185 rue Raymond Losserand, 75014, Paris, France
  • Unité de réanimation, CHU Hôtel Dieu, AP-HP, Place du Parvis-de-Notre-Dame, 75004, Paris, France
  • Inserm U957, Institut Pasteur, France, Paris
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/2110-5820-3-21

    DOI

    http://dx.doi.org/10.1186/2110-5820-3-21

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007570782

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23830525


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Microbiology", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Centre d\u2019investigation clinique, INSERM CIE 1, 7 Boulevard Jeanne d\u2019Arc, 21079, Dijon, France", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Service de r\u00e9animation m\u00e9dicale, CHU Dijon & Universit\u00e9 de Bourgogne, 14 rue Paul Gaffarel, 21970, Dijon, France", 
                "Centre d\u2019investigation clinique, INSERM CIE 1, 7 Boulevard Jeanne d\u2019Arc, 21079, Dijon, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Quenot", 
            "givenName": "Jean-Pierre", 
            "id": "sg:person.0667156247.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667156247.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Service de R\u00e9animation M\u00e9dicale, Institut de Cardiologie, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Universit\u00e9 Pierre et Marie Curie - Paris VI, 47-83 boulevard de l'H\u00f4pital, Cedex 13, 75651, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.462844.8", 
              "name": [
                "Service de R\u00e9animation M\u00e9dicale, Institut de Cardiologie, Groupe Hospitalier Piti\u00e9-Salp\u00eatri\u00e8re, AP-HP, Universit\u00e9 Pierre et Marie Curie - Paris VI, 47-83 boulevard de l'H\u00f4pital, Cedex 13, 75651, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Luyt", 
            "givenName": "Charles-Edouard", 
            "id": "sg:person.01310337776.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310337776.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Service de Pneumologie et Soins Intensifs Respiratoires, H\u00f4pitaux Universitaires Paris Centre, AP-HP & Universit\u00e9 Paris-Descartes, 27 rue du fbg St Jacques, 75679, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.508487.6", 
              "name": [
                "Service de Pneumologie et Soins Intensifs Respiratoires, H\u00f4pitaux Universitaires Paris Centre, AP-HP & Universit\u00e9 Paris-Descartes, 27 rue du fbg St Jacques, 75679, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Roche", 
            "givenName": "Nicolas", 
            "id": "sg:person.01222526046.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222526046.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Inserm U953, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.7429.8", 
              "name": [
                "Service de P\u00e9diatrie G\u00e9n\u00e9rale, CHU Necker-Enfants Malades, AP-HP, Universit\u00e9 Paris Descartes, 149 rue de S\u00e8vres, 75743, Paris, France", 
                "Inserm U953, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chalumeau", 
            "givenName": "Martin", 
            "id": "sg:person.01253161505.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253161505.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratoire Interactions Muqueuses Agents Pathog\u00e8nes, EA562, UFR M\u00e9decine, Universit\u00e9 de Bourgogne, 7 Bd Jeanne d'Arc, 21000, Dijon, France", 
              "id": "http://www.grid.ac/institutes/grid.5613.1", 
              "name": [
                "Service de r\u00e9animation m\u00e9dicale, CHU Dijon & Universit\u00e9 de Bourgogne, 14 rue Paul Gaffarel, 21970, Dijon, France", 
                "Laboratoire Interactions Muqueuses Agents Pathog\u00e8nes, EA562, UFR M\u00e9decine, Universit\u00e9 de Bourgogne, 7 Bd Jeanne d'Arc, 21000, Dijon, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Charles", 
            "givenName": "Pierre-Emmanuel", 
            "id": "sg:person.0660013407.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660013407.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "D\u00e9partement d\u2019Urgences M\u00e9dicales, Centre Hospitalier Princesse Grace, 1 ave Pasteur, BP 489, 98012, Principaut\u00e9 de Monaco, Monaco", 
              "id": "http://www.grid.ac/institutes/grid.452334.7", 
              "name": [
                "D\u00e9partement d\u2019Urgences M\u00e9dicales, Centre Hospitalier Princesse Grace, 1 ave Pasteur, BP 489, 98012, Principaut\u00e9 de Monaco, Monaco"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Claessens", 
            "givenName": "Yann-Eric", 
            "id": "sg:person.01121474764.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121474764.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "P\u00f4le d'Anesth\u00e9sie R\u00e9animation, CHU d\u2019Angers, 4 rue Larrey, 49933 Cedex 9, Angers, France", 
              "id": "http://www.grid.ac/institutes/grid.411147.6", 
              "name": [
                "P\u00f4le d'Anesth\u00e9sie R\u00e9animation, CHU d\u2019Angers, 4 rue Larrey, 49933 Cedex 9, Angers, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lasocki", 
            "givenName": "Sigismond", 
            "id": "sg:person.01070774770.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070774770.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Service de r\u00e9animation, Centre hospitalier de Versailles, 177, rue de Versailles, 78150, Le Chesnay, France", 
              "id": "http://www.grid.ac/institutes/grid.418080.5", 
              "name": [
                "Service de r\u00e9animation, Centre hospitalier de Versailles, 177, rue de Versailles, 78150, Le Chesnay, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bedos", 
            "givenName": "Jean-Pierre", 
            "id": "sg:person.01251245025.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251245025.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratoire de Microbiologie, Institut Mutualiste Montsouris, 42, Bld Jourdan, 75014, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.418120.e", 
              "name": [
                "Laboratoire de Microbiologie, Institut Mutualiste Montsouris, 42, Bld Jourdan, 75014, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "P\u00e9an", 
            "givenName": "Yves", 
            "id": "sg:person.01222161017.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222161017.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Service de r\u00e9animation polyvalente, Groupe hospitalier Paris Saint Joseph, 185 rue Raymond Losserand, 75014, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.414363.7", 
              "name": [
                "Service de r\u00e9animation polyvalente, Groupe hospitalier Paris Saint Joseph, 185 rue Raymond Losserand, 75014, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Philippart", 
            "givenName": "Fran\u00e7ois", 
            "id": "sg:person.0667343437.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667343437.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "P\u00f4le d'Anesth\u00e9sie-R\u00e9animation, H\u00f4pital de Rangueil, CHU de Toulouse, 1, Ave Pr Jean Poulh\u00e8s, TSA 50032, Cedex 9, 31059, Toulouse, France", 
              "id": "http://www.grid.ac/institutes/grid.414295.f", 
              "name": [
                "P\u00f4le d'Anesth\u00e9sie-R\u00e9animation, H\u00f4pital de Rangueil, CHU de Toulouse, 1, Ave Pr Jean Poulh\u00e8s, TSA 50032, Cedex 9, 31059, Toulouse, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ruiz", 
            "givenName": "St\u00e9phanie", 
            "id": "sg:person.01052466414.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052466414.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Clinique M\u00e9dicale et Service d'Urgences P\u00e9diatriques, H\u00f4pital M\u00e8re-Enfant, CHU Nantes, 38 boulevard Jean-Monnet, 44093, cedex 1, Nantes, France", 
              "id": "http://www.grid.ac/institutes/grid.414233.3", 
              "name": [
                "Clinique M\u00e9dicale et Service d'Urgences P\u00e9diatriques, H\u00f4pital M\u00e8re-Enfant, CHU Nantes, 38 boulevard Jean-Monnet, 44093, cedex 1, Nantes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gras-Leguen", 
            "givenName": "Christele", 
            "id": "sg:person.01360573571.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360573571.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "D\u00e9partement de Biochimie, Hopital Lapeyronie, CHU Montpellier, 371, avenue du doyen Gaston Giraud, C\u00e9dex 5, 34295, Montpellier, France", 
              "id": "http://www.grid.ac/institutes/grid.411572.4", 
              "name": [
                "D\u00e9partement de Biochimie, Hopital Lapeyronie, CHU Montpellier, 371, avenue du doyen Gaston Giraud, C\u00e9dex 5, 34295, Montpellier, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dupuy", 
            "givenName": "Anne-Marie", 
            "id": "sg:person.01142462444.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142462444.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Intensive Care - SIRS Unit, University Hospitals of Geneva, 4 rue Gabrielle Perret-Gentil, 1211, Geneva 14, Switzerland", 
              "id": "http://www.grid.ac/institutes/grid.150338.c", 
              "name": [
                "Intensive Care - SIRS Unit, University Hospitals of Geneva, 4 rue Gabrielle Perret-Gentil, 1211, Geneva 14, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pugin", 
            "givenName": "J\u00e9r\u00f4me", 
            "id": "sg:person.0635370733.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635370733.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Service de maladies infectieuses et tropicales, Universit\u00e9 1 de Grenoble, CHU de Grenoble, BP 217, Boulevard de la Chantourne, 38043, Grenoble, France", 
              "id": "http://www.grid.ac/institutes/grid.410529.b", 
              "name": [
                "Service de maladies infectieuses et tropicales, Universit\u00e9 1 de Grenoble, CHU de Grenoble, BP 217, Boulevard de la Chantourne, 38043, Grenoble, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stahl", 
            "givenName": "Jean-Paul", 
            "id": "sg:person.0621155277.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621155277.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre de Recherche Clinique, Groupe hospitalier Paris Saint Joseph, Universit\u00e9 Paris Descartes, 185 rue Raymond Losserand, 75014, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.508487.6", 
              "name": [
                "Service de r\u00e9animation polyvalente, Groupe hospitalier Paris Saint Joseph, 185 rue Raymond Losserand, 75014, Paris, France", 
                "Centre de Recherche Clinique, Groupe hospitalier Paris Saint Joseph, Universit\u00e9 Paris Descartes, 185 rue Raymond Losserand, 75014, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Misset", 
            "givenName": "Benoit", 
            "id": "sg:person.0714512043.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714512043.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Unit\u00e9 de r\u00e9animation, CHU H\u00f4tel Dieu, AP-HP, Place du Parvis-de-Notre-Dame, 75004, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.50550.35", 
              "name": [
                "Unit\u00e9 de r\u00e9animation, CHU H\u00f4tel Dieu, AP-HP, Place du Parvis-de-Notre-Dame, 75004, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gauzit", 
            "givenName": "R\u00e9my", 
            "id": "sg:person.01074001107.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074001107.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Inserm U957, Institut Pasteur, France, Paris", 
              "id": "http://www.grid.ac/institutes/grid.428999.7", 
              "name": [
                "Service de R\u00e9animation m\u00e9dicale, H\u00f4pitaux Universitaires Henri Mondor, AP-HP & Universit\u00e9 Paris-Est, 51, av de Lattre de Tassigny, 94000, Cr\u00e9teil, France", 
                "Inserm U957, Institut Pasteur, France, Paris"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brun-Buisson", 
            "givenName": "Christian", 
            "id": "sg:person.0703430670.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703430670.30"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/1471-2296-8-15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047544729", 
              "https://doi.org/10.1186/1471-2296-8-15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00134-011-2369-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035310861", 
              "https://doi.org/10.1007/s00134-011-2369-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2334-12-247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006155263", 
              "https://doi.org/10.1186/1471-2334-12-247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2334-9-49", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035890551", 
              "https://doi.org/10.1186/1471-2334-9-49"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00423-008-0432-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044881541", 
              "https://doi.org/10.1007/s00423-008-0432-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02900730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000233447", 
              "https://doi.org/10.1007/bf02900730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2296-6-34", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008970177", 
              "https://doi.org/10.1186/1471-2296-6-34"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s100960000287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049088127", 
              "https://doi.org/10.1007/s100960000287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-006-0167-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015162582", 
              "https://doi.org/10.1007/s00268-006-0167-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc7903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031777631", 
              "https://doi.org/10.1186/cc7903"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s001340051136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005895408", 
              "https://doi.org/10.1007/s001340051136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02116518", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049344466", 
              "https://doi.org/10.1007/bf02116518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/ijgc:28:1:41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022851773", 
              "https://doi.org/10.1385/ijgc:28:1:41"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc10254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042026024", 
              "https://doi.org/10.1186/cc10254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/cc3015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004179597", 
              "https://doi.org/10.1186/cc3015"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-07-08", 
        "datePublishedReg": "2013-07-08", 
        "description": "Biomarker-guided initiation of antibiotic therapy has been studied in four conditions: acute pancreatitis, lower respiratory tract infection (LRTI), meningitis, and sepsis in the ICU. In pancreatitis with suspected infected necrosis, initiating antibiotics best relies on fine-needle aspiration and demonstration of infected material. We suggest that PCT be measured to help predict infection; however, available data are insufficient to decide on initiating antibiotics based on PCT levels. In adult patients suspected of community-acquired LRTI, we suggest withholding antibiotic therapy when the serum PCT level is low (<0.25 ng/mL); in patients having nosocomial LRTI, data are insufficient to recommend initiating therapy based on a single PCT level or even repeated measurements. For children with suspected bacterial meningitis, we recommend using a decision rule as an aid to therapeutic decisions, such as the Bacterial Meningitis Score or the Meningitest\u00ae; a single PCT level \u22650.5 ng/mL also may be used, but false-negatives may occur. In adults with suspected bacterial meningitis, we suggest integrating serum PCT measurements in a clinical decision rule to help distinguish between viral and bacterial meningitis, using a 0.5 ng/mL threshold. For ICU patients suspected of community-acquired infection, we do not recommend using a threshold serum PCT value to help the decision to initiate antibiotic therapy; data are insufficient to recommend using PCT serum kinetics for the decision to initiate antibiotic therapy in patients suspected of ICU-acquired infection. In children, CRP can probably be used to help discontinue therapy, although the evidence is limited. In adults, antibiotic discontinuation can be based on an algorithm using repeated PCT measurements. In non-immunocompromised out- or in- patients treated for RTI, antibiotics can be discontinued if the PCT level at day 3 is < 0.25 ng/mL or has decreased by >80-90%, whether or not microbiological documentation has been obtained. For ICU patients who have nonbacteremic sepsis from a known site of infection, antibiotics can be stopped if the PCT level at day 3 is < 0.5 ng/mL or has decreased by >80% relative to the highest level recorded, irrespective of the severity of the infectious episode; in bacteremic patients, a minimal duration of therapy of 5 days is recommended.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/2110-5820-3-21", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1045300", 
            "issn": [
              "2110-5820"
            ], 
            "name": "Annals of Intensive Care", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "3"
          }
        ], 
        "keywords": [
          "lower respiratory tract infections", 
          "PCT levels", 
          "antibiotic therapy", 
          "bacterial meningitis", 
          "ICU patients", 
          "community-acquired lower respiratory tract infections", 
          "nosocomial lower respiratory tract infections", 
          "day 3", 
          "Bacterial Meningitis Score", 
          "serum PCT measurements", 
          "serum PCT values", 
          "respiratory tract infections", 
          "serum PCT levels", 
          "clinical decision rule", 
          "community-acquired infections", 
          "role of biomarkers", 
          "PCT measurements", 
          "fine-needle aspiration", 
          "site of infection", 
          "antibiotic discontinuation", 
          "infected necrosis", 
          "microbiological documentation", 
          "infectious episodes", 
          "tract infections", 
          "adult patients", 
          "bacteremic patients", 
          "acute pancreatitis", 
          "PCT values", 
          "therapeutic decisions", 
          "serum kinetics", 
          "patients", 
          "meningitis", 
          "therapy", 
          "infection", 
          "clinical use", 
          "biomarkers", 
          "sepsis", 
          "discontinuation", 
          "ICU", 
          "pancreatitis", 
          "antibiotics", 
          "infected material", 
          "adults", 
          "minimal duration", 
          "children", 
          "review II", 
          "high levels", 
          "levels", 
          "CRP", 
          "initiation", 
          "necrosis", 
          "available data", 
          "severity", 
          "episodes", 
          "scores", 
          "duration", 
          "days", 
          "aspiration", 
          "data", 
          "evidence", 
          "management", 
          "RTI", 
          "role", 
          "goods relies", 
          "documentation", 
          "decisions", 
          "use", 
          "threshold", 
          "PCT", 
          "sites", 
          "demonstration", 
          "measurements", 
          "decision rules", 
          "aid", 
          "values", 
          "conditions", 
          "relies", 
          "materials", 
          "kinetics", 
          "rules", 
          "algorithm"
        ], 
        "name": "Role of biomarkers in the management of antibiotic therapy: an expert panel review II: clinical use of biomarkers for initiation or discontinuation of antibiotic therapy", 
        "pagination": "21", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1007570782"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/2110-5820-3-21"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23830525"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/2110-5820-3-21", 
          "https://app.dimensions.ai/details/publication/pub.1007570782"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-06-01T22:10", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_596.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/2110-5820-3-21"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/2110-5820-3-21'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/2110-5820-3-21'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/2110-5820-3-21'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/2110-5820-3-21'


     

    This table displays all metadata directly associated to this object as RDF triples.

    380 TRIPLES      22 PREDICATES      123 URIs      99 LITERALS      7 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/2110-5820-3-21 schema:about anzsrc-for:11
    2 anzsrc-for:1103
    3 anzsrc-for:1108
    4 schema:author Nb374c0408c764f2fbd7e327d158bf512
    5 schema:citation sg:pub.10.1007/bf02116518
    6 sg:pub.10.1007/bf02900730
    7 sg:pub.10.1007/s00134-011-2369-z
    8 sg:pub.10.1007/s001340051136
    9 sg:pub.10.1007/s00268-006-0167-5
    10 sg:pub.10.1007/s00423-008-0432-1
    11 sg:pub.10.1007/s100960000287
    12 sg:pub.10.1186/1471-2296-6-34
    13 sg:pub.10.1186/1471-2296-8-15
    14 sg:pub.10.1186/1471-2334-12-247
    15 sg:pub.10.1186/1471-2334-9-49
    16 sg:pub.10.1186/cc10254
    17 sg:pub.10.1186/cc3015
    18 sg:pub.10.1186/cc7903
    19 sg:pub.10.1385/ijgc:28:1:41
    20 schema:datePublished 2013-07-08
    21 schema:datePublishedReg 2013-07-08
    22 schema:description Biomarker-guided initiation of antibiotic therapy has been studied in four conditions: acute pancreatitis, lower respiratory tract infection (LRTI), meningitis, and sepsis in the ICU. In pancreatitis with suspected infected necrosis, initiating antibiotics best relies on fine-needle aspiration and demonstration of infected material. We suggest that PCT be measured to help predict infection; however, available data are insufficient to decide on initiating antibiotics based on PCT levels. In adult patients suspected of community-acquired LRTI, we suggest withholding antibiotic therapy when the serum PCT level is low (<0.25 ng/mL); in patients having nosocomial LRTI, data are insufficient to recommend initiating therapy based on a single PCT level or even repeated measurements. For children with suspected bacterial meningitis, we recommend using a decision rule as an aid to therapeutic decisions, such as the Bacterial Meningitis Score or the Meningitest®; a single PCT level ≥0.5 ng/mL also may be used, but false-negatives may occur. In adults with suspected bacterial meningitis, we suggest integrating serum PCT measurements in a clinical decision rule to help distinguish between viral and bacterial meningitis, using a 0.5 ng/mL threshold. For ICU patients suspected of community-acquired infection, we do not recommend using a threshold serum PCT value to help the decision to initiate antibiotic therapy; data are insufficient to recommend using PCT serum kinetics for the decision to initiate antibiotic therapy in patients suspected of ICU-acquired infection. In children, CRP can probably be used to help discontinue therapy, although the evidence is limited. In adults, antibiotic discontinuation can be based on an algorithm using repeated PCT measurements. In non-immunocompromised out- or in- patients treated for RTI, antibiotics can be discontinued if the PCT level at day 3 is < 0.25 ng/mL or has decreased by >80-90%, whether or not microbiological documentation has been obtained. For ICU patients who have nonbacteremic sepsis from a known site of infection, antibiotics can be stopped if the PCT level at day 3 is < 0.5 ng/mL or has decreased by >80% relative to the highest level recorded, irrespective of the severity of the infectious episode; in bacteremic patients, a minimal duration of therapy of 5 days is recommended.
    23 schema:genre article
    24 schema:inLanguage en
    25 schema:isAccessibleForFree true
    26 schema:isPartOf Nd315b2dbb3114a09a89fe5625da8e178
    27 Ne843611114d8472ab1c22d321f07a9be
    28 sg:journal.1045300
    29 schema:keywords Bacterial Meningitis Score
    30 CRP
    31 ICU
    32 ICU patients
    33 PCT
    34 PCT levels
    35 PCT measurements
    36 PCT values
    37 RTI
    38 acute pancreatitis
    39 adult patients
    40 adults
    41 aid
    42 algorithm
    43 antibiotic discontinuation
    44 antibiotic therapy
    45 antibiotics
    46 aspiration
    47 available data
    48 bacteremic patients
    49 bacterial meningitis
    50 biomarkers
    51 children
    52 clinical decision rule
    53 clinical use
    54 community-acquired infections
    55 community-acquired lower respiratory tract infections
    56 conditions
    57 data
    58 day 3
    59 days
    60 decision rules
    61 decisions
    62 demonstration
    63 discontinuation
    64 documentation
    65 duration
    66 episodes
    67 evidence
    68 fine-needle aspiration
    69 goods relies
    70 high levels
    71 infected material
    72 infected necrosis
    73 infection
    74 infectious episodes
    75 initiation
    76 kinetics
    77 levels
    78 lower respiratory tract infections
    79 management
    80 materials
    81 measurements
    82 meningitis
    83 microbiological documentation
    84 minimal duration
    85 necrosis
    86 nosocomial lower respiratory tract infections
    87 pancreatitis
    88 patients
    89 relies
    90 respiratory tract infections
    91 review II
    92 role
    93 role of biomarkers
    94 rules
    95 scores
    96 sepsis
    97 serum PCT levels
    98 serum PCT measurements
    99 serum PCT values
    100 serum kinetics
    101 severity
    102 site of infection
    103 sites
    104 therapeutic decisions
    105 therapy
    106 threshold
    107 tract infections
    108 use
    109 values
    110 schema:name Role of biomarkers in the management of antibiotic therapy: an expert panel review II: clinical use of biomarkers for initiation or discontinuation of antibiotic therapy
    111 schema:pagination 21
    112 schema:productId N2743152a945b4f53b5b26e175cefc8e3
    113 N808eb38ac75f4d83be08d54fe9aa97b2
    114 Nb2055daf4c264f96984a717fac2ae864
    115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007570782
    116 https://doi.org/10.1186/2110-5820-3-21
    117 schema:sdDatePublished 2022-06-01T22:10
    118 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    119 schema:sdPublisher N6fa89bfa5bb24b3688768c1254f21201
    120 schema:url https://doi.org/10.1186/2110-5820-3-21
    121 sgo:license sg:explorer/license/
    122 sgo:sdDataset articles
    123 rdf:type schema:ScholarlyArticle
    124 N03c465b2f2d14f3db4e88856c2d003fe rdf:first sg:person.0621155277.13
    125 rdf:rest N0a1cb7937b4d4598ba462117fb84000f
    126 N0a1cb7937b4d4598ba462117fb84000f rdf:first sg:person.0714512043.66
    127 rdf:rest N80f0abb11e474560a6ae7a0ef4e1dacf
    128 N2743152a945b4f53b5b26e175cefc8e3 schema:name dimensions_id
    129 schema:value pub.1007570782
    130 rdf:type schema:PropertyValue
    131 N55ce0c26a15c4e069a74f48e2a5856aa rdf:first sg:person.0703430670.30
    132 rdf:rest rdf:nil
    133 N58adb64a63f94482b7b626c9a7fa382c rdf:first sg:person.01070774770.70
    134 rdf:rest Nd36f61c88b88458db38b41e83f50bfb9
    135 N6fa89bfa5bb24b3688768c1254f21201 schema:name Springer Nature - SN SciGraph project
    136 rdf:type schema:Organization
    137 N7700f8c11ebd4dd292e067b1541fc4dd rdf:first sg:person.0667343437.67
    138 rdf:rest Necab466a93064095b9dea6e5ccb86c37
    139 N78700458b2e544e894ebd3ca8ebc2d7e rdf:first sg:person.0635370733.30
    140 rdf:rest N03c465b2f2d14f3db4e88856c2d003fe
    141 N808eb38ac75f4d83be08d54fe9aa97b2 schema:name doi
    142 schema:value 10.1186/2110-5820-3-21
    143 rdf:type schema:PropertyValue
    144 N80f0abb11e474560a6ae7a0ef4e1dacf rdf:first sg:person.01074001107.44
    145 rdf:rest N55ce0c26a15c4e069a74f48e2a5856aa
    146 N906dfd0ca21349789cd0398c1feb73d0 rdf:first sg:person.01253161505.41
    147 rdf:rest Nf3b4af68634e48b68045242f7e06447c
    148 Nb2055daf4c264f96984a717fac2ae864 schema:name pubmed_id
    149 schema:value 23830525
    150 rdf:type schema:PropertyValue
    151 Nb374c0408c764f2fbd7e327d158bf512 rdf:first sg:person.0667156247.07
    152 rdf:rest Nefaf093023424c6e9c6ba5ec0cb0a562
    153 Nd315b2dbb3114a09a89fe5625da8e178 schema:issueNumber 1
    154 rdf:type schema:PublicationIssue
    155 Nd36f61c88b88458db38b41e83f50bfb9 rdf:first sg:person.01251245025.72
    156 rdf:rest Ne473ffc1aee6427a8f5a711a76929008
    157 Nd66e8fc2226044a2bd202fe310629975 rdf:first sg:person.01121474764.40
    158 rdf:rest N58adb64a63f94482b7b626c9a7fa382c
    159 Ndc3d7dcad1b7437bb0b2cd9e693099dc rdf:first sg:person.01360573571.77
    160 rdf:rest Nf4aa96a11a0a493f96f15f00c290a2d2
    161 Ne473ffc1aee6427a8f5a711a76929008 rdf:first sg:person.01222161017.43
    162 rdf:rest N7700f8c11ebd4dd292e067b1541fc4dd
    163 Ne843611114d8472ab1c22d321f07a9be schema:volumeNumber 3
    164 rdf:type schema:PublicationVolume
    165 Necab466a93064095b9dea6e5ccb86c37 rdf:first sg:person.01052466414.16
    166 rdf:rest Ndc3d7dcad1b7437bb0b2cd9e693099dc
    167 Ned852af661a5475ea7560072a43420e3 rdf:first sg:person.01222526046.07
    168 rdf:rest N906dfd0ca21349789cd0398c1feb73d0
    169 Nefaf093023424c6e9c6ba5ec0cb0a562 rdf:first sg:person.01310337776.72
    170 rdf:rest Ned852af661a5475ea7560072a43420e3
    171 Nf3b4af68634e48b68045242f7e06447c rdf:first sg:person.0660013407.69
    172 rdf:rest Nd66e8fc2226044a2bd202fe310629975
    173 Nf4aa96a11a0a493f96f15f00c290a2d2 rdf:first sg:person.01142462444.55
    174 rdf:rest N78700458b2e544e894ebd3ca8ebc2d7e
    175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    176 schema:name Medical and Health Sciences
    177 rdf:type schema:DefinedTerm
    178 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    179 schema:name Clinical Sciences
    180 rdf:type schema:DefinedTerm
    181 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
    182 schema:name Medical Microbiology
    183 rdf:type schema:DefinedTerm
    184 sg:journal.1045300 schema:issn 2110-5820
    185 schema:name Annals of Intensive Care
    186 schema:publisher Springer Nature
    187 rdf:type schema:Periodical
    188 sg:person.01052466414.16 schema:affiliation grid-institutes:grid.414295.f
    189 schema:familyName Ruiz
    190 schema:givenName Stéphanie
    191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052466414.16
    192 rdf:type schema:Person
    193 sg:person.01070774770.70 schema:affiliation grid-institutes:grid.411147.6
    194 schema:familyName Lasocki
    195 schema:givenName Sigismond
    196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070774770.70
    197 rdf:type schema:Person
    198 sg:person.01074001107.44 schema:affiliation grid-institutes:grid.50550.35
    199 schema:familyName Gauzit
    200 schema:givenName Rémy
    201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074001107.44
    202 rdf:type schema:Person
    203 sg:person.01121474764.40 schema:affiliation grid-institutes:grid.452334.7
    204 schema:familyName Claessens
    205 schema:givenName Yann-Eric
    206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121474764.40
    207 rdf:type schema:Person
    208 sg:person.01142462444.55 schema:affiliation grid-institutes:grid.411572.4
    209 schema:familyName Dupuy
    210 schema:givenName Anne-Marie
    211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142462444.55
    212 rdf:type schema:Person
    213 sg:person.01222161017.43 schema:affiliation grid-institutes:grid.418120.e
    214 schema:familyName Péan
    215 schema:givenName Yves
    216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222161017.43
    217 rdf:type schema:Person
    218 sg:person.01222526046.07 schema:affiliation grid-institutes:grid.508487.6
    219 schema:familyName Roche
    220 schema:givenName Nicolas
    221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222526046.07
    222 rdf:type schema:Person
    223 sg:person.01251245025.72 schema:affiliation grid-institutes:grid.418080.5
    224 schema:familyName Bedos
    225 schema:givenName Jean-Pierre
    226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251245025.72
    227 rdf:type schema:Person
    228 sg:person.01253161505.41 schema:affiliation grid-institutes:grid.7429.8
    229 schema:familyName Chalumeau
    230 schema:givenName Martin
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01253161505.41
    232 rdf:type schema:Person
    233 sg:person.01310337776.72 schema:affiliation grid-institutes:grid.462844.8
    234 schema:familyName Luyt
    235 schema:givenName Charles-Edouard
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310337776.72
    237 rdf:type schema:Person
    238 sg:person.01360573571.77 schema:affiliation grid-institutes:grid.414233.3
    239 schema:familyName Gras-Leguen
    240 schema:givenName Christele
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360573571.77
    242 rdf:type schema:Person
    243 sg:person.0621155277.13 schema:affiliation grid-institutes:grid.410529.b
    244 schema:familyName Stahl
    245 schema:givenName Jean-Paul
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621155277.13
    247 rdf:type schema:Person
    248 sg:person.0635370733.30 schema:affiliation grid-institutes:grid.150338.c
    249 schema:familyName Pugin
    250 schema:givenName Jérôme
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635370733.30
    252 rdf:type schema:Person
    253 sg:person.0660013407.69 schema:affiliation grid-institutes:grid.5613.1
    254 schema:familyName Charles
    255 schema:givenName Pierre-Emmanuel
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660013407.69
    257 rdf:type schema:Person
    258 sg:person.0667156247.07 schema:affiliation grid-institutes:None
    259 schema:familyName Quenot
    260 schema:givenName Jean-Pierre
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667156247.07
    262 rdf:type schema:Person
    263 sg:person.0667343437.67 schema:affiliation grid-institutes:grid.414363.7
    264 schema:familyName Philippart
    265 schema:givenName François
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667343437.67
    267 rdf:type schema:Person
    268 sg:person.0703430670.30 schema:affiliation grid-institutes:grid.428999.7
    269 schema:familyName Brun-Buisson
    270 schema:givenName Christian
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703430670.30
    272 rdf:type schema:Person
    273 sg:person.0714512043.66 schema:affiliation grid-institutes:grid.508487.6
    274 schema:familyName Misset
    275 schema:givenName Benoit
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714512043.66
    277 rdf:type schema:Person
    278 sg:pub.10.1007/bf02116518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049344466
    279 https://doi.org/10.1007/bf02116518
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1007/bf02900730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000233447
    282 https://doi.org/10.1007/bf02900730
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1007/s00134-011-2369-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1035310861
    285 https://doi.org/10.1007/s00134-011-2369-z
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1007/s001340051136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005895408
    288 https://doi.org/10.1007/s001340051136
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1007/s00268-006-0167-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015162582
    291 https://doi.org/10.1007/s00268-006-0167-5
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1007/s00423-008-0432-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044881541
    294 https://doi.org/10.1007/s00423-008-0432-1
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1007/s100960000287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049088127
    297 https://doi.org/10.1007/s100960000287
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1186/1471-2296-6-34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008970177
    300 https://doi.org/10.1186/1471-2296-6-34
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1186/1471-2296-8-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047544729
    303 https://doi.org/10.1186/1471-2296-8-15
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1186/1471-2334-12-247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006155263
    306 https://doi.org/10.1186/1471-2334-12-247
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1186/1471-2334-9-49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035890551
    309 https://doi.org/10.1186/1471-2334-9-49
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1186/cc10254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042026024
    312 https://doi.org/10.1186/cc10254
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1186/cc3015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004179597
    315 https://doi.org/10.1186/cc3015
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1186/cc7903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031777631
    318 https://doi.org/10.1186/cc7903
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1385/ijgc:28:1:41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022851773
    321 https://doi.org/10.1385/ijgc:28:1:41
    322 rdf:type schema:CreativeWork
    323 grid-institutes:None schema:alternateName Centre d’investigation clinique, INSERM CIE 1, 7 Boulevard Jeanne d’Arc, 21079, Dijon, France
    324 schema:name Centre d’investigation clinique, INSERM CIE 1, 7 Boulevard Jeanne d’Arc, 21079, Dijon, France
    325 Service de réanimation médicale, CHU Dijon & Université de Bourgogne, 14 rue Paul Gaffarel, 21970, Dijon, France
    326 rdf:type schema:Organization
    327 grid-institutes:grid.150338.c schema:alternateName Intensive Care - SIRS Unit, University Hospitals of Geneva, 4 rue Gabrielle Perret-Gentil, 1211, Geneva 14, Switzerland
    328 schema:name Intensive Care - SIRS Unit, University Hospitals of Geneva, 4 rue Gabrielle Perret-Gentil, 1211, Geneva 14, Switzerland
    329 rdf:type schema:Organization
    330 grid-institutes:grid.410529.b schema:alternateName Service de maladies infectieuses et tropicales, Université 1 de Grenoble, CHU de Grenoble, BP 217, Boulevard de la Chantourne, 38043, Grenoble, France
    331 schema:name Service de maladies infectieuses et tropicales, Université 1 de Grenoble, CHU de Grenoble, BP 217, Boulevard de la Chantourne, 38043, Grenoble, France
    332 rdf:type schema:Organization
    333 grid-institutes:grid.411147.6 schema:alternateName Pôle d'Anesthésie Réanimation, CHU d’Angers, 4 rue Larrey, 49933 Cedex 9, Angers, France
    334 schema:name Pôle d'Anesthésie Réanimation, CHU d’Angers, 4 rue Larrey, 49933 Cedex 9, Angers, France
    335 rdf:type schema:Organization
    336 grid-institutes:grid.411572.4 schema:alternateName Département de Biochimie, Hopital Lapeyronie, CHU Montpellier, 371, avenue du doyen Gaston Giraud, Cédex 5, 34295, Montpellier, France
    337 schema:name Département de Biochimie, Hopital Lapeyronie, CHU Montpellier, 371, avenue du doyen Gaston Giraud, Cédex 5, 34295, Montpellier, France
    338 rdf:type schema:Organization
    339 grid-institutes:grid.414233.3 schema:alternateName Clinique Médicale et Service d'Urgences Pédiatriques, Hôpital Mère-Enfant, CHU Nantes, 38 boulevard Jean-Monnet, 44093, cedex 1, Nantes, France
    340 schema:name Clinique Médicale et Service d'Urgences Pédiatriques, Hôpital Mère-Enfant, CHU Nantes, 38 boulevard Jean-Monnet, 44093, cedex 1, Nantes, France
    341 rdf:type schema:Organization
    342 grid-institutes:grid.414295.f schema:alternateName Pôle d'Anesthésie-Réanimation, Hôpital de Rangueil, CHU de Toulouse, 1, Ave Pr Jean Poulhès, TSA 50032, Cedex 9, 31059, Toulouse, France
    343 schema:name Pôle d'Anesthésie-Réanimation, Hôpital de Rangueil, CHU de Toulouse, 1, Ave Pr Jean Poulhès, TSA 50032, Cedex 9, 31059, Toulouse, France
    344 rdf:type schema:Organization
    345 grid-institutes:grid.414363.7 schema:alternateName Service de réanimation polyvalente, Groupe hospitalier Paris Saint Joseph, 185 rue Raymond Losserand, 75014, Paris, France
    346 schema:name Service de réanimation polyvalente, Groupe hospitalier Paris Saint Joseph, 185 rue Raymond Losserand, 75014, Paris, France
    347 rdf:type schema:Organization
    348 grid-institutes:grid.418080.5 schema:alternateName Service de réanimation, Centre hospitalier de Versailles, 177, rue de Versailles, 78150, Le Chesnay, France
    349 schema:name Service de réanimation, Centre hospitalier de Versailles, 177, rue de Versailles, 78150, Le Chesnay, France
    350 rdf:type schema:Organization
    351 grid-institutes:grid.418120.e schema:alternateName Laboratoire de Microbiologie, Institut Mutualiste Montsouris, 42, Bld Jourdan, 75014, Paris, France
    352 schema:name Laboratoire de Microbiologie, Institut Mutualiste Montsouris, 42, Bld Jourdan, 75014, Paris, France
    353 rdf:type schema:Organization
    354 grid-institutes:grid.428999.7 schema:alternateName Inserm U957, Institut Pasteur, France, Paris
    355 schema:name Inserm U957, Institut Pasteur, France, Paris
    356 Service de Réanimation médicale, Hôpitaux Universitaires Henri Mondor, AP-HP & Université Paris-Est, 51, av de Lattre de Tassigny, 94000, Créteil, France
    357 rdf:type schema:Organization
    358 grid-institutes:grid.452334.7 schema:alternateName Département d’Urgences Médicales, Centre Hospitalier Princesse Grace, 1 ave Pasteur, BP 489, 98012, Principauté de Monaco, Monaco
    359 schema:name Département d’Urgences Médicales, Centre Hospitalier Princesse Grace, 1 ave Pasteur, BP 489, 98012, Principauté de Monaco, Monaco
    360 rdf:type schema:Organization
    361 grid-institutes:grid.462844.8 schema:alternateName Service de Réanimation Médicale, Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Université Pierre et Marie Curie - Paris VI, 47-83 boulevard de l'Hôpital, Cedex 13, 75651, Paris, France
    362 schema:name Service de Réanimation Médicale, Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Université Pierre et Marie Curie - Paris VI, 47-83 boulevard de l'Hôpital, Cedex 13, 75651, Paris, France
    363 rdf:type schema:Organization
    364 grid-institutes:grid.50550.35 schema:alternateName Unité de réanimation, CHU Hôtel Dieu, AP-HP, Place du Parvis-de-Notre-Dame, 75004, Paris, France
    365 schema:name Unité de réanimation, CHU Hôtel Dieu, AP-HP, Place du Parvis-de-Notre-Dame, 75004, Paris, France
    366 rdf:type schema:Organization
    367 grid-institutes:grid.508487.6 schema:alternateName Centre de Recherche Clinique, Groupe hospitalier Paris Saint Joseph, Université Paris Descartes, 185 rue Raymond Losserand, 75014, Paris, France
    368 Service de Pneumologie et Soins Intensifs Respiratoires, Hôpitaux Universitaires Paris Centre, AP-HP & Université Paris-Descartes, 27 rue du fbg St Jacques, 75679, Paris, France
    369 schema:name Centre de Recherche Clinique, Groupe hospitalier Paris Saint Joseph, Université Paris Descartes, 185 rue Raymond Losserand, 75014, Paris, France
    370 Service de Pneumologie et Soins Intensifs Respiratoires, Hôpitaux Universitaires Paris Centre, AP-HP & Université Paris-Descartes, 27 rue du fbg St Jacques, 75679, Paris, France
    371 Service de réanimation polyvalente, Groupe hospitalier Paris Saint Joseph, 185 rue Raymond Losserand, 75014, Paris, France
    372 rdf:type schema:Organization
    373 grid-institutes:grid.5613.1 schema:alternateName Laboratoire Interactions Muqueuses Agents Pathogènes, EA562, UFR Médecine, Université de Bourgogne, 7 Bd Jeanne d'Arc, 21000, Dijon, France
    374 schema:name Laboratoire Interactions Muqueuses Agents Pathogènes, EA562, UFR Médecine, Université de Bourgogne, 7 Bd Jeanne d'Arc, 21000, Dijon, France
    375 Service de réanimation médicale, CHU Dijon & Université de Bourgogne, 14 rue Paul Gaffarel, 21970, Dijon, France
    376 rdf:type schema:Organization
    377 grid-institutes:grid.7429.8 schema:alternateName Inserm U953, Paris, France
    378 schema:name Inserm U953, Paris, France
    379 Service de Pédiatrie Générale, CHU Necker-Enfants Malades, AP-HP, Université Paris Descartes, 149 rue de Sèvres, 75743, Paris, France
    380 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...