Erythropoietin (EPO) in acute kidney injury View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-03-21

AUTHORS

Elizabeth Moore, Rinaldo Bellomo

ABSTRACT

Erythropoietin (EPO) is a 30.4 kDa glycoprotein produced by the kidney, and is mostly well-known for its physiological function in regulating red blood cell production in the bone marrow. Accumulating evidence, however, suggests that EPO has additional organ protective effects, which may be useful in the prevention or treatment of acute kidney injury. These protective mechanisms are multifactorial in nature and include inhibition of apoptotic cell death, stimulation of cellular regeneration, inhibition of deleterious pathways, and promotion of recovery.In this article, we review the physiology of EPO, assess previous work that supports the role of EPO as a general tissue protective agent, and explain the mechanisms by which it may achieve this tissue protective effect. We then focus on experimental and clinical data that suggest that EPO has a kidney protective effect. More... »

PAGES

3-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/2110-5820-1-3

DOI

http://dx.doi.org/10.1186/2110-5820-1-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027290012

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21906325


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