Harnessing RNAi nanomedicine for precision therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Dan Peer

ABSTRACT

Utilizing RNA interference as an innovative therapeutic strategy has an immense likelihood to generate novel concepts in precision medicine. Several clinical trials are on the way with some positive initial results. Yet, targeting of RNAi payloads such as small interfering RNAs (siRNAs), microRNA (miR) mimetic or anti-miR (antagomirs) into specific cell types remains a challenge. Major attempts are done for developing nano-sized carriers that could overcome systemic, local and cellular barriers. This progress report will focus on the recent advances in the RNAi world, detailing strategies of systemic passive tissue targeting and active cellular targeting, which is often considered as the holy grail of drug delivery. More... »

PAGES

5

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/2052-8426-2-5

DOI

http://dx.doi.org/10.1186/2052-8426-2-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025804946

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26056574


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