Extracellular matrix macromolecules: potential tools and targets in cancer gene therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Annele Sainio, Hannu Järveläinen

ABSTRACT

Tumour cells create their own microenvironment where they closely interact with a variety of soluble and non-soluble molecules, different cells and numerous other components within the extracellular matrix (ECM). Interaction between tumour cells and the ECM is bidirectional leading to either progression or inhibition of tumourigenesis. Therefore, development of novel therapies targeted primarily to tumour microenvironment (TME) is highly rational. Here, we give a short overview of different macromolecules of the ECM and introduce mechanisms whereby they contribute to tumourigenesis within the TME. Furthermore, we present examples of individual ECM macromolecules as regulators of cell behaviour during tumourigenesis. Finally, we focus on novel strategies of using ECM macromolecules as tools or targets in cancer gene therapy in the future. More... »

PAGES

14

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/2052-8426-2-14

    DOI

    http://dx.doi.org/10.1186/2052-8426-2-14

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024218478

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26056582


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