Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

David MA Mann, Sara Rollinson, Andrew Robinson, Janis Bennion Callister, Jennifer C Thompson, Julie S Snowden, Tania Gendron, Leonard Petrucelli, Masami Masuda-Suzukake, Masato Hasegawa, Yvonne Davidson, Stuart Pickering-Brown

ABSTRACT

BACKGROUND: Cases of Frontotemporal Lobar Degeneration (FTLD) and Motor Neurone Disease (MND) associated with expansions in C9ORF72 gene are characterised pathologically by the presence of TDP-43 negative, but p62 positive, inclusions in granule cells of the cerebellum and in cells of dentate gyrus and area CA4 of the hippocampus. RESULTS: We screened 84 cases of pathologically confirmed FTLD and 23 cases of MND for the presence of p62 positive inclusions in these three brain regions, and identified 13 positive cases of FTLD and 3 of MND. All cases demonstrated expansions in C9ORF72 by Southern blotting where frozen tissues were available. The p62 positive inclusions in both cerebellum and hippocampus were immunostained by antibodies to dipeptide repeat proteins (DPR), poly Gly-Ala (poly-GA), poly Gly-Pro (poly-GP) and poly Gly-Arg (poly-GR), these arising from a putative non-ATG initiated (RAN) sense translation of the GGGGCC expansion. There was also some slight, but variable, immunostaining with poly-AP antibody implying some antisense translation might also occur, though the relative paucity of immunostaining could reflect poor antigen avidity on the part of the antisense antibodies. Of the FTLD cases with DPR, 6 showed TDP-43 type A and 6 had TDP-43 type B histology; one had FTLD-tau with the pathology of corticobasal degeneration. There were no qualitative or quantitative differences in the pattern of immunostaining with antibodies to DPR, or p62, proteins between TDP-43 type A and type B cases. Ratings for frequency of inclusions immunostained by these poly-GA, poly-GP and poly-GR antibodies broadly correlated with those for immunolabelled by p62 antibody in all three regions. CONCLUSION: We conclude that DPR are a major component of p62 positive inclusions in FTLD and MND. More... »

PAGES

68

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/2051-5960-1-68

DOI

http://dx.doi.org/10.1186/2051-5960-1-68

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051799785

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24252525


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blotting, Southern", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "C9orf72 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Repeat Expansion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Frontotemporal Lobar Degeneration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inclusion Bodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Motor Neuron Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA-Binding Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, M6 8HD, Salford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mann", 
        "givenName": "David MA", 
        "id": "sg:person.07600434432.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07600434432.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Manchester", 
          "id": "https://www.grid.ac/institutes/grid.5379.8", 
          "name": [
            "Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, A V Hill Building, Oxford Rd, M13 9PL, Manchester, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rollinson", 
        "givenName": "Sara", 
        "id": "sg:person.011103430227.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011103430227.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, M6 8HD, Salford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Robinson", 
        "givenName": "Andrew", 
        "id": "sg:person.01071613360.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071613360.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Manchester", 
          "id": "https://www.grid.ac/institutes/grid.5379.8", 
          "name": [
            "Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, A V Hill Building, Oxford Rd, M13 9PL, Manchester, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bennion Callister", 
        "givenName": "Janis", 
        "id": "sg:person.01132045171.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132045171.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, M6 8HD, Salford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thompson", 
        "givenName": "Jennifer C", 
        "id": "sg:person.01124725234.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124725234.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, M6 8HD, Salford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Snowden", 
        "givenName": "Julie S", 
        "id": "sg:person.013172430222.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013172430222.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.417467.7", 
          "name": [
            "Mayo Clinic, FL32224, Jacksonville, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gendron", 
        "givenName": "Tania", 
        "id": "sg:person.01245026531.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245026531.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.417467.7", 
          "name": [
            "Mayo Clinic, FL32224, Jacksonville, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Petrucelli", 
        "givenName": "Leonard", 
        "id": "sg:person.013053751217.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013053751217.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Metropolitan Institute of Medical Science", 
          "id": "https://www.grid.ac/institutes/grid.272456.0", 
          "name": [
            "Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, 156-8506, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Masuda-Suzukake", 
        "givenName": "Masami", 
        "id": "sg:person.01044037023.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044037023.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tokyo Metropolitan Institute of Medical Science", 
          "id": "https://www.grid.ac/institutes/grid.272456.0", 
          "name": [
            "Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, 156-8506, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hasegawa", 
        "givenName": "Masato", 
        "id": "sg:person.01155272521.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155272521.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, M6 8HD, Salford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Davidson", 
        "givenName": "Yvonne", 
        "id": "sg:person.01040623067.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040623067.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Manchester", 
          "id": "https://www.grid.ac/institutes/grid.5379.8", 
          "name": [
            "Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, A V Hill Building, Oxford Rd, M13 9PL, Manchester, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pickering-Brown", 
        "givenName": "Stuart", 
        "id": "sg:person.0751430343.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751430343.49"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.neuron.2011.09.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002524543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2012.05.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003011922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1219643110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003075180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(10)70197-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004831873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/2013.jamaneurol.537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005398003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/2013.jamaneurol.537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005398003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2051-5960-1-50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006123388", 
          "https://doi.org/10.1186/2051-5960-1-50"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2051-5960-1-50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006123388", 
          "https://doi.org/10.1186/2051-5960-1-50"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1474-4422(10)70184-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007677508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2013.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010481064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011035298", 
          "https://doi.org/10.1038/ng.536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011035298", 
          "https://doi.org/10.1038/ng.536"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-006-0138-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011285999", 
          "https://doi.org/10.1007/s00401-006-0138-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-006-0138-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011285999", 
          "https://doi.org/10.1007/s00401-006-0138-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(94)90191-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011575660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(94)90191-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011575660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajhg.2013.01.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011988258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2012.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013161842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-007-0236-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013932978", 
          "https://doi.org/10.1007/s00401-007-0236-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-007-0236-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013932978", 
          "https://doi.org/10.1007/s00401-007-0236-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.57.4.416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013938124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-011-0907-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014597823", 
          "https://doi.org/10.1007/s00401-011-0907-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.2009.204081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015390651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archneur.64.2.240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015832947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016041388", 
          "https://doi.org/10.1038/ng.442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016041388", 
          "https://doi.org/10.1038/ng.442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1789.2010.01171.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016835523"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awr355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019792266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awr361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019894998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-010-0765-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020052640", 
          "https://doi.org/10.1007/s00401-010-0765-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/aws357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020763611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1232927", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023614866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-011-0845-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024051199", 
          "https://doi.org/10.1007/s00401-011-0845-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-013-1088-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027055662", 
          "https://doi.org/10.1007/s00401-013-1088-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmc1113592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027601409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029205851", 
          "https://doi.org/10.1038/nature05017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029205851", 
          "https://doi.org/10.1038/nature05017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029205851", 
          "https://doi.org/10.1038/nature05017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-007-0237-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029516874", 
          "https://doi.org/10.1007/s00401-007-0237-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-007-0237-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029516874", 
          "https://doi.org/10.1007/s00401-007-0237-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/31508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030318669", 
          "https://doi.org/10.1038/31508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/31508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030318669", 
          "https://doi.org/10.1038/31508"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-011-0911-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030353161", 
          "https://doi.org/10.1007/s00401-011-0911-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0004.2012.01903.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031830434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/aws001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032770812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2012.01.109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033797071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-012-0970-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037356128", 
          "https://doi.org/10.1007/s00401-012-0970-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038649717", 
          "https://doi.org/10.1038/nature05016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038649717", 
          "https://doi.org/10.1038/nature05016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038649717", 
          "https://doi.org/10.1038/nature05016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuron.2011.09.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044938477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2012.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045314144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2012.12.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046603903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/brain/awl030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048066840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neurobiolaging.2012.11.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051325819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-005-1079-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053718038", 
          "https://doi.org/10.1007/s00401-005-1079-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-005-1079-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053718038", 
          "https://doi.org/10.1007/s00401-005-1079-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000200048.53766.b4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000200048.53766.b4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000200048.53766.b4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064347855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181a55f1c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181a55f1c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181a55f1c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.51.6.1546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064376963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.51.6.1546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064376963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.51.6.1546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064376963"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "BACKGROUND: Cases of Frontotemporal Lobar Degeneration (FTLD) and Motor Neurone Disease (MND) associated with expansions in C9ORF72 gene are characterised pathologically by the presence of TDP-43 negative, but p62 positive, inclusions in granule cells of the cerebellum and in cells of dentate gyrus and area CA4 of the hippocampus.\nRESULTS: We screened 84 cases of pathologically confirmed FTLD and 23 cases of MND for the presence of p62 positive inclusions in these three brain regions, and identified 13 positive cases of FTLD and 3 of MND. All cases demonstrated expansions in C9ORF72 by Southern blotting where frozen tissues were available. The p62 positive inclusions in both cerebellum and hippocampus were immunostained by antibodies to dipeptide repeat proteins (DPR), poly Gly-Ala (poly-GA), poly Gly-Pro (poly-GP) and poly Gly-Arg (poly-GR), these arising from a putative non-ATG initiated (RAN) sense translation of the GGGGCC expansion. There was also some slight, but variable, immunostaining with poly-AP antibody implying some antisense translation might also occur, though the relative paucity of immunostaining could reflect poor antigen avidity on the part of the antisense antibodies. Of the FTLD cases with DPR, 6 showed TDP-43 type A and 6 had TDP-43 type B histology; one had FTLD-tau with the pathology of corticobasal degeneration. There were no qualitative or quantitative differences in the pattern of immunostaining with antibodies to DPR, or p62, proteins between TDP-43 type A and type B cases. Ratings for frequency of inclusions immunostained by these poly-GA, poly-GP and poly-GR antibodies broadly correlated with those for immunolabelled by p62 antibody in all three regions.\nCONCLUSION: We conclude that DPR are a major component of p62 positive inclusions in FTLD and MND.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/2051-5960-1-68", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6109149", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3637675", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6050132", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2763668", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6068427", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1048594", 
        "issn": [
          "2051-5960"
        ], 
        "name": "Acta Neuropathologica Communications", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "1"
      }
    ], 
    "name": "Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72", 
    "pagination": "68", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f6bec82d8f9dc482838842be1d47c8ac7118bed1f78ab90cd95951212267df13"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24252525"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101610673"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/2051-5960-1-68"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051799785"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/2051-5960-1-68", 
      "https://app.dimensions.ai/details/publication/pub.1051799785"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54328_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2F2051-5960-1-68"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/2051-5960-1-68'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/2051-5960-1-68'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/2051-5960-1-68'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/2051-5960-1-68'


 

This table displays all metadata directly associated to this object as RDF triples.

389 TRIPLES      21 PREDICATES      91 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/2051-5960-1-68 schema:about N066ba592dc5e47adb589d2476f57bb44
2 N17532ce2b3d24da49d9726ba1b7d4fde
3 N1e7978cc1ac2406c9d0da254a3446b09
4 N3a3c77fe43204cf09157a4f8f3d4c382
5 N5997753cf7d845838a7d5493ebe57622
6 N6c3c0ec2d15845f196ef0d69129ca81c
7 N8bafc61536234a8e920f38bee47043da
8 N940c1dfc1b3748e7b5bff74ba4d8ae90
9 N97a5167e515d47ae9cca7bc21bcac520
10 Nb4f16cea661f4637b9aad1ed97a7698c
11 Neb0bb78ed75a4dfca282795bf9c66e68
12 Nebc3f5b7dffd4c66bd82306eeeb163fc
13 Nec859b344476436995bb49fd4ed82010
14 Nf524785e8eea45cfb007713879ef11f1
15 Nf9f1bceebe0c469c972e4017d4d27da3
16 Nfc0da9c806c240c2b104639a0c05d31a
17 anzsrc-for:11
18 anzsrc-for:1109
19 schema:author Nbd6abca32b9c4462b6eee2d40cbc74ae
20 schema:citation sg:pub.10.1007/s00401-005-1079-4
21 sg:pub.10.1007/s00401-006-0138-9
22 sg:pub.10.1007/s00401-007-0236-3
23 sg:pub.10.1007/s00401-007-0237-2
24 sg:pub.10.1007/s00401-010-0765-z
25 sg:pub.10.1007/s00401-011-0845-8
26 sg:pub.10.1007/s00401-011-0907-y
27 sg:pub.10.1007/s00401-011-0911-2
28 sg:pub.10.1007/s00401-012-0970-z
29 sg:pub.10.1007/s00401-013-1088-7
30 sg:pub.10.1038/31508
31 sg:pub.10.1038/nature05016
32 sg:pub.10.1038/nature05017
33 sg:pub.10.1038/ng.442
34 sg:pub.10.1038/ng.536
35 sg:pub.10.1186/2051-5960-1-50
36 https://doi.org/10.1001/2013.jamaneurol.537
37 https://doi.org/10.1001/archneur.64.2.240
38 https://doi.org/10.1016/0022-510x(94)90191-0
39 https://doi.org/10.1016/j.ajhg.2013.01.011
40 https://doi.org/10.1016/j.neurobiolaging.2012.01.109
41 https://doi.org/10.1016/j.neurobiolaging.2012.05.007
42 https://doi.org/10.1016/j.neurobiolaging.2012.10.001
43 https://doi.org/10.1016/j.neurobiolaging.2012.10.003
44 https://doi.org/10.1016/j.neurobiolaging.2012.11.025
45 https://doi.org/10.1016/j.neurobiolaging.2012.12.019
46 https://doi.org/10.1016/j.neuron.2011.09.010
47 https://doi.org/10.1016/j.neuron.2011.09.011
48 https://doi.org/10.1016/j.neuron.2013.02.004
49 https://doi.org/10.1016/s1474-4422(10)70184-8
50 https://doi.org/10.1016/s1474-4422(10)70197-6
51 https://doi.org/10.1056/nejmc1113592
52 https://doi.org/10.1073/pnas.1219643110
53 https://doi.org/10.1093/brain/awl030
54 https://doi.org/10.1093/brain/awr355
55 https://doi.org/10.1093/brain/awr361
56 https://doi.org/10.1093/brain/aws001
57 https://doi.org/10.1093/brain/aws357
58 https://doi.org/10.1111/j.1399-0004.2012.01903.x
59 https://doi.org/10.1111/j.1440-1789.2010.01171.x
60 https://doi.org/10.1126/science.1232927
61 https://doi.org/10.1136/jnnp.2009.204081
62 https://doi.org/10.1136/jnnp.57.4.416
63 https://doi.org/10.1212/01.wnl.0000200048.53766.b4
64 https://doi.org/10.1212/wnl.0b013e3181a55f1c
65 https://doi.org/10.1212/wnl.51.6.1546
66 schema:datePublished 2013-12
67 schema:datePublishedReg 2013-12-01
68 schema:description BACKGROUND: Cases of Frontotemporal Lobar Degeneration (FTLD) and Motor Neurone Disease (MND) associated with expansions in C9ORF72 gene are characterised pathologically by the presence of TDP-43 negative, but p62 positive, inclusions in granule cells of the cerebellum and in cells of dentate gyrus and area CA4 of the hippocampus. RESULTS: We screened 84 cases of pathologically confirmed FTLD and 23 cases of MND for the presence of p62 positive inclusions in these three brain regions, and identified 13 positive cases of FTLD and 3 of MND. All cases demonstrated expansions in C9ORF72 by Southern blotting where frozen tissues were available. The p62 positive inclusions in both cerebellum and hippocampus were immunostained by antibodies to dipeptide repeat proteins (DPR), poly Gly-Ala (poly-GA), poly Gly-Pro (poly-GP) and poly Gly-Arg (poly-GR), these arising from a putative non-ATG initiated (RAN) sense translation of the GGGGCC expansion. There was also some slight, but variable, immunostaining with poly-AP antibody implying some antisense translation might also occur, though the relative paucity of immunostaining could reflect poor antigen avidity on the part of the antisense antibodies. Of the FTLD cases with DPR, 6 showed TDP-43 type A and 6 had TDP-43 type B histology; one had FTLD-tau with the pathology of corticobasal degeneration. There were no qualitative or quantitative differences in the pattern of immunostaining with antibodies to DPR, or p62, proteins between TDP-43 type A and type B cases. Ratings for frequency of inclusions immunostained by these poly-GA, poly-GP and poly-GR antibodies broadly correlated with those for immunolabelled by p62 antibody in all three regions. CONCLUSION: We conclude that DPR are a major component of p62 positive inclusions in FTLD and MND.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree true
72 schema:isPartOf N06613f11ec474af28a1484f12d12d724
73 Ncae1ea35ab9f4c5fbc5b94996d00cd3f
74 sg:journal.1048594
75 schema:name Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72
76 schema:pagination 68
77 schema:productId N0770142caa9e4a8aa5cc26208b07d7b2
78 Nb7d38fb175b34faa83575adb496a8fc4
79 Ncd136b0da5944fc281da64e6fe73e606
80 Ncf8697c19d604c02b9461ea461c3e488
81 Nf803b47d939e4f28821bdc96f67d5f40
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051799785
83 https://doi.org/10.1186/2051-5960-1-68
84 schema:sdDatePublished 2019-04-11T10:20
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher Nd02f1dfc046d45989166175ef04e7a60
87 schema:url https://link.springer.com/10.1186%2F2051-5960-1-68
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N06613f11ec474af28a1484f12d12d724 schema:issueNumber 1
92 rdf:type schema:PublicationIssue
93 N066ba592dc5e47adb589d2476f57bb44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Humans
95 rdf:type schema:DefinedTerm
96 N0770142caa9e4a8aa5cc26208b07d7b2 schema:name readcube_id
97 schema:value f6bec82d8f9dc482838842be1d47c8ac7118bed1f78ab90cd95951212267df13
98 rdf:type schema:PropertyValue
99 N0a51fc1fd1e94549978d1de5b4653a42 schema:name Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, M6 8HD, Salford, UK
100 rdf:type schema:Organization
101 N0e804d580ed043eeb345b574ecb63687 rdf:first sg:person.01132045171.12
102 rdf:rest N8500e188fca44d6fb4e273248a92d8a0
103 N17532ce2b3d24da49d9726ba1b7d4fde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name DNA Repeat Expansion
105 rdf:type schema:DefinedTerm
106 N1b5d82fc82b14edd8297411f259be6ae schema:name Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, M6 8HD, Salford, UK
107 rdf:type schema:Organization
108 N1e7978cc1ac2406c9d0da254a3446b09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Frontotemporal Lobar Degeneration
110 rdf:type schema:DefinedTerm
111 N2bebafbd11fe45999a7ecbbae909cc9a schema:name Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, M6 8HD, Salford, UK
112 rdf:type schema:Organization
113 N34130daf77c94157878949c187f2f92e rdf:first sg:person.01155272521.20
114 rdf:rest N72f17fcd16c344d883c97beea81997c7
115 N3a3c77fe43204cf09157a4f8f3d4c382 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Proteins
117 rdf:type schema:DefinedTerm
118 N521beee6aa08415d9e78f33fd5b6ecc7 schema:name Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, M6 8HD, Salford, UK
119 rdf:type schema:Organization
120 N5997753cf7d845838a7d5493ebe57622 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Female
122 rdf:type schema:DefinedTerm
123 N62142e9233eb42039402f108d75aef9a rdf:first sg:person.01044037023.13
124 rdf:rest N34130daf77c94157878949c187f2f92e
125 N6c3c0ec2d15845f196ef0d69129ca81c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Blotting, Southern
127 rdf:type schema:DefinedTerm
128 N72f17fcd16c344d883c97beea81997c7 rdf:first sg:person.01040623067.27
129 rdf:rest N971cf6b306904606b6c5a860a24cdd15
130 N8500e188fca44d6fb4e273248a92d8a0 rdf:first sg:person.01124725234.59
131 rdf:rest Nf52ed948cb7447cc927dc267c109b1fe
132 N8bafc61536234a8e920f38bee47043da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Brain
134 rdf:type schema:DefinedTerm
135 N940c1dfc1b3748e7b5bff74ba4d8ae90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Aged
137 rdf:type schema:DefinedTerm
138 N971cf6b306904606b6c5a860a24cdd15 rdf:first sg:person.0751430343.49
139 rdf:rest rdf:nil
140 N97a5167e515d47ae9cca7bc21bcac520 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Motor Neuron Disease
142 rdf:type schema:DefinedTerm
143 N98829665d610417588d8f58b37c08f18 rdf:first sg:person.01071613360.03
144 rdf:rest N0e804d580ed043eeb345b574ecb63687
145 Nb4f16cea661f4637b9aad1ed97a7698c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name RNA-Binding Proteins
147 rdf:type schema:DefinedTerm
148 Nb7d38fb175b34faa83575adb496a8fc4 schema:name pubmed_id
149 schema:value 24252525
150 rdf:type schema:PropertyValue
151 Nbd6abca32b9c4462b6eee2d40cbc74ae rdf:first sg:person.07600434432.39
152 rdf:rest Ncf346e5178bc4bf3a26b72dce91c77fd
153 Nc2d479d7332e4177a3a4a07bc6e06612 rdf:first sg:person.01245026531.79
154 rdf:rest Nedcfc077b51940bd906b5259f73d97e0
155 Ncae1ea35ab9f4c5fbc5b94996d00cd3f schema:volumeNumber 1
156 rdf:type schema:PublicationVolume
157 Ncd136b0da5944fc281da64e6fe73e606 schema:name nlm_unique_id
158 schema:value 101610673
159 rdf:type schema:PropertyValue
160 Ncf346e5178bc4bf3a26b72dce91c77fd rdf:first sg:person.011103430227.03
161 rdf:rest N98829665d610417588d8f58b37c08f18
162 Ncf8697c19d604c02b9461ea461c3e488 schema:name doi
163 schema:value 10.1186/2051-5960-1-68
164 rdf:type schema:PropertyValue
165 Nd02f1dfc046d45989166175ef04e7a60 schema:name Springer Nature - SN SciGraph project
166 rdf:type schema:Organization
167 Nd345b3e08306460a8bd2f67b67fe8bd6 schema:name Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, M6 8HD, Salford, UK
168 rdf:type schema:Organization
169 Neb0bb78ed75a4dfca282795bf9c66e68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Male
171 rdf:type schema:DefinedTerm
172 Nebc3f5b7dffd4c66bd82306eeeb163fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name C9orf72 Protein
174 rdf:type schema:DefinedTerm
175 Nec859b344476436995bb49fd4ed82010 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Cytoplasm
177 rdf:type schema:DefinedTerm
178 Nedcfc077b51940bd906b5259f73d97e0 rdf:first sg:person.013053751217.40
179 rdf:rest N62142e9233eb42039402f108d75aef9a
180 Nf524785e8eea45cfb007713879ef11f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Inclusion Bodies
182 rdf:type schema:DefinedTerm
183 Nf52ed948cb7447cc927dc267c109b1fe rdf:first sg:person.013172430222.22
184 rdf:rest Nc2d479d7332e4177a3a4a07bc6e06612
185 Nf803b47d939e4f28821bdc96f67d5f40 schema:name dimensions_id
186 schema:value pub.1051799785
187 rdf:type schema:PropertyValue
188 Nf9f1bceebe0c469c972e4017d4d27da3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Neurons
190 rdf:type schema:DefinedTerm
191 Nfc0da9c806c240c2b104639a0c05d31a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Middle Aged
193 rdf:type schema:DefinedTerm
194 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
195 schema:name Medical and Health Sciences
196 rdf:type schema:DefinedTerm
197 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
198 schema:name Neurosciences
199 rdf:type schema:DefinedTerm
200 sg:grant.2763668 http://pending.schema.org/fundedItem sg:pub.10.1186/2051-5960-1-68
201 rdf:type schema:MonetaryGrant
202 sg:grant.3637675 http://pending.schema.org/fundedItem sg:pub.10.1186/2051-5960-1-68
203 rdf:type schema:MonetaryGrant
204 sg:grant.6050132 http://pending.schema.org/fundedItem sg:pub.10.1186/2051-5960-1-68
205 rdf:type schema:MonetaryGrant
206 sg:grant.6068427 http://pending.schema.org/fundedItem sg:pub.10.1186/2051-5960-1-68
207 rdf:type schema:MonetaryGrant
208 sg:grant.6109149 http://pending.schema.org/fundedItem sg:pub.10.1186/2051-5960-1-68
209 rdf:type schema:MonetaryGrant
210 sg:journal.1048594 schema:issn 2051-5960
211 schema:name Acta Neuropathologica Communications
212 rdf:type schema:Periodical
213 sg:person.01040623067.27 schema:affiliation N2bebafbd11fe45999a7ecbbae909cc9a
214 schema:familyName Davidson
215 schema:givenName Yvonne
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040623067.27
217 rdf:type schema:Person
218 sg:person.01044037023.13 schema:affiliation https://www.grid.ac/institutes/grid.272456.0
219 schema:familyName Masuda-Suzukake
220 schema:givenName Masami
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044037023.13
222 rdf:type schema:Person
223 sg:person.01071613360.03 schema:affiliation N521beee6aa08415d9e78f33fd5b6ecc7
224 schema:familyName Robinson
225 schema:givenName Andrew
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071613360.03
227 rdf:type schema:Person
228 sg:person.011103430227.03 schema:affiliation https://www.grid.ac/institutes/grid.5379.8
229 schema:familyName Rollinson
230 schema:givenName Sara
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011103430227.03
232 rdf:type schema:Person
233 sg:person.01124725234.59 schema:affiliation N1b5d82fc82b14edd8297411f259be6ae
234 schema:familyName Thompson
235 schema:givenName Jennifer C
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124725234.59
237 rdf:type schema:Person
238 sg:person.01132045171.12 schema:affiliation https://www.grid.ac/institutes/grid.5379.8
239 schema:familyName Bennion Callister
240 schema:givenName Janis
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132045171.12
242 rdf:type schema:Person
243 sg:person.01155272521.20 schema:affiliation https://www.grid.ac/institutes/grid.272456.0
244 schema:familyName Hasegawa
245 schema:givenName Masato
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155272521.20
247 rdf:type schema:Person
248 sg:person.01245026531.79 schema:affiliation https://www.grid.ac/institutes/grid.417467.7
249 schema:familyName Gendron
250 schema:givenName Tania
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245026531.79
252 rdf:type schema:Person
253 sg:person.013053751217.40 schema:affiliation https://www.grid.ac/institutes/grid.417467.7
254 schema:familyName Petrucelli
255 schema:givenName Leonard
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013053751217.40
257 rdf:type schema:Person
258 sg:person.013172430222.22 schema:affiliation N0a51fc1fd1e94549978d1de5b4653a42
259 schema:familyName Snowden
260 schema:givenName Julie S
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013172430222.22
262 rdf:type schema:Person
263 sg:person.0751430343.49 schema:affiliation https://www.grid.ac/institutes/grid.5379.8
264 schema:familyName Pickering-Brown
265 schema:givenName Stuart
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751430343.49
267 rdf:type schema:Person
268 sg:person.07600434432.39 schema:affiliation Nd345b3e08306460a8bd2f67b67fe8bd6
269 schema:familyName Mann
270 schema:givenName David MA
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07600434432.39
272 rdf:type schema:Person
273 sg:pub.10.1007/s00401-005-1079-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053718038
274 https://doi.org/10.1007/s00401-005-1079-4
275 rdf:type schema:CreativeWork
276 sg:pub.10.1007/s00401-006-0138-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011285999
277 https://doi.org/10.1007/s00401-006-0138-9
278 rdf:type schema:CreativeWork
279 sg:pub.10.1007/s00401-007-0236-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013932978
280 https://doi.org/10.1007/s00401-007-0236-3
281 rdf:type schema:CreativeWork
282 sg:pub.10.1007/s00401-007-0237-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029516874
283 https://doi.org/10.1007/s00401-007-0237-2
284 rdf:type schema:CreativeWork
285 sg:pub.10.1007/s00401-010-0765-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1020052640
286 https://doi.org/10.1007/s00401-010-0765-z
287 rdf:type schema:CreativeWork
288 sg:pub.10.1007/s00401-011-0845-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024051199
289 https://doi.org/10.1007/s00401-011-0845-8
290 rdf:type schema:CreativeWork
291 sg:pub.10.1007/s00401-011-0907-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1014597823
292 https://doi.org/10.1007/s00401-011-0907-y
293 rdf:type schema:CreativeWork
294 sg:pub.10.1007/s00401-011-0911-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030353161
295 https://doi.org/10.1007/s00401-011-0911-2
296 rdf:type schema:CreativeWork
297 sg:pub.10.1007/s00401-012-0970-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1037356128
298 https://doi.org/10.1007/s00401-012-0970-z
299 rdf:type schema:CreativeWork
300 sg:pub.10.1007/s00401-013-1088-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027055662
301 https://doi.org/10.1007/s00401-013-1088-7
302 rdf:type schema:CreativeWork
303 sg:pub.10.1038/31508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030318669
304 https://doi.org/10.1038/31508
305 rdf:type schema:CreativeWork
306 sg:pub.10.1038/nature05016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038649717
307 https://doi.org/10.1038/nature05016
308 rdf:type schema:CreativeWork
309 sg:pub.10.1038/nature05017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029205851
310 https://doi.org/10.1038/nature05017
311 rdf:type schema:CreativeWork
312 sg:pub.10.1038/ng.442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016041388
313 https://doi.org/10.1038/ng.442
314 rdf:type schema:CreativeWork
315 sg:pub.10.1038/ng.536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011035298
316 https://doi.org/10.1038/ng.536
317 rdf:type schema:CreativeWork
318 sg:pub.10.1186/2051-5960-1-50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006123388
319 https://doi.org/10.1186/2051-5960-1-50
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1001/2013.jamaneurol.537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005398003
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1001/archneur.64.2.240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015832947
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/0022-510x(94)90191-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011575660
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/j.ajhg.2013.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011988258
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/j.neurobiolaging.2012.01.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033797071
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/j.neurobiolaging.2012.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003011922
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1016/j.neurobiolaging.2012.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045314144
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1016/j.neurobiolaging.2012.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013161842
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1016/j.neurobiolaging.2012.11.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051325819
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1016/j.neurobiolaging.2012.12.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046603903
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1016/j.neuron.2011.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044938477
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1016/j.neuron.2011.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002524543
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1016/j.neuron.2013.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010481064
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1016/s1474-4422(10)70184-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007677508
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1016/s1474-4422(10)70197-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004831873
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1056/nejmc1113592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027601409
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1073/pnas.1219643110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003075180
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1093/brain/awl030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048066840
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1093/brain/awr355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019792266
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1093/brain/awr361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019894998
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1093/brain/aws001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032770812
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1093/brain/aws357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020763611
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1111/j.1399-0004.2012.01903.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031830434
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1111/j.1440-1789.2010.01171.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016835523
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1126/science.1232927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023614866
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1136/jnnp.2009.204081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015390651
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1136/jnnp.57.4.416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013938124
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1212/01.wnl.0000200048.53766.b4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064347855
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1212/wnl.0b013e3181a55f1c schema:sameAs https://app.dimensions.ai/details/publication/pub.1064354331
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1212/wnl.51.6.1546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064376963
380 rdf:type schema:CreativeWork
381 https://www.grid.ac/institutes/grid.272456.0 schema:alternateName Tokyo Metropolitan Institute of Medical Science
382 schema:name Department of Neuropathology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, 156-8506, Tokyo, Japan
383 rdf:type schema:Organization
384 https://www.grid.ac/institutes/grid.417467.7 schema:alternateName Mayo Clinic
385 schema:name Mayo Clinic, FL32224, Jacksonville, FL, USA
386 rdf:type schema:Organization
387 https://www.grid.ac/institutes/grid.5379.8 schema:alternateName University of Manchester
388 schema:name Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, A V Hill Building, Oxford Rd, M13 9PL, Manchester, UK
389 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...