Immunologic responses to xenogeneic tyrosinase DNA vaccine administered by electroporation in patients with malignant melanoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Jianda Yuan, Geoffrey Y Ku, Matthew Adamow, Zhenyu Mu, Sapna Tandon, Drew Hannaman, Paul Chapman, Gary Schwartz, Richard Carvajal, Katherine S Panageas, Alan N Houghton, Jedd D Wolchok

ABSTRACT

BACKGROUND: Prior studies show that intramuscular injection and particle-mediated epidermal delivery of xenogeneic melanosomal antigens (tyrosinase or Tyr, gp100) induce CD8(+) T cell responses to the syngeneic protein. To further define the optimal vaccination strategy, we conducted a phase I study of in vivo electroporation (EP) of a murine Tyr DNA vaccine (pINGmuTyr) in malignant melanoma patients. METHODS: Human leukocyte antigen (HLA)-A1, A2, A24 or B35 stage IIb-IV melanoma patients received up to five doses of the mouse tyrosinase DNA vaccine by EP every three weeks at dose levels of 0.2 mg, 0.5 mg, or 1.5 mg per injection. Peripheral blood mononuclear cells (PBMC) were collected, cultured with a peptide pool containing eight HLA class I-restricted Tyr-specific T-cell epitopes, and analyzed by HLA-A*0101-restricted tetramers and intracellular cytokine staining (ICS). RESULTS: Twenty-four patients received ≥1 dose of the pINGmuTyr vaccine; PBMCs from 21 patients who completed all five doses were available for Tyr immune assays. The only common toxicity was grade 1 injection site reaction. Six of 15 patients (40%) in the 1.5 mg dose cohort developed Tyr-reactive CD8(+) T cell responses following stimulation, defined as a ≥3 standard deviation increase in baseline reactivity by tetramer or ICS assays. No Tyr-reactive CD8(+) T cell response was detected in the 0.2 mg and 0.5 mg dose cohort patients. Epitope spreading of CD8(+) T cell response to NY-ESO-1 was observed in one patient with vitiligo. One patient subsequently received ipilimumab and developed an enhanced Tyr-reactive response with polyfunctional cytokine profile. After a median follow-up of 40.9 months, median survival has not been reached. CONCLUSIONS: A regimen of five immunizations with pINGmuTyr administered by EP was found to be safe and resulted in Tyr-reactive immune responses in six of 15 patients at 1.5 mg dose cohort. TRIAL REGISTRATION: ClinicalTrials.gov NCT00471133. More... »

PAGES

20

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/2051-1426-1-20

DOI

http://dx.doi.org/10.1186/2051-1426-1-20

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035943441

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24829756


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Institute, NY10065, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yuan", 
        "givenName": "Jianda", 
        "id": "sg:person.012510205147.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012510205147.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Memorial Sloan Kettering Cancer Center, 10065, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ku", 
        "givenName": "Geoffrey Y", 
        "id": "sg:person.01136712123.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136712123.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Institute, NY10065, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Adamow", 
        "givenName": "Matthew", 
        "id": "sg:person.014666710657.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014666710657.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Institute, NY10065, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mu", 
        "givenName": "Zhenyu", 
        "id": "sg:person.01230352143.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230352143.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Institute, NY10065, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tandon", 
        "givenName": "Sapna", 
        "id": "sg:person.0577557275.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577557275.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Ichor Medical System, Inc., 92121, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hannaman", 
        "givenName": "Drew", 
        "id": "sg:person.01234252565.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234252565.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Memorial Sloan Kettering Cancer Center, 10065, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chapman", 
        "givenName": "Paul", 
        "id": "sg:person.01155324177.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155324177.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Memorial Sloan Kettering Cancer Center, 10065, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schwartz", 
        "givenName": "Gary", 
        "id": "sg:person.012707142152.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012707142152.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Medicine, Memorial Sloan Kettering Cancer Center, 10065, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carvajal", 
        "givenName": "Richard", 
        "id": "sg:person.0726366600.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726366600.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, NY10065, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Panageas", 
        "givenName": "Katherine S", 
        "id": "sg:person.01356724235.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356724235.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Institute, NY10065, New York, USA", 
            "Department of Medicine, Memorial Sloan Kettering Cancer Center, 10065, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Houghton", 
        "givenName": "Alan N", 
        "id": "sg:person.0740431650.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740431650.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Institute, NY10065, New York, USA", 
            "Department of Medicine, Memorial Sloan Kettering Cancer Center, 10065, New York, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wolchok", 
        "givenName": "Jedd D", 
        "id": "sg:person.0645565266.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645565266.33"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.92.18.8125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000609235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cps.2009.07.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001741340"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.mt.6300290", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003128046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.165.3.812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003362413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006865477", 
          "https://doi.org/10.1038/nri2506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.21014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007259273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.26.2063", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011059395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vaccine.2005.08.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014608460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vaccine.2005.08.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014608460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.190.11.1717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015037982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/14653240600868262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015729741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/mt.2008.196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020263617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/msj.20215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020371411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/msj.20215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020371411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-1410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020678879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0019252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024519962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.vaccine.2009.07.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025372116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-1093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025414487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.22.012703.104702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027542915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.178.2.489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033051074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2010.00980.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038171944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2010.00980.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038171944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/era.10.180", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039613877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830240340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040202921"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1939-1676.2010.0627.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040311404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0810114105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041144257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-011-1011-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043032376", 
          "https://doi.org/10.1007/s00262-011-1011-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-1103-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044850066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.iy.12.040194.002005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047387943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-230x(06)95001-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049490303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00268-010-0859-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050504693", 
          "https://doi.org/10.1007/s00268-010-0859-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1003466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052212829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/14653240903136987", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052482775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0344-0338(00)80072-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053284335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3004414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062687608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1566523033347462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069184250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/156652311798192815", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069184656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2460/javma.236.5.488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070770167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075266192", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.170.10.5188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075282171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076998687", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.178.7.4112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077387710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077909606", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "BACKGROUND: Prior studies show that intramuscular injection and particle-mediated epidermal delivery of xenogeneic melanosomal antigens (tyrosinase or Tyr, gp100) induce CD8(+) T cell responses to the syngeneic protein. To further define the optimal vaccination strategy, we conducted a phase I study of in vivo electroporation (EP) of a murine Tyr DNA vaccine (pINGmuTyr) in malignant melanoma patients.\nMETHODS: Human leukocyte antigen (HLA)-A1, A2, A24 or B35 stage IIb-IV melanoma patients received up to five doses of the mouse tyrosinase DNA vaccine by EP every three weeks at dose levels of 0.2\u00a0mg, 0.5\u00a0mg, or 1.5\u00a0mg per injection. Peripheral blood mononuclear cells (PBMC) were collected, cultured with a peptide pool containing eight HLA class I-restricted Tyr-specific T-cell epitopes, and analyzed by HLA-A*0101-restricted tetramers and intracellular cytokine staining (ICS).\nRESULTS: Twenty-four patients received \u22651 dose of the pINGmuTyr vaccine; PBMCs from 21 patients who completed all five doses were available for Tyr immune assays. The only common toxicity was grade 1 injection site reaction. Six of 15 patients (40%) in the 1.5\u00a0mg dose cohort developed Tyr-reactive CD8(+) T cell responses following stimulation, defined as a \u22653 standard deviation increase in baseline reactivity by tetramer or ICS assays. No Tyr-reactive CD8(+) T cell response was detected in the 0.2\u00a0mg and 0.5\u00a0mg dose cohort patients. Epitope spreading of CD8(+) T cell response to NY-ESO-1 was observed in one patient with vitiligo. One patient subsequently received ipilimumab and developed an enhanced Tyr-reactive response with polyfunctional cytokine profile. After a median follow-up of 40.9\u00a0months, median survival has not been reached.\nCONCLUSIONS: A regimen of five immunizations with pINGmuTyr administered by EP was found to be safe and resulted in Tyr-reactive immune responses in six of 15 patients at 1.5\u00a0mg dose cohort.\nTRIAL REGISTRATION: ClinicalTrials.gov NCT00471133.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/2051-1426-1-20", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438793", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2435475", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1049249", 
        "issn": [
          "2051-1426"
        ], 
        "name": "Journal for ImmunoTherapy of Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "1"
      }
    ], 
    "name": "Immunologic responses to xenogeneic tyrosinase DNA vaccine administered by electroporation in patients with malignant melanoma", 
    "pagination": "20", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ab3910d6a4203de2ec2f03ff2cd4dc192da6bf8ca7f942b87315089bbe1a3483"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24829756"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101620585"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/2051-1426-1-20"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035943441"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/2051-1426-1-20", 
      "https://app.dimensions.ai/details/publication/pub.1035943441"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113647_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1186%2F2051-1426-1-20"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/2051-1426-1-20'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/2051-1426-1-20'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/2051-1426-1-20'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/2051-1426-1-20'


 

This table displays all metadata directly associated to this object as RDF triples.

273 TRIPLES      21 PREDICATES      69 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/2051-1426-1-20 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N37177f888900465e990601653d4ac45b
4 schema:citation sg:pub.10.1007/s00262-011-1011-9
5 sg:pub.10.1007/s00268-010-0859-8
6 sg:pub.10.1038/nri2506
7 https://app.dimensions.ai/details/publication/pub.1075266192
8 https://app.dimensions.ai/details/publication/pub.1076998687
9 https://app.dimensions.ai/details/publication/pub.1077909606
10 https://doi.org/10.1002/eji.1830240340
11 https://doi.org/10.1002/ijc.21014
12 https://doi.org/10.1002/msj.20215
13 https://doi.org/10.1016/j.cps.2009.07.008
14 https://doi.org/10.1016/j.vaccine.2005.08.027
15 https://doi.org/10.1016/j.vaccine.2009.07.005
16 https://doi.org/10.1016/s0065-230x(06)95001-5
17 https://doi.org/10.1016/s0344-0338(00)80072-2
18 https://doi.org/10.1038/mt.2008.196
19 https://doi.org/10.1038/sj.mt.6300290
20 https://doi.org/10.1056/nejmoa1003466
21 https://doi.org/10.1073/pnas.0810114105
22 https://doi.org/10.1073/pnas.92.18.8125
23 https://doi.org/10.1080/14653240600868262
24 https://doi.org/10.1084/jem.165.3.812
25 https://doi.org/10.1084/jem.178.2.489
26 https://doi.org/10.1084/jem.190.11.1717
27 https://doi.org/10.1111/j.1600-065x.2010.00980.x
28 https://doi.org/10.1111/j.1939-1676.2010.0627.x
29 https://doi.org/10.1126/scitranslmed.3004414
30 https://doi.org/10.1146/annurev.immunol.22.012703.104702
31 https://doi.org/10.1146/annurev.iy.12.040194.002005
32 https://doi.org/10.1158/1078-0432.ccr-05-1410
33 https://doi.org/10.1158/1078-0432.ccr-10-1093
34 https://doi.org/10.1158/1078-0432.ccr-1103-3
35 https://doi.org/10.1200/jco.2009.26.2063
36 https://doi.org/10.1371/journal.pone.0019252
37 https://doi.org/10.1586/era.10.180
38 https://doi.org/10.2174/1566523033347462
39 https://doi.org/10.2174/156652311798192815
40 https://doi.org/10.2460/javma.236.5.488
41 https://doi.org/10.3109/14653240903136987
42 https://doi.org/10.4049/jimmunol.170.10.5188
43 https://doi.org/10.4049/jimmunol.178.7.4112
44 schema:datePublished 2013-12
45 schema:datePublishedReg 2013-12-01
46 schema:description BACKGROUND: Prior studies show that intramuscular injection and particle-mediated epidermal delivery of xenogeneic melanosomal antigens (tyrosinase or Tyr, gp100) induce CD8(+) T cell responses to the syngeneic protein. To further define the optimal vaccination strategy, we conducted a phase I study of in vivo electroporation (EP) of a murine Tyr DNA vaccine (pINGmuTyr) in malignant melanoma patients. METHODS: Human leukocyte antigen (HLA)-A1, A2, A24 or B35 stage IIb-IV melanoma patients received up to five doses of the mouse tyrosinase DNA vaccine by EP every three weeks at dose levels of 0.2 mg, 0.5 mg, or 1.5 mg per injection. Peripheral blood mononuclear cells (PBMC) were collected, cultured with a peptide pool containing eight HLA class I-restricted Tyr-specific T-cell epitopes, and analyzed by HLA-A*0101-restricted tetramers and intracellular cytokine staining (ICS). RESULTS: Twenty-four patients received ≥1 dose of the pINGmuTyr vaccine; PBMCs from 21 patients who completed all five doses were available for Tyr immune assays. The only common toxicity was grade 1 injection site reaction. Six of 15 patients (40%) in the 1.5 mg dose cohort developed Tyr-reactive CD8(+) T cell responses following stimulation, defined as a ≥3 standard deviation increase in baseline reactivity by tetramer or ICS assays. No Tyr-reactive CD8(+) T cell response was detected in the 0.2 mg and 0.5 mg dose cohort patients. Epitope spreading of CD8(+) T cell response to NY-ESO-1 was observed in one patient with vitiligo. One patient subsequently received ipilimumab and developed an enhanced Tyr-reactive response with polyfunctional cytokine profile. After a median follow-up of 40.9 months, median survival has not been reached. CONCLUSIONS: A regimen of five immunizations with pINGmuTyr administered by EP was found to be safe and resulted in Tyr-reactive immune responses in six of 15 patients at 1.5 mg dose cohort. TRIAL REGISTRATION: ClinicalTrials.gov NCT00471133.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree true
50 schema:isPartOf N5d9429b8b93b4a71ae149277c66a7699
51 Nde7ae2cc427e4a41ba09bf958eeb2def
52 sg:journal.1049249
53 schema:name Immunologic responses to xenogeneic tyrosinase DNA vaccine administered by electroporation in patients with malignant melanoma
54 schema:pagination 20
55 schema:productId N5f1a8dff6163490dab23d359b2f7ed73
56 Ndf57e7ef38664fbfb5c8dbdfca75d9ed
57 Necf8659b4c2d4a4caff6a72ea36e9098
58 Ned6b745c0acb4bd7864398f5f04a464f
59 Nfa342ea4d4384cf790156e8f2f9b37d4
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035943441
61 https://doi.org/10.1186/2051-1426-1-20
62 schema:sdDatePublished 2019-04-11T10:30
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N53116fc0adb243a4aefe2de338ccf316
65 schema:url https://link.springer.com/10.1186%2F2051-1426-1-20
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N10e13485c4434c2dbe410b3429a8ba60 rdf:first sg:person.012707142152.08
70 rdf:rest N502b53b959914d7e82dde5bdb3b13ee8
71 N25bcefa99cca4c66940055e57f610917 rdf:first sg:person.0740431650.46
72 rdf:rest N7eae6c14cca941629854075cd7df812b
73 N262f374c2021442599da7767022899ed rdf:first sg:person.01356724235.54
74 rdf:rest N25bcefa99cca4c66940055e57f610917
75 N37177f888900465e990601653d4ac45b rdf:first sg:person.012510205147.27
76 rdf:rest N7d8b738eb29b40f39e29674f6409d263
77 N502b53b959914d7e82dde5bdb3b13ee8 rdf:first sg:person.0726366600.25
78 rdf:rest N262f374c2021442599da7767022899ed
79 N53116fc0adb243a4aefe2de338ccf316 schema:name Springer Nature - SN SciGraph project
80 rdf:type schema:Organization
81 N5d9429b8b93b4a71ae149277c66a7699 schema:issueNumber 1
82 rdf:type schema:PublicationIssue
83 N5f1a8dff6163490dab23d359b2f7ed73 schema:name nlm_unique_id
84 schema:value 101620585
85 rdf:type schema:PropertyValue
86 N7d8b738eb29b40f39e29674f6409d263 rdf:first sg:person.01136712123.05
87 rdf:rest Ndf96c852b836483fbcfc151f166a483a
88 N7eae6c14cca941629854075cd7df812b rdf:first sg:person.0645565266.33
89 rdf:rest rdf:nil
90 N9c3757d8d3a64d5c9845b60ba9a53c55 rdf:first sg:person.0577557275.28
91 rdf:rest N9cda77504238490d82c4b0aab256a3c0
92 N9cda77504238490d82c4b0aab256a3c0 rdf:first sg:person.01234252565.18
93 rdf:rest Nb8c521d3919d455a85e44512d1858be4
94 Nb8c521d3919d455a85e44512d1858be4 rdf:first sg:person.01155324177.77
95 rdf:rest N10e13485c4434c2dbe410b3429a8ba60
96 Ncfe0436ab36749cea16af9537af33401 schema:name Ichor Medical System, Inc., 92121, San Diego, CA, USA
97 rdf:type schema:Organization
98 Nde7ae2cc427e4a41ba09bf958eeb2def schema:volumeNumber 1
99 rdf:type schema:PublicationVolume
100 Ndf57e7ef38664fbfb5c8dbdfca75d9ed schema:name pubmed_id
101 schema:value 24829756
102 rdf:type schema:PropertyValue
103 Ndf96c852b836483fbcfc151f166a483a rdf:first sg:person.014666710657.34
104 rdf:rest Nf959babe48684effa44e82e9dfaf6bde
105 Necf8659b4c2d4a4caff6a72ea36e9098 schema:name dimensions_id
106 schema:value pub.1035943441
107 rdf:type schema:PropertyValue
108 Ned6b745c0acb4bd7864398f5f04a464f schema:name doi
109 schema:value 10.1186/2051-1426-1-20
110 rdf:type schema:PropertyValue
111 Nf959babe48684effa44e82e9dfaf6bde rdf:first sg:person.01230352143.27
112 rdf:rest N9c3757d8d3a64d5c9845b60ba9a53c55
113 Nfa342ea4d4384cf790156e8f2f9b37d4 schema:name readcube_id
114 schema:value ab3910d6a4203de2ec2f03ff2cd4dc192da6bf8ca7f942b87315089bbe1a3483
115 rdf:type schema:PropertyValue
116 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
117 schema:name Medical and Health Sciences
118 rdf:type schema:DefinedTerm
119 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
120 schema:name Immunology
121 rdf:type schema:DefinedTerm
122 sg:grant.2435475 http://pending.schema.org/fundedItem sg:pub.10.1186/2051-1426-1-20
123 rdf:type schema:MonetaryGrant
124 sg:grant.2438793 http://pending.schema.org/fundedItem sg:pub.10.1186/2051-1426-1-20
125 rdf:type schema:MonetaryGrant
126 sg:journal.1049249 schema:issn 2051-1426
127 schema:name Journal for ImmunoTherapy of Cancer
128 rdf:type schema:Periodical
129 sg:person.01136712123.05 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
130 schema:familyName Ku
131 schema:givenName Geoffrey Y
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136712123.05
133 rdf:type schema:Person
134 sg:person.01155324177.77 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
135 schema:familyName Chapman
136 schema:givenName Paul
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155324177.77
138 rdf:type schema:Person
139 sg:person.01230352143.27 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
140 schema:familyName Mu
141 schema:givenName Zhenyu
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230352143.27
143 rdf:type schema:Person
144 sg:person.01234252565.18 schema:affiliation Ncfe0436ab36749cea16af9537af33401
145 schema:familyName Hannaman
146 schema:givenName Drew
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234252565.18
148 rdf:type schema:Person
149 sg:person.012510205147.27 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
150 schema:familyName Yuan
151 schema:givenName Jianda
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012510205147.27
153 rdf:type schema:Person
154 sg:person.012707142152.08 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
155 schema:familyName Schwartz
156 schema:givenName Gary
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012707142152.08
158 rdf:type schema:Person
159 sg:person.01356724235.54 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
160 schema:familyName Panageas
161 schema:givenName Katherine S
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356724235.54
163 rdf:type schema:Person
164 sg:person.014666710657.34 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
165 schema:familyName Adamow
166 schema:givenName Matthew
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014666710657.34
168 rdf:type schema:Person
169 sg:person.0577557275.28 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
170 schema:familyName Tandon
171 schema:givenName Sapna
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577557275.28
173 rdf:type schema:Person
174 sg:person.0645565266.33 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
175 schema:familyName Wolchok
176 schema:givenName Jedd D
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645565266.33
178 rdf:type schema:Person
179 sg:person.0726366600.25 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
180 schema:familyName Carvajal
181 schema:givenName Richard
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726366600.25
183 rdf:type schema:Person
184 sg:person.0740431650.46 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
185 schema:familyName Houghton
186 schema:givenName Alan N
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740431650.46
188 rdf:type schema:Person
189 sg:pub.10.1007/s00262-011-1011-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043032376
190 https://doi.org/10.1007/s00262-011-1011-9
191 rdf:type schema:CreativeWork
192 sg:pub.10.1007/s00268-010-0859-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050504693
193 https://doi.org/10.1007/s00268-010-0859-8
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/nri2506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006865477
196 https://doi.org/10.1038/nri2506
197 rdf:type schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1075266192 schema:CreativeWork
199 https://app.dimensions.ai/details/publication/pub.1076998687 schema:CreativeWork
200 https://app.dimensions.ai/details/publication/pub.1077909606 schema:CreativeWork
201 https://doi.org/10.1002/eji.1830240340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040202921
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1002/ijc.21014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007259273
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1002/msj.20215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020371411
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.cps.2009.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001741340
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.vaccine.2005.08.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014608460
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.vaccine.2009.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025372116
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/s0065-230x(06)95001-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049490303
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/s0344-0338(00)80072-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053284335
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1038/mt.2008.196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020263617
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1038/sj.mt.6300290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003128046
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1056/nejmoa1003466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052212829
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1073/pnas.0810114105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041144257
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1073/pnas.92.18.8125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000609235
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1080/14653240600868262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015729741
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1084/jem.165.3.812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003362413
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1084/jem.178.2.489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033051074
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1084/jem.190.11.1717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015037982
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1111/j.1600-065x.2010.00980.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038171944
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1111/j.1939-1676.2010.0627.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040311404
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1126/scitranslmed.3004414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062687608
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1146/annurev.immunol.22.012703.104702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027542915
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1146/annurev.iy.12.040194.002005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047387943
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1158/1078-0432.ccr-05-1410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020678879
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1158/1078-0432.ccr-10-1093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025414487
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1158/1078-0432.ccr-1103-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044850066
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1200/jco.2009.26.2063 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011059395
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1371/journal.pone.0019252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024519962
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1586/era.10.180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039613877
256 rdf:type schema:CreativeWork
257 https://doi.org/10.2174/1566523033347462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069184250
258 rdf:type schema:CreativeWork
259 https://doi.org/10.2174/156652311798192815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069184656
260 rdf:type schema:CreativeWork
261 https://doi.org/10.2460/javma.236.5.488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070770167
262 rdf:type schema:CreativeWork
263 https://doi.org/10.3109/14653240903136987 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052482775
264 rdf:type schema:CreativeWork
265 https://doi.org/10.4049/jimmunol.170.10.5188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075282171
266 rdf:type schema:CreativeWork
267 https://doi.org/10.4049/jimmunol.178.7.4112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077387710
268 rdf:type schema:CreativeWork
269 https://www.grid.ac/institutes/grid.51462.34 schema:alternateName Memorial Sloan Kettering Cancer Center
270 schema:name Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, NY10065, New York, USA
271 Department of Medicine, Memorial Sloan Kettering Cancer Center, 10065, New York, NY, USA
272 Ludwig Center for Cancer Immunotherapy, Immunology Program, Sloan-Kettering Institute, NY10065, New York, USA
273 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...