Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-10-04

AUTHORS

Nady Braidy, Wei-Ping Gai, Ying Hua Xu, Perminder Sachdev, Gilles J Guillemin, Xing-Mai Jiang, J William O Ballard, Martin P Horan, Zhi Ming Fang, Beng H Chong, Daniel Kam Yin Chan

ABSTRACT

The accumulation and aggregation of alpha-synuclein (α-syn) in several tissue including the brain is a major pathological hallmark in Parkinson's disease (PD). In this study, we show that α-syn can be taken up by primary human cortical neurons, astrocytes and skin-derived fibroblasts in vitro. Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function, leading to cellular degeneration and cell death, provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. More... »

PAGES

20-20

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/2047-9158-2-20

DOI

http://dx.doi.org/10.1186/2047-9158-2-20

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014890914

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24093918


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