Severe everolimus-induced steatohepatis: a case report View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-07-03

AUTHORS

Gisela Schieren, Edwin Bölke, Axel Scherer, Andreas Raffel, Peter Arne Gerber, Patric Kröpil, Matthias Schott, Jackson Hamilton, Anne Hayman, Wolfram Trudo Knoefel, Wilfried Budach, Christiane Matuschek

ABSTRACT

The mammalian target of rapamycin inhibitors are normally favored as immunosuppressant agents for solid organ transplantation such as kidney, liver or heart. Only in recent years have they been increasingly administered for the treatment of neuroendocrine tumors. Even though mammalian target of rapamycin inhibitors are known to exhibit specific side effects, everolimus-related severe hepatic steatosis has not as yet been described in the literature. We report the case of a 76-year-old man who developed severe hepatic steatosis within four weeks of treatment with everolimus as concomitant tumor therapy for a progressively growing neuroendocrine carcinoma of the ileum. A diagnosis of hepatic steatosis was established using computer tomography and fibroscan©. Other underlying causes for steatosis hepatis could be excluded. Further studies are warranted to explain the underlying mechanisms. More... »

PAGES

22

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/2047-783x-18-22

DOI

http://dx.doi.org/10.1186/2047-783x-18-22

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007440260

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23822543


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