The role of neoadjuvant and adjuvant treatment for adenocarcinoma of the upper gastrointestinal tract View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-06-21

AUTHORS

C Matuschek, E Bölke, M Peiper, WT Knoefel, W Budach, A Erhardt, A Scherer, PA Gerber, BA Buhren, N Gattermann, SE Baldus, E Rusnak, V Shukla, K Orth

ABSTRACT

Both locally advanced adenocarcinoma of the stomach and gastro-esophageal junction are associated with poor prognosis due to the lack of effective treatment. Recently multimodal treatment consisting of neoadjuvant chemotherapy in combination with radiotherapy is reported to improve survival when compared to surgery alone. Neoadjuvant therapy in these locally advanced tumors allows for early tumor responses and the extent of tumor regression that can be achieved is considered a significant prognostic factor. This, in turn, increases the resectability of these tumors. Also due to the high frequency of lymph node metastasis, patients with locally advanced adenocarcinoma should undergo a D2 lymphadenectomy. Postoperative chemoradiation and perioperative chemotherapy have been studied in gastric adenocarcinomas and showed a survival benefit. However, the surgical techniques used in these trials are no longer considered to be standard by today's surgical practice. In addition, there are no standard recommendations for adjuvant chemotherapy or chemoradiation after R0 resection and adequate lymph node dissection. More... »

PAGES

265

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/2047-783x-16-6-265

DOI

http://dx.doi.org/10.1186/2047-783x-16-6-265

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042910397

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21810561


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24 schema:description Both locally advanced adenocarcinoma of the stomach and gastro-esophageal junction are associated with poor prognosis due to the lack of effective treatment. Recently multimodal treatment consisting of neoadjuvant chemotherapy in combination with radiotherapy is reported to improve survival when compared to surgery alone. Neoadjuvant therapy in these locally advanced tumors allows for early tumor responses and the extent of tumor regression that can be achieved is considered a significant prognostic factor. This, in turn, increases the resectability of these tumors. Also due to the high frequency of lymph node metastasis, patients with locally advanced adenocarcinoma should undergo a D2 lymphadenectomy. Postoperative chemoradiation and perioperative chemotherapy have been studied in gastric adenocarcinomas and showed a survival benefit. However, the surgical techniques used in these trials are no longer considered to be standard by today's surgical practice. In addition, there are no standard recommendations for adjuvant chemotherapy or chemoradiation after R0 resection and adequate lymph node dissection.
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31 schema:keywords D2 lymphadenectomy
32 R0 resection
33 addition
34 adenocarcinoma
35 adequate lymph node dissection
36 adjuvant chemotherapy
37 adjuvant treatment
38 advanced adenocarcinoma
39 advanced tumors
40 benefits
41 chemoradiation
42 chemotherapy
43 combination
44 dissection
45 early tumor response
46 effective treatment
47 extent
48 factors
49 frequency
50 gastric adenocarcinoma
51 gastro-esophageal junction
52 gastrointestinal tract
53 high frequency
54 junction
55 lack
56 lymph node dissection
57 lymph node metastasis
58 lymphadenectomy
59 metastasis
60 multimodal treatment
61 neoadjuvant chemotherapy
62 neoadjuvant therapy
63 node dissection
64 node metastasis
65 patients
66 perioperative chemotherapy
67 poor prognosis
68 postoperative chemoradiation
69 practice
70 prognosis
71 prognostic factors
72 radiotherapy
73 recommendations
74 regression
75 resectability
76 resection
77 response
78 role
79 significant prognostic factors
80 standard recommendations
81 stomach
82 surgery
83 surgical practice
84 surgical technique
85 survival
86 survival benefit
87 technique
88 therapy
89 today's surgical practice
90 tract
91 treatment
92 trials
93 tumor regression
94 tumor response
95 tumors
96 turn
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