Ontology type: schema:ScholarlyArticle Open Access: True
2011-12
AUTHORSF Tiba, F Nauwelaers, L Sangare, B Coulibaly, V Mrosek, HG Kräusslich, T Böhler
ABSTRACTOBJECTIVE: It is not exactly known how frequent exposure to Plasmodium falciparum shapes the peripheral blood T-cell population in healthy West Africans. METHODS: The frequency of peripheral blood CD4(+) lymphocytes responding to Plasmodium falciparum merozoite surface protein 1 (PfMSP-1) by production of interferon-gamma (IFN-γ), interleukin-2 (IL-2) or tumor necrosis factor-alpha (TNF-α) was determined using a commercially available flow cytometric activation assay (FastImmune) in 17 healthy adults in Nouna, Burkina Faso. T-cell activation and maturation in peripheral blood of healthy adults in Burkina Faso (n=40) and Germany (n=20) were compared using immunophenotyping and three-colour flow cytometry. RESULTS: Significant numbers of PfMSP-1 -specific CD4(+) lymphocytes producing IFN-γ, IL-2 and/or TNF-α were detected in 14 healthy adults in Nouna. Cytokine profiles showed predominant production of IFN-γ and TNF-α. Compared to Germans, Burkinabé showed markedly lower proportions of CCR7+ CD45RA+ naive CD4(+) cells and slightly higher frequencies of CD95(+)CD4(+) T-cells and of CD38(+) CD8(+) T-cells. The median antibody-binding capacity of CD95(dim) CD4(+) T-cells in Burkinabé was more than twice the value observed in Germans (263 vs. 108 binding sites per cell, p<0.0001). CONCLUSIONS: We hypothesize that an IFN-γ-induced increase in the expression level of CD95 on CD4(+) lymphocytes may lower the activation threshold of resting naive CD4(+) T-cells in healthy adults living in Burkina Faso. Bystander activation of these cells deserves further study as a molecular mechanism linking strong IFN-γ responses against Plasmodium falciparum to decreased susceptibility to parasitemia observed in specific ethnic groups in West Africa. More... »
PAGES519
http://scigraph.springernature.com/pub.10.1186/2047-783x-16-12-519
DOIhttp://dx.doi.org/10.1186/2047-783x-16-12-519
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1021791000
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/22112357
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "ADP-ribosyl Cyclase 1",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Burkina Faso",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "CD4-Positive T-Lymphocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "CD8-Positive T-Lymphocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Germany",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Interferon-gamma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Interleukin-2",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Leukocyte Common Antigens",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphocyte Activation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Membrane Glycoproteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Merozoite Surface Protein 1",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Plasmodium falciparum",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptors, CCR7",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "T-Lymphocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tumor Necrosis Factor-alpha",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Young Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "fas Receptor",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Heidelberg University",
"id": "https://www.grid.ac/institutes/grid.7700.0",
"name": [
"Department of Infectious Diseases, Virology, University of Heidelberg, INF324, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Tiba",
"givenName": "F",
"id": "sg:person.0674170330.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674170330.63"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"BD Biosciences, Erembodegem, Belgium"
],
"type": "Organization"
},
"familyName": "Nauwelaers",
"givenName": "F",
"id": "sg:person.01010416730.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010416730.09"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"University Hospital Ouagadougou, Ouagadougou, Burkina Faso"
],
"type": "Organization"
},
"familyName": "Sangare",
"givenName": "L",
"id": "sg:person.0767666315.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767666315.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre de Recherche en Sant\u00e9 de Nouna",
"id": "https://www.grid.ac/institutes/grid.450607.0",
"name": [
"Centre de Recherche en Sante de Nouna, Nouna, Burkina Faso"
],
"type": "Organization"
},
"familyName": "Coulibaly",
"givenName": "B",
"id": "sg:person.0673756210.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673756210.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberg University",
"id": "https://www.grid.ac/institutes/grid.7700.0",
"name": [
"Department of Infectious Diseases, Virology, University of Heidelberg, INF324, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Mrosek",
"givenName": "V",
"id": "sg:person.01356365362.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356365362.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberg University",
"id": "https://www.grid.ac/institutes/grid.7700.0",
"name": [
"Department of Infectious Diseases, Virology, University of Heidelberg, INF324, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "Kr\u00e4usslich",
"givenName": "HG",
"id": "sg:person.0731120455.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731120455.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Heidelberg University",
"id": "https://www.grid.ac/institutes/grid.7700.0",
"name": [
"Department of Infectious Diseases, Virology, University of Heidelberg, INF324, Heidelberg, Germany"
],
"type": "Organization"
},
"familyName": "B\u00f6hler",
"givenName": "T",
"id": "sg:person.0670637516.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670637516.34"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1002/cyto.b.20467",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002363201"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.virol.2005.07.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007856394"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.virol.2005.07.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007856394"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/jvi.00052-07",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011825594"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1478-811x-9-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012136396",
"https://doi.org/10.1186/1478-811x-9-7"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m302299200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012658909"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/44385",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016546162",
"https://doi.org/10.1038/44385"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/44385",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016546162",
"https://doi.org/10.1038/44385"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2174/1874613600903010004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018651014"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2174/1874613600903010004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018651014"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2174/1874613600903010004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018651014"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/3-540-29967-x_3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020296292",
"https://doi.org/10.1007/3-540-29967-x_3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jmv.20593",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025511670"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jmv.20593",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025511670"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1189/jlb.0310137",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027364617"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/cvi.00044-07",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028465713"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.mad.2005.11.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030864814"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/cvi.00043-07",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031248944"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bmj.322.7302.1567",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038190756"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1086/648596",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038212362"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.0105-2896.2004.00181.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042870216"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1203/00006450-200101000-00021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043447056",
"https://doi.org/10.1203/00006450-200101000-00021"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00002030-200009290-00003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045433328"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00002030-200009290-00003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045433328"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00002030-199905070-00006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048660833"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00002030-199905070-00006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048660833"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00006454-199708000-00005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060265616"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00006454-199708000-00005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060265616"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00006454-199708000-00005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060265616"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.169.1.145",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1075073818"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079521469",
"type": "CreativeWork"
}
],
"datePublished": "2011-12",
"datePublishedReg": "2011-12-01",
"description": "OBJECTIVE: It is not exactly known how frequent exposure to Plasmodium falciparum shapes the peripheral blood T-cell population in healthy West Africans.\nMETHODS: The frequency of peripheral blood CD4(+) lymphocytes responding to Plasmodium falciparum merozoite surface protein 1 (PfMSP-1) by production of interferon-gamma (IFN-\u03b3), interleukin-2 (IL-2) or tumor necrosis factor-alpha (TNF-\u03b1) was determined using a commercially available flow cytometric activation assay (FastImmune) in 17 healthy adults in Nouna, Burkina Faso. T-cell activation and maturation in peripheral blood of healthy adults in Burkina Faso (n=40) and Germany (n=20) were compared using immunophenotyping and three-colour flow cytometry.\nRESULTS: Significant numbers of PfMSP-1 -specific CD4(+) lymphocytes producing IFN-\u03b3, IL-2 and/or TNF-\u03b1 were detected in 14 healthy adults in Nouna. Cytokine profiles showed predominant production of IFN-\u03b3 and TNF-\u03b1. Compared to Germans, Burkinab\u00e9 showed markedly lower proportions of CCR7+ CD45RA+ naive CD4(+) cells and slightly higher frequencies of CD95(+)CD4(+) T-cells and of CD38(+) CD8(+) T-cells. The median antibody-binding capacity of CD95(dim) CD4(+) T-cells in Burkinab\u00e9 was more than twice the value observed in Germans (263 vs. 108 binding sites per cell, p<0.0001).\nCONCLUSIONS: We hypothesize that an IFN-\u03b3-induced increase in the expression level of CD95 on CD4(+) lymphocytes may lower the activation threshold of resting naive CD4(+) T-cells in healthy adults living in Burkina Faso. Bystander activation of these cells deserves further study as a molecular mechanism linking strong IFN-\u03b3 responses against Plasmodium falciparum to decreased susceptibility to parasitemia observed in specific ethnic groups in West Africa.",
"genre": "research_article",
"id": "sg:pub.10.1186/2047-783x-16-12-519",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1114878",
"issn": [
"0949-2321",
"2047-783X"
],
"name": "European Journal of Medical Research",
"type": "Periodical"
},
{
"issueNumber": "12",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "16"
}
],
"name": "Constitutive activation and accelerated maturation of peripheral blood t cells in healthy adults in burkina faso compared to Germany: The case of malaria?",
"pagination": "519",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"67d1ebda9b92aa01a9350a9416575d7ebc85801b5dd90379dcce55aa9f0f71b9"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"22112357"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9517857"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/2047-783x-16-12-519"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1021791000"
]
}
],
"sameAs": [
"https://doi.org/10.1186/2047-783x-16-12-519",
"https://app.dimensions.ai/details/publication/pub.1021791000"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T20:51",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000536.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1186%2F2047-783X-16-12-519"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/2047-783x-16-12-519'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/2047-783x-16-12-519'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/2047-783x-16-12-519'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/2047-783x-16-12-519'
This table displays all metadata directly associated to this object as RDF triples.
271 TRIPLES
21 PREDICATES
72 URIs
42 LITERALS
30 BLANK NODES