Raltegravir in treatment naïve patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-12

AUTHORS

F Cossarini, A Castagna, A Lazzarin

ABSTRACT

Raltegravir is the first integrase inhibitor approved for the treatment of HIV infection based on the superior efficacy it showed compared to optimized backbone therapy alone in patients harboring multidrug resistant viruses. Studies on naive patients showed comparable efficacy of raltegravir and efavirenz and just recently the US Food and Drug Administration (FDA) approved raltegravir for the use in naive patients based on the favorable results of the international double-blind phase III STARTMRK trial. Additional interesting findings were the faster, and not yet explained, decay of HIV-1 RNA and the higher CD4+ cells increase in the raltegravir group as compared to the efavirenz group. Raltegravir is generally well tolerated and adverse events were generally similar in raltegravir and comparator arms throughout all studies. When compared to efavirenz, patients on raltegravir showed less incidence of central nervous system-related adverse events. In studies on experienced patients higher incidence of cancers was found in the raltegravir arm: a relationship with the drug was, however not confirmed in a recent review considering all raltegravir studies. Raltegravir also showed a safe lipid profile especially in naive patients, finding that renders the drug attractive for patients with other cardiovascular risk factors. All this characteristics in association with its specific mechanism of action, make raltegravir an interesting drug for naive patients and a large use in this type of patients is predictable. Only time and experience, however, will tell us whether raltegravir will maintain its promises in the long run. More... »

PAGES

22

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/2047-783x-14-s3-22

DOI

http://dx.doi.org/10.1186/2047-783x-14-s3-22

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008207833

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19959413


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Integrase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyrrolidinones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Raltegravir Potassium", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Department of Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cossarini", 
        "givenName": "F", 
        "id": "sg:person.01153127647.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153127647.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Department of Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Castagna", 
        "givenName": "A", 
        "id": "sg:person.0615450407.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615450407.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vita-Salute San Raffaele University", 
          "id": "https://www.grid.ac/institutes/grid.15496.3f", 
          "name": [
            "Department of Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy", 
            "Vita-Salute San Raffaele University, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lazzarin", 
        "givenName": "A", 
        "id": "sg:person.01254422361.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254422361.62"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1128/aac.00651-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001058301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/512619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006360760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0807252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010123388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00126334-200312010-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010127878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00126334-200312010-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010127878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00126334-200312010-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010127878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0708975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011105865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00126334-200407010-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019144060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00126334-200407010-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019144060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0800050105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019162653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0708978", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020168459"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1468-1293.2007.00533.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021115939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e3282f12377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021919963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e3282f12377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021919963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(08)61593-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023702065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e31802b4956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024676478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e31802b4956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024676478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(08)61081-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025939499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00683-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026358202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(09)60918-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026538115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3181b064b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027459723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3181b064b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027459723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3181b064b0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027459723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkp246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027926051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkp246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027926051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32832d7350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029890881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32832d7350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029890881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32832d7350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029890881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa062744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031211143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0711372105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031240870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.278.5341.1295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032805790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/432916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033954553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa012354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036372754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2334-9-111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037275465", 
          "https://doi.org/10.1186/1471-2334-9-111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(98)03201-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039692940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0903107106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039842491"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0803152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040477846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(08)61591-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040699769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(01)06802-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042749276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.qai.0000243112.91293.26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043027370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.qai.0000243112.91293.26", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043027370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00894-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043366606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e318157131c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044030011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e318157131c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044030011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(07)61048-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045290130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199803263381301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047239361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/8394", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049869736", 
          "https://doi.org/10.1038/8394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.clpt.6100281", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052156710", 
          "https://doi.org/10.1038/sj.clpt.6100281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/368164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053249868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/525283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058794735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1310/hct0901-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064986288"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-12", 
    "datePublishedReg": "2009-12-01", 
    "description": "Raltegravir is the first integrase inhibitor approved for the treatment of HIV infection based on the superior efficacy it showed compared to optimized backbone therapy alone in patients harboring multidrug resistant viruses. Studies on naive patients showed comparable efficacy of raltegravir and efavirenz and just recently the US Food and Drug Administration (FDA) approved raltegravir for the use in naive patients based on the favorable results of the international double-blind phase III STARTMRK trial. Additional interesting findings were the faster, and not yet explained, decay of HIV-1 RNA and the higher CD4+ cells increase in the raltegravir group as compared to the efavirenz group. Raltegravir is generally well tolerated and adverse events were generally similar in raltegravir and comparator arms throughout all studies. When compared to efavirenz, patients on raltegravir showed less incidence of central nervous system-related adverse events. In studies on experienced patients higher incidence of cancers was found in the raltegravir arm: a relationship with the drug was, however not confirmed in a recent review considering all raltegravir studies. Raltegravir also showed a safe lipid profile especially in naive patients, finding that renders the drug attractive for patients with other cardiovascular risk factors. All this characteristics in association with its specific mechanism of action, make raltegravir an interesting drug for naive patients and a large use in this type of patients is predictable. Only time and experience, however, will tell us whether raltegravir will maintain its promises in the long run.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/2047-783x-14-s3-22", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1114878", 
        "issn": [
          "0949-2321", 
          "2047-783X"
        ], 
        "name": "European Journal of Medical Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "Suppl 3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "14"
      }
    ], 
    "name": "Raltegravir in treatment na\u00efve patients", 
    "pagination": "22", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "271a860172677b4db928940c109d0b435bd894e0cc265fa0bf0b4943ef91d7dc"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19959413"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9517857"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/2047-783x-14-s3-22"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1008207833"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/2047-783x-14-s3-22", 
      "https://app.dimensions.ai/details/publication/pub.1008207833"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000536.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F2047-783X-14-S3-22"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/2047-783x-14-s3-22'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/2047-783x-14-s3-22'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/2047-783x-14-s3-22'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/2047-783x-14-s3-22'


 

This table displays all metadata directly associated to this object as RDF triples.

235 TRIPLES      21 PREDICATES      75 URIs      28 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/2047-783x-14-s3-22 schema:about N26146a77d7374feaa2bc6a34f2fa29f3
2 N4f84a97e47ce43d0957ded2eea093b9e
3 N53ba13e271354777a34cd64f6c8401ed
4 N6021ced367574d2ca063053722e7a013
5 N6809c854ea7e490e8259e1b7ad54bcfc
6 N7903f851b9834e689049540028d4ac91
7 Nb2e307cb56164b02bb9bca868daa1efe
8 anzsrc-for:11
9 anzsrc-for:1115
10 schema:author N0693201485dc4046b4e56934fc4fa88b
11 schema:citation sg:pub.10.1038/8394
12 sg:pub.10.1038/sj.clpt.6100281
13 sg:pub.10.1186/1471-2334-9-111
14 https://doi.org/10.1016/s0140-6736(01)06802-7
15 https://doi.org/10.1016/s0140-6736(07)61048-4
16 https://doi.org/10.1016/s0140-6736(08)61081-8
17 https://doi.org/10.1016/s0140-6736(08)61591-3
18 https://doi.org/10.1016/s0140-6736(08)61593-7
19 https://doi.org/10.1016/s0140-6736(09)60918-1
20 https://doi.org/10.1016/s0140-6736(98)03201-2
21 https://doi.org/10.1056/nejm199803263381301
22 https://doi.org/10.1056/nejmoa012354
23 https://doi.org/10.1056/nejmoa062744
24 https://doi.org/10.1056/nejmoa0708975
25 https://doi.org/10.1056/nejmoa0708978
26 https://doi.org/10.1056/nejmoa0803152
27 https://doi.org/10.1056/nejmoa0807252
28 https://doi.org/10.1073/pnas.0711372105
29 https://doi.org/10.1073/pnas.0800050105
30 https://doi.org/10.1073/pnas.0903107106
31 https://doi.org/10.1086/368164
32 https://doi.org/10.1086/432916
33 https://doi.org/10.1086/512619
34 https://doi.org/10.1086/525283
35 https://doi.org/10.1093/jac/dkp246
36 https://doi.org/10.1097/00126334-200312010-00008
37 https://doi.org/10.1097/00126334-200407010-00004
38 https://doi.org/10.1097/01.qai.0000243112.91293.26
39 https://doi.org/10.1097/qad.0b013e3282f12377
40 https://doi.org/10.1097/qad.0b013e32832d7350
41 https://doi.org/10.1097/qai.0b013e31802b4956
42 https://doi.org/10.1097/qai.0b013e318157131c
43 https://doi.org/10.1097/qai.0b013e3181b064b0
44 https://doi.org/10.1111/j.1468-1293.2007.00533.x
45 https://doi.org/10.1126/science.278.5341.1295
46 https://doi.org/10.1128/aac.00651-09
47 https://doi.org/10.1128/jvi.00683-09
48 https://doi.org/10.1128/jvi.00894-09
49 https://doi.org/10.1310/hct0901-1
50 schema:datePublished 2009-12
51 schema:datePublishedReg 2009-12-01
52 schema:description Raltegravir is the first integrase inhibitor approved for the treatment of HIV infection based on the superior efficacy it showed compared to optimized backbone therapy alone in patients harboring multidrug resistant viruses. Studies on naive patients showed comparable efficacy of raltegravir and efavirenz and just recently the US Food and Drug Administration (FDA) approved raltegravir for the use in naive patients based on the favorable results of the international double-blind phase III STARTMRK trial. Additional interesting findings were the faster, and not yet explained, decay of HIV-1 RNA and the higher CD4+ cells increase in the raltegravir group as compared to the efavirenz group. Raltegravir is generally well tolerated and adverse events were generally similar in raltegravir and comparator arms throughout all studies. When compared to efavirenz, patients on raltegravir showed less incidence of central nervous system-related adverse events. In studies on experienced patients higher incidence of cancers was found in the raltegravir arm: a relationship with the drug was, however not confirmed in a recent review considering all raltegravir studies. Raltegravir also showed a safe lipid profile especially in naive patients, finding that renders the drug attractive for patients with other cardiovascular risk factors. All this characteristics in association with its specific mechanism of action, make raltegravir an interesting drug for naive patients and a large use in this type of patients is predictable. Only time and experience, however, will tell us whether raltegravir will maintain its promises in the long run.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree true
56 schema:isPartOf N0a757d29069447fa889c4adcc45ea529
57 N7350df3c2ed94294a42ba9f6b1bbfa89
58 sg:journal.1114878
59 schema:name Raltegravir in treatment naïve patients
60 schema:pagination 22
61 schema:productId N5e39841e6a5646c39167dbf7c4f5dd9f
62 N73c1268bb2354fe5a8ad700787bfb057
63 Nc608fd0dece34af595968a83354d2d2d
64 Nc981d221eb764ccc81ad02136232da41
65 Nf1178a98c1a94f36b81cdb389b59e901
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008207833
67 https://doi.org/10.1186/2047-783x-14-s3-22
68 schema:sdDatePublished 2019-04-10T20:51
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N60c482812314412aa2428289c3ce117e
71 schema:url http://link.springer.com/10.1186%2F2047-783X-14-S3-22
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N0693201485dc4046b4e56934fc4fa88b rdf:first sg:person.01153127647.96
76 rdf:rest Ncfb2a92a4e4f448fa76dedc001f88337
77 N0a757d29069447fa889c4adcc45ea529 schema:volumeNumber 14
78 rdf:type schema:PublicationVolume
79 N26146a77d7374feaa2bc6a34f2fa29f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Humans
81 rdf:type schema:DefinedTerm
82 N39cb90a0bd26437398fa74d9dc4c3dda rdf:first sg:person.01254422361.62
83 rdf:rest rdf:nil
84 N4f84a97e47ce43d0957ded2eea093b9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name HIV Integrase Inhibitors
86 rdf:type schema:DefinedTerm
87 N53ba13e271354777a34cd64f6c8401ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Pyrrolidinones
89 rdf:type schema:DefinedTerm
90 N5e39841e6a5646c39167dbf7c4f5dd9f schema:name doi
91 schema:value 10.1186/2047-783x-14-s3-22
92 rdf:type schema:PropertyValue
93 N6021ced367574d2ca063053722e7a013 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Raltegravir Potassium
95 rdf:type schema:DefinedTerm
96 N60c482812314412aa2428289c3ce117e schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 N6809c854ea7e490e8259e1b7ad54bcfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name HIV-1
100 rdf:type schema:DefinedTerm
101 N7350df3c2ed94294a42ba9f6b1bbfa89 schema:issueNumber Suppl 3
102 rdf:type schema:PublicationIssue
103 N73c1268bb2354fe5a8ad700787bfb057 schema:name readcube_id
104 schema:value 271a860172677b4db928940c109d0b435bd894e0cc265fa0bf0b4943ef91d7dc
105 rdf:type schema:PropertyValue
106 N7903f851b9834e689049540028d4ac91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name RNA, Viral
108 rdf:type schema:DefinedTerm
109 Nb2e307cb56164b02bb9bca868daa1efe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name HIV Infections
111 rdf:type schema:DefinedTerm
112 Nc608fd0dece34af595968a83354d2d2d schema:name dimensions_id
113 schema:value pub.1008207833
114 rdf:type schema:PropertyValue
115 Nc981d221eb764ccc81ad02136232da41 schema:name nlm_unique_id
116 schema:value 9517857
117 rdf:type schema:PropertyValue
118 Ncfb2a92a4e4f448fa76dedc001f88337 rdf:first sg:person.0615450407.15
119 rdf:rest N39cb90a0bd26437398fa74d9dc4c3dda
120 Nf1178a98c1a94f36b81cdb389b59e901 schema:name pubmed_id
121 schema:value 19959413
122 rdf:type schema:PropertyValue
123 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
124 schema:name Medical and Health Sciences
125 rdf:type schema:DefinedTerm
126 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
127 schema:name Pharmacology and Pharmaceutical Sciences
128 rdf:type schema:DefinedTerm
129 sg:journal.1114878 schema:issn 0949-2321
130 2047-783X
131 schema:name European Journal of Medical Research
132 rdf:type schema:Periodical
133 sg:person.01153127647.96 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
134 schema:familyName Cossarini
135 schema:givenName F
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153127647.96
137 rdf:type schema:Person
138 sg:person.01254422361.62 schema:affiliation https://www.grid.ac/institutes/grid.15496.3f
139 schema:familyName Lazzarin
140 schema:givenName A
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254422361.62
142 rdf:type schema:Person
143 sg:person.0615450407.15 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
144 schema:familyName Castagna
145 schema:givenName A
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615450407.15
147 rdf:type schema:Person
148 sg:pub.10.1038/8394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049869736
149 https://doi.org/10.1038/8394
150 rdf:type schema:CreativeWork
151 sg:pub.10.1038/sj.clpt.6100281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052156710
152 https://doi.org/10.1038/sj.clpt.6100281
153 rdf:type schema:CreativeWork
154 sg:pub.10.1186/1471-2334-9-111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037275465
155 https://doi.org/10.1186/1471-2334-9-111
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1016/s0140-6736(01)06802-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042749276
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1016/s0140-6736(07)61048-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045290130
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1016/s0140-6736(08)61081-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025939499
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1016/s0140-6736(08)61591-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040699769
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1016/s0140-6736(08)61593-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023702065
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1016/s0140-6736(09)60918-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026538115
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1016/s0140-6736(98)03201-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039692940
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1056/nejm199803263381301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047239361
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1056/nejmoa012354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036372754
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1056/nejmoa062744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031211143
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1056/nejmoa0708975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011105865
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1056/nejmoa0708978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020168459
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1056/nejmoa0803152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040477846
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1056/nejmoa0807252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010123388
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1073/pnas.0711372105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031240870
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1073/pnas.0800050105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019162653
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1073/pnas.0903107106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039842491
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1086/368164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053249868
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1086/432916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033954553
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1086/512619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006360760
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1086/525283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058794735
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1093/jac/dkp246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027926051
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1097/00126334-200312010-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010127878
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1097/00126334-200407010-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019144060
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1097/01.qai.0000243112.91293.26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043027370
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1097/qad.0b013e3282f12377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021919963
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1097/qad.0b013e32832d7350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029890881
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1097/qai.0b013e31802b4956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024676478
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1097/qai.0b013e318157131c schema:sameAs https://app.dimensions.ai/details/publication/pub.1044030011
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1097/qai.0b013e3181b064b0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027459723
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1111/j.1468-1293.2007.00533.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021115939
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1126/science.278.5341.1295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032805790
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1128/aac.00651-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001058301
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1128/jvi.00683-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026358202
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1128/jvi.00894-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043366606
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1310/hct0901-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064986288
228 rdf:type schema:CreativeWork
229 https://www.grid.ac/institutes/grid.15496.3f schema:alternateName Vita-Salute San Raffaele University
230 schema:name Department of Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
231 Vita-Salute San Raffaele University, Milan, Italy
232 rdf:type schema:Organization
233 https://www.grid.ac/institutes/grid.18887.3e schema:alternateName San Raffaele Hospital
234 schema:name Department of Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
235 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...