Phospho-specific flow cytometry for pharmacodynamic monitoring of immunosuppressive therapy in transplantation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Carla Baan, Anne Bouvy, Ramin Vafadari, Willem Weimar

ABSTRACT

Organ transplant recipients frequently suffer from toxicity or from lack of efficacy of immunosuppressive drugs, which can be attributed to individual variations in drug sensitivity. This problem can be resolved by applying pharmacodynamic monitoring that focuses on measuring the biological effects of drugs. Here we discuss the new technique called phospho-specific flow cytometry to monitor the activity of intracellular immune signaling pathways at the single-cell level in whole blood samples. Through this tool the efficacy of immunosuppressive medication can be assessed, novel targets can be identified, and differences in drug sensitivity between cells and patients can be clarified. More... »

PAGES

20

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/2047-1440-1-20

DOI

http://dx.doi.org/10.1186/2047-1440-1-20

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027637047

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23369224


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