Extensive adipocytic maturation can be seen in myxoid liposarcomas treated with neoadjuvant doxorubicin and ifosfamide and pre-operative radiation therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Wei-Lien Wang, Daniela Katz, Dejka M Araujo, Vinod Ravi, Joseph A Ludwig, Jonathan C Trent, Shreyaskumar R Patel, Patrick P Lin, Ashleigh Guadagnolo, Dolores Lòpez-Terrada, Angelo Paola dei Tos, Valerie O Lewis, Dina Lev, Raphael E Pollock, Gunar K Zagars, Robert S Benjamin, John E Madewell, Alexander J Lazar

ABSTRACT

BACKGROUND: Trabectedin and thioglitazones have been documented to induce adipocytic maturation in myxoid liposarcoma; we have noted this in our experience as well. Intriguingly, we have also encountered this same phenomenon in myxoid liposarcomas exposed to various combinations of neoadjuvant doxorubicin and ifosfamide systemic chemotherapy with preoperative radiation, where the pathological effects have been less characterized. We examined the histological changes, including adipocytic maturation, associated with this treatment in patients with myxoid liposarcoma and evaluated for prognostic significance. METHODS: Twenty-two patients were identified with histologically confirmed myxoid liposarcomas (9 with variable hypercellular areas) who were treated with neoadjuvant doxorubicin (75-90 mg/m2/continous infusion over 72h every 3 week) and ifosfamide (2.5 g/m2 daily x 4 every 3 weeks) for 4-6 cycles. Twenty-one patients received pre-operative radiation including 5 with concurrent gemcitabine. Pre- and post-treatment MRI studies were compared for changes in tumor area, fat content and contrast uptake, with the latter two estimated as: none, <25%, 25-49% and >50%. Post-treatment specimens were evaluated for hyalinization, necrosis and adipocytic maturation. Clinical follow-up was obtained. RESULTS: Median age was 45 (26-72) years with a median tumor size of 11 (2-18) cm. All occurred in the lower extremities except for one case in the neck. As is common in myxoid liposarcoma, all had extensive treatment changes (>90%) with extensive hyalinization (n = 16; >90%) or prominent adipocytic maturation (n = 6; >50%) including 2 cases composed almost entirely of mature-appearing adipose tissue. Variable necrosis was identified (5-30%). MRI revealed a decrease in tumor area in all but one tumor (median, 65%), an increase in fat content in 7 tumors (n = 2, >50%;n = 2, 25-50%;n = 3,<25%), and a decrease in contrast enhancement in most tumors (n = 5, >50%; n = 9, 25-49%; n = 7, <25%). Median follow-up was 57 (12-96) months with 17 alive with no disease/metastases, 3 alive with disease and 2 dead of disease. Six patients developed metastases with median interval of 26 (22-51) months post resection. Four of 6 tumors with increased adipocytic maturation >50% on histology had increased fat detected by MRI (>25%). All 6 are alive but 2 developed metastases. In the remaining patients, 4 developed metastases with 14 alive and 2 dead of disease. CONCLUSION: Myxoid liposarcoma exposed to neoadjuvant doxorubicin and ifosfamide and pre-operative radiation can have prominent adipocytic maturation similar to trabectedin treatment. Myxoid liposarcomas exhibit extensive treatment changes with prominent hyalinization being the most common histological change. Despite this, patients develop metastases regardless of adipocytic maturation. While of unclear significance, no patient with fatty maturation died of disease. More... »

PAGES

25

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/2045-3329-2-25

DOI

http://dx.doi.org/10.1186/2045-3329-2-25

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021770495

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23272660


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Wei-Lien", 
        "id": "sg:person.010331373604.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010331373604.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hadassah Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.17788.31", 
          "name": [
            "Sharette Institute of Oncology, Hadassah-Hebrew University Medical Center, POB 12000, 91120, Jerusalem, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Katz", 
        "givenName": "Daniela", 
        "id": "sg:person.0637451167.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637451167.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Araujo", 
        "givenName": "Dejka M", 
        "id": "sg:person.01171370257.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171370257.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ravi", 
        "givenName": "Vinod", 
        "id": "sg:person.01252467767.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252467767.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ludwig", 
        "givenName": "Joseph A", 
        "id": "sg:person.01246243126.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246243126.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Sarcoma Multidisciplinary Program, The University Of Miami Sylvester Cancer Center, Room#C-050, 1475 Northwest 12th Avenue, Suite 3513, 33136, Miami, FL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Trent", 
        "givenName": "Jonathan C", 
        "id": "sg:person.01016450045.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016450045.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Patel", 
        "givenName": "Shreyaskumar R", 
        "id": "sg:person.013307202747.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013307202747.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Othropeadic Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Patrick P", 
        "id": "sg:person.016135261767.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016135261767.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guadagnolo", 
        "givenName": "Ashleigh", 
        "id": "sg:person.01004722356.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004722356.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Pathology, Texas Children\u2019s Hospital and Baylor College of Medicine, 6621 Fannin St, MC1-2261, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "L\u00f2pez-Terrada", 
        "givenName": "Dolores", 
        "id": "sg:person.014633403267.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014633403267.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Anatomic Pathology, General Hospital of Treviso, Piazza Ospedale 1, 31100, Treviso, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "dei Tos", 
        "givenName": "Angelo Paola", 
        "id": "sg:person.014763423333.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014763423333.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Othropeadic Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lewis", 
        "givenName": "Valerie O", 
        "id": "sg:person.01351625756.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351625756.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA", 
            "Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lev", 
        "givenName": "Dina", 
        "id": "sg:person.0707247605.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707247605.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA", 
            "Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pollock", 
        "givenName": "Raphael E", 
        "id": "sg:person.07756432137.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07756432137.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zagars", 
        "givenName": "Gunar K", 
        "id": "sg:person.014471151217.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014471151217.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benjamin", 
        "givenName": "Robert S", 
        "id": "sg:person.01200333274.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200333274.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of MusculoSkeletal Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Madewell", 
        "givenName": "John E", 
        "id": "sg:person.0775141231.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775141231.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA", 
            "Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lazar", 
        "givenName": "Alexander J", 
        "id": "sg:person.010255222337.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010255222337.53"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1593/neo.101202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000717346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/363640a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000976952", 
          "https://doi.org/10.1038/363640a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00019606-199804000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001935315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00019606-199804000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001935315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-2952(98)00307-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004693237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-197912000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005237630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-197912000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005237630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1525-1578(10)60698-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005501365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006757412", 
          "https://doi.org/10.1038/ng.619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006757412", 
          "https://doi.org/10.1038/ng.619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1309/ajcp90ynokbagcdm", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008059115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.7.3951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016398626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-2912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019463215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181578d5a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020473084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181578d5a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020473084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e3181578d5a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020473084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cco.0b013e32833aaac1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020794897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cco.0b013e32833aaac1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020794897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cco.0b013e32833aaac1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020794897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cco.0b013e32833aaac1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020794897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2012.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021050243", 
          "https://doi.org/10.1038/modpathol.2012.83"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1525-1578(10)60628-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024715225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-08-0848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024837220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1525-1578(10)60472-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024860336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2011.148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025747772", 
          "https://doi.org/10.1038/modpathol.2011.148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdp004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027650892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdp004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027650892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2011/538085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028074890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2010.118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029573652", 
          "https://doi.org/10.1038/modpathol.2010.118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2010.118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029573652", 
          "https://doi.org/10.1038/modpathol.2010.118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.humpath.2009.01.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030998025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdr265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033107792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19960415)77:8<1450::aid-cncr5>3.0.co;2-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033796679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01913120309917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036461930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(07)70175-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037193917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2008.84", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037459426", 
          "https://doi.org/10.1038/modpathol.2008.84"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mpo.10060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037893013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2010.10.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046089386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-9896(199708)182:4<437::aid-path882>3.0.co;2-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046670621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci60015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048892705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200140010-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049217785", 
          "https://doi.org/10.2165/00003088-200140010-00004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200140010-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049217785", 
          "https://doi.org/10.2165/00003088-200140010-00004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00003088-200140010-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049217785", 
          "https://doi.org/10.2165/00003088-200140010-00004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.20478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053173501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074963961", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079887561", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082515580", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082578248", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082596717", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcp/108.1.35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083112083"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-12", 
    "datePublishedReg": "2012-12-01", 
    "description": "BACKGROUND: Trabectedin and thioglitazones have been documented to induce adipocytic maturation in myxoid liposarcoma; we have noted this in our experience as well. Intriguingly, we have also encountered this same phenomenon in myxoid liposarcomas exposed to various combinations of neoadjuvant doxorubicin and ifosfamide systemic chemotherapy with preoperative radiation, where the pathological effects have been less characterized. We examined the histological changes, including adipocytic maturation, associated with this treatment in patients with myxoid liposarcoma and evaluated for prognostic significance.\nMETHODS: Twenty-two patients were identified with histologically confirmed myxoid liposarcomas (9 with variable hypercellular areas) who were treated with neoadjuvant doxorubicin (75-90 mg/m2/continous infusion over 72h every 3 week) and ifosfamide (2.5 g/m2 daily x 4 every 3 weeks) for 4-6 cycles. Twenty-one patients received pre-operative radiation including 5 with concurrent gemcitabine. Pre- and post-treatment MRI studies were compared for changes in tumor area, fat content and contrast uptake, with the latter two estimated as: none, <25%, 25-49% and >50%. Post-treatment specimens were evaluated for hyalinization, necrosis and adipocytic maturation. Clinical follow-up was obtained.\nRESULTS: Median age was 45 (26-72) years with a median tumor size of 11 (2-18) cm. All occurred in the lower extremities except for one case in the neck. As is common in myxoid liposarcoma, all had extensive treatment changes (>90%) with extensive hyalinization (n\u2009=\u200916; >90%) or prominent adipocytic maturation (n\u2009=\u20096; >50%) including 2 cases composed almost entirely of mature-appearing adipose tissue. Variable necrosis was identified (5-30%). MRI revealed a decrease in tumor area in all but one tumor (median, 65%), an increase in fat content in 7 tumors (n\u2009=\u20092, >50%;n\u2009=\u20092, 25-50%;n\u2009=\u20093,<25%), and a decrease in contrast enhancement in most tumors (n\u2009=\u20095, >50%; n\u2009=\u20099, 25-49%; n\u2009=\u20097, <25%). Median follow-up was 57 (12-96) months with 17 alive with no disease/metastases, 3 alive with disease and 2 dead of disease. Six patients developed metastases with median interval of 26 (22-51) months post resection. Four of 6 tumors with increased adipocytic maturation >50% on histology had increased fat detected by MRI (>25%). All 6 are alive but 2 developed metastases. In the remaining patients, 4 developed metastases with 14 alive and 2 dead of disease.\nCONCLUSION: Myxoid liposarcoma exposed to neoadjuvant doxorubicin and ifosfamide and pre-operative radiation can have prominent adipocytic maturation similar to trabectedin treatment. Myxoid liposarcomas exhibit extensive treatment changes with prominent hyalinization being the most common histological change. Despite this, patients develop metastases regardless of adipocytic maturation. While of unclear significance, no patient with fatty maturation died of disease.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/2045-3329-2-25", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2705121", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1046367", 
        "issn": [
          "2045-3329"
        ], 
        "name": "Clinical Sarcoma Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "name": "Extensive adipocytic maturation can be seen in myxoid liposarcomas treated with neoadjuvant doxorubicin and ifosfamide and pre-operative radiation therapy", 
    "pagination": "25", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "67b90ede7659fb35f62f0619903e9cf025079d03b498f102f75258134221b190"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23272660"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101577890"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/2045-3329-2-25"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021770495"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/2045-3329-2-25", 
      "https://app.dimensions.ai/details/publication/pub.1021770495"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:01", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000512.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F2045-3329-2-25"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/2045-3329-2-25'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/2045-3329-2-25'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/2045-3329-2-25'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/2045-3329-2-25'


 

This table displays all metadata directly associated to this object as RDF triples.

321 TRIPLES      21 PREDICATES      67 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/2045-3329-2-25 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N901f5d7b135a4b0bbb4326e2053bd292
4 schema:citation sg:pub.10.1038/363640a0
5 sg:pub.10.1038/modpathol.2008.84
6 sg:pub.10.1038/modpathol.2010.118
7 sg:pub.10.1038/modpathol.2011.148
8 sg:pub.10.1038/modpathol.2012.83
9 sg:pub.10.1038/ng.619
10 sg:pub.10.2165/00003088-200140010-00004
11 https://app.dimensions.ai/details/publication/pub.1074963961
12 https://app.dimensions.ai/details/publication/pub.1079887561
13 https://app.dimensions.ai/details/publication/pub.1082515580
14 https://app.dimensions.ai/details/publication/pub.1082578248
15 https://app.dimensions.ai/details/publication/pub.1082596717
16 https://doi.org/10.1002/(sici)1096-9896(199708)182:4<437::aid-path882>3.0.co;2-x
17 https://doi.org/10.1002/(sici)1097-0142(19960415)77:8<1450::aid-cncr5>3.0.co;2-g
18 https://doi.org/10.1002/gcc.20478
19 https://doi.org/10.1002/mpo.10060
20 https://doi.org/10.1016/j.humpath.2009.01.011
21 https://doi.org/10.1016/j.radonc.2010.10.007
22 https://doi.org/10.1016/s0006-2952(98)00307-4
23 https://doi.org/10.1016/s1470-2045(07)70175-4
24 https://doi.org/10.1016/s1525-1578(10)60472-2
25 https://doi.org/10.1016/s1525-1578(10)60628-9
26 https://doi.org/10.1016/s1525-1578(10)60698-8
27 https://doi.org/10.1073/pnas.96.7.3951
28 https://doi.org/10.1080/01913120309917
29 https://doi.org/10.1093/ajcp/108.1.35
30 https://doi.org/10.1093/annonc/mdp004
31 https://doi.org/10.1093/annonc/mdr265
32 https://doi.org/10.1097/00000478-197912000-00004
33 https://doi.org/10.1097/00019606-199804000-00006
34 https://doi.org/10.1097/cco.0b013e32833aaac1
35 https://doi.org/10.1097/pas.0b013e3181578d5a
36 https://doi.org/10.1155/2011/538085
37 https://doi.org/10.1158/1078-0432.ccr-09-2912
38 https://doi.org/10.1158/1535-7163.mct-08-0848
39 https://doi.org/10.1172/jci60015
40 https://doi.org/10.1309/ajcp90ynokbagcdm
41 https://doi.org/10.1593/neo.101202
42 schema:datePublished 2012-12
43 schema:datePublishedReg 2012-12-01
44 schema:description BACKGROUND: Trabectedin and thioglitazones have been documented to induce adipocytic maturation in myxoid liposarcoma; we have noted this in our experience as well. Intriguingly, we have also encountered this same phenomenon in myxoid liposarcomas exposed to various combinations of neoadjuvant doxorubicin and ifosfamide systemic chemotherapy with preoperative radiation, where the pathological effects have been less characterized. We examined the histological changes, including adipocytic maturation, associated with this treatment in patients with myxoid liposarcoma and evaluated for prognostic significance. METHODS: Twenty-two patients were identified with histologically confirmed myxoid liposarcomas (9 with variable hypercellular areas) who were treated with neoadjuvant doxorubicin (75-90 mg/m2/continous infusion over 72h every 3 week) and ifosfamide (2.5 g/m2 daily x 4 every 3 weeks) for 4-6 cycles. Twenty-one patients received pre-operative radiation including 5 with concurrent gemcitabine. Pre- and post-treatment MRI studies were compared for changes in tumor area, fat content and contrast uptake, with the latter two estimated as: none, <25%, 25-49% and >50%. Post-treatment specimens were evaluated for hyalinization, necrosis and adipocytic maturation. Clinical follow-up was obtained. RESULTS: Median age was 45 (26-72) years with a median tumor size of 11 (2-18) cm. All occurred in the lower extremities except for one case in the neck. As is common in myxoid liposarcoma, all had extensive treatment changes (>90%) with extensive hyalinization (n = 16; >90%) or prominent adipocytic maturation (n = 6; >50%) including 2 cases composed almost entirely of mature-appearing adipose tissue. Variable necrosis was identified (5-30%). MRI revealed a decrease in tumor area in all but one tumor (median, 65%), an increase in fat content in 7 tumors (n = 2, >50%;n = 2, 25-50%;n = 3,<25%), and a decrease in contrast enhancement in most tumors (n = 5, >50%; n = 9, 25-49%; n = 7, <25%). Median follow-up was 57 (12-96) months with 17 alive with no disease/metastases, 3 alive with disease and 2 dead of disease. Six patients developed metastases with median interval of 26 (22-51) months post resection. Four of 6 tumors with increased adipocytic maturation >50% on histology had increased fat detected by MRI (>25%). All 6 are alive but 2 developed metastases. In the remaining patients, 4 developed metastases with 14 alive and 2 dead of disease. CONCLUSION: Myxoid liposarcoma exposed to neoadjuvant doxorubicin and ifosfamide and pre-operative radiation can have prominent adipocytic maturation similar to trabectedin treatment. Myxoid liposarcomas exhibit extensive treatment changes with prominent hyalinization being the most common histological change. Despite this, patients develop metastases regardless of adipocytic maturation. While of unclear significance, no patient with fatty maturation died of disease.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree true
48 schema:isPartOf N4d6dbb7d3c984d52840a1fdca1c7d65c
49 N502a574c357541dda49194f419e0e391
50 sg:journal.1046367
51 schema:name Extensive adipocytic maturation can be seen in myxoid liposarcomas treated with neoadjuvant doxorubicin and ifosfamide and pre-operative radiation therapy
52 schema:pagination 25
53 schema:productId N1a481cf3f54245b0b3346a8aa08d0c37
54 N29954bb3a8af4a15a520329ef25bf811
55 N43f365e26061490482cb0a3f8c605693
56 N7a9a83031ec4475f80072c8ca93c4788
57 Nb0f77df4d3844c439709b71a409b8b62
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021770495
59 https://doi.org/10.1186/2045-3329-2-25
60 schema:sdDatePublished 2019-04-10T15:01
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N665f33d0e17749b18298958489bd0e9c
63 schema:url http://link.springer.com/10.1186%2F2045-3329-2-25
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N1a481cf3f54245b0b3346a8aa08d0c37 schema:name dimensions_id
68 schema:value pub.1021770495
69 rdf:type schema:PropertyValue
70 N1c3a6345efe64790bfb90b13307fa720 rdf:first sg:person.01004722356.51
71 rdf:rest N9a283609c4f6475ca56d578833fcdcaf
72 N29954bb3a8af4a15a520329ef25bf811 schema:name nlm_unique_id
73 schema:value 101577890
74 rdf:type schema:PropertyValue
75 N29f1701b687949f48e921b9a46983a1a schema:name Sarcoma Multidisciplinary Program, The University Of Miami Sylvester Cancer Center, Room#C-050, 1475 Northwest 12th Avenue, Suite 3513, 33136, Miami, FL, USA
76 rdf:type schema:Organization
77 N2e6a233f777c4efc8afe2d10e2e90f25 schema:name Department of Pathology, Texas Children’s Hospital and Baylor College of Medicine, 6621 Fannin St, MC1-2261, 77030, Houston, TX, USA
78 rdf:type schema:Organization
79 N31785227b76b47b98f0dde04afdc119e rdf:first sg:person.01246243126.24
80 rdf:rest N9ffeae6488b7448593dc16dd4d9dc132
81 N3b751f1fab8a49a6a46b3fd5a5c40f5d rdf:first sg:person.014471151217.16
82 rdf:rest Nb562b6bb5a63488899e139106d4cc748
83 N3ef40865155949609164481fcbaa6352 rdf:first sg:person.01171370257.91
84 rdf:rest N9b3572e4c0514060a451e68ff7a778fe
85 N43f365e26061490482cb0a3f8c605693 schema:name doi
86 schema:value 10.1186/2045-3329-2-25
87 rdf:type schema:PropertyValue
88 N4c3fbe91af1b4090a37c4fd62512c4af rdf:first sg:person.0707247605.98
89 rdf:rest N95a4c306cf2b4376937e91f6c016afa8
90 N4d6dbb7d3c984d52840a1fdca1c7d65c schema:volumeNumber 2
91 rdf:type schema:PublicationVolume
92 N502a574c357541dda49194f419e0e391 schema:issueNumber 1
93 rdf:type schema:PublicationIssue
94 N572a41e94f7946a98627bb2275f278df rdf:first sg:person.01351625756.72
95 rdf:rest N4c3fbe91af1b4090a37c4fd62512c4af
96 N611c459a00254932b3a74f7b0495e2cc rdf:first sg:person.0775141231.39
97 rdf:rest Nbf470e1bee1645009fc49bb525c91620
98 N665f33d0e17749b18298958489bd0e9c schema:name Springer Nature - SN SciGraph project
99 rdf:type schema:Organization
100 N7a9a83031ec4475f80072c8ca93c4788 schema:name readcube_id
101 schema:value 67b90ede7659fb35f62f0619903e9cf025079d03b498f102f75258134221b190
102 rdf:type schema:PropertyValue
103 N8edb6ef09ca0499baac87600e996c2e4 rdf:first sg:person.016135261767.27
104 rdf:rest N1c3a6345efe64790bfb90b13307fa720
105 N8f1e7c7596924a60b86cfc323ba34823 rdf:first sg:person.013307202747.74
106 rdf:rest N8edb6ef09ca0499baac87600e996c2e4
107 N901f5d7b135a4b0bbb4326e2053bd292 rdf:first sg:person.010331373604.53
108 rdf:rest Nef4510b5f4664cdba722b4523ebafbce
109 N95a4c306cf2b4376937e91f6c016afa8 rdf:first sg:person.07756432137.83
110 rdf:rest N3b751f1fab8a49a6a46b3fd5a5c40f5d
111 N9a283609c4f6475ca56d578833fcdcaf rdf:first sg:person.014633403267.66
112 rdf:rest Ne7f745b8f9a94601a07b960f5814440c
113 N9b3572e4c0514060a451e68ff7a778fe rdf:first sg:person.01252467767.86
114 rdf:rest N31785227b76b47b98f0dde04afdc119e
115 N9ffeae6488b7448593dc16dd4d9dc132 rdf:first sg:person.01016450045.91
116 rdf:rest N8f1e7c7596924a60b86cfc323ba34823
117 Nb0f77df4d3844c439709b71a409b8b62 schema:name pubmed_id
118 schema:value 23272660
119 rdf:type schema:PropertyValue
120 Nb25fa1b1e4ac4efe9da03cefc4261899 schema:name Department of Anatomic Pathology, General Hospital of Treviso, Piazza Ospedale 1, 31100, Treviso, Italy
121 rdf:type schema:Organization
122 Nb562b6bb5a63488899e139106d4cc748 rdf:first sg:person.01200333274.18
123 rdf:rest N611c459a00254932b3a74f7b0495e2cc
124 Nbf470e1bee1645009fc49bb525c91620 rdf:first sg:person.010255222337.53
125 rdf:rest rdf:nil
126 Ne7f745b8f9a94601a07b960f5814440c rdf:first sg:person.014763423333.17
127 rdf:rest N572a41e94f7946a98627bb2275f278df
128 Nef4510b5f4664cdba722b4523ebafbce rdf:first sg:person.0637451167.49
129 rdf:rest N3ef40865155949609164481fcbaa6352
130 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
131 schema:name Medical and Health Sciences
132 rdf:type schema:DefinedTerm
133 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
134 schema:name Oncology and Carcinogenesis
135 rdf:type schema:DefinedTerm
136 sg:grant.2705121 http://pending.schema.org/fundedItem sg:pub.10.1186/2045-3329-2-25
137 rdf:type schema:MonetaryGrant
138 sg:journal.1046367 schema:issn 2045-3329
139 schema:name Clinical Sarcoma Research
140 rdf:type schema:Periodical
141 sg:person.01004722356.51 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
142 schema:familyName Guadagnolo
143 schema:givenName Ashleigh
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004722356.51
145 rdf:type schema:Person
146 sg:person.01016450045.91 schema:affiliation N29f1701b687949f48e921b9a46983a1a
147 schema:familyName Trent
148 schema:givenName Jonathan C
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016450045.91
150 rdf:type schema:Person
151 sg:person.010255222337.53 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
152 schema:familyName Lazar
153 schema:givenName Alexander J
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010255222337.53
155 rdf:type schema:Person
156 sg:person.010331373604.53 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
157 schema:familyName Wang
158 schema:givenName Wei-Lien
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010331373604.53
160 rdf:type schema:Person
161 sg:person.01171370257.91 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
162 schema:familyName Araujo
163 schema:givenName Dejka M
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171370257.91
165 rdf:type schema:Person
166 sg:person.01200333274.18 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
167 schema:familyName Benjamin
168 schema:givenName Robert S
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200333274.18
170 rdf:type schema:Person
171 sg:person.01246243126.24 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
172 schema:familyName Ludwig
173 schema:givenName Joseph A
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246243126.24
175 rdf:type schema:Person
176 sg:person.01252467767.86 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
177 schema:familyName Ravi
178 schema:givenName Vinod
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252467767.86
180 rdf:type schema:Person
181 sg:person.013307202747.74 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
182 schema:familyName Patel
183 schema:givenName Shreyaskumar R
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013307202747.74
185 rdf:type schema:Person
186 sg:person.01351625756.72 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
187 schema:familyName Lewis
188 schema:givenName Valerie O
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351625756.72
190 rdf:type schema:Person
191 sg:person.014471151217.16 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
192 schema:familyName Zagars
193 schema:givenName Gunar K
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014471151217.16
195 rdf:type schema:Person
196 sg:person.014633403267.66 schema:affiliation N2e6a233f777c4efc8afe2d10e2e90f25
197 schema:familyName Lòpez-Terrada
198 schema:givenName Dolores
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014633403267.66
200 rdf:type schema:Person
201 sg:person.014763423333.17 schema:affiliation Nb25fa1b1e4ac4efe9da03cefc4261899
202 schema:familyName dei Tos
203 schema:givenName Angelo Paola
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014763423333.17
205 rdf:type schema:Person
206 sg:person.016135261767.27 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
207 schema:familyName Lin
208 schema:givenName Patrick P
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016135261767.27
210 rdf:type schema:Person
211 sg:person.0637451167.49 schema:affiliation https://www.grid.ac/institutes/grid.17788.31
212 schema:familyName Katz
213 schema:givenName Daniela
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637451167.49
215 rdf:type schema:Person
216 sg:person.0707247605.98 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
217 schema:familyName Lev
218 schema:givenName Dina
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707247605.98
220 rdf:type schema:Person
221 sg:person.0775141231.39 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
222 schema:familyName Madewell
223 schema:givenName John E
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0775141231.39
225 rdf:type schema:Person
226 sg:person.07756432137.83 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
227 schema:familyName Pollock
228 schema:givenName Raphael E
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07756432137.83
230 rdf:type schema:Person
231 sg:pub.10.1038/363640a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000976952
232 https://doi.org/10.1038/363640a0
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/modpathol.2008.84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037459426
235 https://doi.org/10.1038/modpathol.2008.84
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/modpathol.2010.118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029573652
238 https://doi.org/10.1038/modpathol.2010.118
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/modpathol.2011.148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025747772
241 https://doi.org/10.1038/modpathol.2011.148
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/modpathol.2012.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021050243
244 https://doi.org/10.1038/modpathol.2012.83
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/ng.619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006757412
247 https://doi.org/10.1038/ng.619
248 rdf:type schema:CreativeWork
249 sg:pub.10.2165/00003088-200140010-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049217785
250 https://doi.org/10.2165/00003088-200140010-00004
251 rdf:type schema:CreativeWork
252 https://app.dimensions.ai/details/publication/pub.1074963961 schema:CreativeWork
253 https://app.dimensions.ai/details/publication/pub.1079887561 schema:CreativeWork
254 https://app.dimensions.ai/details/publication/pub.1082515580 schema:CreativeWork
255 https://app.dimensions.ai/details/publication/pub.1082578248 schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1082596717 schema:CreativeWork
257 https://doi.org/10.1002/(sici)1096-9896(199708)182:4<437::aid-path882>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046670621
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1002/(sici)1097-0142(19960415)77:8<1450::aid-cncr5>3.0.co;2-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1033796679
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1002/gcc.20478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053173501
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1002/mpo.10060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037893013
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.humpath.2009.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030998025
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.radonc.2010.10.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046089386
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/s0006-2952(98)00307-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004693237
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s1470-2045(07)70175-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037193917
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s1525-1578(10)60472-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024860336
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s1525-1578(10)60628-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024715225
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s1525-1578(10)60698-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005501365
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1073/pnas.96.7.3951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016398626
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1080/01913120309917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036461930
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1093/ajcp/108.1.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083112083
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1093/annonc/mdp004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027650892
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1093/annonc/mdr265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033107792
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1097/00000478-197912000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005237630
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1097/00019606-199804000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001935315
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1097/cco.0b013e32833aaac1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020794897
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1097/pas.0b013e3181578d5a schema:sameAs https://app.dimensions.ai/details/publication/pub.1020473084
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1155/2011/538085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028074890
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1158/1078-0432.ccr-09-2912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019463215
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1158/1535-7163.mct-08-0848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024837220
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1172/jci60015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048892705
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1309/ajcp90ynokbagcdm schema:sameAs https://app.dimensions.ai/details/publication/pub.1008059115
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1593/neo.101202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000717346
308 rdf:type schema:CreativeWork
309 https://www.grid.ac/institutes/grid.17788.31 schema:alternateName Hadassah Medical Center
310 schema:name Sharette Institute of Oncology, Hadassah-Hebrew University Medical Center, POB 12000, 91120, Jerusalem, Israel
311 rdf:type schema:Organization
312 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
313 schema:name Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA
314 Department of Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA
315 Department of MusculoSkeletal Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA
316 Department of Othropeadic Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA
317 Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA
318 Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA
319 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA
320 Sarcoma Research Center, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd Unit 085, 77030, Houston, TX, USA
321 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...