Linking cytoarchitecture to metabolism: sarcolemma-associated plectin affects glucose uptake by destabilizing microtubule networks in mdx myofibers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Marianne Raith, Rocio G Valencia, Irmgard Fischer, Michael Orthofer, Josef M Penninger, Simone Spuler, Günther A Rezniczek, Gerhard Wiche

ABSTRACT

BACKGROUND: Duchenne muscular dystrophy (DMD) is one of the most frequent forms of muscular disorders. It is caused by the absence of dystrophin, a core component of the sarcolemma-associated junctional complex that links the cytoskeleton to the extracellular matrix. We showed previously that plectin 1f (P1f), one of the major muscle-expressed isoforms of the cytoskeletal linker protein plectin, accumulates at the sarcolemma of DMD patients as well as of mdx mice, a widely studied animal model for DMD.Based on plectin's dual role as structural protein and scaffolding platform for signaling molecules, we speculated that the dystrophic phenotype observed after loss of dystrophin was caused, at least to some extent, by excess plectin. Thus, we hypothesized that elimination of plectin expression in mdx skeletal muscle, while probably resulting in an overall more severe phenotype, may lead to a partial phenotype rescue. In particular, we wanted to assess whether excess sarcolemmal plectin contributes to the dysregulation of sugar metabolism in mdx myofibers. METHODS: We generated plectin/dystrophin double deficient (dKO) mice by breeding mdx with conditional striated muscle-restricted plectin knockout (cKO) mice. The phenotype of these mice was comparatively analyzed with that of mdx, cKO, and wild-type mice, focusing on structural integrity and dysregulation of glucose metabolism. RESULTS: We show that the accumulation of plectin at the sarcolemma of mdx muscle fibers hardly compensated for their loss of structural integrity. Instead, it led to an additional metabolic deficit by impairing glucose uptake. While dKO mice suffered from an overall more severe form of muscular dystrophy compared to mdx or plectin-deficient mice, sarcolemmal integrity as well as glucose uptake of their myofibers were restored to normal levels upon ablation of plectin. Furthermore, microtubule (MT) networks in intact dKO myofibers, including subsarcolemmal areas, were found to be more robust than those in mdx mice. Finally, myotubes differentiated from P1f-overexpressing myoblasts showed an impairment of glucose transporter 4 translocation and a destabilization of MT networks. CONCLUSIONS: Based on these results we propose that sarcolemma-associated plectin acts as an antagonist of MT network formation in myofibers, thereby hindering vesicle-mediated (MT-dependent) transport of glucose transporter 4. This novel role of plectin throws a bridge between extra-sarcomeric cytoarchitecture and metabolism of muscle fibers. Our study thus provides new insights into pathomechanisms of plectinopathies and muscular dystrophies in general. More... »

PAGES

14

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/2044-5040-3-14

DOI

http://dx.doi.org/10.1186/2044-5040-3-14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009884558

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23758845


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, Dr.-Bohr-Gasse 9, 1030, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Raith", 
        "givenName": "Marianne", 
        "id": "sg:person.0632026430.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632026430.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, Dr.-Bohr-Gasse 9, 1030, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Valencia", 
        "givenName": "Rocio G", 
        "id": "sg:person.0700141630.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700141630.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, Dr.-Bohr-Gasse 9, 1030, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fischer", 
        "givenName": "Irmgard", 
        "id": "sg:person.01125015402.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125015402.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Molecular Biotechnology", 
          "id": "https://www.grid.ac/institutes/grid.417521.4", 
          "name": [
            "Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr.-Bohr-Gasse 3, Vienna, 1030, Austria, Dr.-Bohr-Gasse 9, 1030, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orthofer", 
        "givenName": "Michael", 
        "id": "sg:person.01153710366.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153710366.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Molecular Biotechnology", 
          "id": "https://www.grid.ac/institutes/grid.417521.4", 
          "name": [
            "Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr.-Bohr-Gasse 3, Vienna, 1030, Austria, Dr.-Bohr-Gasse 9, 1030, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Penninger", 
        "givenName": "Josef M", 
        "id": "sg:person.014033772663.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014033772663.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Delbr\u00fcck Center for Molecular Medicine", 
          "id": "https://www.grid.ac/institutes/grid.419491.0", 
          "name": [
            "Muscle Research Unit, Experimental and Clinical Research Center, Lindenberger Weg 80, 13125, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spuler", 
        "givenName": "Simone", 
        "id": "sg:person.01110563101.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110563101.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ruhr University Bochum", 
          "id": "https://www.grid.ac/institutes/grid.5570.7", 
          "name": [
            "Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, Dr.-Bohr-Gasse 9, 1030, Vienna, Austria", 
            "Department of Obstetrics and Gynecology (Marienhospital Herne), Ruhr-Universit\u00e4t Bochum, D\u00fcngelstrasse 33, 44623, Herne, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rezniczek", 
        "givenName": "G\u00fcnther A", 
        "id": "sg:person.01035207117.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035207117.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Vienna", 
          "id": "https://www.grid.ac/institutes/grid.10420.37", 
          "name": [
            "Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, Dr.-Bohr-Gasse 9, 1030, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wiche", 
        "givenName": "Gerhard", 
        "id": "sg:person.01062543302.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062543302.58"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.81.4.1189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001793181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0074-7696(08)60158-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003015672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddg345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004773558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.131.6.1747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005258493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e12-06-0488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005590894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200605172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007702494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0010122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010488125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20080723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011982729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20080723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011982729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0019189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013489638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0854.2007.00622.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014693955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016092099", 
          "https://doi.org/10.1038/nm1345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016092099", 
          "https://doi.org/10.1038/nm1345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1529/biophysj.103.038422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017631680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.05.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019409643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200711058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019468351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000197785.51819.e8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019703339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000197785.51819.e8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019703339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1471-4159.1996.67031235.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020425505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80532-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022093504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajhg.2010.10.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023222707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3040649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023472427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3040649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023472427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2001.5620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023758958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/cclm.2010.179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024011607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-006-0044-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025662329", 
          "https://doi.org/10.1007/s10495-006-0044-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10495-006-0044-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025662329", 
          "https://doi.org/10.1007/s10495-006-0044-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.07-099036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027355373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/361647a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028318958", 
          "https://doi.org/10.1038/361647a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mus.21211", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028669190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m608473200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029180025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00401-012-1026-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029309430", 
          "https://doi.org/10.1007/s00401-012-1026-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200710151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030385127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.1523-1747.2003.12027.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031843797", 
          "https://doi.org/10.1046/j.1523-1747.2003.12027.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1523-1747.2003.12027.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031843797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ana.22024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032552623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200905048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032557296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.02891", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033479633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.11.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035527066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.11.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035527066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.det.2009.10.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036072888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m312382200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037136871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.00125.2012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039116590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/8.13.2461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040923431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(87)90579-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041056645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2009.06.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041609721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.00028.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044608797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.06-7353com", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044946807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1742-4658.2007.06232.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045881475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e10-02-0094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046482361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2044-5040-1-35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047612024", 
          "https://doi.org/10.1186/2044-5040-1-35"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200604179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052127672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05756", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053507775", 
          "https://doi.org/10.1038/nature05756"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi2000356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055203972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi2000356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055203972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/0264-6021:3520267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056715134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3520267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056720122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj3520267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056720122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2001-16613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057409519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/bioa.1.1.14630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072291422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079513582", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083166397", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "BACKGROUND: Duchenne muscular dystrophy (DMD) is one of the most frequent forms of muscular disorders. It is caused by the absence of dystrophin, a core component of the sarcolemma-associated junctional complex that links the cytoskeleton to the extracellular matrix. We showed previously that plectin 1f (P1f), one of the major muscle-expressed isoforms of the cytoskeletal linker protein plectin, accumulates at the sarcolemma of DMD patients as well as of mdx mice, a widely studied animal model for DMD.Based on plectin's dual role as structural protein and scaffolding platform for signaling molecules, we speculated that the dystrophic phenotype observed after loss of dystrophin was caused, at least to some extent, by excess plectin. Thus, we hypothesized that elimination of plectin expression in mdx skeletal muscle, while probably resulting in an overall more severe phenotype, may lead to a partial phenotype rescue. In particular, we wanted to assess whether excess sarcolemmal plectin contributes to the dysregulation of sugar metabolism in mdx myofibers.\nMETHODS: We generated plectin/dystrophin double deficient (dKO) mice by breeding mdx with conditional striated muscle-restricted plectin knockout (cKO) mice. The phenotype of these mice was comparatively analyzed with that of mdx, cKO, and wild-type mice, focusing on structural integrity and dysregulation of glucose metabolism.\nRESULTS: We show that the accumulation of plectin at the sarcolemma of mdx muscle fibers hardly compensated for their loss of structural integrity. Instead, it led to an additional metabolic deficit by impairing glucose uptake. While dKO mice suffered from an overall more severe form of muscular dystrophy compared to mdx or plectin-deficient mice, sarcolemmal integrity as well as glucose uptake of their myofibers were restored to normal levels upon ablation of plectin. Furthermore, microtubule (MT) networks in intact dKO myofibers, including subsarcolemmal areas, were found to be more robust than those in mdx mice. Finally, myotubes differentiated from P1f-overexpressing myoblasts showed an impairment of glucose transporter 4 translocation and a destabilization of MT networks.\nCONCLUSIONS: Based on these results we propose that sarcolemma-associated plectin acts as an antagonist of MT network formation in myofibers, thereby hindering vesicle-mediated (MT-dependent) transport of glucose transporter 4. This novel role of plectin throws a bridge between extra-sarcomeric cytoarchitecture and metabolism of muscle fibers. Our study thus provides new insights into pathomechanisms of plectinopathies and muscular dystrophies in general.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/2044-5040-3-14", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6190695", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6208293", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6187100", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6190951", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045175", 
        "issn": [
          "2044-5040"
        ], 
        "name": "Skeletal Muscle", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "name": "Linking cytoarchitecture to metabolism: sarcolemma-associated plectin affects glucose uptake by destabilizing microtubule networks in mdx myofibers", 
    "pagination": "14", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2f16c4d89b35b15934b7e3868598d4f07e89f57d9d9b1abaf7f77536c9817cd6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23758845"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101561193"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/2044-5040-3-14"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1009884558"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/2044-5040-3-14", 
      "https://app.dimensions.ai/details/publication/pub.1009884558"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F2044-5040-3-14"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/2044-5040-3-14'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/2044-5040-3-14'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/2044-5040-3-14'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/2044-5040-3-14'


 

This table displays all metadata directly associated to this object as RDF triples.

302 TRIPLES      21 PREDICATES      83 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/2044-5040-3-14 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N115e2eb43ab944e6bb4b268e3bbff37b
4 schema:citation sg:pub.10.1007/s00401-012-1026-0
5 sg:pub.10.1007/s10495-006-0044-6
6 sg:pub.10.1038/361647a0
7 sg:pub.10.1038/nature05756
8 sg:pub.10.1038/nm1345
9 sg:pub.10.1046/j.1523-1747.2003.12027.x
10 sg:pub.10.1186/2044-5040-1-35
11 https://app.dimensions.ai/details/publication/pub.1079513582
12 https://app.dimensions.ai/details/publication/pub.1083166397
13 https://doi.org/10.1002/ana.22024
14 https://doi.org/10.1002/mus.21211
15 https://doi.org/10.1006/bbrc.2001.5620
16 https://doi.org/10.1016/0092-8674(87)90579-4
17 https://doi.org/10.1016/j.ajhg.2010.10.017
18 https://doi.org/10.1016/j.bbrc.2009.06.053
19 https://doi.org/10.1016/j.cell.2008.05.049
20 https://doi.org/10.1016/j.cell.2010.11.039
21 https://doi.org/10.1016/j.det.2009.10.004
22 https://doi.org/10.1016/s0074-7696(08)60158-8
23 https://doi.org/10.1016/s0092-8674(00)80532-2
24 https://doi.org/10.1021/bi2000356
25 https://doi.org/10.1042/0264-6021:3520267
26 https://doi.org/10.1042/bj20080723
27 https://doi.org/10.1042/bj3040649
28 https://doi.org/10.1042/bj3520267
29 https://doi.org/10.1046/j.1471-4159.1996.67031235.x
30 https://doi.org/10.1046/j.1523-1747.2003.12027.x
31 https://doi.org/10.1055/s-2001-16613
32 https://doi.org/10.1073/pnas.81.4.1189
33 https://doi.org/10.1074/jbc.m312382200
34 https://doi.org/10.1074/jbc.m608473200
35 https://doi.org/10.1083/jcb.131.6.1747
36 https://doi.org/10.1083/jcb.200604179
37 https://doi.org/10.1083/jcb.200605172
38 https://doi.org/10.1083/jcb.200710151
39 https://doi.org/10.1083/jcb.200711058
40 https://doi.org/10.1083/jcb.200905048
41 https://doi.org/10.1091/mbc.e10-02-0094
42 https://doi.org/10.1091/mbc.e12-06-0488
43 https://doi.org/10.1093/hmg/8.13.2461
44 https://doi.org/10.1093/hmg/ddg345
45 https://doi.org/10.1096/fj.06-7353com
46 https://doi.org/10.1096/fj.07-099036
47 https://doi.org/10.1111/j.1600-0854.2007.00622.x
48 https://doi.org/10.1111/j.1742-4658.2007.06232.x
49 https://doi.org/10.1152/ajpcell.00125.2012
50 https://doi.org/10.1152/physrev.00028.2001
51 https://doi.org/10.1161/01.res.0000197785.51819.e8
52 https://doi.org/10.1242/jcs.02891
53 https://doi.org/10.1371/journal.pone.0010122
54 https://doi.org/10.1371/journal.pone.0019189
55 https://doi.org/10.1515/cclm.2010.179
56 https://doi.org/10.1529/biophysj.103.038422
57 https://doi.org/10.4161/bioa.1.1.14630
58 schema:datePublished 2013-12
59 schema:datePublishedReg 2013-12-01
60 schema:description BACKGROUND: Duchenne muscular dystrophy (DMD) is one of the most frequent forms of muscular disorders. It is caused by the absence of dystrophin, a core component of the sarcolemma-associated junctional complex that links the cytoskeleton to the extracellular matrix. We showed previously that plectin 1f (P1f), one of the major muscle-expressed isoforms of the cytoskeletal linker protein plectin, accumulates at the sarcolemma of DMD patients as well as of mdx mice, a widely studied animal model for DMD.Based on plectin's dual role as structural protein and scaffolding platform for signaling molecules, we speculated that the dystrophic phenotype observed after loss of dystrophin was caused, at least to some extent, by excess plectin. Thus, we hypothesized that elimination of plectin expression in mdx skeletal muscle, while probably resulting in an overall more severe phenotype, may lead to a partial phenotype rescue. In particular, we wanted to assess whether excess sarcolemmal plectin contributes to the dysregulation of sugar metabolism in mdx myofibers. METHODS: We generated plectin/dystrophin double deficient (dKO) mice by breeding mdx with conditional striated muscle-restricted plectin knockout (cKO) mice. The phenotype of these mice was comparatively analyzed with that of mdx, cKO, and wild-type mice, focusing on structural integrity and dysregulation of glucose metabolism. RESULTS: We show that the accumulation of plectin at the sarcolemma of mdx muscle fibers hardly compensated for their loss of structural integrity. Instead, it led to an additional metabolic deficit by impairing glucose uptake. While dKO mice suffered from an overall more severe form of muscular dystrophy compared to mdx or plectin-deficient mice, sarcolemmal integrity as well as glucose uptake of their myofibers were restored to normal levels upon ablation of plectin. Furthermore, microtubule (MT) networks in intact dKO myofibers, including subsarcolemmal areas, were found to be more robust than those in mdx mice. Finally, myotubes differentiated from P1f-overexpressing myoblasts showed an impairment of glucose transporter 4 translocation and a destabilization of MT networks. CONCLUSIONS: Based on these results we propose that sarcolemma-associated plectin acts as an antagonist of MT network formation in myofibers, thereby hindering vesicle-mediated (MT-dependent) transport of glucose transporter 4. This novel role of plectin throws a bridge between extra-sarcomeric cytoarchitecture and metabolism of muscle fibers. Our study thus provides new insights into pathomechanisms of plectinopathies and muscular dystrophies in general.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree true
64 schema:isPartOf N61e3a2f5dddc46a5995a8488efa40430
65 Nf8411d71fd9a4328b6fecc84a44e24b9
66 sg:journal.1045175
67 schema:name Linking cytoarchitecture to metabolism: sarcolemma-associated plectin affects glucose uptake by destabilizing microtubule networks in mdx myofibers
68 schema:pagination 14
69 schema:productId N13c8bc60fa7e4fc3afc2b23621cdee31
70 N29e29ce8c1e54d36855d65b08f08dbf5
71 N64445f893ebf42e4b30e0f3787dbce13
72 Nac2754d90cd44ceeae72405e9795a7ec
73 Ne456ef59e3b64332ab2d846bc637f1d0
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009884558
75 https://doi.org/10.1186/2044-5040-3-14
76 schema:sdDatePublished 2019-04-10T13:15
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher N9254656cf7d247b0a05fb41103df271e
79 schema:url http://link.springer.com/10.1186%2F2044-5040-3-14
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N115e2eb43ab944e6bb4b268e3bbff37b rdf:first sg:person.0632026430.40
84 rdf:rest Ndbcb3385ba7d4d50be2b79ca5f0e5701
85 N13c8bc60fa7e4fc3afc2b23621cdee31 schema:name pubmed_id
86 schema:value 23758845
87 rdf:type schema:PropertyValue
88 N29e29ce8c1e54d36855d65b08f08dbf5 schema:name readcube_id
89 schema:value 2f16c4d89b35b15934b7e3868598d4f07e89f57d9d9b1abaf7f77536c9817cd6
90 rdf:type schema:PropertyValue
91 N61e3a2f5dddc46a5995a8488efa40430 schema:volumeNumber 3
92 rdf:type schema:PublicationVolume
93 N64445f893ebf42e4b30e0f3787dbce13 schema:name dimensions_id
94 schema:value pub.1009884558
95 rdf:type schema:PropertyValue
96 N9254656cf7d247b0a05fb41103df271e schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 N9668fc4d18a3489488123ddc92f6606f rdf:first sg:person.01110563101.52
99 rdf:rest Ndce4cfddcce54792acf146dd475c2979
100 Nac2754d90cd44ceeae72405e9795a7ec schema:name nlm_unique_id
101 schema:value 101561193
102 rdf:type schema:PropertyValue
103 Nc6d666b6d24e4ca8a950af6124c63c7c rdf:first sg:person.01153710366.07
104 rdf:rest Ndc0dceb95bc54c3785711cebee0c3a2a
105 Ncb48ac2088e5427da20cea50957fbb81 rdf:first sg:person.01062543302.58
106 rdf:rest rdf:nil
107 Nd73b3b556e4f417cbad861a54828dc3a rdf:first sg:person.01125015402.00
108 rdf:rest Nc6d666b6d24e4ca8a950af6124c63c7c
109 Ndbcb3385ba7d4d50be2b79ca5f0e5701 rdf:first sg:person.0700141630.06
110 rdf:rest Nd73b3b556e4f417cbad861a54828dc3a
111 Ndc0dceb95bc54c3785711cebee0c3a2a rdf:first sg:person.014033772663.36
112 rdf:rest N9668fc4d18a3489488123ddc92f6606f
113 Ndce4cfddcce54792acf146dd475c2979 rdf:first sg:person.01035207117.51
114 rdf:rest Ncb48ac2088e5427da20cea50957fbb81
115 Ne456ef59e3b64332ab2d846bc637f1d0 schema:name doi
116 schema:value 10.1186/2044-5040-3-14
117 rdf:type schema:PropertyValue
118 Nf8411d71fd9a4328b6fecc84a44e24b9 schema:issueNumber 1
119 rdf:type schema:PublicationIssue
120 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
121 schema:name Medical and Health Sciences
122 rdf:type schema:DefinedTerm
123 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
124 schema:name Neurosciences
125 rdf:type schema:DefinedTerm
126 sg:grant.6187100 http://pending.schema.org/fundedItem sg:pub.10.1186/2044-5040-3-14
127 rdf:type schema:MonetaryGrant
128 sg:grant.6190695 http://pending.schema.org/fundedItem sg:pub.10.1186/2044-5040-3-14
129 rdf:type schema:MonetaryGrant
130 sg:grant.6190951 http://pending.schema.org/fundedItem sg:pub.10.1186/2044-5040-3-14
131 rdf:type schema:MonetaryGrant
132 sg:grant.6208293 http://pending.schema.org/fundedItem sg:pub.10.1186/2044-5040-3-14
133 rdf:type schema:MonetaryGrant
134 sg:journal.1045175 schema:issn 2044-5040
135 schema:name Skeletal Muscle
136 rdf:type schema:Periodical
137 sg:person.01035207117.51 schema:affiliation https://www.grid.ac/institutes/grid.5570.7
138 schema:familyName Rezniczek
139 schema:givenName Günther A
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035207117.51
141 rdf:type schema:Person
142 sg:person.01062543302.58 schema:affiliation https://www.grid.ac/institutes/grid.10420.37
143 schema:familyName Wiche
144 schema:givenName Gerhard
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062543302.58
146 rdf:type schema:Person
147 sg:person.01110563101.52 schema:affiliation https://www.grid.ac/institutes/grid.419491.0
148 schema:familyName Spuler
149 schema:givenName Simone
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110563101.52
151 rdf:type schema:Person
152 sg:person.01125015402.00 schema:affiliation https://www.grid.ac/institutes/grid.10420.37
153 schema:familyName Fischer
154 schema:givenName Irmgard
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125015402.00
156 rdf:type schema:Person
157 sg:person.01153710366.07 schema:affiliation https://www.grid.ac/institutes/grid.417521.4
158 schema:familyName Orthofer
159 schema:givenName Michael
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153710366.07
161 rdf:type schema:Person
162 sg:person.014033772663.36 schema:affiliation https://www.grid.ac/institutes/grid.417521.4
163 schema:familyName Penninger
164 schema:givenName Josef M
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014033772663.36
166 rdf:type schema:Person
167 sg:person.0632026430.40 schema:affiliation https://www.grid.ac/institutes/grid.10420.37
168 schema:familyName Raith
169 schema:givenName Marianne
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632026430.40
171 rdf:type schema:Person
172 sg:person.0700141630.06 schema:affiliation https://www.grid.ac/institutes/grid.10420.37
173 schema:familyName Valencia
174 schema:givenName Rocio G
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700141630.06
176 rdf:type schema:Person
177 sg:pub.10.1007/s00401-012-1026-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029309430
178 https://doi.org/10.1007/s00401-012-1026-0
179 rdf:type schema:CreativeWork
180 sg:pub.10.1007/s10495-006-0044-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025662329
181 https://doi.org/10.1007/s10495-006-0044-6
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/361647a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028318958
184 https://doi.org/10.1038/361647a0
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/nature05756 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053507775
187 https://doi.org/10.1038/nature05756
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/nm1345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016092099
190 https://doi.org/10.1038/nm1345
191 rdf:type schema:CreativeWork
192 sg:pub.10.1046/j.1523-1747.2003.12027.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031843797
193 https://doi.org/10.1046/j.1523-1747.2003.12027.x
194 rdf:type schema:CreativeWork
195 sg:pub.10.1186/2044-5040-1-35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047612024
196 https://doi.org/10.1186/2044-5040-1-35
197 rdf:type schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1079513582 schema:CreativeWork
199 https://app.dimensions.ai/details/publication/pub.1083166397 schema:CreativeWork
200 https://doi.org/10.1002/ana.22024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032552623
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1002/mus.21211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028669190
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1006/bbrc.2001.5620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023758958
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/0092-8674(87)90579-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041056645
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.ajhg.2010.10.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023222707
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.bbrc.2009.06.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041609721
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.cell.2008.05.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019409643
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.cell.2010.11.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035527066
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.det.2009.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036072888
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/s0074-7696(08)60158-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003015672
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/s0092-8674(00)80532-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022093504
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1021/bi2000356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055203972
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1042/0264-6021:3520267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056715134
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1042/bj20080723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011982729
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1042/bj3040649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023472427
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1042/bj3520267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056720122
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1046/j.1471-4159.1996.67031235.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020425505
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1046/j.1523-1747.2003.12027.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031843797
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1055/s-2001-16613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057409519
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1073/pnas.81.4.1189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001793181
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1074/jbc.m312382200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037136871
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1074/jbc.m608473200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029180025
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1083/jcb.131.6.1747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005258493
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1083/jcb.200604179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052127672
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1083/jcb.200605172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007702494
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1083/jcb.200710151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030385127
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1083/jcb.200711058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019468351
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1083/jcb.200905048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032557296
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1091/mbc.e10-02-0094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046482361
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1091/mbc.e12-06-0488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005590894
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1093/hmg/8.13.2461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040923431
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1093/hmg/ddg345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004773558
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1096/fj.06-7353com schema:sameAs https://app.dimensions.ai/details/publication/pub.1044946807
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1096/fj.07-099036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027355373
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1111/j.1600-0854.2007.00622.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014693955
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1111/j.1742-4658.2007.06232.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045881475
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1152/ajpcell.00125.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039116590
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1152/physrev.00028.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044608797
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1161/01.res.0000197785.51819.e8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019703339
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1242/jcs.02891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033479633
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1371/journal.pone.0010122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010488125
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1371/journal.pone.0019189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013489638
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1515/cclm.2010.179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024011607
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1529/biophysj.103.038422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017631680
287 rdf:type schema:CreativeWork
288 https://doi.org/10.4161/bioa.1.1.14630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072291422
289 rdf:type schema:CreativeWork
290 https://www.grid.ac/institutes/grid.10420.37 schema:alternateName University of Vienna
291 schema:name Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, Dr.-Bohr-Gasse 9, 1030, Vienna, Austria
292 rdf:type schema:Organization
293 https://www.grid.ac/institutes/grid.417521.4 schema:alternateName Institute of Molecular Biotechnology
294 schema:name Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr.-Bohr-Gasse 3, Vienna, 1030, Austria, Dr.-Bohr-Gasse 9, 1030, Vienna, Austria
295 rdf:type schema:Organization
296 https://www.grid.ac/institutes/grid.419491.0 schema:alternateName Max Delbrück Center for Molecular Medicine
297 schema:name Muscle Research Unit, Experimental and Clinical Research Center, Lindenberger Weg 80, 13125, Berlin, Germany
298 rdf:type schema:Organization
299 https://www.grid.ac/institutes/grid.5570.7 schema:alternateName Ruhr University Bochum
300 schema:name Department of Biochemistry and Cell Biology, Max F. Perutz Laboratories, University of Vienna, Dr.-Bohr-Gasse 9, 1030, Vienna, Austria
301 Department of Obstetrics and Gynecology (Marienhospital Herne), Ruhr-Universität Bochum, Düngelstrasse 33, 44623, Herne, Germany
302 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...