The Translational Medicine Ontology and Knowledge Base: driving personalized medicine by bridging the gap between bench and bedside View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Joanne S Luciano, Bosse Andersson, Colin Batchelor, Olivier Bodenreider, Tim Clark, Christine K Denney, Christopher Domarew, Thomas Gambet, Lee Harland, Anja Jentzsch, Vipul Kashyap, Peter Kos, Julia Kozlovsky, Timothy Lebo, Scott M Marshall, James P McCusker, Deborah L McGuinness, Chimezie Ogbuji, Elgar Pichler, Robert L Powers, Eric Prud’hommeaux, Matthias Samwald, Lynn Schriml, Peter J Tonellato, Patricia L Whetzel, Jun Zhao, Susie Stephens, Michel Dumontier

ABSTRACT

BACKGROUND: Translational medicine requires the integration of knowledge using heterogeneous data from health care to the life sciences. Here, we describe a collaborative effort to produce a prototype Translational Medicine Knowledge Base (TMKB) capable of answering questions relating to clinical practice and pharmaceutical drug discovery. RESULTS: We developed the Translational Medicine Ontology (TMO) as a unifying ontology to integrate chemical, genomic and proteomic data with disease, treatment, and electronic health records. We demonstrate the use of Semantic Web technologies in the integration of patient and biomedical data, and reveal how such a knowledge base can aid physicians in providing tailored patient care and facilitate the recruitment of patients into active clinical trials. Thus, patients, physicians and researchers may explore the knowledge base to better understand therapeutic options, efficacy, and mechanisms of action. CONCLUSIONS: This work takes an important step in using Semantic Web technologies to facilitate integration of relevant, distributed, external sources and progress towards a computational platform to support personalized medicine. AVAILABILITY: TMO can be downloaded from http://code.google.com/p/translationalmedicineontology and TMKB can be accessed at http://tm.semanticscience.org/sparql. More... »

PAGES

s1

References to SciGraph publications

  • 2008-10. Pharmacogenetics in drug discovery and development: a translational perspective in NATURE REVIEWS DRUG DISCOVERY
  • 2007-04. Stratified medicine: strategic and economic implications of combining drugs and clinical biomarkers in NATURE REVIEWS DRUG DISCOVERY
  • 2010-09. The BioPAX community standard for pathway data sharing in NATURE BIOTECHNOLOGY
  • 2007-05. e-Science and biological pathway semantics in BMC BIOINFORMATICS
  • 2007-05. Advancing translational research with the Semantic Web in BMC BIOINFORMATICS
  • 2010. Provenance Context Entity (PaCE): Scalable Provenance Tracking for Scientific RDF Data in SCIENTIFIC AND STATISTICAL DATABASE MANAGEMENT
  • 2010. SameAs Networks and Beyond: Analyzing Deployment Status and Implications of owl:sameAs in Linked Data in THE SEMANTIC WEB – ISWC 2010
  • 2008-12. Drug interaction prediction using ontology-driven hypothetical assertion framework for pathway generation followed by numerical simulation in BMC BIOINFORMATICS
  • 2010. When owl:sameAs Isn’t the Same: An Analysis of Identity in Linked Data in THE SEMANTIC WEB – ISWC 2010
  • 2009-02. Ontology driven integration platform for clinical and translational research in BMC BIOINFORMATICS
  • 2005-05. Relations in biomedical ontologies in GENOME BIOLOGY
  • 2009-02. Ontology-driven indexing of public datasets for translational bioinformatics in BMC BIOINFORMATICS
  • 2009-10-16. BioPortal: Ontologies and Integrated Data Resources at the Click of a Mouse in NATURE PRECEDINGS
  • 2006. Suggested Ontology for Pharmacogenomics (SO-Pharm): Modular Construction and Preliminary Testing in ON THE MOVE TO MEANINGFUL INTERNET SYSTEMS 2006: OTM 2006 WORKSHOPS
  • 2007. Can Semantic Web Technologies Enable Translational Medicine? in SEMANTIC WEB
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/2041-1480-2-s2-s1

    DOI

    http://dx.doi.org/10.1186/2041-1480-2-s2-s1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026078352

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21624155


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0806", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Information Systems", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/08", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Information and Computing Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Rensselaer Polytechnic Institute", 
              "id": "https://www.grid.ac/institutes/grid.33647.35", 
              "name": [
                "Rensselaer Polytechnic Institute, Troy, NY, USA", 
                "Predictive Medicine Inc., Belmont, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Luciano", 
            "givenName": "Joanne S", 
            "id": "sg:person.01112335735.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112335735.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "AstraZeneca (Sweden)", 
              "id": "https://www.grid.ac/institutes/grid.418151.8", 
              "name": [
                "AstraZeneca, Lund, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Andersson", 
            "givenName": "Bosse", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Royal Society of Chemistry", 
              "id": "https://www.grid.ac/institutes/grid.431456.1", 
              "name": [
                "Royal Society of Chemistry, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Batchelor", 
            "givenName": "Colin", 
            "id": "sg:person.0755540211.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755540211.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "United States National Library of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.280285.5", 
              "name": [
                "National Library of Medicine, Bethesda, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bodenreider", 
            "givenName": "Olivier", 
            "id": "sg:person.01033503431.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033503431.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Manchester", 
              "id": "https://www.grid.ac/institutes/grid.5379.8", 
              "name": [
                "Harvard Medical School, Boston, MA, USA", 
                "University of Manchester, Manchester, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Clark", 
            "givenName": "Tim", 
            "id": "sg:person.01307535417.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307535417.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Eli Lilly (United States)", 
              "id": "https://www.grid.ac/institutes/grid.417540.3", 
              "name": [
                "Eli Lilly and Company, Indianapolis, IN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Denney", 
            "givenName": "Christine K", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Albany Medical Center Hospital", 
              "id": "https://www.grid.ac/institutes/grid.413558.e", 
              "name": [
                "Albany Medical Center, NY, Albany, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Domarew", 
            "givenName": "Christopher", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "W3C, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gambet", 
            "givenName": "Thomas", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pfizer (United Kingdom)", 
              "id": "https://www.grid.ac/institutes/grid.418566.8", 
              "name": [
                "Pfizer, Sandwich, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Harland", 
            "givenName": "Lee", 
            "id": "sg:person.0625034223.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625034223.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Freie Universit\u00e4t Berlin", 
              "id": "https://www.grid.ac/institutes/grid.14095.39", 
              "name": [
                "Freie Universit\u00e4t, Berlin, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jentzsch", 
            "givenName": "Anja", 
            "id": "sg:person.0750743522.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750743522.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cigna (United States)", 
              "id": "https://www.grid.ac/institutes/grid.467318.f", 
              "name": [
                "Cigna, Hartford, CT, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kashyap", 
            "givenName": "Vipul", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kos", 
            "givenName": "Peter", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "AstraZeneca (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418152.b", 
              "name": [
                "AstraZeneca, Waltham, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kozlovsky", 
            "givenName": "Julia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Rensselaer Polytechnic Institute", 
              "id": "https://www.grid.ac/institutes/grid.33647.35", 
              "name": [
                "Rensselaer Polytechnic Institute, Troy, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lebo", 
            "givenName": "Timothy", 
            "id": "sg:person.015756017417.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015756017417.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Amsterdam", 
              "id": "https://www.grid.ac/institutes/grid.7177.6", 
              "name": [
                "Leiden University Medical Center, Leiden, NL", 
                "University of Amsterdam, Amsterdam, NL"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marshall", 
            "givenName": "Scott M", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Rensselaer Polytechnic Institute", 
              "id": "https://www.grid.ac/institutes/grid.33647.35", 
              "name": [
                "Rensselaer Polytechnic Institute, Troy, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McCusker", 
            "givenName": "James P", 
            "id": "sg:person.01230424175.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230424175.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Rensselaer Polytechnic Institute", 
              "id": "https://www.grid.ac/institutes/grid.33647.35", 
              "name": [
                "Rensselaer Polytechnic Institute, Troy, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McGuinness", 
            "givenName": "Deborah L", 
            "id": "sg:person.0647077144.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647077144.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Case Western Reserve University", 
              "id": "https://www.grid.ac/institutes/grid.67105.35", 
              "name": [
                "Case Western Reserve University School of Medicine, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ogbuji", 
            "givenName": "Chimezie", 
            "id": "sg:person.010627036523.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010627036523.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "W3C HCLSIG, W3C, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pichler", 
            "givenName": "Elgar", 
            "id": "sg:person.01274677535.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274677535.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Predictive Medicine Inc., Belmont, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Powers", 
            "givenName": "Robert L", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "W3C, Cambridge, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Prud\u2019hommeaux", 
            "givenName": "Eric", 
            "id": "sg:person.01343012735.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343012735.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National University of Ireland, Galway", 
              "id": "https://www.grid.ac/institutes/grid.6142.1", 
              "name": [
                "Medical University of Vienna, Vienna, Austria", 
                "Information Retrieval Facility (IRF), Vienna, Austria", 
                "Digital Enterprise Research Institute (DERI), National University of Ireland Galway, Ireland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Samwald", 
            "givenName": "Matthias", 
            "id": "sg:person.0661660735.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661660735.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "University of Maryland, Institute for Genome Sciences, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schriml", 
            "givenName": "Lynn", 
            "id": "sg:person.01366305022.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366305022.56"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Harvard Medical School, Boston, MA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tonellato", 
            "givenName": "Peter J", 
            "id": "sg:person.01052034706.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052034706.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford University", 
              "id": "https://www.grid.ac/institutes/grid.168010.e", 
              "name": [
                "Stanford University, StanfordCA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Whetzel", 
            "givenName": "Patricia L", 
            "id": "sg:person.01227231333.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227231333.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Oxford", 
              "id": "https://www.grid.ac/institutes/grid.4991.5", 
              "name": [
                "University of Oxford, Oxford, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhao", 
            "givenName": "Jun", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Janssen (United States)", 
              "id": "https://www.grid.ac/institutes/grid.497530.c", 
              "name": [
                "Johnson & Johnson Pharmaceutical Research & Development L.L.C., Radnor, PA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stephens", 
            "givenName": "Susie", 
            "id": "sg:person.01314676145.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314676145.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Carleton University", 
              "id": "https://www.grid.ac/institutes/grid.34428.39", 
              "name": [
                "Carleton University, Ottawa, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dumontier", 
            "givenName": "Michel", 
            "id": "sg:person.01324655201.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324655201.14"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrd2593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000034028", 
              "https://doi.org/10.1038/nrd2593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmsb053723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001673580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2251", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002728270", 
              "https://doi.org/10.1038/nrd2251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rsta.2003.1224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003559877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bib/bbn056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004892751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1503/cmaj.070796", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006686531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1503/cmaj.070796", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006686531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.future.2010.07.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008845212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkq1126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010727021"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awq277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010781685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awq277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010781685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkp440", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010962830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.websem.2006.05.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013263864"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-8-s3-s2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013842120", 
              "https://doi.org/10.1186/1471-2105-8-s3-s2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbi.2006.02.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014198679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2005-6-5-r46", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015285227", 
              "https://doi.org/10.1186/gb-2005-6-5-r46"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-10-s2-s1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015890425", 
              "https://doi.org/10.1186/1471-2105-10-s2-s1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.00033208", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017432872"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jamia.2009.000893", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019080707"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.websem.2004.06.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020225200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/pgs.10.15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023168257"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-8-s3-s3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023645192", 
              "https://doi.org/10.1186/1471-2105-8-s3-s3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/b978-155860933-4/50013-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024913994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1666", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025620867", 
              "https://doi.org/10.1038/nbt.1666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1666", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025620867", 
              "https://doi.org/10.1038/nbt.1666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-17746-0_20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026158851", 
              "https://doi.org/10.1007/978-3-642-17746-0_20"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-17746-0_20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026158851", 
              "https://doi.org/10.1007/978-3-642-17746-0_20"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbi.2008.03.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030920077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(07)70178-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032800719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npre.2009.3868.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033880916", 
              "https://doi.org/10.1038/npre.2009.3868.1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2009.965", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036417899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/11915034_89", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036522785", 
              "https://doi.org/10.1007/11915034_89"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/11915034_89", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036522785", 
              "https://doi.org/10.1007/11915034_89"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-13818-8_32", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036586839", 
              "https://doi.org/10.1007/978-3-642-13818-8_32"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/mis.2009.19", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037905615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1359-6446(05)03501-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038113615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1145/1645953.1646084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039283481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-9-s6-s11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041272526", 
              "https://doi.org/10.1186/1471-2105-9-s6-s11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2007.26", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045501751"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-48438-9_13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047833776", 
              "https://doi.org/10.1007/978-0-387-48438-9_13"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-17746-0_10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048046730", 
              "https://doi.org/10.1007/978-3-642-17746-0_10"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-17746-0_10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048046730", 
              "https://doi.org/10.1007/978-3-642-17746-0_10"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-10-s2-s2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048904958", 
              "https://doi.org/10.1186/1471-2105-10-s2-s2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1110410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062452040"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1533317508328602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064038578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1533317508328602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064038578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074991673", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078353958", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1109/hicss.2009.263", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1093457959"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-12", 
        "datePublishedReg": "2011-12-01", 
        "description": "BACKGROUND: Translational medicine requires the integration of knowledge using heterogeneous data from health care to the life sciences. Here, we describe a collaborative effort to produce a prototype Translational Medicine Knowledge Base (TMKB) capable of answering questions relating to clinical practice and pharmaceutical drug discovery.\nRESULTS: We developed the Translational Medicine Ontology (TMO) as a unifying ontology to integrate chemical, genomic and proteomic data with disease, treatment, and electronic health records. We demonstrate the use of Semantic Web technologies in the integration of patient and biomedical data, and reveal how such a knowledge base can aid physicians in providing tailored patient care and facilitate the recruitment of patients into active clinical trials. Thus, patients, physicians and researchers may explore the knowledge base to better understand therapeutic options, efficacy, and mechanisms of action.\nCONCLUSIONS: This work takes an important step in using Semantic Web technologies to facilitate integration of relevant, distributed, external sources and progress towards a computational platform to support personalized medicine.\nAVAILABILITY: TMO can be downloaded from http://code.google.com/p/translationalmedicineontology and TMKB can be accessed at http://tm.semanticscience.org/sparql.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/2041-1480-2-s2-s1", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2545608", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2545661", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1043573", 
            "issn": [
              "2041-1480"
            ], 
            "name": "Journal of Biomedical Semantics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "Suppl 2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "2"
          }
        ], 
        "name": "The Translational Medicine Ontology and Knowledge Base: driving personalized medicine by bridging the gap between bench and bedside", 
        "pagination": "s1", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "7c3c515ec890b026050a5b03424c339e737601c71a943085334fbeb4db524180"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21624155"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101531992"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/2041-1480-2-s2-s1"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1026078352"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/2041-1480-2-s2-s1", 
          "https://app.dimensions.ai/details/publication/pub.1026078352"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:25", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000550.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2F2041-1480-2-S2-S1"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/2041-1480-2-s2-s1'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/2041-1480-2-s2-s1'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/2041-1480-2-s2-s1'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/2041-1480-2-s2-s1'


     

    This table displays all metadata directly associated to this object as RDF triples.

    459 TRIPLES      21 PREDICATES      71 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/2041-1480-2-s2-s1 schema:about anzsrc-for:08
    2 anzsrc-for:0806
    3 schema:author N1819a51e903841be84b9897010525bb1
    4 schema:citation sg:pub.10.1007/11915034_89
    5 sg:pub.10.1007/978-0-387-48438-9_13
    6 sg:pub.10.1007/978-3-642-13818-8_32
    7 sg:pub.10.1007/978-3-642-17746-0_10
    8 sg:pub.10.1007/978-3-642-17746-0_20
    9 sg:pub.10.1038/nbt.1666
    10 sg:pub.10.1038/npre.2009.3868.1
    11 sg:pub.10.1038/nrd2251
    12 sg:pub.10.1038/nrd2593
    13 sg:pub.10.1186/1471-2105-10-s2-s1
    14 sg:pub.10.1186/1471-2105-10-s2-s2
    15 sg:pub.10.1186/1471-2105-8-s3-s2
    16 sg:pub.10.1186/1471-2105-8-s3-s3
    17 sg:pub.10.1186/1471-2105-9-s6-s11
    18 sg:pub.10.1186/gb-2005-6-5-r46
    19 https://app.dimensions.ai/details/publication/pub.1074991673
    20 https://app.dimensions.ai/details/publication/pub.1078353958
    21 https://doi.org/10.1001/jama.2007.26
    22 https://doi.org/10.1001/jama.2009.965
    23 https://doi.org/10.1016/b978-155860933-4/50013-4
    24 https://doi.org/10.1016/j.future.2010.07.005
    25 https://doi.org/10.1016/j.jbi.2006.02.013
    26 https://doi.org/10.1016/j.jbi.2008.03.004
    27 https://doi.org/10.1016/j.websem.2004.06.002
    28 https://doi.org/10.1016/j.websem.2006.05.004
    29 https://doi.org/10.1016/s1359-6446(05)03501-4
    30 https://doi.org/10.1016/s1474-4422(07)70178-3
    31 https://doi.org/10.1056/nejmsb053723
    32 https://doi.org/10.1093/bib/bbn056
    33 https://doi.org/10.1093/brain/awq277
    34 https://doi.org/10.1093/nar/gkp440
    35 https://doi.org/10.1093/nar/gkq1126
    36 https://doi.org/10.1098/rsta.2003.1224
    37 https://doi.org/10.1109/hicss.2009.263
    38 https://doi.org/10.1109/mis.2009.19
    39 https://doi.org/10.1126/science.1110410
    40 https://doi.org/10.1136/jamia.2009.000893
    41 https://doi.org/10.1145/1645953.1646084
    42 https://doi.org/10.1177/1533317508328602
    43 https://doi.org/10.1183/09031936.00033208
    44 https://doi.org/10.1503/cmaj.070796
    45 https://doi.org/10.2217/pgs.10.15
    46 schema:datePublished 2011-12
    47 schema:datePublishedReg 2011-12-01
    48 schema:description BACKGROUND: Translational medicine requires the integration of knowledge using heterogeneous data from health care to the life sciences. Here, we describe a collaborative effort to produce a prototype Translational Medicine Knowledge Base (TMKB) capable of answering questions relating to clinical practice and pharmaceutical drug discovery. RESULTS: We developed the Translational Medicine Ontology (TMO) as a unifying ontology to integrate chemical, genomic and proteomic data with disease, treatment, and electronic health records. We demonstrate the use of Semantic Web technologies in the integration of patient and biomedical data, and reveal how such a knowledge base can aid physicians in providing tailored patient care and facilitate the recruitment of patients into active clinical trials. Thus, patients, physicians and researchers may explore the knowledge base to better understand therapeutic options, efficacy, and mechanisms of action. CONCLUSIONS: This work takes an important step in using Semantic Web technologies to facilitate integration of relevant, distributed, external sources and progress towards a computational platform to support personalized medicine. AVAILABILITY: TMO can be downloaded from http://code.google.com/p/translationalmedicineontology and TMKB can be accessed at http://tm.semanticscience.org/sparql.
    49 schema:genre research_article
    50 schema:inLanguage en
    51 schema:isAccessibleForFree true
    52 schema:isPartOf N2db00612d2ab4d809dd80bf24efa4789
    53 Ncf6468178650498ca4616e305bce4379
    54 sg:journal.1043573
    55 schema:name The Translational Medicine Ontology and Knowledge Base: driving personalized medicine by bridging the gap between bench and bedside
    56 schema:pagination s1
    57 schema:productId N0a809c0f2a9d4155bcba968912ea18e2
    58 N7d2debe6ebda49449cf2dd31f2de31c3
    59 Nac5e659283934b59a5914a40ca9dd647
    60 Nd0564e786e1d4c248071faed3fd4d66b
    61 Nd20c6d69a3dc4bc1a96de437e049de0e
    62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026078352
    63 https://doi.org/10.1186/2041-1480-2-s2-s1
    64 schema:sdDatePublished 2019-04-10T13:25
    65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    66 schema:sdPublisher Ndd6dc64e242e4427b74a29519c53df27
    67 schema:url http://link.springer.com/10.1186%2F2041-1480-2-S2-S1
    68 sgo:license sg:explorer/license/
    69 sgo:sdDataset articles
    70 rdf:type schema:ScholarlyArticle
    71 N055aab2317d84bf687fb9cfe64a0f616 rdf:first N524f6f0ba9f4418182bcd20054f7f87f
    72 rdf:rest Ne28c051468334c939b0e42e533ab2107
    73 N07c54f7890be45f49a3b199ee0f49efe rdf:first N465a49768e194d3fbb00d89f06e09d9e
    74 rdf:rest Naa14f0c824c64961942ebb6fa6834971
    75 N0a809c0f2a9d4155bcba968912ea18e2 schema:name dimensions_id
    76 schema:value pub.1026078352
    77 rdf:type schema:PropertyValue
    78 N0c3a46bad7294d42bb18c2809f702019 rdf:first sg:person.0755540211.17
    79 rdf:rest Nd45c3d081fd64c12b8889cf16a726f59
    80 N0e1671dc66f349e7b453d97b97e8adac schema:affiliation Necad0514ecaf4a0d853a3f2f908dd27a
    81 schema:familyName Powers
    82 schema:givenName Robert L
    83 rdf:type schema:Person
    84 N1639a944037e4fd898e065719ff12fff rdf:first Nddad679574b7440f9965311c96c284af
    85 rdf:rest N4fcefe51728c4f449a0c7b7219b37e41
    86 N1819a51e903841be84b9897010525bb1 rdf:first sg:person.01112335735.57
    87 rdf:rest Ndd27ba2acb9b4f47a7f88ef67a096168
    88 N1d41e006ec3a4b679ac989cfcabf4bc3 rdf:first N0e1671dc66f349e7b453d97b97e8adac
    89 rdf:rest Nd3851a800402408dba3e462e1056b3f3
    90 N25f23bca57b548bea858016ce6d75488 schema:name University of Maryland, Institute for Genome Sciences, USA
    91 rdf:type schema:Organization
    92 N2db00612d2ab4d809dd80bf24efa4789 schema:volumeNumber 2
    93 rdf:type schema:PublicationVolume
    94 N3254cf4cb83a4b98967ad79707f7366b schema:name W3C, Cambridge, MA, USA
    95 rdf:type schema:Organization
    96 N465a49768e194d3fbb00d89f06e09d9e schema:affiliation https://www.grid.ac/institutes/grid.4991.5
    97 schema:familyName Zhao
    98 schema:givenName Jun
    99 rdf:type schema:Person
    100 N4fcefe51728c4f449a0c7b7219b37e41 rdf:first Nb6ce9091c9d84de4aa8e8ddb8507cce6
    101 rdf:rest Ne2a991787fb248068c8ecf082c84fa73
    102 N524f6f0ba9f4418182bcd20054f7f87f schema:affiliation https://www.grid.ac/institutes/grid.7177.6
    103 schema:familyName Marshall
    104 schema:givenName Scott M
    105 rdf:type schema:Person
    106 N5a7072d7f1124bbeb8243de3cf5c315d rdf:first Nfdda89eacd3e4ab2ab557619b2c02134
    107 rdf:rest N9f0edcaa380a48f3ae1a3de6755f32d0
    108 N5ce5ccef29bd4961be69277ec642b9cd rdf:first sg:person.0625034223.51
    109 rdf:rest N9257c6cc374e4735a486fce0fbff42cc
    110 N6831e6a87bf74a0c82449857006c1af5 rdf:first sg:person.01324655201.14
    111 rdf:rest rdf:nil
    112 N6bdcedf369bb4ee8b9da3ddf4835a759 rdf:first sg:person.01307535417.85
    113 rdf:rest N5a7072d7f1124bbeb8243de3cf5c315d
    114 N6e061eaa3a444372b3b392fb04694747 schema:name W3C, Cambridge, MA, USA
    115 rdf:type schema:Organization
    116 N7c3eceadbc834613bfb091369c5837ad rdf:first N98f41a3ff2dc4f39b3d608f2d27404df
    117 rdf:rest N1639a944037e4fd898e065719ff12fff
    118 N7d2debe6ebda49449cf2dd31f2de31c3 schema:name pubmed_id
    119 schema:value 21624155
    120 rdf:type schema:PropertyValue
    121 N8b99a5519920436ca57434c95b72336b rdf:first sg:person.010627036523.59
    122 rdf:rest Nc0c81b7364dd40cf9a25df741f1c262b
    123 N8ee822b5f1e544abae07448ae3340b0c rdf:first sg:person.01052034706.31
    124 rdf:rest Ncfbb18c68b7a4a25a67db8673ee9f5b2
    125 N9257c6cc374e4735a486fce0fbff42cc rdf:first sg:person.0750743522.13
    126 rdf:rest N7c3eceadbc834613bfb091369c5837ad
    127 N98f41a3ff2dc4f39b3d608f2d27404df schema:affiliation https://www.grid.ac/institutes/grid.467318.f
    128 schema:familyName Kashyap
    129 schema:givenName Vipul
    130 rdf:type schema:Person
    131 N9f0edcaa380a48f3ae1a3de6755f32d0 rdf:first Naa657b45857342f880612bb74fc67848
    132 rdf:rest Ne48ac58ea1c04087bae7d6548ecf1229
    133 Na91d318e69014ea484175bee0cc3e4f3 schema:affiliation https://www.grid.ac/institutes/grid.418151.8
    134 schema:familyName Andersson
    135 schema:givenName Bosse
    136 rdf:type schema:Person
    137 Naa14f0c824c64961942ebb6fa6834971 rdf:first sg:person.01314676145.12
    138 rdf:rest N6831e6a87bf74a0c82449857006c1af5
    139 Naa657b45857342f880612bb74fc67848 schema:affiliation https://www.grid.ac/institutes/grid.413558.e
    140 schema:familyName Domarew
    141 schema:givenName Christopher
    142 rdf:type schema:Person
    143 Nac5e659283934b59a5914a40ca9dd647 schema:name doi
    144 schema:value 10.1186/2041-1480-2-s2-s1
    145 rdf:type schema:PropertyValue
    146 Naed797fef1b24a3c81894fa69520dced rdf:first sg:person.01366305022.56
    147 rdf:rest N8ee822b5f1e544abae07448ae3340b0c
    148 Nb6ce9091c9d84de4aa8e8ddb8507cce6 schema:affiliation https://www.grid.ac/institutes/grid.418152.b
    149 schema:familyName Kozlovsky
    150 schema:givenName Julia
    151 rdf:type schema:Person
    152 Nc0c81b7364dd40cf9a25df741f1c262b rdf:first sg:person.01274677535.23
    153 rdf:rest N1d41e006ec3a4b679ac989cfcabf4bc3
    154 Nc8a2007e615a421bb1c6a5fa26a5d0ef schema:name W3C HCLSIG, W3C, Cambridge, MA, USA
    155 rdf:type schema:Organization
    156 Ncf6468178650498ca4616e305bce4379 schema:issueNumber Suppl 2
    157 rdf:type schema:PublicationIssue
    158 Ncfbb18c68b7a4a25a67db8673ee9f5b2 rdf:first sg:person.01227231333.61
    159 rdf:rest N07c54f7890be45f49a3b199ee0f49efe
    160 Nd0564e786e1d4c248071faed3fd4d66b schema:name nlm_unique_id
    161 schema:value 101531992
    162 rdf:type schema:PropertyValue
    163 Nd20c6d69a3dc4bc1a96de437e049de0e schema:name readcube_id
    164 schema:value 7c3c515ec890b026050a5b03424c339e737601c71a943085334fbeb4db524180
    165 rdf:type schema:PropertyValue
    166 Nd3851a800402408dba3e462e1056b3f3 rdf:first sg:person.01343012735.34
    167 rdf:rest Nd779846281ea463e9dc23e3a1cab44f4
    168 Nd45c3d081fd64c12b8889cf16a726f59 rdf:first sg:person.01033503431.82
    169 rdf:rest N6bdcedf369bb4ee8b9da3ddf4835a759
    170 Nd779846281ea463e9dc23e3a1cab44f4 rdf:first sg:person.0661660735.59
    171 rdf:rest Naed797fef1b24a3c81894fa69520dced
    172 Ndd27ba2acb9b4f47a7f88ef67a096168 rdf:first Na91d318e69014ea484175bee0cc3e4f3
    173 rdf:rest N0c3a46bad7294d42bb18c2809f702019
    174 Ndd6dc64e242e4427b74a29519c53df27 schema:name Springer Nature - SN SciGraph project
    175 rdf:type schema:Organization
    176 Nddad679574b7440f9965311c96c284af schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    177 schema:familyName Kos
    178 schema:givenName Peter
    179 rdf:type schema:Person
    180 Ne244ddffae12423aaa6e78ed91466068 schema:affiliation N6e061eaa3a444372b3b392fb04694747
    181 schema:familyName Gambet
    182 schema:givenName Thomas
    183 rdf:type schema:Person
    184 Ne28c051468334c939b0e42e533ab2107 rdf:first sg:person.01230424175.13
    185 rdf:rest Nf9ef7f1078764628829a783ba86ac89f
    186 Ne2a991787fb248068c8ecf082c84fa73 rdf:first sg:person.015756017417.99
    187 rdf:rest N055aab2317d84bf687fb9cfe64a0f616
    188 Ne48ac58ea1c04087bae7d6548ecf1229 rdf:first Ne244ddffae12423aaa6e78ed91466068
    189 rdf:rest N5ce5ccef29bd4961be69277ec642b9cd
    190 Necad0514ecaf4a0d853a3f2f908dd27a schema:name Predictive Medicine Inc., Belmont, MA, USA
    191 rdf:type schema:Organization
    192 Nf9ef7f1078764628829a783ba86ac89f rdf:first sg:person.0647077144.23
    193 rdf:rest N8b99a5519920436ca57434c95b72336b
    194 Nfdda89eacd3e4ab2ab557619b2c02134 schema:affiliation https://www.grid.ac/institutes/grid.417540.3
    195 schema:familyName Denney
    196 schema:givenName Christine K
    197 rdf:type schema:Person
    198 anzsrc-for:08 schema:inDefinedTermSet anzsrc-for:
    199 schema:name Information and Computing Sciences
    200 rdf:type schema:DefinedTerm
    201 anzsrc-for:0806 schema:inDefinedTermSet anzsrc-for:
    202 schema:name Information Systems
    203 rdf:type schema:DefinedTerm
    204 sg:grant.2545608 http://pending.schema.org/fundedItem sg:pub.10.1186/2041-1480-2-s2-s1
    205 rdf:type schema:MonetaryGrant
    206 sg:grant.2545661 http://pending.schema.org/fundedItem sg:pub.10.1186/2041-1480-2-s2-s1
    207 rdf:type schema:MonetaryGrant
    208 sg:journal.1043573 schema:issn 2041-1480
    209 schema:name Journal of Biomedical Semantics
    210 rdf:type schema:Periodical
    211 sg:person.01033503431.82 schema:affiliation https://www.grid.ac/institutes/grid.280285.5
    212 schema:familyName Bodenreider
    213 schema:givenName Olivier
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033503431.82
    215 rdf:type schema:Person
    216 sg:person.01052034706.31 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    217 schema:familyName Tonellato
    218 schema:givenName Peter J
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052034706.31
    220 rdf:type schema:Person
    221 sg:person.010627036523.59 schema:affiliation https://www.grid.ac/institutes/grid.67105.35
    222 schema:familyName Ogbuji
    223 schema:givenName Chimezie
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010627036523.59
    225 rdf:type schema:Person
    226 sg:person.01112335735.57 schema:affiliation https://www.grid.ac/institutes/grid.33647.35
    227 schema:familyName Luciano
    228 schema:givenName Joanne S
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112335735.57
    230 rdf:type schema:Person
    231 sg:person.01227231333.61 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
    232 schema:familyName Whetzel
    233 schema:givenName Patricia L
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227231333.61
    235 rdf:type schema:Person
    236 sg:person.01230424175.13 schema:affiliation https://www.grid.ac/institutes/grid.33647.35
    237 schema:familyName McCusker
    238 schema:givenName James P
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230424175.13
    240 rdf:type schema:Person
    241 sg:person.01274677535.23 schema:affiliation Nc8a2007e615a421bb1c6a5fa26a5d0ef
    242 schema:familyName Pichler
    243 schema:givenName Elgar
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274677535.23
    245 rdf:type schema:Person
    246 sg:person.01307535417.85 schema:affiliation https://www.grid.ac/institutes/grid.5379.8
    247 schema:familyName Clark
    248 schema:givenName Tim
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307535417.85
    250 rdf:type schema:Person
    251 sg:person.01314676145.12 schema:affiliation https://www.grid.ac/institutes/grid.497530.c
    252 schema:familyName Stephens
    253 schema:givenName Susie
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314676145.12
    255 rdf:type schema:Person
    256 sg:person.01324655201.14 schema:affiliation https://www.grid.ac/institutes/grid.34428.39
    257 schema:familyName Dumontier
    258 schema:givenName Michel
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324655201.14
    260 rdf:type schema:Person
    261 sg:person.01343012735.34 schema:affiliation N3254cf4cb83a4b98967ad79707f7366b
    262 schema:familyName Prud’hommeaux
    263 schema:givenName Eric
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343012735.34
    265 rdf:type schema:Person
    266 sg:person.01366305022.56 schema:affiliation N25f23bca57b548bea858016ce6d75488
    267 schema:familyName Schriml
    268 schema:givenName Lynn
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366305022.56
    270 rdf:type schema:Person
    271 sg:person.015756017417.99 schema:affiliation https://www.grid.ac/institutes/grid.33647.35
    272 schema:familyName Lebo
    273 schema:givenName Timothy
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015756017417.99
    275 rdf:type schema:Person
    276 sg:person.0625034223.51 schema:affiliation https://www.grid.ac/institutes/grid.418566.8
    277 schema:familyName Harland
    278 schema:givenName Lee
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625034223.51
    280 rdf:type schema:Person
    281 sg:person.0647077144.23 schema:affiliation https://www.grid.ac/institutes/grid.33647.35
    282 schema:familyName McGuinness
    283 schema:givenName Deborah L
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647077144.23
    285 rdf:type schema:Person
    286 sg:person.0661660735.59 schema:affiliation https://www.grid.ac/institutes/grid.6142.1
    287 schema:familyName Samwald
    288 schema:givenName Matthias
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661660735.59
    290 rdf:type schema:Person
    291 sg:person.0750743522.13 schema:affiliation https://www.grid.ac/institutes/grid.14095.39
    292 schema:familyName Jentzsch
    293 schema:givenName Anja
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750743522.13
    295 rdf:type schema:Person
    296 sg:person.0755540211.17 schema:affiliation https://www.grid.ac/institutes/grid.431456.1
    297 schema:familyName Batchelor
    298 schema:givenName Colin
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755540211.17
    300 rdf:type schema:Person
    301 sg:pub.10.1007/11915034_89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036522785
    302 https://doi.org/10.1007/11915034_89
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1007/978-0-387-48438-9_13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047833776
    305 https://doi.org/10.1007/978-0-387-48438-9_13
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1007/978-3-642-13818-8_32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036586839
    308 https://doi.org/10.1007/978-3-642-13818-8_32
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1007/978-3-642-17746-0_10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048046730
    311 https://doi.org/10.1007/978-3-642-17746-0_10
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1007/978-3-642-17746-0_20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026158851
    314 https://doi.org/10.1007/978-3-642-17746-0_20
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1038/nbt.1666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025620867
    317 https://doi.org/10.1038/nbt.1666
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/npre.2009.3868.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033880916
    320 https://doi.org/10.1038/npre.2009.3868.1
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/nrd2251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002728270
    323 https://doi.org/10.1038/nrd2251
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/nrd2593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000034028
    326 https://doi.org/10.1038/nrd2593
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1186/1471-2105-10-s2-s1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015890425
    329 https://doi.org/10.1186/1471-2105-10-s2-s1
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1186/1471-2105-10-s2-s2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048904958
    332 https://doi.org/10.1186/1471-2105-10-s2-s2
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1186/1471-2105-8-s3-s2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013842120
    335 https://doi.org/10.1186/1471-2105-8-s3-s2
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1186/1471-2105-8-s3-s3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023645192
    338 https://doi.org/10.1186/1471-2105-8-s3-s3
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1186/1471-2105-9-s6-s11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041272526
    341 https://doi.org/10.1186/1471-2105-9-s6-s11
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1186/gb-2005-6-5-r46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015285227
    344 https://doi.org/10.1186/gb-2005-6-5-r46
    345 rdf:type schema:CreativeWork
    346 https://app.dimensions.ai/details/publication/pub.1074991673 schema:CreativeWork
    347 https://app.dimensions.ai/details/publication/pub.1078353958 schema:CreativeWork
    348 https://doi.org/10.1001/jama.2007.26 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045501751
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1001/jama.2009.965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036417899
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1016/b978-155860933-4/50013-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024913994
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1016/j.future.2010.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008845212
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1016/j.jbi.2006.02.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014198679
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1016/j.jbi.2008.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030920077
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1016/j.websem.2004.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020225200
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1016/j.websem.2006.05.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013263864
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1016/s1359-6446(05)03501-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038113615
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1016/s1474-4422(07)70178-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032800719
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1056/nejmsb053723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001673580
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1093/bib/bbn056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004892751
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1093/brain/awq277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010781685
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1093/nar/gkp440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010962830
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1093/nar/gkq1126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010727021
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1098/rsta.2003.1224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003559877
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1109/hicss.2009.263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093457959
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1109/mis.2009.19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037905615
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1126/science.1110410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062452040
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1136/jamia.2009.000893 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019080707
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1145/1645953.1646084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039283481
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1177/1533317508328602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064038578
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1183/09031936.00033208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017432872
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1503/cmaj.070796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006686531
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.2217/pgs.10.15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023168257
    397 rdf:type schema:CreativeWork
    398 https://www.grid.ac/institutes/grid.14095.39 schema:alternateName Freie Universität Berlin
    399 schema:name Freie Universität, Berlin, Germany
    400 rdf:type schema:Organization
    401 https://www.grid.ac/institutes/grid.168010.e schema:alternateName Stanford University
    402 schema:name Stanford University, StanfordCA, USA
    403 rdf:type schema:Organization
    404 https://www.grid.ac/institutes/grid.280285.5 schema:alternateName United States National Library of Medicine
    405 schema:name National Library of Medicine, Bethesda, MD, USA
    406 rdf:type schema:Organization
    407 https://www.grid.ac/institutes/grid.33647.35 schema:alternateName Rensselaer Polytechnic Institute
    408 schema:name Predictive Medicine Inc., Belmont, MA, USA
    409 Rensselaer Polytechnic Institute, Troy, NY, USA
    410 rdf:type schema:Organization
    411 https://www.grid.ac/institutes/grid.34428.39 schema:alternateName Carleton University
    412 schema:name Carleton University, Ottawa, Canada
    413 rdf:type schema:Organization
    414 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
    415 schema:name Harvard Medical School, Boston, MA, USA
    416 rdf:type schema:Organization
    417 https://www.grid.ac/institutes/grid.413558.e schema:alternateName Albany Medical Center Hospital
    418 schema:name Albany Medical Center, NY, Albany, USA
    419 rdf:type schema:Organization
    420 https://www.grid.ac/institutes/grid.417540.3 schema:alternateName Eli Lilly (United States)
    421 schema:name Eli Lilly and Company, Indianapolis, IN, USA
    422 rdf:type schema:Organization
    423 https://www.grid.ac/institutes/grid.418151.8 schema:alternateName AstraZeneca (Sweden)
    424 schema:name AstraZeneca, Lund, Sweden
    425 rdf:type schema:Organization
    426 https://www.grid.ac/institutes/grid.418152.b schema:alternateName AstraZeneca (United States)
    427 schema:name AstraZeneca, Waltham, MA, USA
    428 rdf:type schema:Organization
    429 https://www.grid.ac/institutes/grid.418566.8 schema:alternateName Pfizer (United Kingdom)
    430 schema:name Pfizer, Sandwich, UK
    431 rdf:type schema:Organization
    432 https://www.grid.ac/institutes/grid.431456.1 schema:alternateName Royal Society of Chemistry
    433 schema:name Royal Society of Chemistry, Cambridge, UK
    434 rdf:type schema:Organization
    435 https://www.grid.ac/institutes/grid.467318.f schema:alternateName Cigna (United States)
    436 schema:name Cigna, Hartford, CT, USA
    437 rdf:type schema:Organization
    438 https://www.grid.ac/institutes/grid.497530.c schema:alternateName Janssen (United States)
    439 schema:name Johnson & Johnson Pharmaceutical Research & Development L.L.C., Radnor, PA, USA
    440 rdf:type schema:Organization
    441 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
    442 schema:name University of Oxford, Oxford, UK
    443 rdf:type schema:Organization
    444 https://www.grid.ac/institutes/grid.5379.8 schema:alternateName University of Manchester
    445 schema:name Harvard Medical School, Boston, MA, USA
    446 University of Manchester, Manchester, UK
    447 rdf:type schema:Organization
    448 https://www.grid.ac/institutes/grid.6142.1 schema:alternateName National University of Ireland, Galway
    449 schema:name Digital Enterprise Research Institute (DERI), National University of Ireland Galway, Ireland
    450 Information Retrieval Facility (IRF), Vienna, Austria
    451 Medical University of Vienna, Vienna, Austria
    452 rdf:type schema:Organization
    453 https://www.grid.ac/institutes/grid.67105.35 schema:alternateName Case Western Reserve University
    454 schema:name Case Western Reserve University School of Medicine, Cleveland, OH, USA
    455 rdf:type schema:Organization
    456 https://www.grid.ac/institutes/grid.7177.6 schema:alternateName University of Amsterdam
    457 schema:name Leiden University Medical Center, Leiden, NL
    458 University of Amsterdam, Amsterdam, NL
    459 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...