The Translational Medicine Ontology and Knowledge Base: driving personalized medicine by bridging the gap between bench and bedside View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Joanne S Luciano, Bosse Andersson, Colin Batchelor, Olivier Bodenreider, Tim Clark, Christine K Denney, Christopher Domarew, Thomas Gambet, Lee Harland, Anja Jentzsch, Vipul Kashyap, Peter Kos, Julia Kozlovsky, Timothy Lebo, Scott M Marshall, James P McCusker, Deborah L McGuinness, Chimezie Ogbuji, Elgar Pichler, Robert L Powers, Eric Prud’hommeaux, Matthias Samwald, Lynn Schriml, Peter J Tonellato, Patricia L Whetzel, Jun Zhao, Susie Stephens, Michel Dumontier

ABSTRACT

BACKGROUND: Translational medicine requires the integration of knowledge using heterogeneous data from health care to the life sciences. Here, we describe a collaborative effort to produce a prototype Translational Medicine Knowledge Base (TMKB) capable of answering questions relating to clinical practice and pharmaceutical drug discovery. RESULTS: We developed the Translational Medicine Ontology (TMO) as a unifying ontology to integrate chemical, genomic and proteomic data with disease, treatment, and electronic health records. We demonstrate the use of Semantic Web technologies in the integration of patient and biomedical data, and reveal how such a knowledge base can aid physicians in providing tailored patient care and facilitate the recruitment of patients into active clinical trials. Thus, patients, physicians and researchers may explore the knowledge base to better understand therapeutic options, efficacy, and mechanisms of action. CONCLUSIONS: This work takes an important step in using Semantic Web technologies to facilitate integration of relevant, distributed, external sources and progress towards a computational platform to support personalized medicine. AVAILABILITY: TMO can be downloaded from http://code.google.com/p/translationalmedicineontology and TMKB can be accessed at http://tm.semanticscience.org/sparql. More... »

PAGES

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References to SciGraph publications

  • 2008-10. Pharmacogenetics in drug discovery and development: a translational perspective in NATURE REVIEWS DRUG DISCOVERY
  • 2007-04. Stratified medicine: strategic and economic implications of combining drugs and clinical biomarkers in NATURE REVIEWS DRUG DISCOVERY
  • 2010-09. The BioPAX community standard for pathway data sharing in NATURE BIOTECHNOLOGY
  • 2007-05. e-Science and biological pathway semantics in BMC BIOINFORMATICS
  • 2007-05. Advancing translational research with the Semantic Web in BMC BIOINFORMATICS
  • 2010. Provenance Context Entity (PaCE): Scalable Provenance Tracking for Scientific RDF Data in SCIENTIFIC AND STATISTICAL DATABASE MANAGEMENT
  • 2010. SameAs Networks and Beyond: Analyzing Deployment Status and Implications of owl:sameAs in Linked Data in THE SEMANTIC WEB – ISWC 2010
  • 2008-12. Drug interaction prediction using ontology-driven hypothetical assertion framework for pathway generation followed by numerical simulation in BMC BIOINFORMATICS
  • 2010. When owl:sameAs Isn’t the Same: An Analysis of Identity in Linked Data in THE SEMANTIC WEB – ISWC 2010
  • 2009-02. Ontology driven integration platform for clinical and translational research in BMC BIOINFORMATICS
  • 2005-05. Relations in biomedical ontologies in GENOME BIOLOGY
  • 2009-02. Ontology-driven indexing of public datasets for translational bioinformatics in BMC BIOINFORMATICS
  • 2009-10-16. BioPortal: Ontologies and Integrated Data Resources at the Click of a Mouse in NATURE PRECEDINGS
  • 2006. Suggested Ontology for Pharmacogenomics (SO-Pharm): Modular Construction and Preliminary Testing in ON THE MOVE TO MEANINGFUL INTERNET SYSTEMS 2006: OTM 2006 WORKSHOPS
  • 2007. Can Semantic Web Technologies Enable Translational Medicine? in SEMANTIC WEB
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/2041-1480-2-s2-s1

    DOI

    http://dx.doi.org/10.1186/2041-1480-2-s2-s1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026078352

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21624155


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