Efficacy of ‘Itrifal Saghir’, a combination of three medicinal plants in the treatment of obesity; A randomized controlled trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Seyed Hamid Kamali, Ali Reza Khalaj, Shirin Hasani-Ranjbar, Mohammad Mehdi Esfehani, Mohammad Kamalinejad, Omidmalayeri Soheil, Seyed Ali Kamali

ABSTRACT

BACKGROUND: Herbal combination of Itrifal Saghir (triphala) has been widely used in traditional medicine. And brings health benefits such as antioxidant effect and scavenger of hydroxyl radicals and nitric oxide radicals activity and substantiated in traditional medicine a anti-obesity. MATERIAL AND METHOD: In this study we aimed to assess the efficacy of this herbal medicinal on reduction of weight and body mass index (BMI) of simple obese subjects in comparison with placebo. Obese subjects aged between 16 and 60 years were selected for 12-week, double-blind, randomized, placebo-controlled trial using a parallel design. Subjects were randomly assigned to take 5 grams of either the Itrifal Saghir (n = 31) or placebo (n = 31), 2 times daily for 12 weeks. Measures of body weight, BMI, waist circumference (WC), hip circumference (HC), were assessed at baseline and once every four weeks during the 12 week treatment period. The safety was evaluated by means of measuring the liver and kidney function. Homeostasis model of insulin resistance (HOMA-IR) was calculated as [fasting insulin (μU/mL) × fasting glucose (mmol/L)/22.5]. RESULTS: Compared to placebo group, in treatment group the mean difference of effective weight loss was 4.82Kg (CI95% 3.52 - 6.11, ρ < 0.001), the mean of decrease in waist circumference was 4.01 cm (CI 95% 2.13 - 5.90, ρ < 0.001), and the mean decrease in hip circumference was 3. 21 cm (CI 95% 1.96 - 4.45, ρ < 0.001) in treated subjects. No adverse effects or significant changes in liver and kidney function tests were observed in both placebo and treated groups. CONCLUSIONS: Itrifal Saghir appears to produce a positive effect on weight loss in obese subjects. More... »

PAGES

33

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/2008-2231-20-33

DOI

http://dx.doi.org/10.1186/2008-2231-20-33

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040267269

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23351558


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