Two large-scale analyses of Ty1 LTR-retrotransposon de novo insertion events indicate that Ty1 targets nucleosomal DNA near the H2A/H2B interface View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Antoine Bridier-Nahmias, Pascale Lesage

ABSTRACT

BACKGROUND: Over the years, a number of reports have revealed that Ty1 integration occurs in a 1-kb window upstream of Pol III-transcribed genes with an approximate 80-bp periodicity between each integration hotspot and that this targeting requires active Pol III transcription at the site of integration. However, the molecular bases of Ty1 targeting are still not understood. FINDINGS: The publications by Baller et al. and Mularoni et al. in the April issue of Genome Res. report the first high-throughput sequencing analysis of Ty1 de novo insertion events. Their observations converge to the same conclusion, that Ty1 targets a specific surface of the nucleosome at he H2A/H2B interface. CONCLUSION: This discovery is important, and should help identifying factor(s) involved in Ty1 targeting. Recent data on transposable elements and retroviruses integration site choice obtained by large-scale analyses indicate that transcription and chromatin structure play an important role in this process. The studies reported in this commentary add a new evidence of the importance of chromatin in integration selectivity that should be of interest for everyone interested in transposable elements integration. More... »

PAGES

22

Journal

TITLE

Mobile DNA

ISSUE

1

VOLUME

3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1759-8753-3-22

DOI

http://dx.doi.org/10.1186/1759-8753-3-22

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019433856

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23244340


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