Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-12-15

AUTHORS

Sébastien Van de Velde, Stéphane Carryn, Françoise Van Bambeke, Colin Hill, Paul M Tulkens, Roy D Sleator

ABSTRACT

While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria monocytogenes. Herein we reveal that both PBP4 and Lmo0441 (a PBP-like protein) play a direct role in cephalosporin activity in L. monocytogenes while PBP4 additionally has a protective affect against both penicillin and carbapenem. More... »

PAGES

23-23

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1757-4749-1-23

DOI

http://dx.doi.org/10.1186/1757-4749-1-23

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032703811

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20003484


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