The expression and significance of IDH1 and p53 in osteosarcoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Xiang Hu, Ai-Xi Yu, Bai-Wen Qi, Tao Fu, Gang Wu, Min Zhou, Jun Luo, Jun-Hua Xu

ABSTRACT

BACKGROUND: To detect the expression of isocitrate dehydrogenase 1 (IDH1) and transformation-related protein 53 (p53) in osteosarcoma and analyze the correlation between them and the clinico-pathological features. METHODS: The expressions of IDH1 and p53 were detected in human osteosarcoma cell lines (MG-63 and U2OS) by immunocytochemistry, Real-time PCR and Western Blotting. The expressions of IDH1 and p53 in formalin-fixed paraffin-embedded tissue sections from 44 osteosarcoma patients were determined by immunohistochemistry, and the correlation between them and clinicopagthological features were analyzed. None of these patients received chemotherapy prior to surgery. RESULTS: IDH1 is detected in osteosarcoma cell lines and biopsies. IDH1 expresses higher in U2OS cells with wild type p53 than in MG-63 cells with mutation p53. IDH1 correlates with histological Rosen grade and metastasis negatively. P53 correlates with histological Rosen grade, metastasis and overall survival in clinical osteosarcoma biopsies. Osteosarcoma patients with High IDH1 expression have a very high p53 expression. CONCLUSION: IDH1 may correlate with p53 and be a candidate biomarker for osteosarcoma correlate with histological Rosen grade and metastasis. More... »

PAGES

43

References to SciGraph publications

  • 2009-12. Genome wide analysis and clinical correlation of chromosomal and transcriptional mutations in cancers of the biliary tract in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • 2010-12. Utility of immunohistochemical markers in differentiating benign from malignant follicular-derived thyroid nodules in DIAGNOSTIC PATHOLOGY
  • 2009-08. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity in NATURE
  • 1993-12. p53 expression and its relationship to DNA alterations in bone and soft tissue sarcomas in BRITISH JOURNAL OF CANCER
  • 2006-08. Adenovirus-mediated p53 tumor suppressor gene therapy of osteosarcoma in LABORATORY INVESTIGATION
  • 2009-08. Down-regulation of ribosomal protein L7A in human osteosarcoma in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2007-04. p53 in health and disease in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1996-01. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours in NATURE
  • 1993-03. Analysis of mutant P53 protein in osteosarcomas and other malignant and benign lesions of bone in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2010-12. Coronin-1C is a novel biomarker for hepatocellular carcinoma invasive progression identified by proteomics analysis and clinical validation in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • 1992-02. Inactivation of p53 gene in human and murine osteosarcoma cells in BRITISH JOURNAL OF CANCER
  • 2008-12. Immunohistochemical expression of promyelocytic leukemia body in soft tissue sarcomas in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1756-9966-29-43

    DOI

    http://dx.doi.org/10.1186/1756-9966-29-43

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044966861

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20459648


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biopsy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Transformation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Isocitrate Dehydrogenase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Osteosarcoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Suppressor Protein p53", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Zhongnan Hospital of Wuhan University", 
              "id": "https://www.grid.ac/institutes/grid.413247.7", 
              "name": [
                "Department of Orthopedics, Zhongnan Hospital of Wuhan University, No 169 Donghu Road, Wuchang District, 430071, Wuhan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hu", 
            "givenName": "Xiang", 
            "id": "sg:person.01203041521.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203041521.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Zhongnan Hospital of Wuhan University", 
              "id": "https://www.grid.ac/institutes/grid.413247.7", 
              "name": [
                "Department of Orthopedics, Zhongnan Hospital of Wuhan University, No 169 Donghu Road, Wuchang District, 430071, Wuhan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yu", 
            "givenName": "Ai-Xi", 
            "id": "sg:person.0701002212.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701002212.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Zhongnan Hospital of Wuhan University", 
              "id": "https://www.grid.ac/institutes/grid.413247.7", 
              "name": [
                "Department of Orthopedics, Zhongnan Hospital of Wuhan University, No 169 Donghu Road, Wuchang District, 430071, Wuhan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Qi", 
            "givenName": "Bai-Wen", 
            "id": "sg:person.01102066031.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102066031.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Zhongnan Hospital of Wuhan University", 
              "id": "https://www.grid.ac/institutes/grid.413247.7", 
              "name": [
                "Department of Orthopedics, Zhongnan Hospital of Wuhan University, No 169 Donghu Road, Wuchang District, 430071, Wuhan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fu", 
            "givenName": "Tao", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Zhongnan Hospital of Wuhan University", 
              "id": "https://www.grid.ac/institutes/grid.413247.7", 
              "name": [
                "Department of Orthopedics, Zhongnan Hospital of Wuhan University, No 169 Donghu Road, Wuchang District, 430071, Wuhan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wu", 
            "givenName": "Gang", 
            "id": "sg:person.01251727736.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251727736.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Zhongnan Hospital of Wuhan University", 
              "id": "https://www.grid.ac/institutes/grid.413247.7", 
              "name": [
                "Department of Orthopedics, Zhongnan Hospital of Wuhan University, No 169 Donghu Road, Wuchang District, 430071, Wuhan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhou", 
            "givenName": "Min", 
            "id": "sg:person.01306766351.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306766351.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Zhongnan Hospital of Wuhan University", 
              "id": "https://www.grid.ac/institutes/grid.413247.7", 
              "name": [
                "Department of pathology, Zhongnan Hospital of Wuhan University, Wuhan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Luo", 
            "givenName": "Jun", 
            "id": "sg:person.0732371566.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732371566.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Zhongnan Hospital of Wuhan University", 
              "id": "https://www.grid.ac/institutes/grid.413247.7", 
              "name": [
                "Department of Orthopedics, Zhongnan Hospital of Wuhan University, No 169 Donghu Road, Wuchang District, 430071, Wuhan, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xu", 
            "givenName": "Jun-Hua", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1128/mcb.01927-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001376052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1756-9966-28-62", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001482353", 
              "https://doi.org/10.1186/1756-9966-28-62"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2147", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002243416", 
              "https://doi.org/10.1038/nrm2147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-4345", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002507020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0005-2744(76)90180-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002871581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0005-2744(76)90180-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002871581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.8.4240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006420032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/379088a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007643465", 
              "https://doi.org/10.1038/379088a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1081/cnv-100102557", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007913345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1756-9966-29-17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008670716", 
              "https://doi.org/10.1186/1756-9966-29-17"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.3700444", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008748221", 
              "https://doi.org/10.1038/labinvest.3700444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.3700444", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008748221", 
              "https://doi.org/10.1038/labinvest.3700444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.3700444", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008748221", 
              "https://doi.org/10.1038/labinvest.3700444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009337647", 
              "https://doi.org/10.1038/nature08287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009337647", 
              "https://doi.org/10.1038/nature08287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0009578", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010599488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cdp.2005.01.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010610875"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01229533", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011317438", 
              "https://doi.org/10.1007/bf01229533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01229533", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011317438", 
              "https://doi.org/10.1007/bf01229533"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199310283291807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011878128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1993.493", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013588887", 
              "https://doi.org/10.1038/bjc.1993.493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1993.493", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013588887", 
              "https://doi.org/10.1038/bjc.1993.493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(197601)37:1<1::aid-cncr2820370102>3.0.co;2-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015441198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0903840", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019484764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.2910020505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020554703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1756-9966-27-73", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021231029", 
              "https://doi.org/10.1186/1756-9966-27-73"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1339905", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022277460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/20.9.1819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024177817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1170944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025009423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1308805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025289271"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0142(19970415)79:8<1541::aid-cncr15>3.0.co;2-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027415836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.87.15.5863", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030364399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80674-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030672427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.23782", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032361935"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/eje.0.1430217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032524332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/eje.0.1430217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032524332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1530/eje.0.1430217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032524332"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1746-1596-5-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034053774", 
              "https://doi.org/10.1186/1746-1596-5-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0808710", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035319148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000225298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036771177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1194/jlr.m300285-jlr200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038621311"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.84.21.7716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040664625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jor.21088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042526125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jor.21088", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042526125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1992.43", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042687062", 
              "https://doi.org/10.1038/bjc.1992.43"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1992.43", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042687062", 
              "https://doi.org/10.1038/bjc.1992.43"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-008-0538-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046292038", 
              "https://doi.org/10.1007/s00432-008-0538-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-008-0538-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046292038", 
              "https://doi.org/10.1007/s00432-008-0538-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.24259", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046549085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/oxfordjournals.molbev.a025894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048024534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1164382", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048029720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1934852100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049002636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(19950915)76:6<972::aid-cncr2820760610>3.0.co;2-t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050144159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(197906)43:6<2163::aid-cncr2820430602>3.0.co;2-s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052766441"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2448875", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062538000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2649981", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062548429"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7903477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062650586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2003.08.132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064203806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079499974", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082692511", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083375840", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2010-12", 
        "datePublishedReg": "2010-12-01", 
        "description": "BACKGROUND: To detect the expression of isocitrate dehydrogenase 1 (IDH1) and transformation-related protein 53 (p53) in osteosarcoma and analyze the correlation between them and the clinico-pathological features.\nMETHODS: The expressions of IDH1 and p53 were detected in human osteosarcoma cell lines (MG-63 and U2OS) by immunocytochemistry, Real-time PCR and Western Blotting. The expressions of IDH1 and p53 in formalin-fixed paraffin-embedded tissue sections from 44 osteosarcoma patients were determined by immunohistochemistry, and the correlation between them and clinicopagthological features were analyzed. None of these patients received chemotherapy prior to surgery.\nRESULTS: IDH1 is detected in osteosarcoma cell lines and biopsies. IDH1 expresses higher in U2OS cells with wild type p53 than in MG-63 cells with mutation p53. IDH1 correlates with histological Rosen grade and metastasis negatively. P53 correlates with histological Rosen grade, metastasis and overall survival in clinical osteosarcoma biopsies. Osteosarcoma patients with High IDH1 expression have a very high p53 expression.\nCONCLUSION: IDH1 may correlate with p53 and be a candidate biomarker for osteosarcoma correlate with histological Rosen grade and metastasis.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/1756-9966-29-43", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1094159", 
            "issn": [
              "0392-9078", 
              "1756-9966"
            ], 
            "name": "Journal of Experimental & Clinical Cancer Research", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "29"
          }
        ], 
        "name": "The expression and significance of IDH1 and p53 in osteosarcoma", 
        "pagination": "43", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "d63122bead9389a8c51301e093b4cd54d7fbb45c30cba9285178933339051087"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "20459648"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8308647"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/1756-9966-29-43"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1044966861"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/1756-9966-29-43", 
          "https://app.dimensions.ai/details/publication/pub.1044966861"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T21:37", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000515.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2F1756-9966-29-43"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1756-9966-29-43'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1756-9966-29-43'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1756-9966-29-43'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1756-9966-29-43'


     

    This table displays all metadata directly associated to this object as RDF triples.

    336 TRIPLES      21 PREDICATES      94 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/1756-9966-29-43 schema:about N19542e9026694779b7c9b13eba968ae9
    2 N19c9368646df4a7da78fea126cd78761
    3 N2ae0453a005a4347b60b2d080801cae3
    4 N323699887b15405ab121f5aa598775ea
    5 N59b3f20f58c24dca984cb4cca5720452
    6 N5f7ca3b0428543f1a73aa48eb96820e8
    7 N6ddda7eb3dcc41cd93b4b5c179e84ca5
    8 N6edbd4dce663422d83f2569579e8b6cf
    9 N80ce7fe8ce33437d90f3233b59dee4c2
    10 N8b66bfbce5de4a86950c636d0c1e7d11
    11 N9c42334f5f5044fc9546b9d3dc52cc77
    12 Nb76281e194af42969e1d519e6ccf722b
    13 Ne92d2edfcbf8454c800c6788e3880594
    14 Nead187a626d149048255c497639f12c4
    15 Nf4c1d6eb94204019b95499a0f02d204d
    16 anzsrc-for:11
    17 anzsrc-for:1112
    18 schema:author N83d09fbcb8314ddaadc6a2aa5dcbcc1a
    19 schema:citation sg:pub.10.1007/bf01229533
    20 sg:pub.10.1007/s00432-008-0538-4
    21 sg:pub.10.1038/379088a0
    22 sg:pub.10.1038/bjc.1992.43
    23 sg:pub.10.1038/bjc.1993.493
    24 sg:pub.10.1038/labinvest.3700444
    25 sg:pub.10.1038/nature08287
    26 sg:pub.10.1038/nrm2147
    27 sg:pub.10.1186/1746-1596-5-9
    28 sg:pub.10.1186/1756-9966-27-73
    29 sg:pub.10.1186/1756-9966-28-62
    30 sg:pub.10.1186/1756-9966-29-17
    31 https://app.dimensions.ai/details/publication/pub.1079499974
    32 https://app.dimensions.ai/details/publication/pub.1082692511
    33 https://app.dimensions.ai/details/publication/pub.1083375840
    34 https://doi.org/10.1002/(sici)1097-0142(19970415)79:8<1541::aid-cncr15>3.0.co;2-y
    35 https://doi.org/10.1002/1097-0142(197601)37:1<1::aid-cncr2820370102>3.0.co;2-3
    36 https://doi.org/10.1002/1097-0142(197906)43:6<2163::aid-cncr2820430602>3.0.co;2-s
    37 https://doi.org/10.1002/1097-0142(19950915)76:6<972::aid-cncr2820760610>3.0.co;2-t
    38 https://doi.org/10.1002/cncr.23782
    39 https://doi.org/10.1002/ijc.24259
    40 https://doi.org/10.1002/ijc.2910020505
    41 https://doi.org/10.1002/jor.21088
    42 https://doi.org/10.1016/0005-2744(76)90180-7
    43 https://doi.org/10.1016/j.cdp.2005.01.002
    44 https://doi.org/10.1016/s0092-8674(00)80674-1
    45 https://doi.org/10.1056/nejm199310283291807
    46 https://doi.org/10.1056/nejmoa0808710
    47 https://doi.org/10.1056/nejmoa0903840
    48 https://doi.org/10.1073/pnas.1934852100
    49 https://doi.org/10.1073/pnas.84.21.7716
    50 https://doi.org/10.1073/pnas.87.15.5863
    51 https://doi.org/10.1073/pnas.96.8.4240
    52 https://doi.org/10.1081/cnv-100102557
    53 https://doi.org/10.1093/carcin/20.9.1819
    54 https://doi.org/10.1093/oxfordjournals.molbev.a025894
    55 https://doi.org/10.1101/gad.1308805
    56 https://doi.org/10.1101/gad.1339905
    57 https://doi.org/10.1126/science.1164382
    58 https://doi.org/10.1126/science.1170944
    59 https://doi.org/10.1126/science.2448875
    60 https://doi.org/10.1126/science.2649981
    61 https://doi.org/10.1126/science.7903477
    62 https://doi.org/10.1128/mcb.01927-06
    63 https://doi.org/10.1158/0008-5472.can-06-4345
    64 https://doi.org/10.1159/000225298
    65 https://doi.org/10.1194/jlr.m300285-jlr200
    66 https://doi.org/10.1200/jco.2003.08.132
    67 https://doi.org/10.1371/journal.pone.0009578
    68 https://doi.org/10.1530/eje.0.1430217
    69 schema:datePublished 2010-12
    70 schema:datePublishedReg 2010-12-01
    71 schema:description BACKGROUND: To detect the expression of isocitrate dehydrogenase 1 (IDH1) and transformation-related protein 53 (p53) in osteosarcoma and analyze the correlation between them and the clinico-pathological features. METHODS: The expressions of IDH1 and p53 were detected in human osteosarcoma cell lines (MG-63 and U2OS) by immunocytochemistry, Real-time PCR and Western Blotting. The expressions of IDH1 and p53 in formalin-fixed paraffin-embedded tissue sections from 44 osteosarcoma patients were determined by immunohistochemistry, and the correlation between them and clinicopagthological features were analyzed. None of these patients received chemotherapy prior to surgery. RESULTS: IDH1 is detected in osteosarcoma cell lines and biopsies. IDH1 expresses higher in U2OS cells with wild type p53 than in MG-63 cells with mutation p53. IDH1 correlates with histological Rosen grade and metastasis negatively. P53 correlates with histological Rosen grade, metastasis and overall survival in clinical osteosarcoma biopsies. Osteosarcoma patients with High IDH1 expression have a very high p53 expression. CONCLUSION: IDH1 may correlate with p53 and be a candidate biomarker for osteosarcoma correlate with histological Rosen grade and metastasis.
    72 schema:genre research_article
    73 schema:inLanguage en
    74 schema:isAccessibleForFree true
    75 schema:isPartOf N991e3d5034754179b12d206b7d105737
    76 Nfdb4b005adad487cad619f1d6786f6f2
    77 sg:journal.1094159
    78 schema:name The expression and significance of IDH1 and p53 in osteosarcoma
    79 schema:pagination 43
    80 schema:productId N04145c24377e4891b1ac3a514a53937e
    81 N0f4d19f4852d457d91eb3e7da7a1c0ee
    82 N1b19fbcac48c4810bbb0b2966e2e7559
    83 N6123d8f70e2c4139b382304947ee9e8c
    84 Nbe17e6e8d6a64559b46862eb97a46863
    85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044966861
    86 https://doi.org/10.1186/1756-9966-29-43
    87 schema:sdDatePublished 2019-04-10T21:37
    88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    89 schema:sdPublisher N3ae1262a936b42afba70c1b794cb2c55
    90 schema:url http://link.springer.com/10.1186%2F1756-9966-29-43
    91 sgo:license sg:explorer/license/
    92 sgo:sdDataset articles
    93 rdf:type schema:ScholarlyArticle
    94 N02ee9da0c8974450bb87ce3bdecf2461 rdf:first sg:person.0732371566.05
    95 rdf:rest N2bed30cc30c24a36ad6112e7bc57a8cf
    96 N04145c24377e4891b1ac3a514a53937e schema:name nlm_unique_id
    97 schema:value 8308647
    98 rdf:type schema:PropertyValue
    99 N0f4d19f4852d457d91eb3e7da7a1c0ee schema:name dimensions_id
    100 schema:value pub.1044966861
    101 rdf:type schema:PropertyValue
    102 N19542e9026694779b7c9b13eba968ae9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Adolescent
    104 rdf:type schema:DefinedTerm
    105 N19c9368646df4a7da78fea126cd78761 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Humans
    107 rdf:type schema:DefinedTerm
    108 N1b19fbcac48c4810bbb0b2966e2e7559 schema:name readcube_id
    109 schema:value d63122bead9389a8c51301e093b4cd54d7fbb45c30cba9285178933339051087
    110 rdf:type schema:PropertyValue
    111 N2ae0453a005a4347b60b2d080801cae3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Adult
    113 rdf:type schema:DefinedTerm
    114 N2bed30cc30c24a36ad6112e7bc57a8cf rdf:first Naa446e817eae413ca8a8e068511c30d1
    115 rdf:rest rdf:nil
    116 N323699887b15405ab121f5aa598775ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Osteosarcoma
    118 rdf:type schema:DefinedTerm
    119 N37624bed917345409762514239b1e633 rdf:first N76a7bcdafbff4bb79912a637a8198b87
    120 rdf:rest N6463b4a6d29d40f4a305e99a54c3d58c
    121 N3ae1262a936b42afba70c1b794cb2c55 schema:name Springer Nature - SN SciGraph project
    122 rdf:type schema:Organization
    123 N59b3f20f58c24dca984cb4cca5720452 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Middle Aged
    125 rdf:type schema:DefinedTerm
    126 N5a024a3eb73344b69a916284995e790a rdf:first sg:person.01306766351.83
    127 rdf:rest N02ee9da0c8974450bb87ce3bdecf2461
    128 N5f7ca3b0428543f1a73aa48eb96820e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Female
    130 rdf:type schema:DefinedTerm
    131 N6123d8f70e2c4139b382304947ee9e8c schema:name doi
    132 schema:value 10.1186/1756-9966-29-43
    133 rdf:type schema:PropertyValue
    134 N6463b4a6d29d40f4a305e99a54c3d58c rdf:first sg:person.01251727736.50
    135 rdf:rest N5a024a3eb73344b69a916284995e790a
    136 N6ddda7eb3dcc41cd93b4b5c179e84ca5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Male
    138 rdf:type schema:DefinedTerm
    139 N6e304855cd7d4a1f9da1800508116e74 rdf:first sg:person.0701002212.89
    140 rdf:rest N8dc985746f874c1ea654591117550b84
    141 N6edbd4dce663422d83f2569579e8b6cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Bone Neoplasms
    143 rdf:type schema:DefinedTerm
    144 N76a7bcdafbff4bb79912a637a8198b87 schema:affiliation https://www.grid.ac/institutes/grid.413247.7
    145 schema:familyName Fu
    146 schema:givenName Tao
    147 rdf:type schema:Person
    148 N80ce7fe8ce33437d90f3233b59dee4c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Isocitrate Dehydrogenase
    150 rdf:type schema:DefinedTerm
    151 N83d09fbcb8314ddaadc6a2aa5dcbcc1a rdf:first sg:person.01203041521.84
    152 rdf:rest N6e304855cd7d4a1f9da1800508116e74
    153 N8b66bfbce5de4a86950c636d0c1e7d11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Tumor Suppressor Protein p53
    155 rdf:type schema:DefinedTerm
    156 N8dc985746f874c1ea654591117550b84 rdf:first sg:person.01102066031.18
    157 rdf:rest N37624bed917345409762514239b1e633
    158 N991e3d5034754179b12d206b7d105737 schema:issueNumber 1
    159 rdf:type schema:PublicationIssue
    160 N9c42334f5f5044fc9546b9d3dc52cc77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Biopsy
    162 rdf:type schema:DefinedTerm
    163 Naa446e817eae413ca8a8e068511c30d1 schema:affiliation https://www.grid.ac/institutes/grid.413247.7
    164 schema:familyName Xu
    165 schema:givenName Jun-Hua
    166 rdf:type schema:Person
    167 Nb76281e194af42969e1d519e6ccf722b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Cell Transformation, Neoplastic
    169 rdf:type schema:DefinedTerm
    170 Nbe17e6e8d6a64559b46862eb97a46863 schema:name pubmed_id
    171 schema:value 20459648
    172 rdf:type schema:PropertyValue
    173 Ne92d2edfcbf8454c800c6788e3880594 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Gene Expression Regulation, Neoplastic
    175 rdf:type schema:DefinedTerm
    176 Nead187a626d149048255c497639f12c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Neoplasm Metastasis
    178 rdf:type schema:DefinedTerm
    179 Nf4c1d6eb94204019b95499a0f02d204d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Child
    181 rdf:type schema:DefinedTerm
    182 Nfdb4b005adad487cad619f1d6786f6f2 schema:volumeNumber 29
    183 rdf:type schema:PublicationVolume
    184 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    185 schema:name Medical and Health Sciences
    186 rdf:type schema:DefinedTerm
    187 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    188 schema:name Oncology and Carcinogenesis
    189 rdf:type schema:DefinedTerm
    190 sg:journal.1094159 schema:issn 0392-9078
    191 1756-9966
    192 schema:name Journal of Experimental & Clinical Cancer Research
    193 rdf:type schema:Periodical
    194 sg:person.01102066031.18 schema:affiliation https://www.grid.ac/institutes/grid.413247.7
    195 schema:familyName Qi
    196 schema:givenName Bai-Wen
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102066031.18
    198 rdf:type schema:Person
    199 sg:person.01203041521.84 schema:affiliation https://www.grid.ac/institutes/grid.413247.7
    200 schema:familyName Hu
    201 schema:givenName Xiang
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203041521.84
    203 rdf:type schema:Person
    204 sg:person.01251727736.50 schema:affiliation https://www.grid.ac/institutes/grid.413247.7
    205 schema:familyName Wu
    206 schema:givenName Gang
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251727736.50
    208 rdf:type schema:Person
    209 sg:person.01306766351.83 schema:affiliation https://www.grid.ac/institutes/grid.413247.7
    210 schema:familyName Zhou
    211 schema:givenName Min
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306766351.83
    213 rdf:type schema:Person
    214 sg:person.0701002212.89 schema:affiliation https://www.grid.ac/institutes/grid.413247.7
    215 schema:familyName Yu
    216 schema:givenName Ai-Xi
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701002212.89
    218 rdf:type schema:Person
    219 sg:person.0732371566.05 schema:affiliation https://www.grid.ac/institutes/grid.413247.7
    220 schema:familyName Luo
    221 schema:givenName Jun
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732371566.05
    223 rdf:type schema:Person
    224 sg:pub.10.1007/bf01229533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011317438
    225 https://doi.org/10.1007/bf01229533
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1007/s00432-008-0538-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046292038
    228 https://doi.org/10.1007/s00432-008-0538-4
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/379088a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007643465
    231 https://doi.org/10.1038/379088a0
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1038/bjc.1992.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042687062
    234 https://doi.org/10.1038/bjc.1992.43
    235 rdf:type schema:CreativeWork
    236 sg:pub.10.1038/bjc.1993.493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013588887
    237 https://doi.org/10.1038/bjc.1993.493
    238 rdf:type schema:CreativeWork
    239 sg:pub.10.1038/labinvest.3700444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008748221
    240 https://doi.org/10.1038/labinvest.3700444
    241 rdf:type schema:CreativeWork
    242 sg:pub.10.1038/nature08287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009337647
    243 https://doi.org/10.1038/nature08287
    244 rdf:type schema:CreativeWork
    245 sg:pub.10.1038/nrm2147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002243416
    246 https://doi.org/10.1038/nrm2147
    247 rdf:type schema:CreativeWork
    248 sg:pub.10.1186/1746-1596-5-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034053774
    249 https://doi.org/10.1186/1746-1596-5-9
    250 rdf:type schema:CreativeWork
    251 sg:pub.10.1186/1756-9966-27-73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021231029
    252 https://doi.org/10.1186/1756-9966-27-73
    253 rdf:type schema:CreativeWork
    254 sg:pub.10.1186/1756-9966-28-62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001482353
    255 https://doi.org/10.1186/1756-9966-28-62
    256 rdf:type schema:CreativeWork
    257 sg:pub.10.1186/1756-9966-29-17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008670716
    258 https://doi.org/10.1186/1756-9966-29-17
    259 rdf:type schema:CreativeWork
    260 https://app.dimensions.ai/details/publication/pub.1079499974 schema:CreativeWork
    261 https://app.dimensions.ai/details/publication/pub.1082692511 schema:CreativeWork
    262 https://app.dimensions.ai/details/publication/pub.1083375840 schema:CreativeWork
    263 https://doi.org/10.1002/(sici)1097-0142(19970415)79:8<1541::aid-cncr15>3.0.co;2-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1027415836
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1002/1097-0142(197601)37:1<1::aid-cncr2820370102>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015441198
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1002/1097-0142(197906)43:6<2163::aid-cncr2820430602>3.0.co;2-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1052766441
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1002/1097-0142(19950915)76:6<972::aid-cncr2820760610>3.0.co;2-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1050144159
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1002/cncr.23782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032361935
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1002/ijc.24259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046549085
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1002/ijc.2910020505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020554703
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1002/jor.21088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042526125
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/0005-2744(76)90180-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002871581
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.cdp.2005.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010610875
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/s0092-8674(00)80674-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030672427
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1056/nejm199310283291807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011878128
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1056/nejmoa0808710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035319148
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1056/nejmoa0903840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019484764
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1073/pnas.1934852100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049002636
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1073/pnas.84.21.7716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040664625
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1073/pnas.87.15.5863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030364399
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1073/pnas.96.8.4240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006420032
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1081/cnv-100102557 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007913345
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1093/carcin/20.9.1819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024177817
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1093/oxfordjournals.molbev.a025894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048024534
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1101/gad.1308805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025289271
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1101/gad.1339905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022277460
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1126/science.1164382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048029720
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1126/science.1170944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025009423
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1126/science.2448875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062538000
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1126/science.2649981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062548429
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1126/science.7903477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062650586
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1128/mcb.01927-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001376052
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1158/0008-5472.can-06-4345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002507020
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1159/000225298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036771177
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1194/jlr.m300285-jlr200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038621311
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1200/jco.2003.08.132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203806
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1371/journal.pone.0009578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010599488
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1530/eje.0.1430217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032524332
    332 rdf:type schema:CreativeWork
    333 https://www.grid.ac/institutes/grid.413247.7 schema:alternateName Zhongnan Hospital of Wuhan University
    334 schema:name Department of Orthopedics, Zhongnan Hospital of Wuhan University, No 169 Donghu Road, Wuchang District, 430071, Wuhan, China
    335 Department of pathology, Zhongnan Hospital of Wuhan University, Wuhan, China
    336 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...