The expression and significance of IDH1 and p53 in osteosarcoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Xiang Hu, Ai-Xi Yu, Bai-Wen Qi, Tao Fu, Gang Wu, Min Zhou, Jun Luo, Jun-Hua Xu

ABSTRACT

BACKGROUND: To detect the expression of isocitrate dehydrogenase 1 (IDH1) and transformation-related protein 53 (p53) in osteosarcoma and analyze the correlation between them and the clinico-pathological features. METHODS: The expressions of IDH1 and p53 were detected in human osteosarcoma cell lines (MG-63 and U2OS) by immunocytochemistry, Real-time PCR and Western Blotting. The expressions of IDH1 and p53 in formalin-fixed paraffin-embedded tissue sections from 44 osteosarcoma patients were determined by immunohistochemistry, and the correlation between them and clinicopagthological features were analyzed. None of these patients received chemotherapy prior to surgery. RESULTS: IDH1 is detected in osteosarcoma cell lines and biopsies. IDH1 expresses higher in U2OS cells with wild type p53 than in MG-63 cells with mutation p53. IDH1 correlates with histological Rosen grade and metastasis negatively. P53 correlates with histological Rosen grade, metastasis and overall survival in clinical osteosarcoma biopsies. Osteosarcoma patients with High IDH1 expression have a very high p53 expression. CONCLUSION: IDH1 may correlate with p53 and be a candidate biomarker for osteosarcoma correlate with histological Rosen grade and metastasis. More... »

PAGES

43

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1756-9966-29-43

    DOI

    http://dx.doi.org/10.1186/1756-9966-29-43

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044966861

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20459648


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