Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Irina A Maksakova, Peter J Thompson, Preeti Goyal, Steven JM Jones, Prim B Singh, Mohammad M Karimi, Matthew C Lorincz

ABSTRACT

BACKGROUND: In mouse embryonic stem cells (mESCs), transcriptional silencing of numerous class I and II endogenous retroviruses (ERVs), including IAP, ETn and MMERVK10C, is dependent upon the H3K9 methyltransferase (KMTase) SETDB1/ESET and its binding partner KAP1/TRIM28. In contrast, the H3K9 KMTases G9a and GLP and HP1 proteins are dispensable for this process. Intriguingly, MERVL retroelements are actively transcribed exclusively in the two-cell (2C) embryo, but the molecular basis of silencing of these class III ERVs at later developmental stages has not been systematically addressed. RESULTS: Here, we characterized the roles of these chromatin factors in MERVL silencing in mESCs. While MMERVK10C and IAP ERVs are bound by SETDB1 and KAP1 and are induced following their deletion, MERVL ERVs show relatively low levels of SETDB1 and KAP1 binding and are upregulated exclusively following KAP1 depletion, indicating that KAP1 influences MERVL expression independent of SETDB1. In contrast to class I and class II ERVs, MERVL and MERVL LTR-driven genic transcripts are also upregulated following depletion of G9a or GLP, and G9a binds directly to these ERVs. Consistent with a direct role for H3K9me2 in MERVL repression, these elements are highly enriched for G9a-dependent H3K9me2, and catalytically active G9a is required for silencing of MERVL LTR-driven transcripts. MERVL is also derepressed in HP1α and HP1β KO ESCs. However, like KAP1, HP1α and HP1β are only modestly enriched at MERVL relative to IAP LTRs. Intriguingly, as recently shown for KAP1, RYBP, LSD1 and G9a-deficient mESCs, many genes normally expressed in the 2C embryo are also induced in HP1 KO mESCs, revealing that aberrant expression of a subset of 2C-specific genes is a common feature in each of these KO lines. CONCLUSIONS: Our results indicate that G9a and GLP, which are not required for silencing of class I and II ERVs, are recruited to MERVL elements and play a direct role in silencing of these class III ERVs, dependent upon G9a catalytic activity. In contrast, induction of MERVL expression in KAP1, HP1α and HP1β KO ESCs may occur predominantly as a consequence of indirect effects, in association with activation of a subset of 2C-specific genes. More... »

PAGES

15

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1756-8935-6-15

DOI

http://dx.doi.org/10.1186/1756-8935-6-15

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053030605

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23735015


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Medical Genetics, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, V6T 1Z3, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maksakova", 
        "givenName": "Irina A", 
        "id": "sg:person.01215351736.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215351736.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Medical Genetics, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, V6T 1Z3, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thompson", 
        "givenName": "Peter J", 
        "id": "sg:person.01162254740.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162254740.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Medical Genetics, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, V6T 1Z3, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goyal", 
        "givenName": "Preeti", 
        "id": "sg:person.01101123336.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101123336.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "British Columbia Cancer Agency, Genome Sciences Centre, 675 West 10th Avenue, V5Z 4S6, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "Steven JM", 
        "id": "sg:person.011076371162.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011076371162.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "F\u00e4chereverbund Anatomie, Institut f\u00fcr Zell and Neurobiologie, Charite - Universit\u00e4tsmedizin, Charit\u00e9platz 1, 10117, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Singh", 
        "givenName": "Prim B", 
        "id": "sg:person.011057537062.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011057537062.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BC Cancer Agency", 
          "id": "https://www.grid.ac/institutes/grid.248762.d", 
          "name": [
            "Department of Medical Genetics, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, V6T 1Z3, Vancouver, British Columbia, Canada", 
            "British Columbia Cancer Agency, Genome Sciences Centre, 675 West 10th Avenue, V5Z 4S6, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Karimi", 
        "givenName": "Mohammad M", 
        "id": "sg:person.0716561536.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716561536.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Department of Medical Genetics, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, V6T 1Z3, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lorincz", 
        "givenName": "Matthew C", 
        "id": "sg:person.0623761643.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623761643.75"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/emboj/18.22.6385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000287558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02097-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000960173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m110.125674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002169335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrd.20387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002793861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrd.20387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002793861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2011.08.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003544325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/2413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003781258", 
          "https://doi.org/10.1038/2413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/2413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003781258", 
          "https://doi.org/10.1038/2413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/30.1.207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005297170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-genet-110711-155621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005304003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0021208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005485812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tibs.2011.11.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005687234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.19.6.4366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005857101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.82.5.1451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006472315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008081317", 
          "https://doi.org/10.1038/nature11244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/11.5.1475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008969197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gks686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009601082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/29.1.137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011277574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.949803", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011609775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.1371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011651858", 
          "https://doi.org/10.1038/nmeth.1371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.989402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012494380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2011.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014271428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.20.17.6449-6465.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014352072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkp972", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014907180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00934-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016765730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/mrd.10218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018020592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00487-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018064085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35065138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018164085", 
          "https://doi.org/10.1038/35065138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35065138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018164085", 
          "https://doi.org/10.1038/35065138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-8935-4-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018307289", 
          "https://doi.org/10.1186/1756-8935-4-12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00036-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018556433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1284005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019430805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gene.2003.09.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020364015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35065132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020526163", 
          "https://doi.org/10.1038/35065132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35065132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020526163", 
          "https://doi.org/10.1038/35065132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2003-4-10-231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020882271", 
          "https://doi.org/10.1186/gb-2003-4-10-231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.121749.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021580218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod.102.007906", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022073900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btn305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022099792"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1831909", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023158710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2004.01.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024751702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024952748", 
          "https://doi.org/10.1038/sj.onc.1210631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m413246200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025257210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btq351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025257348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026444453", 
          "https://doi.org/10.1038/nature08674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08674", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026444453", 
          "https://doi.org/10.1038/nature08674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1002301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027045799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2007.11.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028308157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1047-8477(02)00536-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028355034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1047-8477(02)00536-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028355034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1083558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028888669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.10.16.2067", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029053345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-213x-4-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029682700", 
          "https://doi.org/10.1186/1471-213x-4-12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.973302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030170977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e08-05-0510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030621946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000078195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031098689"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031637176", 
          "https://doi.org/10.1038/nature02886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031637176", 
          "https://doi.org/10.1038/nature02886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000078208", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032390246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bies.201000138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032578404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.2008511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034372281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-genet-102108-134802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034859326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gene.2009.06.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036985358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037699392", 
          "https://doi.org/10.1038/nature08858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037699392", 
          "https://doi.org/10.1038/nature08858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btp324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038266369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkp939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038538216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkp939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038538216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.0020002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039201483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039445188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pcbi.1002486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039509577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2008.192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039628742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039854529", 
          "https://doi.org/10.1038/nature01262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01262", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039854529", 
          "https://doi.org/10.1038/nature01262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkm726", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040565980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2005.01.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041828696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043011516", 
          "https://doi.org/10.1038/nature07844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043011516", 
          "https://doi.org/10.1038/nature07844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.1000869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043792705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2004.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045283233"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.1226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045381177", 
          "https://doi.org/10.1038/nmeth.1226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-4690-2-50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046286062", 
          "https://doi.org/10.1186/1742-4690-2-50"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(01)00218-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046890870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2004.12.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046965942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.078212.108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047542880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2008.193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049173964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ydbio.2007.05.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049220589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2007.07.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050314157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.06441-11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052246629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2010.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052307055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2144/000112900", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069095857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074263447", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077173174", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078332534", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "BACKGROUND: In mouse embryonic stem cells (mESCs), transcriptional silencing of numerous class I and II endogenous retroviruses (ERVs), including IAP, ETn and MMERVK10C, is dependent upon the H3K9 methyltransferase (KMTase) SETDB1/ESET and its binding partner KAP1/TRIM28. In contrast, the H3K9 KMTases G9a and GLP and HP1 proteins are dispensable for this process. Intriguingly, MERVL retroelements are actively transcribed exclusively in the two-cell (2C) embryo, but the molecular basis of silencing of these class III ERVs at later developmental stages has not been systematically addressed.\nRESULTS: Here, we characterized the roles of these chromatin factors in MERVL silencing in mESCs. While MMERVK10C and IAP ERVs are bound by SETDB1 and KAP1 and are induced following their deletion, MERVL ERVs show relatively low levels of SETDB1 and KAP1 binding and are upregulated exclusively following KAP1 depletion, indicating that KAP1 influences MERVL expression independent of SETDB1. In contrast to class I and class II ERVs, MERVL and MERVL LTR-driven genic transcripts are also upregulated following depletion of G9a or GLP, and G9a binds directly to these ERVs. Consistent with a direct role for H3K9me2 in MERVL repression, these elements are highly enriched for G9a-dependent H3K9me2, and catalytically active G9a is required for silencing of MERVL LTR-driven transcripts. MERVL is also derepressed in HP1\u03b1 and HP1\u03b2 KO ESCs. However, like KAP1, HP1\u03b1 and HP1\u03b2 are only modestly enriched at MERVL relative to IAP LTRs. Intriguingly, as recently shown for KAP1, RYBP, LSD1 and G9a-deficient mESCs, many genes normally expressed in the 2C embryo are also induced in HP1 KO mESCs, revealing that aberrant expression of a subset of 2C-specific genes is a common feature in each of these KO lines.\nCONCLUSIONS: Our results indicate that G9a and GLP, which are not required for silencing of class I and II ERVs, are recruited to MERVL elements and play a direct role in silencing of these class III ERVs, dependent upon G9a catalytic activity. In contrast, induction of MERVL expression in KAP1, HP1\u03b1 and HP1\u03b2 KO ESCs may occur predominantly as a consequence of indirect effects, in association with activation of a subset of 2C-specific genes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1756-8935-6-15", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1039921", 
        "issn": [
          "1756-8935"
        ], 
        "name": "Epigenetics & Chromatin", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "name": "Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells", 
    "pagination": "15", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fc99a5179e3dd23b024ff64ca34c979ac3e4e174edd9023e4d4278022c969328"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23735015"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101471619"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1756-8935-6-15"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1053030605"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1756-8935-6-15", 
      "https://app.dimensions.ai/details/publication/pub.1053030605"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000516.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1756-8935-6-15"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1756-8935-6-15'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1756-8935-6-15'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1756-8935-6-15'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1756-8935-6-15'


 

This table displays all metadata directly associated to this object as RDF triples.

379 TRIPLES      21 PREDICATES      112 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1756-8935-6-15 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author Nebd1ac54c3254ebf96d27405bd433ade
4 schema:citation sg:pub.10.1038/2413
5 sg:pub.10.1038/35065132
6 sg:pub.10.1038/35065138
7 sg:pub.10.1038/nature01262
8 sg:pub.10.1038/nature02886
9 sg:pub.10.1038/nature07844
10 sg:pub.10.1038/nature08674
11 sg:pub.10.1038/nature08858
12 sg:pub.10.1038/nature11244
13 sg:pub.10.1038/nmeth.1226
14 sg:pub.10.1038/nmeth.1371
15 sg:pub.10.1038/sj.onc.1210631
16 sg:pub.10.1186/1471-213x-4-12
17 sg:pub.10.1186/1742-4690-2-50
18 sg:pub.10.1186/1756-8935-4-12
19 sg:pub.10.1186/gb-2003-4-10-231
20 https://app.dimensions.ai/details/publication/pub.1074263447
21 https://app.dimensions.ai/details/publication/pub.1077173174
22 https://app.dimensions.ai/details/publication/pub.1078332534
23 https://doi.org/10.1002/bies.201000138
24 https://doi.org/10.1002/mrd.10218
25 https://doi.org/10.1002/mrd.20387
26 https://doi.org/10.1016/j.cell.2007.07.026
27 https://doi.org/10.1016/j.devcel.2004.09.004
28 https://doi.org/10.1016/j.gene.2003.09.022
29 https://doi.org/10.1016/j.gene.2009.06.020
30 https://doi.org/10.1016/j.molcel.2004.12.001
31 https://doi.org/10.1016/j.molcel.2007.11.012
32 https://doi.org/10.1016/j.molcel.2011.08.032
33 https://doi.org/10.1016/j.stem.2011.04.004
34 https://doi.org/10.1016/j.tibs.2011.11.006
35 https://doi.org/10.1016/j.virol.2010.12.007
36 https://doi.org/10.1016/j.ydbio.2004.01.028
37 https://doi.org/10.1016/j.ydbio.2005.01.025
38 https://doi.org/10.1016/j.ydbio.2007.05.003
39 https://doi.org/10.1016/s0092-8674(03)00934-6
40 https://doi.org/10.1016/s1047-8477(02)00536-1
41 https://doi.org/10.1016/s1097-2765(01)00218-0
42 https://doi.org/10.1038/emboj.2008.192
43 https://doi.org/10.1038/emboj.2008.193
44 https://doi.org/10.1038/sj.emboj.7600088
45 https://doi.org/10.1073/pnas.82.5.1451
46 https://doi.org/10.1074/jbc.m110.125674
47 https://doi.org/10.1074/jbc.m413246200
48 https://doi.org/10.1091/mbc.e08-05-0510
49 https://doi.org/10.1093/bioinformatics/btn305
50 https://doi.org/10.1093/bioinformatics/btp324
51 https://doi.org/10.1093/bioinformatics/btq351
52 https://doi.org/10.1093/emboj/18.22.6385
53 https://doi.org/10.1093/nar/11.5.1475
54 https://doi.org/10.1093/nar/29.1.137
55 https://doi.org/10.1093/nar/30.1.207
56 https://doi.org/10.1093/nar/gkm726
57 https://doi.org/10.1093/nar/gkp939
58 https://doi.org/10.1093/nar/gkp972
59 https://doi.org/10.1093/nar/gks686
60 https://doi.org/10.1095/biolreprod.102.007906
61 https://doi.org/10.1101/gad.10.16.2067
62 https://doi.org/10.1101/gad.1284005
63 https://doi.org/10.1101/gad.1831909
64 https://doi.org/10.1101/gad.2008511
65 https://doi.org/10.1101/gad.973302
66 https://doi.org/10.1101/gad.989402
67 https://doi.org/10.1101/gr.078212.108
68 https://doi.org/10.1101/gr.121749.111
69 https://doi.org/10.1101/gr.949803
70 https://doi.org/10.1126/science.1083558
71 https://doi.org/10.1128/jvi.02097-07
72 https://doi.org/10.1128/mcb.00036-07
73 https://doi.org/10.1128/mcb.00487-06
74 https://doi.org/10.1128/mcb.06441-11
75 https://doi.org/10.1128/mcb.19.6.4366
76 https://doi.org/10.1128/mcb.20.17.6449-6465.2000
77 https://doi.org/10.1146/annurev-genet-102108-134802
78 https://doi.org/10.1146/annurev-genet-110711-155621
79 https://doi.org/10.1159/000078195
80 https://doi.org/10.1159/000078208
81 https://doi.org/10.1371/journal.pcbi.1002486
82 https://doi.org/10.1371/journal.pgen.0020002
83 https://doi.org/10.1371/journal.pgen.1000869
84 https://doi.org/10.1371/journal.pgen.1002301
85 https://doi.org/10.1371/journal.pone.0021208
86 https://doi.org/10.2144/000112900
87 schema:datePublished 2013-12
88 schema:datePublishedReg 2013-12-01
89 schema:description BACKGROUND: In mouse embryonic stem cells (mESCs), transcriptional silencing of numerous class I and II endogenous retroviruses (ERVs), including IAP, ETn and MMERVK10C, is dependent upon the H3K9 methyltransferase (KMTase) SETDB1/ESET and its binding partner KAP1/TRIM28. In contrast, the H3K9 KMTases G9a and GLP and HP1 proteins are dispensable for this process. Intriguingly, MERVL retroelements are actively transcribed exclusively in the two-cell (2C) embryo, but the molecular basis of silencing of these class III ERVs at later developmental stages has not been systematically addressed. RESULTS: Here, we characterized the roles of these chromatin factors in MERVL silencing in mESCs. While MMERVK10C and IAP ERVs are bound by SETDB1 and KAP1 and are induced following their deletion, MERVL ERVs show relatively low levels of SETDB1 and KAP1 binding and are upregulated exclusively following KAP1 depletion, indicating that KAP1 influences MERVL expression independent of SETDB1. In contrast to class I and class II ERVs, MERVL and MERVL LTR-driven genic transcripts are also upregulated following depletion of G9a or GLP, and G9a binds directly to these ERVs. Consistent with a direct role for H3K9me2 in MERVL repression, these elements are highly enriched for G9a-dependent H3K9me2, and catalytically active G9a is required for silencing of MERVL LTR-driven transcripts. MERVL is also derepressed in HP1α and HP1β KO ESCs. However, like KAP1, HP1α and HP1β are only modestly enriched at MERVL relative to IAP LTRs. Intriguingly, as recently shown for KAP1, RYBP, LSD1 and G9a-deficient mESCs, many genes normally expressed in the 2C embryo are also induced in HP1 KO mESCs, revealing that aberrant expression of a subset of 2C-specific genes is a common feature in each of these KO lines. CONCLUSIONS: Our results indicate that G9a and GLP, which are not required for silencing of class I and II ERVs, are recruited to MERVL elements and play a direct role in silencing of these class III ERVs, dependent upon G9a catalytic activity. In contrast, induction of MERVL expression in KAP1, HP1α and HP1β KO ESCs may occur predominantly as a consequence of indirect effects, in association with activation of a subset of 2C-specific genes.
90 schema:genre research_article
91 schema:inLanguage en
92 schema:isAccessibleForFree true
93 schema:isPartOf N3d8688abee844938b124555a32e80a53
94 Nd88d4361cdbd4c08b4293020c26215be
95 sg:journal.1039921
96 schema:name Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells
97 schema:pagination 15
98 schema:productId N534f561869944ca69556292c879615d1
99 N7dc4c084c5e84f4eac285f2a0e527d79
100 Nc2823d8954c045579299ca6e1be746ac
101 Nc8a470d991ae43aa8613bb973ea0bca4
102 Ne2dec31662a4429dad615750dc52afcc
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053030605
104 https://doi.org/10.1186/1756-8935-6-15
105 schema:sdDatePublished 2019-04-10T19:10
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher N16b46e732a2442a8adf41c383d2464ff
108 schema:url http://link.springer.com/10.1186%2F1756-8935-6-15
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N16b46e732a2442a8adf41c383d2464ff schema:name Springer Nature - SN SciGraph project
113 rdf:type schema:Organization
114 N2c6ee8f6da46422f83fe332b6777ac17 rdf:first sg:person.0623761643.75
115 rdf:rest rdf:nil
116 N3d8688abee844938b124555a32e80a53 schema:volumeNumber 6
117 rdf:type schema:PublicationVolume
118 N425ab4baa1f6455b978eb0afc9817e21 rdf:first sg:person.011076371162.80
119 rdf:rest Ne50167a1594c4f89a5d7762c06e1c1f3
120 N47ea4cee434f45b28c5cf99482bb4c9f rdf:first sg:person.0716561536.97
121 rdf:rest N2c6ee8f6da46422f83fe332b6777ac17
122 N534f561869944ca69556292c879615d1 schema:name dimensions_id
123 schema:value pub.1053030605
124 rdf:type schema:PropertyValue
125 N59703693b5574ca89dbe635a7c0cda8c rdf:first sg:person.01162254740.31
126 rdf:rest Ne84ce208853b4bc98984f203f3adc152
127 N7dc4c084c5e84f4eac285f2a0e527d79 schema:name readcube_id
128 schema:value fc99a5179e3dd23b024ff64ca34c979ac3e4e174edd9023e4d4278022c969328
129 rdf:type schema:PropertyValue
130 Nc2823d8954c045579299ca6e1be746ac schema:name nlm_unique_id
131 schema:value 101471619
132 rdf:type schema:PropertyValue
133 Nc8a470d991ae43aa8613bb973ea0bca4 schema:name pubmed_id
134 schema:value 23735015
135 rdf:type schema:PropertyValue
136 Nd88d4361cdbd4c08b4293020c26215be schema:issueNumber 1
137 rdf:type schema:PublicationIssue
138 Ne2dec31662a4429dad615750dc52afcc schema:name doi
139 schema:value 10.1186/1756-8935-6-15
140 rdf:type schema:PropertyValue
141 Ne50167a1594c4f89a5d7762c06e1c1f3 rdf:first sg:person.011057537062.14
142 rdf:rest N47ea4cee434f45b28c5cf99482bb4c9f
143 Ne84ce208853b4bc98984f203f3adc152 rdf:first sg:person.01101123336.35
144 rdf:rest N425ab4baa1f6455b978eb0afc9817e21
145 Nebd1ac54c3254ebf96d27405bd433ade rdf:first sg:person.01215351736.65
146 rdf:rest N59703693b5574ca89dbe635a7c0cda8c
147 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
148 schema:name Biological Sciences
149 rdf:type schema:DefinedTerm
150 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
151 schema:name Genetics
152 rdf:type schema:DefinedTerm
153 sg:journal.1039921 schema:issn 1756-8935
154 schema:name Epigenetics & Chromatin
155 rdf:type schema:Periodical
156 sg:person.01101123336.35 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
157 schema:familyName Goyal
158 schema:givenName Preeti
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101123336.35
160 rdf:type schema:Person
161 sg:person.011057537062.14 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
162 schema:familyName Singh
163 schema:givenName Prim B
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011057537062.14
165 rdf:type schema:Person
166 sg:person.011076371162.80 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
167 schema:familyName Jones
168 schema:givenName Steven JM
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011076371162.80
170 rdf:type schema:Person
171 sg:person.01162254740.31 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
172 schema:familyName Thompson
173 schema:givenName Peter J
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162254740.31
175 rdf:type schema:Person
176 sg:person.01215351736.65 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
177 schema:familyName Maksakova
178 schema:givenName Irina A
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215351736.65
180 rdf:type schema:Person
181 sg:person.0623761643.75 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
182 schema:familyName Lorincz
183 schema:givenName Matthew C
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623761643.75
185 rdf:type schema:Person
186 sg:person.0716561536.97 schema:affiliation https://www.grid.ac/institutes/grid.248762.d
187 schema:familyName Karimi
188 schema:givenName Mohammad M
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716561536.97
190 rdf:type schema:Person
191 sg:pub.10.1038/2413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003781258
192 https://doi.org/10.1038/2413
193 rdf:type schema:CreativeWork
194 sg:pub.10.1038/35065132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020526163
195 https://doi.org/10.1038/35065132
196 rdf:type schema:CreativeWork
197 sg:pub.10.1038/35065138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018164085
198 https://doi.org/10.1038/35065138
199 rdf:type schema:CreativeWork
200 sg:pub.10.1038/nature01262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039854529
201 https://doi.org/10.1038/nature01262
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/nature02886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031637176
204 https://doi.org/10.1038/nature02886
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/nature07844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043011516
207 https://doi.org/10.1038/nature07844
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/nature08674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026444453
210 https://doi.org/10.1038/nature08674
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/nature08858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037699392
213 https://doi.org/10.1038/nature08858
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/nature11244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008081317
216 https://doi.org/10.1038/nature11244
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/nmeth.1226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045381177
219 https://doi.org/10.1038/nmeth.1226
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/nmeth.1371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011651858
222 https://doi.org/10.1038/nmeth.1371
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/sj.onc.1210631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024952748
225 https://doi.org/10.1038/sj.onc.1210631
226 rdf:type schema:CreativeWork
227 sg:pub.10.1186/1471-213x-4-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029682700
228 https://doi.org/10.1186/1471-213x-4-12
229 rdf:type schema:CreativeWork
230 sg:pub.10.1186/1742-4690-2-50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046286062
231 https://doi.org/10.1186/1742-4690-2-50
232 rdf:type schema:CreativeWork
233 sg:pub.10.1186/1756-8935-4-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018307289
234 https://doi.org/10.1186/1756-8935-4-12
235 rdf:type schema:CreativeWork
236 sg:pub.10.1186/gb-2003-4-10-231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020882271
237 https://doi.org/10.1186/gb-2003-4-10-231
238 rdf:type schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1074263447 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1077173174 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1078332534 schema:CreativeWork
242 https://doi.org/10.1002/bies.201000138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032578404
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1002/mrd.10218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018020592
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1002/mrd.20387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002793861
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.cell.2007.07.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050314157
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.devcel.2004.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045283233
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.gene.2003.09.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020364015
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.gene.2009.06.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036985358
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.molcel.2004.12.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046965942
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.molcel.2007.11.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028308157
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.molcel.2011.08.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003544325
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.stem.2011.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014271428
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.tibs.2011.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005687234
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.virol.2010.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052307055
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.ydbio.2004.01.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024751702
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.ydbio.2005.01.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041828696
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.ydbio.2007.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049220589
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/s0092-8674(03)00934-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016765730
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/s1047-8477(02)00536-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028355034
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/s1097-2765(01)00218-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046890870
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1038/emboj.2008.192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039628742
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1038/emboj.2008.193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049173964
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1038/sj.emboj.7600088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039445188
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1073/pnas.82.5.1451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006472315
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1074/jbc.m110.125674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002169335
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1074/jbc.m413246200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025257210
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1091/mbc.e08-05-0510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030621946
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1093/bioinformatics/btn305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022099792
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1093/bioinformatics/btp324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038266369
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1093/bioinformatics/btq351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025257348
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1093/emboj/18.22.6385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000287558
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1093/nar/11.5.1475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008969197
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1093/nar/29.1.137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011277574
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1093/nar/30.1.207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005297170
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1093/nar/gkm726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040565980
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1093/nar/gkp939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038538216
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1093/nar/gkp972 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014907180
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1093/nar/gks686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009601082
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1095/biolreprod.102.007906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022073900
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1101/gad.10.16.2067 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029053345
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1101/gad.1284005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019430805
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1101/gad.1831909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023158710
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1101/gad.2008511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034372281
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1101/gad.973302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030170977
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1101/gad.989402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012494380
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1101/gr.078212.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047542880
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1101/gr.121749.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021580218
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1101/gr.949803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011609775
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1126/science.1083558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028888669
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1128/jvi.02097-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000960173
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1128/mcb.00036-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018556433
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1128/mcb.00487-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018064085
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1128/mcb.06441-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052246629
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1128/mcb.19.6.4366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005857101
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1128/mcb.20.17.6449-6465.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014352072
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1146/annurev-genet-102108-134802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034859326
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1146/annurev-genet-110711-155621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005304003
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1159/000078195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031098689
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1159/000078208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032390246
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1371/journal.pcbi.1002486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039509577
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1371/journal.pgen.0020002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039201483
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1371/journal.pgen.1000869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043792705
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1371/journal.pgen.1002301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027045799
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1371/journal.pone.0021208 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005485812
367 rdf:type schema:CreativeWork
368 https://doi.org/10.2144/000112900 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069095857
369 rdf:type schema:CreativeWork
370 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
371 schema:name Department of Medical Genetics, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, V6T 1Z3, Vancouver, British Columbia, Canada
372 rdf:type schema:Organization
373 https://www.grid.ac/institutes/grid.248762.d schema:alternateName BC Cancer Agency
374 schema:name British Columbia Cancer Agency, Genome Sciences Centre, 675 West 10th Avenue, V5Z 4S6, Vancouver, British Columbia, Canada
375 Department of Medical Genetics, Life Sciences Institute, 2350 Health Sciences Mall, University of British Columbia, V6T 1Z3, Vancouver, British Columbia, Canada
376 rdf:type schema:Organization
377 https://www.grid.ac/institutes/grid.6363.0 schema:alternateName Charité
378 schema:name Fächereverbund Anatomie, Institut für Zell and Neurobiologie, Charite - Universitätsmedizin, Charitéplatz 1, 10117, Berlin, Germany
379 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...