Acute myeloid leukemia of donor origin after allogeneic stem cell transplantation from a sibling who harbors germline XPD and XRCC3 ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Hilda Rachel Diamond, Maria Helena Ornellas, Alberto Orfao, Bernadete E Gomes, Mércia M Campos, Teresa S Fernandez, Roberto I da Silva, Gilda Alves, Claudia Lage, Dayse A da Silva, Arthur Moellmann-Coelho, Geydson S da Cruz, Luis Fernando Bouzas, Eliana Abdelhay

ABSTRACT

A 54-year-old woman was diagnosed with infiltrative ductal breast carcinoma. Two years after treatment, the patient developed an acute myeloid leukemia (AML) which harbored del(11q23) in 8% of the blast cells. The patient was submitted for allogeneic stem cell transplantation (aSCT) from her HLA-compatible sister. Ten months after transplantation, she relapsed with an AML with basophilic maturation characterized by CD45(low) CD33(high), CD117⁺, CD13(-/+), HLA Dr(high), CD123(high), and CD203c⁺ blast cells lacking expression of CD7, CD10, CD34, CD15, CD14, CD56, CD36, CD64, and cytoplasmic tryptase. Karyotype analysis showed the emergence of a new clone with t(2;14) and FISH analysis indicated the presence of MLL gene rearrangement consistent with del(11q23). Interestingly, AML blast cell DNA tested with microsatellite markers showed the same pattern as the donor's, suggesting that this AML emerged from donor cells. Additionally, polymorphisms of the XPA, XPD, XRCC1, XRCC3 and RAD51 DNA repair genes revealed three unfavorable alleles with low DNA repair capacity.In summary, we report the first case of AML involving XPD and XRCC3 polymorphisms from donor origin following allogeneic stem cell transplantation and highlight the potential need for careful analysis of DNA repair gene polymorphisms in selecting candidate donors prior to allogeneic stem cell transplantation. More... »

PAGES

39

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1756-8722-4-39

DOI

http://dx.doi.org/10.1186/1756-8722-4-39

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020155168

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21951951


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